Aliases for GUCA1B Gene
External Ids for GUCA1B Gene
Previous GeneCards Identifiers for GUCA1B Gene
The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009]
GeneCards Summary for GUCA1B Gene
GUCA1B (Guanylate Cyclase Activator 1B) is a Protein Coding gene. Diseases associated with GUCA1B include retinitis pigmentosa 48 and guca1b-related retinitis pigmentosa. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. GO annotations related to this gene include calcium ion binding and guanylate cyclase regulator activity. An important paralog of this gene is KCNIP3.
UniProtKB/Swiss-Prot for GUCA1B Gene
Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.