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Aliases for PARVB Gene

Aliases for PARVB Gene

  • Parvin Beta 2 3 5
  • Affixin 2 3 4
  • Parvin, Beta 3
  • CGI-56 3

External Ids for PARVB Gene

Previous GeneCards Identifiers for PARVB Gene

  • GC22P041036
  • GC22P042653
  • GC22P042678
  • GC22P042545
  • GC22P042719
  • GC22P044395
  • GC22P027349

Summaries for PARVB Gene

Entrez Gene Summary for PARVB Gene

  • This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for PARVB Gene

PARVB (Parvin Beta) is a Protein Coding gene. Among its related pathways are Cell junction organization and ERK Signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is PARVA.

UniProtKB/Swiss-Prot for PARVB Gene

  • Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.

Gene Wiki entry for PARVB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARVB Gene

Genomics for PARVB Gene

Regulatory Elements for PARVB Gene

Enhancers for PARVB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PARVB on UCSC Golden Path with GeneCards custom track

Genomic Location for PARVB Gene

43,999,211 bp from pter
44,172,949 bp from pter
173,739 bases
Plus strand

Genomic View for PARVB Gene

Genes around PARVB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARVB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARVB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARVB Gene

Proteins for PARVB Gene

  • Protein details for PARVB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B0QYM8
    • B0QYN1
    • B2R9X6
    • Q5TGJ5
    • Q86X93
    • Q96PN1
    • Q9NSP7
    • Q9UGT3
    • Q9Y368
    • Q9Y3L6
    • Q9Y3L7

    Protein attributes for PARVB Gene

    364 amino acids
    Molecular mass:
    41714 Da
    Quaternary structure:
    • Interacts with DYSF. Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin.
    • Sequence=AAD34051.1; Type=Frameshift; Positions=4, 14, 48, 58, 155, 162, 171, 327, 331, 344; Evidence={ECO:0000305}; Sequence=BG743702; Type=Frameshift; Positions=136, 232, 237; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARVB Gene

    Alternative splice isoforms for PARVB Gene


neXtProt entry for PARVB Gene

Proteomics data for PARVB Gene at MOPED

Post-translational modifications for PARVB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PARVB Gene

Domains & Families for PARVB Gene

Gene Families for PARVB Gene

Protein Domains for PARVB Gene


Suggested Antigen Peptide Sequences for PARVB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 CH (calponin-homology) domains.
  • Belongs to the parvin family.
  • Contains 2 CH (calponin-homology) domains.
  • Belongs to the parvin family.
genes like me logo Genes that share domains with PARVB: view

Function for PARVB Gene

Molecular function for PARVB Gene

UniProtKB/Swiss-Prot Function:
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.
genes like me logo Genes that share phenotypes with PARVB: view

Animal Models for PARVB Gene

MGI Knock Outs for PARVB:

Animal Model Products

miRNA for PARVB Gene

miRTarBase miRNAs that target PARVB

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARVB Gene

Localization for PARVB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARVB Gene

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.

Subcellular locations from

Jensen Localization Image for PARVB Gene COMPARTMENTS Subcellular localization image for PARVB gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 5
nucleus 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PARVB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with PARVB: view

Pathways & Interactions for PARVB Gene

genes like me logo Genes that share pathways with PARVB: view

Pathways by source for PARVB Gene

1 GeneGo (Thomson Reuters) pathway for PARVB Gene
1 Qiagen pathway for PARVB Gene

Gene Ontology (GO) - Biological Process for PARVB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0071963 establishment or maintenance of cell polarity regulating cell shape IMP 15005707
genes like me logo Genes that share ontologies with PARVB: view

No data available for SIGNOR curated interactions for PARVB Gene

Drugs & Compounds for PARVB Gene

No Compound Related Data Available

Transcripts for PARVB Gene

Unigene Clusters for PARVB Gene

Parvin, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARVB Gene

No ASD Table

Relevant External Links for PARVB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PARVB Gene

mRNA expression in normal human tissues for PARVB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARVB Gene

This gene is overexpressed in Muscle - Skeletal (x5.7).

Protein differential expression in normal tissues from HIPED for PARVB Gene

This gene is overexpressed in Platelet (45.6) and Peripheral blood mononuclear cells (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PARVB Gene

SOURCE GeneReport for Unigene cluster for PARVB Gene Hs.475074

mRNA Expression by UniProt/SwissProt for PARVB Gene

Tissue specificity: Expressed predominantly in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with PARVB: view

Primer Products

No data available for Protein tissue co-expression partners for PARVB Gene

Orthologs for PARVB Gene

This gene was present in the common ancestor of animals.

Orthologs for PARVB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PARVB 35
  • 87.09 (n)
  • 90.66 (a)
  • 91 (a)
(Canis familiaris)
Mammalia PARVB 35
  • 88.69 (n)
  • 92.73 (a)
(Mus musculus)
Mammalia Parvb 35
  • 85.81 (n)
  • 92.86 (a)
Parvb 16
Parvb 36
  • 85 (a)
(Pan troglodytes)
Mammalia PARVB 35
  • 99.18 (n)
  • 98.9 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Parvb 35
  • 86.38 (n)
  • 92.57 (a)
(Ornithorhynchus anatinus)
Mammalia PARVB 36
  • 63 (a)
(Gallus gallus)
Aves PARVB 35
  • 79.52 (n)
  • 91.43 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia PARVB 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia parvb 35
  • 78.1 (n)
  • 86.86 (a)
Str.5959 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.29274 35
(Danio rerio)
Actinopterygii parvb 35
  • 71.63 (n)
  • 77.08 (a)
wufd02e01 35
parvb 36
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002356 35
  • 64.05 (n)
  • 62.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta parvin 35
  • 65.03 (n)
  • 60.4 (a)
CG32528 36
  • 54 (a)
(Caenorhabditis elegans)
Secernentea pat-6 37
  • 46 (a)
pat-6 36
  • 44 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3317 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
Species with no ortholog for PARVB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PARVB Gene

Gene Tree for PARVB (if available)
Gene Tree for PARVB (if available)

Paralogs for PARVB Gene

Paralogs for PARVB Gene

(3) SIMAP similar genes for PARVB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PARVB: view

Variants for PARVB Gene

Sequence variations from dbSNP and Humsavar for PARVB Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1983609 - 44,093,988(+) CCTGG(C/T)GGATG reference, missense
rs34476853 - 44,093,970(+) CTCAC(C/G/T)GATGT reference, missense, utr-variant-5-prime
rs79470 -- 44,159,072(+) GAGAG(A/C)GAGCG intron-variant
rs79471 -- 44,159,148(+) ACCAG(A/G)TGCCT intron-variant
rs79472 -- 44,160,221(+) CTGTC(C/G)AGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PARVB Gene

Variant ID Type Subtype PubMed ID
nsv834219 CNV Gain 17160897
nsv459895 CNV Gain 19166990
nsv471206 CNV Gain 18288195
esv2676055 CNV Deletion 23128226
esv991955 CNV Insertion 20482838
esv2724331 CNV Deletion 23290073
nsv915266 CNV Loss 21882294
esv2724332 CNV Deletion 23290073
esv2670736 CNV Deletion 23128226
nsv510809 CNV Loss 20534489
esv2724333 CNV Deletion 23290073
esv2005538 CNV Deletion 18987734
nsv820857 CNV Deletion 20802225
esv2724334 CNV Deletion 23290073
esv22732 CNV Gain 19812545
esv1420958 CNV Insertion 17803354
esv2356466 CNV Deletion 18987734
esv1973166 CNV Deletion 18987734
esv2724335 CNV Deletion 23290073
esv2724336 CNV Deletion 23290073
esv2724337 CNV Deletion 23290073
esv2724338 CNV Deletion 23290073
nsv915267 CNV Loss 21882294
esv2724340 CNV Deletion 23290073
esv2724341 CNV Deletion 23290073
nsv508740 CNV Insertion 20534489
nsv915268 CNV Loss 21882294
esv2724342 CNV Deletion 23290073
esv2724343 CNV Deletion 23290073
esv2724344 CNV Deletion 23290073
esv2724345 CNV Deletion 23290073
esv2672411 CNV Deletion 23128226
esv2660969 CNV Deletion 23128226
esv27983 CNV Loss 19812545

Variation tolerance for PARVB Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PARVB Gene

Disorders for PARVB Gene

Relevant External Links for PARVB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PARVB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARVB Gene

Publications for PARVB Gene

  1. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. (PMID: 11171322) Olski T.M. … Korenbaum E. (J. Cell Sci. 2001) 2 3 4 23 67
  2. Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism. (PMID: 19885839) GagnAc D. … Beaulieu J.F. (J. Cell. Physiol. 2010) 3 23
  3. Functional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of beta-parvin. (PMID: 20164304) Kimura M. … Kobayashi E. (J. Cell. Sci. 2010) 3 23
  4. Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation. (PMID: 17998334) Johnstone C.N. … Rustgi A.K. (Mol. Cell. Biol. 2008) 3 23
  5. Affixin activates Rac1 via betaPIX in C2C12 myoblast. (PMID: 18325335) Matsuda C. … Hayashi Y.K. (FEBS Lett. 2008) 3 23

Products for PARVB Gene

Sources for PARVB Gene