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Aliases for GUCY1A2 Gene

Aliases for GUCY1A2 Gene

  • Guanylate Cyclase 1, Soluble, Alpha 2 2 3
  • GUC1A2 3 4 6
  • GCS-Alpha-2 3 4
  • EC 4.6.1.2 4 63
  • Guanylate Cyclase Soluble Subunit Alpha-2 3
  • GC-SA2 3
  • GUCSA2 4

External Ids for GUCY1A2 Gene

Previous Symbols for GUCY1A2 Gene

  • GUC1A2

Summaries for GUCY1A2 Gene

Entrez Gene Summary for GUCY1A2 Gene

  • Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for GUCY1A2 Gene

GUCY1A2 (Guanylate Cyclase 1, Soluble, Alpha 2) is a Protein Coding gene. Diseases associated with GUCY1A2 include colorectal cancer. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include GTP binding and guanylate cyclase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for GUCY1A2 Gene

  • Has guanylyl cyclase on binding to the beta-1 subunit

  • Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits

Tocris Summary for GUCY1A2 Gene

  • Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or Mn2+, convert guanosine-5-triphosphate (GTP) into 3,5-guanosine monophosphate (cGMP) and pyrophosphate. The second messenger cGMP participates in signaling by stimulating protein kinase G enzymes, altering the conductance of cGMP-gated ion channels and changing the activity of cGMP-regulated phosphodiesterases. There are two main groups of guanylyl cyclase; soluble GC (sGC), which are the receptor for nitric oxide (NO) and transmembrane GC (pGC), which serves as a receptor for natriuretic peptides. Key physiological roles for guanylyl cyclases include regulation of cell hyperplasia, hypertrophy, migration, extracellular matrix production, cell differentiation and tumor progression. In addition, guanylyl cyclases mediate important communication between the heart, intestine and kidney to regulate blood volume and Na+ balance.

Gene Wiki entry for GUCY1A2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCY1A2 Gene

Genomics for GUCY1A2 Gene

Genomic Location for GUCY1A2 Gene

Start:
106,674,012 bp from pter
End:
107,018,524 bp from pter
Size:
344,513 bases
Orientation:
Minus strand

Genomic View for GUCY1A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GUCY1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCY1A2 Gene

Regulatory Elements for GUCY1A2 Gene

Proteins for GUCY1A2 Gene

  • Protein details for GUCY1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33402-GCYA2_HUMAN
    Recommended name:
    Guanylate cyclase soluble subunit alpha-2
    Protein Accession:
    P33402
    Secondary Accessions:
    • A1L4C4
    • B7ZLT5

    Protein attributes for GUCY1A2 Gene

    Size:
    732 amino acids
    Molecular mass:
    81750 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta chain
    Miscellaneous:
    • There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms

    Alternative splice isoforms for GUCY1A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GUCY1A2 Gene

Proteomics data for GUCY1A2 Gene at MOPED

Post-translational modifications for GUCY1A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GUCY1A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GUCY1A2 Gene

Gene Families for GUCY1A2 Gene

Suggested Antigen Peptide Sequences for GUCY1A2 Gene

Graphical View of Domain Structure for InterPro Entry

P33402

UniProtKB/Swiss-Prot:

GCYA2_HUMAN
Domain:
  • Contains 1 guanylate cyclase domain.:
    • P33402
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.:
    • P33402
genes like me logo Genes that share domains with GUCY1A2: view

Function for GUCY1A2 Gene

Molecular function for GUCY1A2 Gene

GENATLAS Biochemistry: guanylate cyclase,soluble,alpha-2 subunit,79kDa,heterodimerizing with GUCY1B1
UniProtKB/Swiss-Prot CatalyticActivity: GTP = 3,5-cyclic GMP + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by nitric oxide in the presence of magnesium or manganese ions
UniProtKB/Swiss-Prot Function: Has guanylyl cyclase on binding to the beta-1 subunit
UniProtKB/Swiss-Prot Function: Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits

Enzyme Numbers (IUBMB) for GUCY1A2 Gene

Gene Ontology (GO) - Molecular Function for GUCY1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004383 guanylate cyclase activity IEA --
GO:0005515 protein binding --
GO:0005525 GTP binding IEA --
GO:0016849 phosphorus-oxygen lyase activity --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with GUCY1A2: view
genes like me logo Genes that share phenotypes with GUCY1A2: view

Animal Models for GUCY1A2 Gene

MGI Knock Outs for GUCY1A2:

miRNA for GUCY1A2 Gene

miRTarBase miRNAs that target GUCY1A2

No data available for Transcription Factor Targeting and HOMER Transcription for GUCY1A2 Gene

Localization for GUCY1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCY1A2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GUCY1A2 Gene COMPARTMENTS Subcellular localization image for GUCY1A2 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GUCY1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GUCY1A2: view

Pathways for GUCY1A2 Gene

genes like me logo Genes that share pathways with GUCY1A2: view

Gene Ontology (GO) - Biological Process for GUCY1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006182 cGMP biosynthetic process IEA --
GO:0007165 signal transduction TAS 1683630
GO:0007596 blood coagulation TAS --
GO:0009190 cyclic nucleotide biosynthetic process --
GO:0030828 positive regulation of cGMP biosynthetic process IEA --
genes like me logo Genes that share ontologies with GUCY1A2: view

Compounds for GUCY1A2 Gene

(5) Tocris Compounds for GUCY1A2 Gene

Compound Action Cas Number
A 350619 hydrochloride Soluble guanylyl cyclase (sGC) activator [538368-27-3]
BAY 41-2272 Soluble guanylyl cyclase (sGC) activator [256376-24-6]
NS 2028 Potent soluble guanylyl cyclase (sGC) inhibitor [204326-43-2]
YC 1 Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest [170632-47-0]
Zinc protoporphyrin IX Heme oxygenase and guanylyl cyclase inhibitor [15442-64-5]

(6) HMDB Compounds for GUCY1A2 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine triphosphate
  • 5'-GTP
86-01-1
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2

(2) Drugbank Compounds for GUCY1A2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Isosorbide Mononitrate
  • IHD
16051-77-7 target inducer
Nitric Oxide
10102-43-9 target inducer
genes like me logo Genes that share compounds with GUCY1A2: view

Transcripts for GUCY1A2 Gene

mRNA/cDNA for GUCY1A2 Gene

Unigene Clusters for GUCY1A2 Gene

Guanylate cyclase 1, soluble, alpha 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY1A2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: -

Relevant External Links for GUCY1A2 Gene

GeneLoc Exon Structure for
GUCY1A2
ECgene alternative splicing isoforms for
GUCY1A2

Expression for GUCY1A2 Gene

mRNA expression in normal human tissues for GUCY1A2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GUCY1A2 Gene

SOURCE GeneReport for Unigene cluster for GUCY1A2 Gene Hs.24321

mRNA Expression by UniProt/SwissProt for GUCY1A2 Gene

P33402-GCYA2_HUMAN
Tissue specificity: Isoform 1 is expressed in fetal brain, liver, colon, endothelium and testis. Isoform 2 is expressed only in liver, colon and endothelium
genes like me logo Genes that share expressions with GUCY1A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GUCY1A2 Gene

Orthologs for GUCY1A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GUCY1A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GUCY1A2 35
  • 99.08 (n)
  • 99.21 (a)
GUCY1A2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GUCY1A2 35
  • 91.74 (n)
  • 93.97 (a)
GUCY1A2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GUCY1A2 35
  • 89.98 (n)
  • 92.49 (a)
GUCY1A2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gucy1a2 35
  • 87.03 (n)
  • 90.55 (a)
Gucy1a2 16
Gucy1a2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GUCY1A2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GUCY1A2 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gucy1a2 35
  • 87.17 (n)
  • 91.23 (a)
chicken
(Gallus gallus)
Aves GUCY1A2 35
  • 80.57 (n)
  • 86.49 (a)
GUCY1A2 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GUCY1A2 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gucy1a2 35
  • 76.01 (n)
  • 81.97 (a)
zebrafish
(Danio rerio)
Actinopterygii GUCY1A2 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000280 35
  • 48.09 (n)
  • 41.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gycalpha99B 35
  • 50.74 (n)
  • 43.64 (a)
Gycalpha99B 36
  • 36 (a)
OneToMany
Gycalpha99B 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea gcy-5 36
  • 12 (a)
ManyToMany
gcy-31 37
  • 34 (a)
gcy-37 37
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for GUCY1A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GUCY1A2 Gene

ENSEMBL:
Gene Tree for GUCY1A2 (if available)
TreeFam:
Gene Tree for GUCY1A2 (if available)

Paralogs for GUCY1A2 Gene

Selected SIMAP similar genes for GUCY1A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GUCY1A2: view

Variants for GUCY1A2 Gene

Sequence variations from dbSNP and Humsavar for GUCY1A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs544260 -- 106,721,153(-) tgaac(C/G)tggga intron-variant
rs544482 -- 106,721,081(-) tgtct(C/T)aaaaa intron-variant
rs550674 -- 106,710,985(-) ATTAG(C/T)TTCAA intron-variant
rs563070 -- 106,724,219(-) GCAGG(A/G)CTGAG intron-variant
rs584719 -- 106,700,857(-) GATCC(A/C)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GUCY1A2 Gene

Variant ID Type Subtype PubMed ID
nsv898359 CNV Loss 21882294
dgv1311n71 CNV Loss 21882294
esv1074601 CNV Insertion 17803354
esv1117785 CNV Insertion 17803354
esv2745032 CNV Deletion 23290073
esv2745033 CNV Deletion 23290073
esv2667580 CNV Deletion 23128226
esv2745034 CNV Deletion 23290073
esv2590906 CNV Deletion 19546169
esv2222990 CNV Deletion 18987734
esv2745035 CNV Deletion 23290073
esv2663324 CNV Deletion 23128226
esv997476 CNV Deletion 20482838
esv9628 CNV Loss 19470904
esv1462632 CNV Deletion 17803354
nsv39784 CNV Loss 16902084
esv2675821 CNV Deletion 23128226
esv5504 CNV Gain 19470904
esv2620868 CNV Insertion 19546169
nsv527620 CNV Loss 19592680
esv2745036 CNV Deletion 23290073
nsv898362 CNV Loss 21882294
nsv474 CNV Loss 18451855
dgv239n67 CNV Loss 20364138
esv28258 CNV Loss 19812545
esv2745037 CNV Deletion 23290073
nsv498770 CNV Loss 21111241
esv2669729 CNV Deletion 23128226
nsv514589 CNV Loss 21397061
esv7117 CNV Gain 19470904
esv9111 CNV Gain 19470904
esv1005254 CNV Insertion 20482838
esv1671016 CNV Insertion 17803354
nsv39525 CNV Insertion 16902084
nsv38495 CNV Insertion 16902084
esv2745038 CNV Deletion 23290073
dgv166e201 CNV Deletion 23290073
esv2661753 CNV Deletion 23128226
esv2745040 CNV Deletion 23290073

Relevant External Links for GUCY1A2 Gene

HapMap Linkage Disequilibrium report
GUCY1A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GUCY1A2 Gene

Disorders for GUCY1A2 Gene

(1) MalaCards Diseases for GUCY1A2 Gene

Search for GUCY1A2 Gene in MalaCards »

Relevant External Links for GUCY1A2

Genetic Association Database (GAD)
GUCY1A2
Human Genome Epidemiology (HuGE) Navigator
GUCY1A2
genes like me logo Genes that share disorders with GUCY1A2: view

No data available for UniProtKB/Swiss-Prot for GUCY1A2 Gene

Publications for GUCY1A2 Gene

  1. Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme. (PMID: 1683630) Harteneck C. … Schultz G. (FEBS Lett. 1991) 2 3 4
  2. A variant of the alpha 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein. (PMID: 7673142) Behrends S. … Koesling D. (J. Biol. Chem. 1995) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  5. Role of soluble guanylyl cyclase-cyclic GMP signaling in tumor cell proliferation. (PMID: 19948239) Mujoo K. … Murad F. (Nitric Oxide 2010) 3

Products for GUCY1A2 Gene

Sources for GUCY1A2 Gene

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