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Aliases for GTF3C2 Gene

Aliases for GTF3C2 Gene

  • General Transcription Factor IIIC Subunit 2 2 3 5
  • General Transcription Factor IIIC, Polypeptide 2, Beta 110kDa 2 3
  • Transcription Factor IIIC 110 KDa Subunit 3 4
  • Transcription Factor IIIC Subunit Beta 3 4
  • TFIIIC 110 KDa Subunit 3 4
  • TF3C-Beta 3 4
  • TFIIIC110 3 4
  • General Transcription Factor IIIC, Polypeptide 2 (Beta Subunit, 110kD) 2
  • TFIIIC-BETA 3
  • KIAA0011 4

External Ids for GTF3C2 Gene

Previous GeneCards Identifiers for GTF3C2 Gene

  • GC02M027470
  • GC02M027641
  • GC02M027523
  • GC02M027460
  • GC02M027402
  • GC02M027548

Summaries for GTF3C2 Gene

GeneCards Summary for GTF3C2 Gene

GTF3C2 (General Transcription Factor IIIC Subunit 2) is a Protein Coding gene. Among its related pathways are Transcription of tRNA and Gene Expression.

UniProtKB/Swiss-Prot for GTF3C2 Gene

  • Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.

Gene Wiki entry for GTF3C2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3C2 Gene

Genomics for GTF3C2 Gene

Regulatory Elements for GTF3C2 Gene

Enhancers for GTF3C2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GTF3C2 on UCSC Golden Path with GeneCards custom track

Promoters for GTF3C2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GTF3C2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GTF3C2 Gene

Chromosome:
2
Start:
27,325,849 bp from pter
End:
27,357,034 bp from pter
Size:
31,186 bases
Orientation:
Minus strand

Genomic View for GTF3C2 Gene

Genes around GTF3C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C2 Gene

Proteins for GTF3C2 Gene

  • Protein details for GTF3C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUA4-TF3C2_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 2
    Protein Accession:
    Q8WUA4
    Secondary Accessions:
    • D6W557
    • Q16632
    • Q9BWI7

    Protein attributes for GTF3C2 Gene

    Size:
    911 amino acids
    Molecular mass:
    100680 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6.

    Alternative splice isoforms for GTF3C2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTF3C2 Gene

Proteomics data for GTF3C2 Gene at MOPED

Post-translational modifications for GTF3C2 Gene

  • Ubiquitination at Lys 602
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GTF3C2 Gene

Domains & Families for GTF3C2 Gene

Protein Domains for GTF3C2 Gene

Suggested Antigen Peptide Sequences for GTF3C2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUA4

UniProtKB/Swiss-Prot:

TF3C2_HUMAN :
  • Contains 6 WD repeats.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with GTF3C2: view

Function for GTF3C2 Gene

Molecular function for GTF3C2 Gene

UniProtKB/Swiss-Prot Function:
Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.
genes like me logo Genes that share phenotypes with GTF3C2: view

Animal Model Products

miRNA for GTF3C2 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3C2 Gene

Localization for GTF3C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF3C2 Gene COMPARTMENTS Subcellular localization image for GTF3C2 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for GTF3C2 Gene

Pathways & Interactions for GTF3C2 Gene

genes like me logo Genes that share pathways with GTF3C2: view

Gene Ontology (GO) - Biological Process for GTF3C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006383 transcription from RNA polymerase III promoter IDA,TAS 17409385
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with GTF3C2: view

No data available for SIGNOR curated interactions for GTF3C2 Gene

Drugs & Compounds for GTF3C2 Gene

No Compound Related Data Available

Transcripts for GTF3C2 Gene

Unigene Clusters for GTF3C2 Gene

General transcription factor IIIC, polypeptide 2, beta 110kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - - - - - - - - -
SP4: -
SP5: -
SP6: - - - - - -
SP7: - - -
SP8:
SP9: - - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - -

ExUns: 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23a · 23b
SP1: - -
SP2:
SP3: - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:

Relevant External Links for GTF3C2 Gene

GeneLoc Exon Structure for
GTF3C2
ECgene alternative splicing isoforms for
GTF3C2

Expression for GTF3C2 Gene

mRNA expression in normal human tissues for GTF3C2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GTF3C2 Gene

This gene is overexpressed in Serum (23.7) and Lung (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF3C2 Gene



SOURCE GeneReport for Unigene cluster for GTF3C2 Gene Hs.75782

genes like me logo Genes that share expression patterns with GTF3C2: view

Protein tissue co-expression partners for GTF3C2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF3C2 Gene

Orthologs for GTF3C2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GTF3C2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTF3C2 35
  • 90.98 (n)
  • 89.55 (a)
GTF3C2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF3C2 35
  • 92.2 (n)
  • 93.74 (a)
GTF3C2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf3c2 35
  • 88.45 (n)
  • 88.96 (a)
Gtf3c2 16
Gtf3c2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTF3C2 35
  • 99.7 (n)
  • 100 (a)
GTF3C2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf3c2 35
  • 88.62 (n)
  • 89.21 (a)
oppossum
(Monodelphis domestica)
Mammalia GTF3C2 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF3C2 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF3C2 35
  • 63.6 (n)
  • 63.6 (a)
GTF3C2 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF3C2 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497817 35
  • 56.58 (n)
  • 50.2 (a)
zebrafish
(Danio rerio)
Actinopterygii gtf3c2 35
  • 52.98 (n)
  • 43.26 (a)
gtf3c2 36
  • 39 (a)
OneToOne
Species with no ortholog for GTF3C2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF3C2 Gene

ENSEMBL:
Gene Tree for GTF3C2 (if available)
TreeFam:
Gene Tree for GTF3C2 (if available)

Paralogs for GTF3C2 Gene

No data available for Paralogs for GTF3C2 Gene

Variants for GTF3C2 Gene

Sequence variations from dbSNP and Humsavar for GTF3C2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1804410 -- 27,328,901(-) ATTGA(C/T)GCTGG reference, synonymous-codon
rs1049817 -- 27,328,100(-) CCTCC(C/T)AAGGC reference, synonymous-codon
rs9711708 -- 27,346,330(+) GATAC(A/C)TTTTT intron-variant
rs11689803 -- 27,343,653(+) CATCT(A/T)TTCTC intron-variant
rs11693959 -- 27,351,292(+) ACTTG(C/T)AGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTF3C2 Gene

Variant ID Type Subtype PubMed ID
nsv873754 CNV Loss 21882294
nsv833614 CNV Gain 17160897
nsv2654 CNV Insertion 18451855
dgv4072n71 CNV Loss 21882294

Variation tolerance for GTF3C2 Gene

Residual Variation Intolerance Score: 4.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF3C2 Gene

HapMap Linkage Disequilibrium report
GTF3C2
Human Gene Mutation Database (HGMD)
GTF3C2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF3C2 Gene

Disorders for GTF3C2 Gene

Relevant External Links for GTF3C2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF3C2

No disorders were found for GTF3C2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF3C2 Gene

Publications for GTF3C2 Gene

  1. Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors. (PMID: 7729686) Sinn E. … Roeder R.G. (Genes Dev. 1995) 2 3 4 23 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3

Products for GTF3C2 Gene

Sources for GTF3C2 Gene

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