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Aliases for GTF3A Gene

Aliases for GTF3A Gene

  • General Transcription Factor IIIA 2 3 5
  • TFIIIA 3 4
  • Transcription Factor IIIA 3
  • AP2 3

External Ids for GTF3A Gene

Previous GeneCards Identifiers for GTF3A Gene

  • GC13P025978
  • GC13P021978
  • GC13P026928
  • GC13P025796
  • GC13P026896
  • GC13P027998
  • GC13P008820

Summaries for GTF3A Gene

Entrez Gene Summary for GTF3A Gene

  • The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTF3A Gene

GTF3A (General Transcription Factor IIIA) is a Protein Coding gene. Among its related pathways are IL4-mediated signaling events and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ZXDC.

UniProtKB/Swiss-Prot for GTF3A Gene

  • Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNAs. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes.

Gene Wiki entry for GTF3A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3A Gene

Genomics for GTF3A Gene

Regulatory Elements for GTF3A Gene

Enhancers for GTF3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G027444 1.6 Ensembl ENCODE dbSUPER 18.3 +23.8 23759 7.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 KLF13 MTIF3 GTF3A PIR36871 GC13M027437
GH13G027459 0.9 ENCODE 16.9 +35.2 35191 0.5 TBP TBL1XR1 WRNIP1 YY1 EGR1 ELK1 ZNF143 PCBP1 ZNF263 USF2 GTF3A MTIF3 RNU6-63P GC13P027459
GH13G027455 1.2 Ensembl ENCODE dbSUPER 11.6 +31.2 31248 1.3 ESRRA IRF2 L3MBTL2 NR2F1 ZBTB40 FOXM1 POLR2A CEBPA IRF1 IKZF2 MTIF3 GTF3A RNU6-63P GC13P027459
GH13G027423 1.3 ENCODE dbSUPER 10.2 +2.2 2152 5.8 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 MTIF3 GTF3A GC13M027437
GH13G027372 1 Ensembl ENCODE 11.8 -50.6 -50622 2.8 CTCF FOXA2 CREB3L1 ARID4B MAX RAD21 E2F1 GATA3 POLR2A ZNF143 GTF3A LNX2 POLR1D RNU6-63P LOC105370126 LINC01079
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GTF3A on UCSC Golden Path with GeneCards custom track

Promoters for GTF3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000060338 56 1201 PKNOX1 ATF1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ELK1 ZNF143
ENSR00000271323 1556 601 HDGF ATF1 ARNT WRNIP1 ARID4B SIN3A ZNF2 YY1 GATA2 FOS

Genomic Location for GTF3A Gene

Chromosome:
13
Start:
27,424,544 bp from pter
End:
27,435,823 bp from pter
Size:
11,280 bases
Orientation:
Plus strand

Genomic View for GTF3A Gene

Genes around GTF3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3A Gene

Proteins for GTF3A Gene

  • Protein details for GTF3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92664-TF3A_HUMAN
    Recommended name:
    Transcription factor IIIA
    Protein Accession:
    Q92664
    Secondary Accessions:
    • B7ZBK5
    • Q12963
    • Q13097

    Protein attributes for GTF3A Gene

    Size:
    365 amino acids
    Molecular mass:
    41515 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA06988.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA06988.1; Type=Frameshift; Positions=319, 330; Evidence={ECO:0000305};

    Alternative splice isoforms for GTF3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTF3A Gene

Post-translational modifications for GTF3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GTF3A Gene

No data available for DME Specific Peptides for GTF3A Gene

Domains & Families for GTF3A Gene

Protein Domains for GTF3A Gene

Suggested Antigen Peptide Sequences for GTF3A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GTF3A: view

No data available for UniProtKB/Swiss-Prot for GTF3A Gene

Function for GTF3A Gene

Molecular function for GTF3A Gene

GENATLAS Biochemistry:
general transcription factor IIIA,Xenopus homolog,required for initiation of transcription of 5S RNA
UniProtKB/Swiss-Prot Function:
Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNAs. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes.

Gene Ontology (GO) - Molecular Function for GTF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GTF3A: view
genes like me logo Genes that share phenotypes with GTF3A: view

Animal Model Products

CRISPR Products

miRNA for GTF3A Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3A Gene

Localization for GTF3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF3A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for GTF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GTF3A: view

Pathways & Interactions for GTF3A Gene

genes like me logo Genes that share pathways with GTF3A: view

Gene Ontology (GO) - Biological Process for GTF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006383 transcription from RNA polymerase III promoter TAS 7789179
GO:0009303 rRNA transcription TAS 8063702
genes like me logo Genes that share ontologies with GTF3A: view

No data available for SIGNOR curated interactions for GTF3A Gene

Drugs & Compounds for GTF3A Gene

(11) Drugs for GTF3A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for GTF3A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GTF3A: view

Transcripts for GTF3A Gene

Unigene Clusters for GTF3A Gene

General transcription factor IIIA:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - -
SP9: -
SP10: - - - -
SP11:

Relevant External Links for GTF3A Gene

GeneLoc Exon Structure for
GTF3A
ECgene alternative splicing isoforms for
GTF3A

Expression for GTF3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GTF3A Gene

Protein differential expression in normal tissues from HIPED for GTF3A Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GTF3A Gene



Protein tissue co-expression partners for GTF3A Gene

NURSA nuclear receptor signaling pathways regulating expression of GTF3A Gene:

GTF3A

SOURCE GeneReport for Unigene cluster for GTF3A Gene:

Hs.445977

mRNA Expression by UniProt/SwissProt for GTF3A Gene:

Q92664-TF3A_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for GTF3A Gene

  • Nervous system(4.7)
  • Intestine(2.8)
  • Heart(2.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with GTF3A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF3A Gene

Orthologs for GTF3A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTF3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF3A 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia GTF3A 34 35
  • 86.2 (n)
rat
(Rattus norvegicus)
Mammalia Gtf3a 34
  • 80.94 (n)
cow
(Bos Taurus)
Mammalia GTF3A 34 35
  • 80.41 (n)
mouse
(Mus musculus)
Mammalia Gtf3a 34 16 35
  • 80.2 (n)
oppossum
(Monodelphis domestica)
Mammalia GTF3A 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF3A 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF3A 34 35
  • 68.18 (n)
lizard
(Anolis carolinensis)
Reptilia GTF3A 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf3a 34
  • 61.06 (n)
Str.17731 34
African clawed frog
(Xenopus laevis)
Amphibia LOC397777 34
zebrafish
(Danio rerio)
Actinopterygii gtf3aa 34 35
  • 61.49 (n)
gtf3ab 35
  • 41 (a)
OneToMany
GTF3A (2 of 3) 35
  • 29 (a)
OneToMany
Dr.14750 34
fruit fly
(Drosophila melanogaster)
Insecta CG9609 34 35 36
  • 42.89 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWI5 35
  • 6 (a)
ManyToMany
ACE2 35
  • 5 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sfc2 34
  • 50 (n)
Species where no ortholog for GTF3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF3A Gene

ENSEMBL:
Gene Tree for GTF3A (if available)
TreeFam:
Gene Tree for GTF3A (if available)

Paralogs for GTF3A Gene

Paralogs for GTF3A Gene

genes like me logo Genes that share paralogs with GTF3A: view

Variants for GTF3A Gene

Sequence variations from dbSNP and Humsavar for GTF3A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000323459 -- 27,429,755(+) TATTT(C/T)ATAGT intron-variant
rs1000760497 -- 27,431,732(+) AGGAT(C/T)CATCC intron-variant
rs1000846928 -- 27,425,255(+) AAACA(A/C)TGGCC intron-variant
rs1000866716 -- 27,432,344(+) CTGTC(C/T)CGCAC intron-variant
rs1001194290 -- 27,432,143(+) CCAGC(A/G)GCTCT intron-variant

Variation tolerance for GTF3A Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.61; 72.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GTF3A Gene

Disorders for GTF3A Gene

Relevant External Links for GTF3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF3A

No disorders were found for GTF3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF3A Gene

Publications for GTF3A Gene

  1. Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA. (PMID: 7789179) Arakawa H. … Nakamura Y. (Cytogenet. Cell Genet. 1995) 2 3 4 22 64
  2. Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA. (PMID: 7622052) Drew P.D. … Becker K.G. (Gene 1995) 3 4 22 64
  3. Purification and characterization of human transcription factor IIIA. (PMID: 8063702) Moorefield B. … Roeder R.G. (J. Biol. Chem. 1994) 3 4 22 64
  4. cDNA cloning, DNA binding, and evolution of mammalian transcription factor IIIA. (PMID: 11814676) Hanas J.S. … Moreland R.J. (Gene 2002) 3 22 64
  5. Identification of a transcription factor IIIA-interacting protein. (PMID: 10756201) Moreland R.J. … Hanas J.S. (Nucleic Acids Res. 2000) 3 22 64

Products for GTF3A Gene

Sources for GTF3A Gene

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