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Aliases for GTF2E2 Gene

Aliases for GTF2E2 Gene

  • General Transcription Factor IIE, Polypeptide 2, Beta 34kDa 2 3
  • General Transcription Factor IIE Subunit 2 3 4
  • TFIIE-Beta 3 4
  • TF2E2 3 4
  • General Transcription Factor IIE, Polypeptide 2 (Beta Subunit, 34kD) 2
  • Transcription Initiation Factor IIE Subunit Beta 3
  • TFIIE-B 3
  • FE 3

External Ids for GTF2E2 Gene

Summaries for GTF2E2 Gene

GeneCards Summary for GTF2E2 Gene

GTF2E2 (General Transcription Factor IIE, Polypeptide 2, Beta 34kDa) is a Protein Coding gene. Among its related pathways are Disease and GPCR Pathway.

UniProtKB/Swiss-Prot for GTF2E2 Gene

  • Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase

Gene Wiki entry for GTF2E2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2E2 Gene

Genomics for GTF2E2 Gene

Genomic Location for GTF2E2 Gene

Start:
30,578,318 bp from pter
End:
30,658,251 bp from pter
Size:
79,934 bases
Orientation:
Minus strand

Genomic View for GTF2E2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GTF2E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2E2 Gene

Regulatory Elements for GTF2E2 Gene

Proteins for GTF2E2 Gene

  • Protein details for GTF2E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29084-T2EB_HUMAN
    Recommended name:
    Transcription initiation factor IIE subunit beta
    Protein Accession:
    P29084
    Secondary Accessions:
    • D3DSV2
    • Q9H2B9

    Protein attributes for GTF2E2 Gene

    Size:
    291 amino acids
    Molecular mass:
    33044 Da
    Quaternary structure:
    • Tetramer of two alpha and two beta chains. Interacts with FACT subunit SUPT16H. Interacts with ATF7IP.

    Three dimensional structures from OCA and Proteopedia for GTF2E2 Gene

neXtProt entry for GTF2E2 Gene

Proteomics data for GTF2E2 Gene at MOPED

Post-translational modifications for GTF2E2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GTF2E2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GTF2E2 Gene

Domains for GTF2E2 Gene

Gene Families for GTF2E2 Gene

HGNC:
  • GTF :General transcription factors

Protein Domains for GTF2E2 Gene

UniProtKB/Swiss-Prot:

T2EB_HUMAN
Domain:
  • Contains 1 TFIIE beta DNA-binding domain.:
    • P29084
Family:
  • Belongs to the TFIIE beta subunit family.:
    • P29084
genes like me logo Genes that share domains with GTF2E2: view

Function for GTF2E2 Gene

Molecular function for GTF2E2 Gene

GENATLAS Biochemistry: general transcription factor IIE,beta polypeptide (34kDa)
UniProtKB/Swiss-Prot Function: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase

Gene Ontology (GO) - Molecular Function for GTF2E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16547462
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GTF2E2: view

Phenotypes for GTF2E2 Gene

genes like me logo Genes that share phenotypes with GTF2E2: view

miRNA for GTF2E2 Gene

miRTarBase miRNAs that target GTF2E2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GTF2E2 Gene

Localization for GTF2E2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2E2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF2E2 Gene COMPARTMENTS Subcellular localization image for GTF2E2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for GTF2E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005673 transcription factor TFIIE complex IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with GTF2E2: view

Pathways for GTF2E2 Gene

genes like me logo Genes that share pathways with GTF2E2: view

Gene Ontology (GO) - Biological Process for GTF2E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with GTF2E2: view

Transcripts for GTF2E2 Gene

Unigene Clusters for GTF2E2 Gene

General transcription factor IIE, polypeptide 2, beta 34kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2E2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: - - -
SP2:
SP3:

Relevant External Links for GTF2E2 Gene

GeneLoc Exon Structure for
GTF2E2
ECgene alternative splicing isoforms for
GTF2E2

Expression for GTF2E2 Gene

mRNA expression in normal human tissues for GTF2E2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF2E2 Gene

SOURCE GeneReport for Unigene cluster for GTF2E2 Gene Hs.77100

genes like me logo Genes that share expressions with GTF2E2: view

Orthologs for GTF2E2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GTF2E2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF2E2 36
  • 99.77 (n)
  • 100 (a)
GTF2E2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GTF2E2 36
  • 91.46 (n)
  • 94.12 (a)
GTF2E2 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF2E2 36
  • 93.7 (n)
  • 95.53 (a)
GTF2E2 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf2e2 36
  • 90.49 (n)
  • 94.5 (a)
Gtf2e2 16
Gtf2e2 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GTF2E2 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2E2 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf2e2 36
  • 89.69 (n)
  • 94.16 (a)
chicken
(Gallus gallus)
Aves GTF2E2 36
  • 78.21 (n)
  • 82.17 (a)
GTF2E2 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF2E2 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8438 36
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2e2 36
  • 75.77 (n)
  • 83.33 (a)
Str.6435 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14079 36
zebrafish
(Danio rerio)
Actinopterygii gtf2e2 36
  • 72.18 (n)
  • 78.28 (a)
gtf2e2 37
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005382 36
  • 56.92 (n)
  • 57.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta TfIIEbeta 36
  • 56.93 (n)
  • 58.76 (a)
TfIIEbeta 37
  • 55 (a)
OneToOne
TfIIEbgr 38
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_F54D5.11 36
  • 49.52 (n)
  • 41.3 (a)
F54D5.11 37
  • 37 (a)
OneToOne
F54D5.11 38
  • 36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8548 36
Species with no ortholog for GTF2E2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2E2 Gene

ENSEMBL:
Gene Tree for GTF2E2 (if available)
TreeFam:
Gene Tree for GTF2E2 (if available)

Paralogs for GTF2E2 Gene

Pseudogenes.org Pseudogenes for GTF2E2 Gene

genes like me logo Genes that share paralogs with GTF2E2: view

No data available for Paralogs for GTF2E2 Gene

Variants for GTF2E2 Gene

Sequence variations from dbSNP and Humsavar for GTF2E2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs4923 -- 30,580,340(-) AAATT(A/G)AAGAA missense, reference
rs716942 -- 30,596,615(-) actac(C/G)agaca intron-variant
rs1114279 -- 30,595,551(+) TTTGC(C/T)GGATG intron-variant
rs2229299 - 30,612,450(-) AGTAA(C/T)AGATG missense, reference
rs2294085 -- 30,579,262(+) GCAGG(C/T)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTF2E2 Gene

Variant ID Type Subtype PubMed ID
nsv526509 CNV Gain 19592680
esv2668521 CNV Deletion 23128226
nsv890703 CNV Loss 21882294
esv2661538 CNV Deletion 23128226
esv2678843 CNV Deletion 23128226

Relevant External Links for GTF2E2 Gene

HapMap Linkage Disequilibrium report
GTF2E2

Disorders for GTF2E2 Gene

(1) University of Copenhagen DISEASES for GTF2E2 Gene

Relevant External Links for GTF2E2

Genetic Association Database (GAD)
GTF2E2
Human Genome Epidemiology (HuGE) Navigator
GTF2E2
genes like me logo Genes that share disorders with GTF2E2: view

No data available for UniProtKB/Swiss-Prot for GTF2E2 Gene

Publications for GTF2E2 Gene

  1. Conserved sequence motifs in the small subunit of human general transcription factor TFIIE. (PMID: 1956404) Sumimoto H. … Roeder R.G. (Nature 1991) 2 3 4
  2. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PMID: 19861958) Festen E.A. … Weersma R.K. (Am. J. Gastroenterol. 2010) 3 49
  3. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli E.T. … Goldstein D.B. (Eur. J. Hum. Genet. 2010) 3 49
  4. Functional interaction of general transcription initiation factor TFIIE with general chromatin factor SPT16/CDC68. (PMID: 10792464) Kang S.-W. … Horikoshi M. (Genes Cells 2000) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for GTF2E2 Gene

Sources for GTF2E2 Gene

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