Aliases for GTF2B Gene
External Ids for GTF2B Gene
Previous GeneCards Identifiers for GTF2B Gene
This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]
GeneCards Summary for GTF2B Gene
GTF2B (General Transcription Factor IIB) is a Protein Coding gene. Diseases associated with GTF2B include Herpes Simplex and Familial Atrial Fibrillation. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include transcription factor binding and thyroid hormone receptor binding.
UniProtKB/Swiss-Prot for GTF2B Gene
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.