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Aliases for GTF2B Gene

Aliases for GTF2B Gene

  • General Transcription Factor IIB 2 3 5
  • General Transcription Factor TFIIB 3 4
  • S300-II 3 4
  • TFIIB 3 4
  • TF2B 3 4
  • RNA Polymerase II Transcription Factor IIB 3

External Ids for GTF2B Gene

Previous GeneCards Identifiers for GTF2B Gene

  • GC01M089795
  • GC01M088488
  • GC01M088655
  • GC01M088785
  • GC01M089030
  • GC01M089318
  • GC01M087435

Summaries for GTF2B Gene

Entrez Gene Summary for GTF2B Gene

  • This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTF2B Gene

GTF2B (General Transcription Factor IIB) is a Protein Coding gene. Diseases associated with GTF2B include Herpes Simplex and Familial Atrial Fibrillation. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Gene Expression. GO annotations related to this gene include transcription factor binding and thyroid hormone receptor binding.

UniProtKB/Swiss-Prot for GTF2B Gene

  • General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.

Gene Wiki entry for GTF2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2B Gene

Genomics for GTF2B Gene

Regulatory Elements for GTF2B Gene

Enhancers for GTF2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GTF2B on UCSC Golden Path with GeneCards custom track

Promoters for GTF2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GTF2B on UCSC Golden Path with GeneCards custom track

Genomic Location for GTF2B Gene

Chromosome:
1
Start:
88,852,638 bp from pter
End:
88,891,944 bp from pter
Size:
39,307 bases
Orientation:
Minus strand

Genomic View for GTF2B Gene

Genes around GTF2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2B Gene

Proteins for GTF2B Gene

  • Protein details for GTF2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00403-TF2B_HUMAN
    Recommended name:
    Transcription initiation factor IIB
    Protein Accession:
    Q00403
    Secondary Accessions:
    • A8K1A7
    • Q5JS30

    Protein attributes for GTF2B Gene

    Size:
    316 amino acids
    Molecular mass:
    34833 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1 (By similarity). Interacts with Epstein-Barr virus EBNA2. Interacts with herpes simplex virus 1 protein ICP4.

    Three dimensional structures from OCA and Proteopedia for GTF2B Gene

neXtProt entry for GTF2B Gene

Proteomics data for GTF2B Gene at MOPED

Post-translational modifications for GTF2B Gene

  • Ubiquitination at Lys 100 and Lys 178
  • Modification sites at PhosphoSitePlus

Other Protein References for GTF2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GTF2B Gene

Domains & Families for GTF2B Gene

Gene Families for GTF2B Gene

Protein Domains for GTF2B Gene

Suggested Antigen Peptide Sequences for GTF2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00403

UniProtKB/Swiss-Prot:

TF2B_HUMAN :
  • Belongs to the TFIIB family.
  • Contains 1 TFIIB-type zinc finger.
Family:
  • Belongs to the TFIIB family.
Similarity:
  • Contains 1 TFIIB-type zinc finger.
genes like me logo Genes that share domains with GTF2B: view

Function for GTF2B Gene

Molecular function for GTF2B Gene

GENATLAS Biochemistry:
general transcription factor IIB,35 kDa
UniProtKB/Swiss-Prot Function:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.

Gene Ontology (GO) - Molecular Function for GTF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8006019
GO:0046966 thyroid hormone receptor binding IPI 8524305
genes like me logo Genes that share ontologies with GTF2B: view
genes like me logo Genes that share phenotypes with GTF2B: view

Animal Models for GTF2B Gene

MGI Knock Outs for GTF2B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GTF2B Gene

Localization for GTF2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF2B Gene COMPARTMENTS Subcellular localization image for GTF2B gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for GTF2B Gene

Pathways & Interactions for GTF2B Gene

genes like me logo Genes that share pathways with GTF2B: view

Pathways by source for GTF2B Gene

Gene Ontology (GO) - Biological Process for GTF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0016032 viral process IEA,TAS --
genes like me logo Genes that share ontologies with GTF2B: view

No data available for SIGNOR curated interactions for GTF2B Gene

Drugs & Compounds for GTF2B Gene

(12) Drugs for GTF2B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for GTF2B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GTF2B: view

Transcripts for GTF2B Gene

Unigene Clusters for GTF2B Gene

General transcription factor IIB:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -
SP4: - -
SP5:

Relevant External Links for GTF2B Gene

GeneLoc Exon Structure for
GTF2B
ECgene alternative splicing isoforms for
GTF2B

Expression for GTF2B Gene

mRNA expression in normal human tissues for GTF2B Gene

Protein differential expression in normal tissues from HIPED for GTF2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.1) and Lung (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF2B Gene



SOURCE GeneReport for Unigene cluster for GTF2B Gene Hs.481852

genes like me logo Genes that share expression patterns with GTF2B: view

Protein tissue co-expression partners for GTF2B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF2B Gene

Orthologs for GTF2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GTF2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTF2B 35
  • 93.67 (n)
  • 99.68 (a)
GTF2B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF2B 35
  • 95.68 (n)
  • 100 (a)
GTF2B 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf2b 35
  • 89.98 (n)
  • 99.68 (a)
Gtf2b 16
Gtf2b 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTF2B 35
  • 99.37 (n)
  • 100 (a)
GTF2B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf2b 35
  • 89.87 (n)
  • 99.68 (a)
oppossum
(Monodelphis domestica)
Mammalia GTF2B 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2B 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF2B 35
  • 85.55 (n)
  • 97.78 (a)
GTF2B 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF2B 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2b 35
  • 80.49 (n)
  • 95.25 (a)
Str.18092 35
African clawed frog
(Xenopus laevis)
Amphibia gtf2b-A 35
zebrafish
(Danio rerio)
Actinopterygii gtf2b 35
  • 78.06 (n)
  • 93.67 (a)
wufc44c11 35
gtf2b 36
  • 94 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.422 35
fruit fly
(Drosophila melanogaster)
Insecta TfIIB 37
  • 79 (a)
TfIIB 35
  • 65.71 (n)
  • 79.37 (a)
TfIIB 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009558 35
  • 64.33 (n)
  • 79.94 (a)
worm
(Caenorhabditis elegans)
Secernentea ttb-1 37
  • 61 (a)
ttb-1 35
  • 60.67 (n)
  • 62.33 (a)
ttb-1 36
  • 61 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR007C 35
  • 46.44 (n)
  • 38.67 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13640g 35
  • 48.45 (n)
  • 38.21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUA7 35
  • 48.15 (n)
  • 38.71 (a)
SUA7 36
  • 30 (a)
OneToOne
SUA7 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TFIIB 35
  • 55.64 (n)
  • 49.28 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3214 35
rice
(Oryza sativa)
Liliopsida Os09g0534800 35
  • 53.78 (n)
  • 49.65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2391 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07289 35
  • 49.25 (n)
  • 44.25 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC16E8.16 35
  • 51.46 (n)
  • 47.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6926 36
  • 72 (a)
OneToOne
Species with no ortholog for GTF2B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2B Gene

ENSEMBL:
Gene Tree for GTF2B (if available)
TreeFam:
Gene Tree for GTF2B (if available)

Paralogs for GTF2B Gene

No data available for Paralogs for GTF2B Gene

Variants for GTF2B Gene

Sequence variations from dbSNP and Humsavar for GTF2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1804499 - 88,887,330(-) ACCAT(C/T)CAGAT nc-transcript-variant, reference, missense, utr-variant-5-prime
VAR_035722 A colorectal cancer sample
rs10922 -- 88,853,103(-) TGGTA(A/C/T)GCATT utr-variant-3-prime
rs2794316 -- 88,853,507(+) AAAGG(C/T)AGAAA intron-variant
rs2794317 -- 88,856,271(+) caaaa(A/C)caaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTF2B Gene

Variant ID Type Subtype PubMed ID
nsv830514 CNV Loss 17160897
nsv830525 CNV Loss 17160897
nsv830537 CNV Gain 17160897
dgv22n27 CNV Gain 19166990
nsv462472 CNV Loss 19166990

Variation tolerance for GTF2B Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GTF2B Gene

Disorders for GTF2B Gene

MalaCards: The human disease database

(2) MalaCards diseases for GTF2B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
familial atrial fibrillation
  • atrial fibrillation, familial, 1
- elite association - COSMIC cancer census association via MalaCards
Search GTF2B in MalaCards View complete list of genes associated with diseases

Relevant External Links for GTF2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF2B
genes like me logo Genes that share disorders with GTF2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTF2B Gene

Publications for GTF2B Gene

  1. Cloning of a human gene encoding the general transcription initiation factor IIB. (PMID: 1876184) Ha I. … Reinberg D. (Nature 1991) 2 3 4 67
  2. Phosphorylation of TFIIB links transcription initiation and termination. (PMID: 20226668) Wang Y. … Roberts S.G. (Curr. Biol. 2010) 3 23
  3. Minimal promoter systems reveal the importance of conserved residues in the B-finger of human transcription factor IIB. (PMID: 19590095) Thompson N.E. … Burgess R.R. (J. Biol. Chem. 2009) 3 23
  4. Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration. (PMID: 17994014) Friedman M.J. … Li X.J. (Nat. Neurosci. 2007) 3 23
  5. Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly. (PMID: 16595664) Baek H.J. … Roeder R.G. (J. Biol. Chem. 2006) 3 23

Products for GTF2B Gene

Sources for GTF2B Gene

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