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Aliases for GTF2B Gene

Aliases for GTF2B Gene

  • General Transcription Factor IIB 2 3
  • TFIIB 3 4 6
  • TF2B 3 4 6
  • General Transcription Factor TFIIB 3 4
  • S300-II 3 4
  • RNA Polymerase II Transcription Factor IIB 3
  • Transcription Initiation Factor IIB 3

External Ids for GTF2B Gene

Summaries for GTF2B Gene

Entrez Gene Summary for GTF2B Gene

  • This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTF2B Gene

GTF2B (General Transcription Factor IIB) is a Protein Coding gene. Among its related pathways are Disease and GPCR Pathway. GO annotations related to this gene include transcription factor binding and core promoter binding.

UniProtKB/Swiss-Prot for GTF2B Gene

  • General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II

Gene Wiki entry for GTF2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2B Gene

Genomics for GTF2B Gene

Genomic Location for GTF2B Gene

Start:
88,852,638 bp from pter
End:
88,891,944 bp from pter
Size:
39,307 bases
Orientation:
Minus strand

Genomic View for GTF2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GTF2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2B Gene

Regulatory Elements for GTF2B Gene

Proteins for GTF2B Gene

  • Protein details for GTF2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00403-TF2B_HUMAN
    Recommended name:
    Transcription initiation factor IIB
    Protein Accession:
    Q00403
    Secondary Accessions:
    • A8K1A7
    • Q5JS30

    Protein attributes for GTF2B Gene

    Size:
    316 amino acids
    Molecular mass:
    34833 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1 (By similarity). Interacts with Epstein-Barr virus EBNA2. Interacts with herpes simplex virus 1 protein ICP4.

    Three dimensional structures from OCA and Proteopedia for GTF2B Gene

neXtProt entry for GTF2B Gene

Proteomics data for GTF2B Gene at MOPED

Post-translational modifications for GTF2B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys100 and Lys178

Other Protein References for GTF2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GTF2B Gene

Domains for GTF2B Gene

Gene Families for GTF2B Gene

HGNC:
  • GTF :General transcription factors

UniProtKB/Swiss-Prot:

TF2B_HUMAN
Family:
  • Belongs to the TFIIB family.:
    • Q00403
Similarity:
  • Contains 1 TFIIB-type zinc finger.:
    • Q00403
genes like me logo Genes that share domains with GTF2B: view

Function for GTF2B Gene

Molecular function for GTF2B Gene

GENATLAS Biochemistry: general transcription factor IIB,35 kDa
UniProtKB/Swiss-Prot Function: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II

Gene Ontology (GO) - Molecular Function for GTF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding IEA --
GO:0003677 DNA binding --
GO:0005515 protein binding IPI 10330164
GO:0008134 transcription factor binding IPI 9722567
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with GTF2B: view
genes like me logo Genes that share phenotypes with GTF2B: view

miRNA for GTF2B Gene

miRTarBase miRNAs that target GTF2B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GTF2B Gene

Localization for GTF2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF2B Gene COMPARTMENTS Subcellular localization image for GTF2B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for GTF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with GTF2B: view

Pathways for GTF2B Gene

genes like me logo Genes that share pathways with GTF2B: view

Pathways by source for GTF2B Gene

Gene Ontology (GO) - Biological Process for GTF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006352 DNA-templated transcription, initiation --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with GTF2B: view

Compounds for GTF2B Gene

(16) Novoseek inferred chemical compound relationships for GTF2B Gene

Compound -log(P) Hits PubMed IDs
tbps 60.6 1
1,25 dihydroxy vitamin d3 43.7 1
zinc 40.4 19
phosphodiester 31 2
vitamin d 25.3 5
genes like me logo Genes that share compounds with GTF2B: view

Transcripts for GTF2B Gene

Unigene Clusters for GTF2B Gene

General transcription factor IIB:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -
SP4: - -
SP5:

Relevant External Links for GTF2B Gene

GeneLoc Exon Structure for
GTF2B
ECgene alternative splicing isoforms for
GTF2B

Expression for GTF2B Gene

mRNA expression in normal human tissues for GTF2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF2B Gene

SOURCE GeneReport for Unigene cluster for GTF2B Gene Hs.481852

genes like me logo Genes that share expressions with GTF2B: view

Orthologs for GTF2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GTF2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF2B 36
  • 99.37 (n)
  • 100 (a)
GTF2B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GTF2B 36
  • 93.67 (n)
  • 99.68 (a)
GTF2B 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF2B 36
  • 95.68 (n)
  • 100 (a)
GTF2B 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf2b 36
  • 89.98 (n)
  • 99.68 (a)
Gtf2b 16
Gtf2b 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GTF2B 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2B 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf2b 36
  • 89.87 (n)
  • 99.68 (a)
chicken
(Gallus gallus)
Aves GTF2B 36
  • 85.55 (n)
  • 97.78 (a)
GTF2B 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF2B 37
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia gtf2b-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2b 36
  • 80.49 (n)
  • 95.25 (a)
Str.18092 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.422 36
zebrafish
(Danio rerio)
Actinopterygii gtf2b 36
  • 78.06 (n)
  • 93.67 (a)
gtf2b 37
  • 94 (a)
OneToOne
wufc44c11 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009558 36
  • 64.33 (n)
  • 79.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta TfIIB 36
  • 65.71 (n)
  • 79.37 (a)
TfIIB 37
  • 79 (a)
OneToOne
TfIIB 38
  • 79 (a)
worm
(Caenorhabditis elegans)
Secernentea ttb-1 36
  • 60.67 (n)
  • 62.33 (a)
ttb-1 37
  • 61 (a)
OneToOne
ttb-1 38
  • 61 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR007C 36
  • 46.44 (n)
  • 38.67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUA7 36
  • 48.15 (n)
  • 38.71 (a)
SUA7 37
  • 30 (a)
OneToOne
SUA7 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13640g 36
  • 48.45 (n)
  • 38.21 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3214 36
thale cress
(Arabidopsis thaliana)
eudicotyledons TFIIB 36
  • 55.64 (n)
  • 49.28 (a)
rice
(Oryza sativa)
Liliopsida Os09g0534800 36
  • 53.78 (n)
  • 49.65 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07289 36
  • 49.25 (n)
  • 44.25 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC16E8.16 36
  • 51.46 (n)
  • 47.45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2391 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6926 37
  • 72 (a)
OneToOne
Species with no ortholog for GTF2B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2B Gene

ENSEMBL:
Gene Tree for GTF2B (if available)
TreeFam:
Gene Tree for GTF2B (if available)

Paralogs for GTF2B Gene

No data available for Paralogs for GTF2B Gene

Variants for GTF2B Gene

Sequence variations from dbSNP and Humsavar for GTF2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10922 -- 88,853,103(-) TGGTA(A/C/T)GCATT utr-variant-3-prime
rs1804499 - 88,887,330(-) ACCAT(C/T)CAGAT reference, missense
rs2275669 -- 88,860,019(+) TCAAA(A/G)CAGAG intron-variant
rs2794316 -- 88,853,507(+) AAAGG(C/T)AGAAA intron-variant
rs2794317 -- 88,856,271(+) caaaa(A/C)caaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTF2B Gene

Variant ID Type Subtype PubMed ID
nsv830514 CNV Loss 17160897
nsv830525 CNV Loss 17160897
nsv830537 CNV Gain 17160897
dgv22n27 CNV Gain 19166990
nsv462472 CNV Loss 19166990

Relevant External Links for GTF2B Gene

HapMap Linkage Disequilibrium report
GTF2B

Disorders for GTF2B Gene

(6) Novoseek inferred disease relationships for GTF2B Gene

Disease -log(P) Hits PubMed IDs
herpes simplex 39.7 7
retinoblastoma 36 3
carcinoma embryonal 10.9 2
immunodeficiency 3.52 3
tumors 0.441 1
genes like me logo Genes that share disorders with GTF2B: view

No data available for UniProtKB/Swiss-Prot for GTF2B Gene

Publications for GTF2B Gene

  1. Sequence of general transcription factor TFIIB and relationships to other initiation factors. (PMID: 1946368) Malik S. … Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 23
  2. Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein. (PMID: 7671313) Bagby S. … Ikura M. (Cell 1995) 3 4 23
  3. The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB. (PMID: 8800208) Agostini I. … Sire J. (J. Mol. Biol. 1996) 3 4 23
  4. The HIV-1 Vpr co-activator induces a conformational change in TFIIB. (PMID: 10359081) Agostini I. … Sire J. (FEBS Lett. 1999) 3 4 23
  5. Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription. (PMID: 11045620) Chen H.T. … Scott R.A. (Protein Sci. 2000) 3 4 23

Products for GTF2B Gene

  • Addgene plasmids for GTF2B

Sources for GTF2B Gene

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