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Aliases for GTF2A1 Gene

Aliases for GTF2A1 Gene

  • General Transcription Factor IIA Subunit 1 2 3 4 5
  • Transcription Initiation Factor TFIIA 42 KDa Subunit 3 4
  • General Transcription Factor IIA, 1, 19/37kDa 2 3
  • Glucose Regulated Protein, 58kD Pseudogene 2 3
  • General Transcription Factor IIA 1 2 3
  • TFIIA Alpha/Beta Subunits 2 3
  • TFIIA-42 3 4
  • TFIIAL 3 4
  • TF2A1 3 4
  • Transcription Initiation Factor IIA Subunit 1 3
  • TFIIA Alpha, P55 3
  • TFIIA 3

External Ids for GTF2A1 Gene

Previous GeneCards Identifiers for GTF2A1 Gene

  • GC14M079152
  • GC14M075463
  • GC14M079634
  • GC14M079636
  • GC14M080716
  • GC14M081646
  • GC14M061813

Summaries for GTF2A1 Gene

Entrez Gene Summary for GTF2A1 Gene

  • Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]

GeneCards Summary for GTF2A1 Gene

GTF2A1 (General Transcription Factor IIA Subunit 1) is a Protein Coding gene. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and HIV Life Cycle. GO annotations related to this gene include protein heterodimerization activity and transcription coactivator activity. An important paralog of this gene is GTF2A1L.

UniProtKB/Swiss-Prot for GTF2A1 Gene

  • TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

Gene Wiki entry for GTF2A1 Gene

Additional gene information for GTF2A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2A1 Gene

Genomics for GTF2A1 Gene

Regulatory Elements for GTF2A1 Gene

Enhancers for GTF2A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H081218 1.9 FANTOM5 ENCODE dbSUPER 29.2 +0.7 726 4 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 GTF2A1 CEP128 LOC101928504 GC14M081203 SNORA79
GH14H081176 1.6 Ensembl ENCODE 15.6 +44.4 44361 1 YY1 GTF2A1 SNORA79 GC14M081176 LOC101928462
GH14H081398 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -179.4 -179408 4 PKNOX1 ATF1 ARNT ZNF133 FEZF1 TCF12 GATA2 FOS ATF7 RUNX3 GTF2A1 STON2 LINC02308 GC14P081410 RPS24P3
GH14H080996 1.1 FANTOM5 Ensembl 21.3 +224.9 224865 0 CTCF PKNOX1 CEBPG RAD21 SMC3 ZNF143 FOS CREM CEBPB TRIM22 GTF2A1 CEP128 SNORA79 NMNAT1P1 RPL17P3 GC14P080982
GH14H081208 1.3 FANTOM5 Ensembl ENCODE 16.3 +12.0 12014 1 SMARCA5 JUNB ELF1 DPF2 BATF ZNF316 ATF3 BCL11A TARDBP IKZF1 GTF2A1 CEP128 SNORA79 GC14M081203 LOC101928504
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GTF2A1 on UCSC Golden Path with GeneCards custom track

Promoters for GTF2A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000071401 1177 3201 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for GTF2A1 Gene

Chromosome:
14
Start:
81,175,452 bp from pter
End:
81,221,377 bp from pter
Size:
45,926 bases
Orientation:
Minus strand

Genomic View for GTF2A1 Gene

Genes around GTF2A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2A1 Gene

Proteins for GTF2A1 Gene

  • Protein details for GTF2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52655-TF2AA_HUMAN
    Recommended name:
    Transcription initiation factor IIA subunit 1
    Protein Accession:
    P52655
    Secondary Accessions:
    • Q3KNQ9

    Protein attributes for GTF2A1 Gene

    Size:
    376 amino acids
    Molecular mass:
    41514 Da
    Quaternary structure:
    • TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). TFIIA forms a complex with TBP.

    Three dimensional structures from OCA and Proteopedia for GTF2A1 Gene

    Alternative splice isoforms for GTF2A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTF2A1 Gene

Post-translational modifications for GTF2A1 Gene

  • The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GTF2A1 Gene

No data available for DME Specific Peptides for GTF2A1 Gene

Domains & Families for GTF2A1 Gene

Gene Families for GTF2A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GTF2A1 Gene

Suggested Antigen Peptide Sequences for GTF2A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52655

UniProtKB/Swiss-Prot:

TF2AA_HUMAN :
  • Belongs to the TFIIA subunit 1 family.
Family:
  • Belongs to the TFIIA subunit 1 family.
genes like me logo Genes that share domains with GTF2A1: view

Function for GTF2A1 Gene

Molecular function for GTF2A1 Gene

UniProtKB/Swiss-Prot Function:
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

Phenotypes From GWAS Catalog for GTF2A1 Gene

Gene Ontology (GO) - Molecular Function for GTF2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001103 RNA polymerase II repressing transcription factor binding IEA --
GO:0003677 DNA binding IDA 7724559
GO:0003713 transcription coactivator activity TAS 8224850
GO:0005515 protein binding IPI 8006019
GO:0008134 transcription factor binding IPI 8626665
genes like me logo Genes that share ontologies with GTF2A1: view
genes like me logo Genes that share phenotypes with GTF2A1: view

Animal Models for GTF2A1 Gene

MGI Knock Outs for GTF2A1:

Animal Model Products

CRISPR Products

miRNA for GTF2A1 Gene

miRTarBase miRNAs that target GTF2A1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GTF2A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GTF2A1 Gene

Localization for GTF2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF2A1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GTF2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 27193682
GO:0005672 transcription factor TFIIA complex IDA 7724559
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GTF2A1: view

Pathways & Interactions for GTF2A1 Gene

genes like me logo Genes that share pathways with GTF2A1: view

SIGNOR curated interactions for GTF2A1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GTF2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS,IDA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with GTF2A1: view

Drugs & Compounds for GTF2A1 Gene

No Compound Related Data Available

Transcripts for GTF2A1 Gene

Unigene Clusters for GTF2A1 Gene

General transcription factor IIA, 1, 19/37kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GTF2A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2A1 Gene

No ASD Table

Relevant External Links for GTF2A1 Gene

GeneLoc Exon Structure for
GTF2A1
ECgene alternative splicing isoforms for
GTF2A1

Expression for GTF2A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GTF2A1 Gene

Protein differential expression in normal tissues from HIPED for GTF2A1 Gene

This gene is overexpressed in Fetal Brain (9.6), CD4 Tcells (8.6), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTF2A1 Gene



Protein tissue co-expression partners for GTF2A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GTF2A1 Gene:

GTF2A1

SOURCE GeneReport for Unigene cluster for GTF2A1 Gene:

Hs.592334

Evidence on tissue expression from TISSUES for GTF2A1 Gene

  • Liver(4.2)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with GTF2A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF2A1 Gene

Orthologs for GTF2A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GTF2A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF2A1 33 34
  • 99.56 (n)
cow
(Bos Taurus)
Mammalia GTF2A1 33 34
  • 94.46 (n)
dog
(Canis familiaris)
Mammalia GTF2A1 33 34
  • 93.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2A1 34
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf2a1 33
  • 92.11 (n)
mouse
(Mus musculus)
Mammalia Gtf2a1 33 16 34
  • 90.07 (n)
Gm5435 34
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GTF2A1 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF2A1 33 34
  • 84.04 (n)
lizard
(Anolis carolinensis)
Reptilia GTF2A1 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2a1 33
  • 77.87 (n)
Str.5955 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.29248 33
zebrafish
(Danio rerio)
Actinopterygii gtf2a1 33 34
  • 71.59 (n)
Dr.24669 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1071 33
fruit fly
(Drosophila melanogaster)
Insecta TfIIA-L 34
  • 34 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3030 33
Species where no ortholog for GTF2A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF2A1 Gene

ENSEMBL:
Gene Tree for GTF2A1 (if available)
TreeFam:
Gene Tree for GTF2A1 (if available)

Paralogs for GTF2A1 Gene

Paralogs for GTF2A1 Gene

genes like me logo Genes that share paralogs with GTF2A1: view

Variants for GTF2A1 Gene

Sequence variations from dbSNP and Humsavar for GTF2A1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_035667 A breast cancer sample
rs1000042907 -- 81,221,684(+) TAGTC(C/G)TCTAC nc-transcript-variant, upstream-variant-2KB
rs1000095806 -- 81,177,870(+) GGACA(C/T)GATGC utr-variant-3-prime
rs1000116247 -- 81,194,398(+) TTTCT(A/C)TTTGT intron-variant
rs1000164876 -- 81,179,548(+) ATTTA(A/G)TAAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GTF2A1 Gene

Variant ID Type Subtype PubMed ID
esv3581341 CNV loss 25503493
esv3581342 CNV loss 25503493
esv3635076 CNV gain 21293372
nsv832841 CNV gain 17160897

Variation tolerance for GTF2A1 Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF2A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF2A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF2A1 Gene

Disorders for GTF2A1 Gene

Relevant External Links for GTF2A1

Genetic Association Database (GAD)
GTF2A1
Human Genome Epidemiology (HuGE) Navigator
GTF2A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF2A1

No disorders were found for GTF2A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF2A1 Gene

Publications for GTF2A1 Gene

  1. A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA. (PMID: 8224848) DeJong J … Roeder RG (Genes & development 1993) 2 3 4 22 60
  2. Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA. (PMID: 15257296) Høiby T … Stunnenberg HG (The EMBO journal 2004) 3 4 22 60
  3. Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity. (PMID: 11278496) Solow S … Lieberman PM (The Journal of biological chemistry 2001) 3 4 22 60
  4. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PMID: 18950845) Vega A … Carracedo A (Gynecologic oncology 2009) 3 45 60
  5. TFIIA changes the conformation of the DNA in TBP/TATA complexes and increases their kinetic stability. (PMID: 17681538) Hieb AR … Goodrich JA (Journal of molecular biology 2007) 3 22 60

Products for GTF2A1 Gene

Sources for GTF2A1 Gene

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