Aliases for GSTT1 Gene
Previous GeneCards Identifiers for GSTT1 Gene
The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
GeneCards Summary for GSTT1 Gene
GSTT1 (Glutathione S-Transferase Theta 1) is a Protein Coding gene. Diseases associated with GSTT1 include laryngeal carcinoma and asbestosis. Among its related pathways are Metabolism of xenobiotics by cytochrome P450 and Glutathione metabolism. GO annotations related to this gene include glutathione transferase activity and glutathione peroxidase activity.
UniProtKB/Swiss-Prot for GSTT1 Gene
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.