Aliases for GSTT1 Gene
Aliases for GSTT1 Gene
Previous GeneCards Identifiers for GSTT1 Gene
- GC22M021072
- GC22M020995
- GC22M022700
- GC22M022706
- GC22M024377
- GC22M024341
- GC22M007324
- GC22M024378
- GC22M024380
- GC22M024506
- GC22M024776
- GC22M024952
- GC22M025171
Summaries for GSTT1 Gene
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The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
GeneCards Summary for GSTT1 Gene
GSTT1 (Glutathione S-Transferase Theta 1) is a Protein Coding gene. Diseases associated with GSTT1 include Larynx Cancer and Mutagen Sensitivity. Among its related pathways are Etoposide Pathway, Pharmacokinetics/Pharmacodynamics and Glutathione metabolism. GO annotations related to this gene include glutathione transferase activity and glutathione peroxidase activity.
UniProtKB/Swiss-Prot for GSTT1 Gene
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Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
No data available for CIViC summary , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for GSTT1 Gene
Genomics for GSTT1 Gene
Regulatory Elements for GSTT1 Gene
- Transcription factor binding sites by QIAGEN in the GSTT1 gene promoter:
Regulatory Element Products
Genomic Location for GSTT1 Gene
- Chromosome:
- 22
- Start:
- 270,308 bp from pter
- End:
- 278,486 bp from pter
- Size:
- 8,179 bases
- Orientation:
- Minus strand
Genomic View for GSTT1 Gene
Genes around GSTT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.23 by Entrez Gene
- 22q11.23 alternate reference locus by HGNC
Gene Density RefSeq DNA sequence for GSTT1 Gene
Proteins for GSTT1 Gene
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Protein details for GSTT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P30711-GSTT1_HUMAN
- Recommended name:
- Glutathione S-transferase theta-1
- Protein Accession:
- P30711
- O00226
- Q5TZY2
- Q6IC69
- Q969K8
- Q96IY3
Protein attributes for GSTT1 Gene
- Size:
- 240 amino acids
- Molecular mass:
- 27335 Da
- Quaternary structure:
-
- Homodimer.
Protein Expression for GSTT1 Gene
Selected DME Specific Peptides for GSTT1 Gene
- P30711:
-
- YIFAKKN
- ARVDEYLAWQHT
Post-translational modifications for GSTT1 Gene
Other Protein References for GSTT1 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for GSTT1
- Novus Biologicals Antibodies for GSTT1
-
Abcam antibodies for GSTT1
- Invitrogen Antibodies for GSTT1
- antibodies-online Antibodies for GSTT1: See all 83
- GeneTex GSTT1 antibody for GSTT1
-
Santa Cruz Biotechnology (SCBT) Antibodies for GSTT1
Protein Products
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OriGene Purified Proteins for GSTT1
- Search Origene for MassSpec and Protein Over-expression Lysates for GSTT1
- Origene Custom Protein Services for GSTT1
- Novus Biologicals proteins for GSTT1
- antibodies-online Proteins for GSTT1: See all 21
- Search antibodies-online for peptides
- GeneTex Proteins for GSTT1
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Abcam proteins for GSTT1
Assay Products
- antibodies-online Kits for GSTT1: See all 16
Domains & Families for GSTT1 Gene
Gene Families for GSTT1 Gene
Protein Domains for GSTT1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GSTT1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P30711- Family:
-
- Belongs to the GST superfamily. Theta family.
Function for GSTT1 Gene
Molecular function for GSTT1 Gene
- GENATLAS Biochemistry:
- glutathione-S-transferase 1,theta class,deleted in bladder cancer
- UniProtKB/Swiss-Prot CatalyticActivity:
- RX + glutathione = HX + R-S-glutathione.
- UniProtKB/Swiss-Prot Function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
Enzyme Numbers (IUBMB) for GSTT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004364 | glutathione transferase activity | TAS | -- |
| GO:0004602 | glutathione peroxidase activity | IDA | 9307035 |
| GO:0005515 | protein binding | IPI | 25910212 |
Phenotypes for GSTT1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for GSTT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GSTT1 gene
- Search ViGene Biosciences for GSTT1
miRNA Products
- Search ViGene Biosciences for GSTT1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for GSTT1
- Browse OriGene Inhibitory RNA Products For GSTT1
-
ViGene Biosciences ready-to-package AAV shRNAs for GSTT1 gene
Clone Products
- Sino Biological Human cDNA Clone for GSTT1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for GSTT1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GSTT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GSTT1 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GSTT1 Gene
Localization for GSTT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GSTT1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 3 |
| mitochondrion | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | IDA | 23376485 |
Pathways & Interactions for GSTT1 Gene
Pathways by source for GSTT1 Gene
2 BioSystems pathways for GSTT1 Gene
4 Reactome pathways for GSTT1 Gene
6 KEGG pathways for GSTT1 Gene
2 GeneGo (Thomson Reuters) pathways for GSTT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006749 | glutathione metabolic process | IDA | 9307035 |
| GO:0098869 | cellular oxidant detoxification | IEA | -- |
| GO:1901687 | glutathione derivative biosynthetic process | TAS | -- |
No data available for SIGNOR curated interactions for GSTT1 Gene
Drugs & Compounds for GSTT1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cisplatin | Approved | Pharma | Enzyme, substrate | Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 | 2770 | |
| Glutathione | Approved | Nutra | Target | 0 | ||
| Oxaliplatin | Approved, Investigational | Pharma | Enzyme, substrate | Antitumor agent, Platinum | 1460 | |
| Carboplatin | Approved | Pharma | Enzyme, substrate | Antitumor agent that forms platinum-DNA adducts., Platinum | 2050 | |
| Etoposide | Approved | Pharma | Enzyme, substrate | Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor | 1269 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene |
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| (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene |
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| (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene |
|
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| (1S,2R)-Naphthalene 1,2-oxide |
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| 1,1-Dichloroethylene epoxide |
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Transcripts for GSTT1 Gene
mRNA/cDNA for GSTT1 Gene
- (9) REFSEQ mRNAs :
- (235) Selected AceView cDNA sequences:
miRNA Products
- Search ViGene Biosciences for GSTT1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for GSTT1
- Browse OriGene Inhibitory RNA Products For GSTT1
-
ViGene Biosciences ready-to-package AAV shRNAs for GSTT1 gene
Clone Products
- Sino Biological Human cDNA Clone for GSTT1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for GSTT1 Gene
This gene is overexpressed in Uterus (11.0) and Skin (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTT1 Gene
NURSA nuclear receptor signaling pathways regulating expression of GSTT1 Gene:
GSTT1SOURCE GeneReport for Unigene cluster for GSTT1 Gene:
Hs.268573mRNA Expression by UniProt/SwissProt for GSTT1 Gene:
P30711-GSTT1_HUMAN
Tissue specificity:
Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles.
Evidence on tissue expression from TISSUES for GSTT1 Gene
- Liver(4.6)
- Lung(4.5)
- Blood(2.9)
- Kidney(2.4)
- Skin(2.4)
- Thyroid gland(2.3)
- Intestine(2.2)
- Urine(2.1)
- Muscle(2)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for GSTT1
-
OriGene qPCR primer pairs for GSTT1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTT1 Gene
Orthologs for GSTT1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.935 34 |
|
- Species where no ortholog for GSTT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
No data available for Evolution for GSTT1 Gene
Paralogs for GSTT1 Gene
(4) SIMAP similar genes for GSTT1 Gene using alignment to 12 proteins:
No data available for Paralogs for GSTT1 Gene
Variants for GSTT1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for GSTT1 Gene
- GSTT1_HUMAN-P30711
- The GSTT1 gene is absent from 38% of the population. The presence or absence of the GSTT1 gene is coincident with the conjugator (GSST1+) and non-conjugator (GSTT1-) phenotypes respectively. The GSTT1+ phenotype can catalyze the glutathione conjugation of dichloromethane.
Residual Variation Intolerance Score:
93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.23;
62.20% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for GSTT1 Gene
No data available for Structural Variations from Database of Genomic Variants (DGV) for GSTT1 Gene
Disorders for GSTT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| larynx cancer |
|
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| mutagen sensitivity |
|
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| senile cataract |
|
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| asbestosis |
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| multiple chemical sensitivity |
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Search GSTT1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for GSTT1
No data available for UniProtKB/Swiss-Prot and Genatlas for GSTT1 Gene
Publications for GSTT1 Gene
- Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries. (PMID: 17333241) JAPnsson L.S. … JAPnsson B.A. (Int Arch Occup Environ Health 2007) 3 22 25 46 64
- Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations. (PMID: 19430957) Rafiee L. … Saadat M. (Mol. Biol. Rep. 2010) 3 22 46 64
- GSTT1 and GSTP1 polymorphisms and breast cancer risk: a meta-analysis. (PMID: 19760040) Sergentanis T.N. … Economopoulos K.P. (Breast Cancer Res. Treat. 2010) 3 22 46 64
- Estrogen receptor 1, glutathione S-transferase P1, glutathione S-transferase M1, and glutathione S-transferase T1 genes with dysmenorrhea in Korean female adolescents. (PMID: 20197727) Woo H.Y. … Lim S.W. (Korean J Lab Med 2010) 3 22 46 64
- Glutathione-S-transferase genotypes influence the risk of chemotherapy-related toxicities and prognosis in Korean patients with diffuse large B-cell lymphoma. (PMID: 20303013) Cho H.J. … Kong S.Y. (Cancer Genet. Cytogenet. 2010) 3 22 46 64
Products for GSTT1 Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GSTT1
- Search Origene for MassSpec and Protein Over-expression Lysates for GSTT1
- Origene Custom Protein Services for GSTT1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for GSTT1
- Browse OriGene Inhibitory RNA Products For GSTT1
- OriGene qPCR primer pairs and template standards for GSTT1
- OriGene qPCR primer pairs for GSTT1
- OriGene CRISPR knockouts for GSTT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for GSTT1
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- Novus Biologicals Antibodies for GSTT1
- Novus Biologicals proteins for GSTT1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for GSTT1
- Abcam proteins for GSTT1
- Search for Assays for GSTT1 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- antibodies-online Antibodies for GSTT1: See all 83
- antibodies-online Kits for GSTT1: See all 16
- antibodies-online Proteins for GSTT1: See all 21
- Search antibodies-online for peptides
- GeneTex GSTT1 antibody for GSTT1
- GeneTex Proteins for GSTT1
- ViGene Biosciences adenoviral particle packaged cDNA for GSTT1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GSTT1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GSTT1 gene
- Search ViGene Biosciences for GSTT1
- Santa Cruz Biotechnology (SCBT) Antibodies for GSTT1
- Search Santa Cruz Biotechnology (SCBT) for GSTT1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GSTT1
- Cyagen custom Knockout/knockin (KOKI) mouse models for GSTT1
- VectorBuilder custom plasmid, inducible vectors for GSTT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GSTT1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for GSTT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (115) ProteomicsDB
- (116) SCBT
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- (141) ENCODE
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- (148) SNPedia
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer