Aliases for GSTT1 Gene
Aliases for GSTT1 Gene
Previous GeneCards Identifiers for GSTT1 Gene
- GC22M021072
- GC22M020995
- GC22M022700
- GC22M022706
- GC22M024377
- GC22M024341
- GC22M007324
- GC22M024378
- GC22M024380
- GC22M024506
- GC22M024776
- GC22M024952
- GC22M025171
Summaries for GSTT1 Gene
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The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
GeneCards Summary for GSTT1 Gene
GSTT1 (Glutathione S-Transferase Theta 1) is a Protein Coding gene. Diseases associated with GSTT1 include Laryngeal Carcinoma and Asbestosis. Among its related pathways are Phase II conjugation and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include glutathione transferase activity and glutathione peroxidase activity.
UniProtKB/Swiss-Prot for GSTT1 Gene
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Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for GSTT1 Gene
Genomics for GSTT1 Gene
Regulatory Elements for GSTT1 Gene
- Transcription factor binding sites by QIAGEN in the GSTT1 gene promoter:
Regulatory Element Products
Genomic Location for GSTT1 Gene
- Chromosome:
- 22
- Start:
- 270,308 bp from pter
- End:
- 278,486 bp from pter
- Size:
- 8,179 bases
- Orientation:
- Minus strand
Genomic View for GSTT1 Gene
Genes around GSTT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.23 by Entrez Gene
- 22q11.23 alternate reference locus by HGNC
Gene Density RefSeq DNA sequence for GSTT1 Gene
Proteins for GSTT1 Gene
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Protein details for GSTT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P30711-GSTT1_HUMAN
- Recommended name:
- Glutathione S-transferase theta-1
- Protein Accession:
- P30711
- O00226
- Q5TZY2
- Q6IC69
- Q969K8
- Q96IY3
Protein attributes for GSTT1 Gene
- Size:
- 240 amino acids
- Molecular mass:
- 27335 Da
- Quaternary structure:
-
- Homodimer.
Protein Expression for GSTT1 Gene
Selected DME Specific Peptides for GSTT1 Gene
Post-translational modifications for GSTT1 Gene
Other Protein References for GSTT1 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for GSTT1
- Novus Biologicals Antibodies for GSTT1
- Abcam antibodies for Glutathione S Transferase theta 1
- Abcam antibodies for Glutathione S Transferase theta 1 + Glutathione S Transferase theta 4
-
Cloud-Clone Corp. Antibodies for GSTT1
- Invitrogen Antibodies for GSTT1
- antibodies-online Antibodies for GSTT1: See all 83
- GeneTex GSTT1 antibody for GSTT1
-
Santa Cruz Biotechnology (SCBT) Antibodies for GSTT1
Protein Products
-
OriGene Purified Proteins for GSTT1
- Search Origene for MassSpec and Protein Over-expression Lysates for GSTT1
- Origene Custom Protein Services for GSTT1
- Novus Biologicals proteins for GSTT1
- ProSpec Recombinant Proteins for GSTT1
-
Cloud-Clone Corp. Proteins for GSTT1
- antibodies-online Proteins for GSTT1: See all 21
- Search antibodies-online for peptides
- GeneTex GSTT1 Protein (GTX109250-pro) for GSTT1
- Abcam proteins for Glutathione S Transferase theta 1
Domains & Families for GSTT1 Gene
Gene Families for GSTT1 Gene
Protein Domains for GSTT1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GSTT1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P30711UniProtKB/Swiss-Prot:
GSTT1_HUMAN :- Contains 1 GST C-terminal domain.
- Belongs to the GST superfamily. Theta family.
- Domain:
-
- Contains 1 GST C-terminal domain.
- Contains 1 GST N-terminal domain.
- Family:
-
- Belongs to the GST superfamily. Theta family.
Function for GSTT1 Gene
Molecular function for GSTT1 Gene
- GENATLAS Biochemistry:
- glutathione-S-transferase 1,theta class,deleted in bladder cancer
- UniProtKB/Swiss-Prot CatalyticActivity:
- RX + glutathione = HX + R-S-glutathione.
- UniProtKB/Swiss-Prot Function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
Enzyme Numbers (IUBMB) for GSTT1 Gene
- EC 2.5.1.18 63 4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004364 | glutathione transferase activity | TAS | -- |
| GO:0004602 | glutathione peroxidase activity | IDA | 9307035 |
Phenotypes for GSTT1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for GSTT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GSTT1 gene
- Search ViGene Biosciences for GSTT1
miRNA Products
- Search ViGene Biosciences for GSTT1
Clone Products
- OriGene clones in human for GSTT1
- OriGene ORF clones in human,mouse,rat for GSTT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GSTT1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for GSTT1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GSTT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GSTT1 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GSTT1 Gene
Localization for GSTT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GSTT1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 5 |
| nucleus | 3 |
| mitochondrion | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | IDA | 23376485 |
Pathways & Interactions for GSTT1 Gene
More details on SuperPathways for GSTT1Pathways by source for GSTT1 Gene
4 BioSystems pathways for GSTT1 Gene
4 Reactome pathways for GSTT1 Gene
4 KEGG pathways for GSTT1 Gene
2 GeneGo (Thomson Reuters) pathways for GSTT1 Gene
Interacting Proteins for GSTT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006749 | glutathione metabolic process | IDA | 9307035 |
| GO:0098869 | cellular oxidant detoxification | IDA | 9307035 |
| GO:1901687 | glutathione derivative biosynthetic process | TAS | -- |
No data available for SIGNOR curated interactions for GSTT1 Gene
Drugs & Compounds for GSTT1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cisplatin | Approved | Pharma | Enzyme, substrate | Inhibits DNA synthesis,chemotherapy drug, Platinum | 2569 | |
| Glutathione | Approved | Nutra | Target | 0 | ||
| Oxaliplatin | Approved, Investigational | Pharma | Enzyme, substrate | Antitumor agent, Platinum | 1338 | |
| Carboplatin | Approved | Pharma | Enzyme, substrate | Antitumor agent that forms platinum-DNA adducts., Platinum | 1910 | |
| Etoposide | Approved | Pharma | Enzyme, substrate | Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor | 1189 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene |
|
|
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| (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene |
|
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| (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene |
|
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| (1S,2R)-Naphthalene 1,2-oxide |
|
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| 1,1-Dichloroethylene epoxide |
|
|
|
Transcripts for GSTT1 Gene
mRNA/cDNA for GSTT1 Gene
- (10) REFSEQ mRNAs :
- (235) Selected AceView cDNA sequences:
miRNA Products
- Search ViGene Biosciences for GSTT1
Clone Products
- OriGene clones in human for GSTT1
- OriGene ORF clones in human,mouse,rat for GSTT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GSTT1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for GSTT1 Gene
This gene is overexpressed in Uterus (11.0) and Skin (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GSTT1 Gene
SOURCE GeneReport for Unigene cluster for GSTT1 Gene Hs.268573
mRNA Expression by UniProt/SwissProt for GSTT1 Gene
P30711-GSTT1_HUMAN
Tissue specificity:
Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles.
Primer Products
-
OriGene qPCR primer pairs and template standards for GSTT1
-
OriGene qPCR primer pairs for GSTT1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for GSTT1 Gene
Orthologs for GSTT1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.935 35 |
|
- Species with no ortholog for GSTT1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
No data available for Evolution for GSTT1 Gene
Paralogs for GSTT1 Gene
(4) SIMAP similar genes for GSTT1 Gene using alignment to 12 proteins:
No data available for Paralogs for GSTT1 Gene
Variants for GSTT1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for GSTT1 Gene
- GSTT1_HUMAN-P30711
- The GSTT1 gene is absent from 38% of the population. The presence or absence of the GSTT1 gene is coincident with the conjugator (GSST1+) and non-conjugator (GSTT1-) phenotypes respectively. The GSTT1+ phenotype can catalyze the glutathione conjugation of dichloromethane.
| SNP ID | Clin | Chr 22 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_014501 | - | ||||
| VAR_014502 | - | ||||
| VAR_014503 | - | ||||
| VAR_014504 | - |
Residual Variation Intolerance Score:
93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.23;
62.20% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for GSTT1 Gene
- Human Gene Mutation Database (HGMD)
- GSTT1
Disorders for GSTT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| laryngeal carcinoma |
|
|
| asbestosis |
|
|
| larynx cancer |
|
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| senile cataract |
|
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| multiple chemical sensitivity |
|
|
Search GSTT1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for GSTT1
No data available for UniProtKB/Swiss-Prot and Genatlas for GSTT1 Gene
Publications for GSTT1 Gene
- Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries. (PMID: 17333241) JAPnsson L.S. … JAPnsson B.A. (Int Arch Occup Environ Health 2007) 3 23 25 26
- Glutathione S-transferases M1, T1 genotypes and the risk of gastric cancer: a case-control study. (PMID: 11819818) Cai L. … Zhang Z.F. (World J. Gastroenterol. 2001) 3 23 48 67
- An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. (PMID: 17372252) Schwartzbaum J.A. … Feychting M. (Cancer Epidemiol. Biomarkers Prev. 2007) 3 25 26
- Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. (PMID: 17617661) Moore L.E. … Chow W.H. (Carcinogenesis 2007) 3 25 26
- The role of genetic factor in etiopathogenesis of squamous cell carcinoma of the head and neck in young adults. (PMID: 17653748) Gawecki W. … Szyfter W. (Eur Arch Otorhinolaryngol 2007) 3 25 26
Products for GSTT1 Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GSTT1
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- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for GSTT1
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- OriGene qPCR primer pairs for GSTT1
- OriGene qPCR primer pairs and template standards for GSTT1
- OriGene CRISPR knockouts for GSTT1
- OriGene clones in human for GSTT1
- OriGene ORF clones in human,mouse,rat for GSTT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript Custom Purified and Recombinant Proteins Services for GSTT1
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- Browse GenScript CRISPR for GSTT1
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- Novus Biologicals Antibodies for GSTT1
- Novus Biologicals proteins for GSTT1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for Glutathione S Transferase theta 1
- Abcam antibodies for Glutathione S Transferase theta 1 + Glutathione S Transferase theta 4
- Abcam proteins for Glutathione S Transferase theta 1
- Search for Assays for GSTT1 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- ProSpec Recombinant Proteins for GSTT1
- Cloud-Clone Corp. Antibodies for GSTT1
- Cloud-Clone Corp. Proteins for GSTT1
- Cloud-Clone Corp Assay Kits for GSTT1
- antibodies-online Antibodies for GSTT1: See all 83
- antibodies-online Kits for GSTT1: See all 16
- antibodies-online Proteins for GSTT1: See all 21
- Search antibodies-online for peptides
- GeneTex GSTT1 antibody for GSTT1
- GeneTex GSTT1 Protein (GTX109250-pro) for GSTT1
- ViGene Biosciences adenoviral particle packaged cDNA for GSTT1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GSTT1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GSTT1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GSTT1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GSTT1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GSTT1 gene
- Search ViGene Biosciences for GSTT1
- Search ViGene Biosciences for GSTT1
- Santa Cruz Biotechnology (SCBT) Antibodies for GSTT1
- Search Santa Cruz Biotechnology (SCBT) for GSTT1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GSTT1
Sources for GSTT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (17) IUBMB
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
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- (151) Horizon