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Aliases for GSTM3 Gene

Aliases for GSTM3 Gene

  • Glutathione S-Transferase Mu 3 (Brain) 2 3
  • GST5 3 4 6
  • Glutathione S-Transferase M3 (Brain) 2 3
  • GST Class-Mu 3 3 4
  • EC 2.5.1.18 4 63
  • HGSTM3-3 3 4
  • GSTM3-3 3 4
  • Brain Type Mu-Glutathione S-Transferase 3
  • S-(Hydroxyalkyl)Glutathione Lyase M3 3
  • Glutathione S-Aralkyltransferase M3 3
  • Glutathione S-Alkyltransferase M3 3
  • Glutathione S-Aryltransferase M3 3
  • Glutathione S-Transferase, Mu-3 3
  • Glutathione S-Transferase Mu 3 3
  • Brain GST 3
  • GSTB 3
  • GTM3 3

External Ids for GSTM3 Gene

Previous GeneCards Identifiers for GSTM3 Gene

  • GC01M110758
  • GC01M109208
  • GC01M109381
  • GC01M109577
  • GC01M109576
  • GC01M109988
  • GC01M110276
  • GC01M108146

Summaries for GSTM3 Gene

Entrez Gene Summary for GSTM3 Gene

  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

GeneCards Summary for GSTM3 Gene

GSTM3 (Glutathione S-Transferase Mu 3 (Brain)) is a Protein Coding gene. Diseases associated with GSTM3 include laryngeal squamous cell carcinoma and oral cancer. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is GSTM5.

UniProtKB/Swiss-Prot for GSTM3 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.

Gene Wiki entry for GSTM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTM3 Gene

Genomics for GSTM3 Gene

Regulatory Elements for GSTM3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GSTM3 Gene

Start:
109,733,932 bp from pter
End:
109,741,038 bp from pter
Size:
7,107 bases
Orientation:
Minus strand

Genomic View for GSTM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSTM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTM3 Gene

Proteins for GSTM3 Gene

  • Protein details for GSTM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21266-GSTM3_HUMAN
    Recommended name:
    Glutathione S-transferase Mu 3
    Protein Accession:
    P21266
    Secondary Accessions:
    • O60550
    • Q96HA3

    Protein attributes for GSTM3 Gene

    Size:
    225 amino acids
    Molecular mass:
    26560 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTM3 Gene

neXtProt entry for GSTM3 Gene

Proteomics data for GSTM3 Gene at MOPED

Selected DME Specific Peptides for GSTM3 Gene

Post-translational modifications for GSTM3 Gene

Other Protein References for GSTM3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GSTM3 Gene

Gene Families for GSTM3 Gene

HGNC:
  • SGST :Glutathione S-transferases / Soluble

Graphical View of Domain Structure for InterPro Entry

P21266

UniProtKB/Swiss-Prot:

GSTM3_HUMAN :
  • P21266
Domain:
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
Family:
  • Belongs to the GST superfamily. Mu family.
genes like me logo Genes that share domains with GSTM3: view

Function for GSTM3 Gene

Molecular function for GSTM3 Gene

GENATLAS Biochemistry: glutathione-S-transferase 3,mu class,expressed in brain
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=1.1 mM for 1-chloro-2,4-dinitrobenzene {ECO:0000269 PubMed:10587441}; KM=0.084 mM for glutathione {ECO:0000269 PubMed:10587441};
UniProtKB/Swiss-Prot CatalyticActivity: RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.

Enzyme Numbers (IUBMB) for GSTM3 Gene

Gene Ontology (GO) - Molecular Function for GSTM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IDA 10587441
GO:0005515 protein binding --
GO:0019899 enzyme binding IPI 8373352
GO:0042802 identical protein binding IPI 16189514
GO:0042803 protein homodimerization activity IPI 8373352
genes like me logo Genes that share ontologies with GSTM3: view

Phenotypes for GSTM3 Gene

genes like me logo Genes that share phenotypes with GSTM3: view

Animal Model Products

CRISPR Products

miRNA for GSTM3 Gene

miRTarBase miRNAs that target GSTM3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GSTM3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GSTM3 Gene

Localization for GSTM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTM3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTM3 Gene COMPARTMENTS Subcellular localization image for GSTM3 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for GSTM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IDA 8373352
GO:0005829 cytosol TAS --
GO:0035686 sperm fibrous sheath IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GSTM3: view

Pathways for GSTM3 Gene

genes like me logo Genes that share pathways with GSTM3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GSTM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IDA 10587441
GO:0006805 xenobiotic metabolic process TAS --
GO:0008065 establishment of blood-nerve barrier TAS 2345169
GO:0018916 nitrobenzene metabolic process IDA 8373352
GO:0042178 xenobiotic catabolic process IDA 8373352
genes like me logo Genes that share ontologies with GSTM3: view

Compounds for GSTM3 Gene

(12) HMDB Compounds for GSTM3 Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxyestrone-1-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione
Not Available
2-Hydroxyestrone-4-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione
Not Available
4-Hydroxyestrone-2-S-glutathione
  • 3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione
Not Available
Adrenochrome
  • adrenochrome oxidised
54-06-8
Estrone-2,3-quinone
  • catecholestrogen quinone
40551-33-5

(2) Drugbank Compounds for GSTM3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glutathione
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8 target
Vitamin E
  • alpha-Tocopherol
59-02-9 enzyme inducer

(3) Novoseek inferred chemical compound relationships for GSTM3 Gene

Compound -log(P) Hits PubMed IDs
gsts 84.4 1
epoxide 46.2 3
oxygen 0 1

(2) PharmGKB related drug/compound annotations for GSTM3 Gene

Drug/compound Annotation
cisplatin CA
cyclophosphamide CA
genes like me logo Genes that share compounds with GSTM3: view

Transcripts for GSTM3 Gene

Unigene Clusters for GSTM3 Gene

Glutathione S-transferase mu 3 (brain):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GSTM3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTM3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for GSTM3 Gene

GeneLoc Exon Structure for
GSTM3
ECgene alternative splicing isoforms for
GSTM3

Expression for GSTM3 Gene

mRNA expression in normal human tissues for GSTM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTM3 Gene

This gene is overexpressed in Testis (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GSTM3 Gene

SOURCE GeneReport for Unigene cluster for GSTM3 Gene Hs.2006

mRNA Expression by UniProt/SwissProt for GSTM3 Gene

P21266-GSTM3_HUMAN
Tissue specificity: Testis and brain
genes like me logo Genes that share expressions with GSTM3: view

In Situ Assay Products

Orthologs for GSTM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTM3 35
  • 99.41 (n)
  • 99.56 (a)
GSTM3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GSTM3 35
  • 87.11 (n)
  • 85.33 (a)
GSTM3 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GSTM3 35
  • 89.34 (n)
  • 87.39 (a)
GSTM3 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gstm3 16
Gstm5 35
  • 87.88 (n)
  • 89.55 (a)
Gstm5 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GSTM3 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100912430 35
  • 86.37 (n)
  • 88 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii gstm 36
  • 65 (a)
ManyToMany
gstm3 36
  • 64 (a)
ManyToMany
wufc26g06 35
zgc:173994 35
  • 67.59 (n)
  • 66.67 (a)
zgc:173994 36
  • 66 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea gst-1 36
  • 33 (a)
ManyToMany
gst-23 36
  • 32 (a)
ManyToMany
gst-25 36
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
Species with no ortholog for GSTM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GSTM3 Gene

ENSEMBL:
Gene Tree for GSTM3 (if available)
TreeFam:
Gene Tree for GSTM3 (if available)

Paralogs for GSTM3 Gene

Paralogs for GSTM3 Gene

Selected SIMAP similar genes for GSTM3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GSTM3 Gene

genes like me logo Genes that share paralogs with GSTM3: view

Variants for GSTM3 Gene

Sequence variations from dbSNP and Humsavar for GSTM3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7483 - 109,737,079(-) AGCCT(A/G)TATGC missense, reference, nc-transcript-variant
rs1055259 -- 109,734,239(-) AGCTC(A/G)TTATA utr-variant-3-prime, nc-transcript-variant
rs1109138 -- 109,735,327(-) GCGCA(A/G)TTGCT utr-variant-3-prime, nc-transcript-variant
rs1332018 -- 109,740,350(+) TACCC(G/T)ACATA utr-variant-5-prime, nc-transcript-variant
rs1537234 -- 109,737,199(-) GGGTC(G/T)TTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTM3 Gene

Variant ID Type Subtype PubMed ID
nsv872143 CNV Loss 21882294

Relevant External Links for GSTM3 Gene

HapMap Linkage Disequilibrium report
GSTM3
Human Gene Mutation Database (HGMD)
GSTM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTM3 Gene

Disorders for GSTM3 Gene

(18) Novoseek inferred disease relationships for GSTM3 Gene

Disease -log(P) Hits PubMed IDs
laryngeal squamous cell carcinoma 55.6 1
pharyngeal cancer 53.9 3
carcinoma basal cell 45.1 2
oral cancer 42.3 8
laryngeal cancer 40.9 4

Relevant External Links for GSTM3

Genetic Association Database (GAD)
GSTM3
Human Genome Epidemiology (HuGE) Navigator
GSTM3
genes like me logo Genes that share disorders with GSTM3: view

No data available for UniProtKB/Swiss-Prot for GSTM3 Gene

Publications for GSTM3 Gene

  1. An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. (PMID: 17372252) Schwartzbaum J.A. … Feychting M. (Cancer Epidemiol. Biomarkers Prev. 2007) 3 23 25 48
  2. Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians. (PMID: 11040079) Juronen E. … Mikelsaar A.V. (Exp. Eye Res. 2000) 3 23 48
  3. Susceptibility genes: GSTM1 and GSTM3 as genetic risk factors in bladder cancer. (PMID: 11173863) Schnakenberg E. … Schloot W. (Cytogenet. Cell Genet. 2000) 3 23 48
  4. A case-control study of microsomal epoxide hydrolase, smoking, meat consumption, glutathione S-transferase M3, and risk of colorectal adenomas. (PMID: 11289100) Cortessis V. … Levy D. (Cancer Res. 2001) 3 23 48
  5. Glutathione-S-transferase gene polymorphisms in colorectal cancer patients: interaction between GSTM1 and GSTM3 allele variants as a risk-modulating factor. (PMID: 11408349) Loktionov A. … Bingham S.A. (Carcinogenesis 2001) 3 23 48

Products for GSTM3 Gene

Sources for GSTM3 Gene

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