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Aliases for GSTA4 Gene

Aliases for GSTA4 Gene

  • Glutathione S-Transferase Alpha 4 2 3
  • Glutathione S-Transferase A4-4 3 4
  • Glutathione S-Transferase A4 2 3
  • GST Class-Alpha Member 4 3 4
  • EC 2.5.1.18 4 64
  • S-(Hydroxyalkyl)Glutathione Lyase A4 3
  • Glutathione S-Aralkyltransferase A4 3
  • Glutathione S-Alkyltransferase A4 3
  • Glutathione S-Aryltransferase A4 3
  • Glutathione Transferase A4-4 3
  • GSTA4-4 3
  • GTA4 3

External Ids for GSTA4 Gene

Summaries for GSTA4 Gene

Entrez Gene Summary for GSTA4 Gene

  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for GSTA4 Gene

GSTA4 (Glutathione S-Transferase Alpha 4) is a Protein Coding gene. Diseases associated with GSTA4 include atherosclerosis and malignant pleural mesothelioma. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include protein homodimerization activity and glutathione transferase activity. An important paralog of this gene is GSTA5.

UniProtKB/Swiss-Prot for GSTA4 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).

Gene Wiki entry for GSTA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTA4 Gene

Genomics for GSTA4 Gene

Genomic Location for GSTA4 Gene

Start:
52,977,948 bp from pter
End:
52,995,380 bp from pter
Size:
17,433 bases
Orientation:
Minus strand

Genomic View for GSTA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSTA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTA4 Gene

Regulatory Elements for GSTA4 Gene

Proteins for GSTA4 Gene

  • Protein details for GSTA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15217-GSTA4_HUMAN
    Recommended name:
    Glutathione S-transferase A4
    Protein Accession:
    O15217
    Secondary Accessions:
    • B2RD15
    • Q5T7Q8
    • Q6P4G1
    • Q9BX18
    • Q9H414

    Protein attributes for GSTA4 Gene

    Size:
    222 amino acids
    Molecular mass:
    25704 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTA4 Gene

    Alternative splice isoforms for GSTA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTA4 Gene

Proteomics data for GSTA4 Gene at MOPED

Selected DME Specific Peptides for GSTA4 Gene

Post-translational modifications for GSTA4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys127 and Lys138

Other Protein References for GSTA4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GSTA4 Gene

Gene Families for GSTA4 Gene

HGNC:
  • SGST :Glutathione S-transferases / Soluble

UniProtKB/Swiss-Prot:

GSTA4_HUMAN
Domain:
  • Contains 1 GST C-terminal domain.:
    • O15217
  • Contains 1 GST N-terminal domain.:
    • O15217
Family:
  • Belongs to the GST superfamily. Alpha family.:
    • O15217
genes like me logo Genes that share domains with GSTA4: view

Function for GSTA4 Gene

Molecular function for GSTA4 Gene

GENATLAS Biochemistry: glutathione S-transferase,alpha 4,ubiquitously expressed
UniProtKB/Swiss-Prot CatalyticActivity: RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).

Enzyme Numbers (IUBMB) for GSTA4 Gene

Gene Ontology (GO) - Molecular Function for GSTA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IDA 10329152
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IPI 10329152
genes like me logo Genes that share ontologies with GSTA4: view
genes like me logo Genes that share phenotypes with GSTA4: view

Animal Models for GSTA4 Gene

MGI Knock Outs for GSTA4:

miRNA for GSTA4 Gene

miRTarBase miRNAs that target GSTA4

No data available for Transcription Factor Targeting and HOMER Transcription for GSTA4 Gene

Localization for GSTA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTA4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTA4 Gene COMPARTMENTS Subcellular localization image for GSTA4 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
peroxisome 2
vacuole 2
endosome 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GSTA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GSTA4: view

Pathways for GSTA4 Gene

genes like me logo Genes that share pathways with GSTA4: view

Gene Ontology (GO) - Biological Process for GSTA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IDA 10329152
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with GSTA4: view

Compounds for GSTA4 Gene

(13) HMDB Compounds for GSTA4 Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxyestrone-1-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione
Not Available
2-Hydroxyestrone-4-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione
Not Available
4-Hydroxyestrone-2-S-glutathione
  • 3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione
Not Available
4-Hydroxynonenal
  • 4-hydroxynon-2-enal
75899-68-2
Adrenochrome
  • adrenochrome oxidised
54-06-8

(1) Drugbank Compounds for GSTA4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glutathione
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8 target

(3) Novoseek inferred chemical compound relationships for GSTA4 Gene

Compound -log(P) Hits PubMed IDs
4-hydroxynonenal 86.3 17
gsts 84.8 3
lipid 45.9 8
genes like me logo Genes that share compounds with GSTA4: view

Transcripts for GSTA4 Gene

Unigene Clusters for GSTA4 Gene

Glutathione S-transferase alpha 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSTA4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - -
SP14: - -
SP15: - - - - - - -
SP16: - - -
SP17: - - - - - - - - - - - - -
SP18: - - -

ExUns: 9a · 9b · 9c · 9d · 9e · 9f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for GSTA4 Gene

GeneLoc Exon Structure for
GSTA4
ECgene alternative splicing isoforms for
GSTA4

Expression for GSTA4 Gene

mRNA expression in normal human tissues for GSTA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTA4 Gene

This gene is overexpressed in Adrenal Gland (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GSTA4 Gene

SOURCE GeneReport for Unigene cluster for GSTA4 Gene Hs.485557

mRNA Expression by UniProt/SwissProt for GSTA4 Gene

O15217-GSTA4_HUMAN
Tissue specificity: Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and liver
genes like me logo Genes that share expressions with GSTA4: view

Orthologs for GSTA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTA4 36
  • 99.1 (n)
  • 99.55 (a)
GSTA4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GSTA4 36
  • 90.39 (n)
  • 93.69 (a)
GSTA4 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 86 (a)
OneToMany
GSTA4 36
  • 91.14 (n)
  • 92.79 (a)
GSTA4 37
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gsta3 37
  • 50 (a)
ManyToMany
Gsta4 16
oppossum
(Monodelphis domestica)
Mammalia GSTA4 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GSTA4 37
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves GSTA 37
  • 59 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 62 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii gstal 37
  • 53 (a)
ManyToMany
zgc:173961 37
  • 53 (a)
ManyToMany
zgc:173962 37
  • 53 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F56A4.3 37
  • 22 (a)
ManyToMany
F56A4.4 37
  • 25 (a)
ManyToMany
gst-10 37
  • 26 (a)
ManyToMany
gst-41 37
  • 26 (a)
ManyToMany
Y45G12C.3 37
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToMany
Species with no ortholog for GSTA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GSTA4 Gene

ENSEMBL:
Gene Tree for GSTA4 (if available)
TreeFam:
Gene Tree for GSTA4 (if available)

Paralogs for GSTA4 Gene

Paralogs for GSTA4 Gene

Selected SIMAP similar genes for GSTA4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GSTA4: view

Variants for GSTA4 Gene

Sequence variations from dbSNP and Humsavar for GSTA4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs7496 -- 52,978,041(-) GTCTA(A/G)TAAAT utr-variant-3-prime
rs182623 -- 52,997,060(-) AGCAA(A/T)TGCTT upstream-variant-2KB
rs316127 -- 52,986,007(-) ATGGC(A/G)CGATC intron-variant
rs316128 -- 52,984,348(-) CTAAC(A/C)TAAGC intron-variant
rs316129 -- 52,984,107(-) TTGTC(A/G)AACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTA4 Gene

Variant ID Type Subtype PubMed ID
dgv1954e1 CNV Complex 17122850

Relevant External Links for GSTA4 Gene

HapMap Linkage Disequilibrium report
GSTA4

Disorders for GSTA4 Gene

(2) Novoseek inferred disease relationships for GSTA4 Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 14.8 1
parkinson disease 6.78 1

Relevant External Links for GSTA4

Genetic Association Database (GAD)
GSTA4
Human Genome Epidemiology (HuGE) Navigator
GSTA4
genes like me logo Genes that share disorders with GSTA4: view

No data available for UniProtKB/Swiss-Prot for GSTA4 Gene

Publications for GSTA4 Gene

  1. Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4. (PMID: 9480897) Board P.G. (Biochem. J. 1998) 2 3 4 23
  2. Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products. (PMID: 10329152) Bruns C.M. … Tainer J.A. (J. Mol. Biol. 1999) 3 4 23
  3. Molecular implications of the human glutathione transferase A-4 gene (hGSTA4) polymorphisms in neurodegenerative diseases. (PMID: 16054170) CoppedA" F. … Migliore L. (Mutat. Res. 2005) 3 23 49
  4. Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. (PMID: 20085333) Balogh L.M. … Atkins W.M. (Biochemistry 2010) 3 4 23
  5. Antioxidant genes, diabetes and dietary antioxidants in association with risk of pancreatic cancer. (PMID: 20097730) Tang H. … Li D. (Carcinogenesis 2010) 3 23 49

Products for GSTA4 Gene

Sources for GSTA4 Gene

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