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Aliases for GSTA2 Gene

Aliases for GSTA2 Gene

  • Glutathione S-Transferase Alpha 2 2 3 5
  • GST Class-Alpha Member 2 3 4
  • GST HA Subunit 2 3 4
  • EC 4 63
  • GST-Gamma 3 4
  • GSTA2-2 3 4
  • GST2 3 4
  • GTH2 3 4
  • Testis Tissue Sperm-Binding Protein Li 59n 3
  • S-(Hydroxyalkyl)Glutathione Lyase A2 3
  • Glutathione S-Aralkyltransferase A2 3
  • Glutathione S-Alkyltransferase A2 3
  • Glutathione S-Aryltransferase A2 3
  • Glutathione S-Transferase A2 2
  • Liver GST2 3
  • GTA2 3

External Ids for GSTA2 Gene

Previous HGNC Symbols for GSTA2 Gene

  • GST2

Previous GeneCards Identifiers for GSTA2 Gene

  • GC06M052617
  • GC06M052662
  • GC06M052723
  • GC06M052614
  • GC06M052446

Summaries for GSTA2 Gene

Entrez Gene Summary for GSTA2 Gene

  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008]

GeneCards Summary for GSTA2 Gene

GSTA2 (Glutathione S-Transferase Alpha 2) is a Protein Coding gene. Diseases associated with GSTA2 include Prostate Leiomyosarcoma and Skin Carcinoma In Situ. Among its related pathways are Phase II conjugation and Glutathione metabolism. GO annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA4.

UniProtKB/Swiss-Prot for GSTA2 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Gene Wiki entry for GSTA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTA2 Gene

Genomics for GSTA2 Gene

Regulatory Elements for GSTA2 Gene

Enhancers for GSTA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GSTA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GSTA2 Gene

52,750,087 bp from pter
52,763,569 bp from pter
13,483 bases
Minus strand

Genomic View for GSTA2 Gene

Genes around GSTA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTA2 Gene

Proteins for GSTA2 Gene

  • Protein details for GSTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutathione S-transferase A2
    Protein Accession:
    Secondary Accessions:
    • Q12759
    • Q16491
    • Q9NTY6

    Protein attributes for GSTA2 Gene

    222 amino acids
    Molecular mass:
    25664 Da
    Quaternary structure:
    • Homodimer or heterodimer of GSTA1 and GSTA2.

    Three dimensional structures from OCA and Proteopedia for GSTA2 Gene

neXtProt entry for GSTA2 Gene

Proteomics data for GSTA2 Gene at MOPED

Post-translational modifications for GSTA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GSTA2 Gene

Gene Families for GSTA2 Gene

Suggested Antigen Peptide Sequences for GSTA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GST C-terminal domain.
  • Belongs to the GST superfamily. Alpha family.
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
  • Belongs to the GST superfamily. Alpha family.
genes like me logo Genes that share domains with GSTA2: view

Function for GSTA2 Gene

Molecular function for GSTA2 Gene

GENATLAS Biochemistry:
glutathione S-transferase 2,alpha,expressed in liver,with a proximal promoter essential for the binding of activating transcription factor complexes
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Enzyme Numbers (IUBMB) for GSTA2 Gene

Gene Ontology (GO) - Molecular Function for GSTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with GSTA2: view
genes like me logo Genes that share phenotypes with GSTA2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GSTA2

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GSTA2 Gene

Localization for GSTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTA2 Gene


Subcellular locations from

Jensen Localization Image for GSTA2 Gene COMPARTMENTS Subcellular localization image for GSTA2 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
lysosome 2
peroxisome 2
plasma membrane 2
vacuole 2
chloroplast 1

No data available for Gene Ontology (GO) - Cellular Components for GSTA2 Gene

Pathways & Interactions for GSTA2 Gene

genes like me logo Genes that share pathways with GSTA2: view

Gene Ontology (GO) - Biological Process for GSTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with GSTA2: view

No data available for SIGNOR curated interactions for GSTA2 Gene

Drugs & Compounds for GSTA2 Gene

(11) Drugs for GSTA2 Gene - From: DrugBank, ApexBio, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Busulfan Approved, Investigational Pharma Enzyme, substrate 527
chloroquine Approved Pharma Agonist, Target 142
Clofibrate Approved Pharma Agonist, Enzyme, inhibitor 2
Ethacrynic acid Approved Pharma Enzyme, inhibitor 2
Glutathione Approved Nutra Target, Enzyme, substrate 0

(46) Additional Compounds for GSTA2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide

(1) ApexBio Compounds for GSTA2 Gene

Compound Action Cas Number
Ezatiostat hydrochloride GST inhibitor 286942-97-0
genes like me logo Genes that share compounds with GSTA2: view

Transcripts for GSTA2 Gene

mRNA/cDNA for GSTA2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(152) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GSTA2 Gene

Glutathione S-transferase alpha 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSTA2 Gene

No ASD Table

Relevant External Links for GSTA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GSTA2 Gene

mRNA expression in normal human tissues for GSTA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTA2 Gene

This gene is overexpressed in Liver (x18.1), Pancreas (x15.8), and Kidney - Cortex (x10.3).

Protein differential expression in normal tissues from HIPED for GSTA2 Gene

This gene is overexpressed in Pancreas (24.6), Liver (19.5), and Gallbladder (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GSTA2 Gene

SOURCE GeneReport for Unigene cluster for GSTA2 Gene Hs.94107

mRNA Expression by UniProt/SwissProt for GSTA2 Gene

Tissue specificity: Liver.
genes like me logo Genes that share expression patterns with GSTA2: view

Protein tissue co-expression partners for GSTA2 Gene

Primer Products

Orthologs for GSTA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GSTA2 35
  • 99.4 (n)
  • 99.1 (a)
GSTA2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC501110 35
  • 78.08 (n)
  • 71.62 (a)
(Bos Taurus)
Mammalia GSTA5 36
  • 77 (a)
(Canis familiaris)
Mammalia -- 36
  • 60 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
(Mus musculus)
Mammalia Gm10639 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
(Gallus gallus)
Aves GSTA 35
  • 69.67 (n)
  • 68.47 (a)
-- 36
  • 64 (a)
GSTA3 36
  • 63 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
-- 36
  • 68 (a)
-- 36
  • 65 (a)
-- 36
  • 65 (a)
(Danio rerio)
Actinopterygii gstal 36
  • 54 (a)
zgc:173961 36
  • 53 (a)
zgc:173962 36
  • 54 (a)
(Caenorhabditis elegans)
Secernentea F56A4.3 36
  • 28 (a)
F56A4.4 36
  • 26 (a)
gst-10 36
  • 27 (a)
gst-41 36
  • 29 (a)
Y45G12C.3 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for GSTA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GSTA2 Gene

Gene Tree for GSTA2 (if available)
Gene Tree for GSTA2 (if available)

Paralogs for GSTA2 Gene

Paralogs for GSTA2 Gene

(6) SIMAP similar genes for GSTA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GSTA2: view

Variants for GSTA2 Gene

Sequence variations from dbSNP and Humsavar for GSTA2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2180314 - 52,752,933(+) GTTGA(C/G)TAAAG reference, missense
rs6577 - 52,750,617(-) GGATG(A/C)GAAAT reference, missense
rs2234951 - 52,752,940(-) TTCTG(C/T)CCTTT reference, missense
rs2266631 - 52,751,677(-) CCTTG(C/T)TGGCA reference, missense
rs1009062 -- 52,758,955(-) CTGAG(A/C)AAGTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GSTA2 Gene

Variant ID Type Subtype PubMed ID
nsv462945 CNV Loss 19166990
nsv470818 CNV Loss 18288195
nsv523124 CNV Loss 19592680
esv2752126 CNV Gain 17911159
esv2732085 CNV Deletion 23290073
esv9378 CNV Loss 19470904
esv4858 CNV Duplication 18987735
nsv885883 CNV Gain 21882294
dgv1952e1 CNV Complex 17122850
esv2436160 CNV Deletion 19546169
esv2666271 CNV Deletion 23128226

Variation tolerance for GSTA2 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTA2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTA2 Gene

Disorders for GSTA2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for GSTA2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate leiomyosarcoma
  • leiomyosarcoma of the prostate
skin carcinoma in situ
  • carcinoma in situ of ear
  • dracontiasis
pthirus pubis infestation
  • crabs
periventricular nodular heterotopia
  • paroxysmal nocturnal hemoglobinuria
- elite association - COSMIC cancer census association via MalaCards
Search GSTA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSTA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GSTA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTA2 Gene

Publications for GSTA2 Gene

  1. Human glutathione S-transferase A2 polymorphisms: variant expression, distribution in prostate cancer cases/controls and a novel form. (PMID: 15128049) Ning B. … Coles B. (Pharmacogenetics 2004) 3 23 48 67
  2. No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (PMID: 19859803) Andonova I.E. … Brauch H. (Breast Cancer Res. Treat. 2010) 3 23
  3. I+-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. (PMID: 20153624) Feng Z. … Liu J. (J. Nutr. Biochem. 2010) 25 26
  4. The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: a case-control study in the Portuguese population. (PMID: 19639209) Silva S.N. … Gaspar J.F. (Oncol. Rep. 2009) 3 23
  5. Endothelial cells do not express GSTA1: potential relevance to busulfan-mediated endothelial damage during haematopoietic stem cell transplantation. (PMID: 18194479) Vassord C. … Krishnamoorthy R. (Eur. J. Haematol. 2008) 25 26

Products for GSTA2 Gene

Sources for GSTA2 Gene