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Aliases for GSK3B Gene

Aliases for GSK3B Gene

  • Glycogen Synthase Kinase 3 Beta 2 3 5
  • EC 2.7.11.26 4 61
  • Serine/Threonine-Protein Kinase GSK3B 4
  • EC 2.7.11.1 4
  • GSK-3 Beta 4
  • EC 2.7.11 61

External Ids for GSK3B Gene

Previous GeneCards Identifiers for GSK3B Gene

  • GC03M116184
  • GC03M119174
  • GC03M120822
  • GC03M120866
  • GC03M121028
  • GC03M119540
  • GC03M116916

Summaries for GSK3B Gene

Entrez Gene Summary for GSK3B Gene

  • The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for GSK3B Gene

GSK3B (Glycogen Synthase Kinase 3 Beta) is a Protein Coding gene. Diseases associated with GSK3B include Alzheimer Disease and Bipolar Disorder. Among its related pathways are Development IGF-1 receptor signaling and Constitutive Signaling by AKT1 E17K in Cancer. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is GSK3A.

UniProtKB/Swiss-Prot for GSK3B Gene

  • Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on Thr-548, decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at Thr-182, leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at Thr-687 upon T-cell activation. Phosphorylates NR1D1 st Ser-55 and Ser-59 and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT Ser-427 and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at Ser-17 and Ser-21 and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at Ser-3 or Ser-4 which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509).

Tocris Summary for GSK3B Gene

  • Glycogen synthase kinase 3 (GSK-3) is a serine-threonine kinase with two isoforms (alpha and beta), that was originally discovered as an important enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cellular division, proliferation, motility and survival.

Gene Wiki entry for GSK3B Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSK3B Gene

Genomics for GSK3B Gene

Regulatory Elements for GSK3B Gene

Enhancers for GSK3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G120090 1.4 ENCODE dbSUPER 16.4 +0.5 480 7.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 GSK3B GC03M119752
GH03G120143 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.2 -52.4 -52365 5.9 ELF3 PKNOX1 FOXA2 RAD21 RCOR1 FOS SMARCC1 ZHX2 CEBPB ELF1 GSK3B LOC100130701 GPR156 COX17 LOC105374065 PIR46565
GH03G120157 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.9 -66.2 -66191 6.9 HDAC1 ELF3 TBP HNRNPUL1 BRCA1 RAD21 RFX5 FOS RCOR1 CEBPB GSK3B GPR156 LOC100130701 PIR46565 GC03P120211
GH03G119841 0.7 ENCODE 17.1 +252.9 252886 0.9 CTCF NFIB ZBTB40 CTBP1 GATA3 ZNF366 POLR2A TCF7L2 EZH2 SMAD5 GSK3B PHBP8 GC03P119973
GH03G120151 1.5 FANTOM5 Ensembl ENCODE dbSUPER 7.7 -58.8 -58794 3.4 ELF3 STAT1 RFX1 ZNF680 NFIA JUN CEBPB CEBPG REST EP300 GSK3B GPR156 PIR46565 GC03P120211
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GSK3B on UCSC Golden Path with GeneCards custom track

Promoters for GSK3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000157158 817 5601 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143

Genomic Location for GSK3B Gene

Chromosome:
3
Start:
119,821,321 bp from pter
End:
120,094,417 bp from pter
Size:
273,097 bases
Orientation:
Minus strand

Genomic View for GSK3B Gene

Genes around GSK3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSK3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSK3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSK3B Gene

Proteins for GSK3B Gene

  • Protein details for GSK3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49841-GSK3B_HUMAN
    Recommended name:
    Glycogen synthase kinase-3 beta
    Protein Accession:
    P49841
    Secondary Accessions:
    • D3DN89
    • Q9BWH3
    • Q9UL47

    Protein attributes for GSK3B Gene

    Size:
    420 amino acids
    Molecular mass:
    46744 Da
    Quaternary structure:
    • Monomer. Interacts with ARRB2, DISC1 and ZBED3 (By similarity). Interacts with CABYR, MMP2, MUC1, NIN and PRUNE Interacts with AXIN1; the interaction mediates hyperphosphorylation of CTNNB1 leading to its ubiquitination and destruction. Interacts with and phosphorylates SNAI1. Interacts with DNM1L (via a C-terminal domain). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Interacts with SGK3. Interacts with DAB2IP (via C2 domain); the interaction stimulates GSK3B kinase activation. Interacts (via C2 domain) with PPP2CA. Interacts with the CLOCK-ARNTL/BMAL1 heterodimer. Interacts with the ARNTL/BMAL1. Interacts with CTNND2 (PubMed:19706605). Interacts with NCYM (PubMed:24391509).
    Miscellaneous:
    • Higher expression and activity of GSK3B are found in the skeletal muscle (vastus lateralis) of patients with type 2 diabetes (PubMed:10868943). Several potent GSK3 (GSK3A and GSK3B) inhibitors have been identified and characterized in preclinical models for treatments of type 2 diabetes (PubMed:19366350).

    Three dimensional structures from OCA and Proteopedia for GSK3B Gene

    Alternative splice isoforms for GSK3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSK3B Gene

Selected DME Specific Peptides for GSK3B Gene

P49841:
  • TPPEAIALCS
  • VAIKKVLQD
  • HRDIKPQNLL
  • IKVLGTPTRE
  • IFPGDSGVDQ
  • SYICSRYYRAPEL
  • PLEACAHSFFDELR
  • FAESCKP
  • YVPETVYRVARH
  • RAKQTLPV
  • ELLLGQP
  • CDFGSAK
  • YFFYSSG
  • MNPNYTEFKFPQIK
  • FPQIKAHPW
  • QEVSYTDTKVIGNGSFGVV
  • DFGSAKQL
  • VPETVYR
  • DQLVEIIK
  • YRAPELIFG

Post-translational modifications for GSK3B Gene

  • Mono-ADP-ribosylation by PARP10 negatively regulates kinase activity.
  • Phosphorylated by AKT1 and ILK1. Upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3B, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-216.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSK3B Gene

Domains & Families for GSK3B Gene

Gene Families for GSK3B Gene

Graphical View of Domain Structure for InterPro Entry

P49841

UniProtKB/Swiss-Prot:

GSK3B_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
genes like me logo Genes that share domains with GSK3B: view

Function for GSK3B Gene

Molecular function for GSK3B Gene

GENATLAS Biochemistry:
glycogen synthase kinase 3 beta,dual specificity protein-kinase,regulating glycogen synthesis in skeletal muscle through Tyr activating or Ser/Thr inactivating prosphorylation,key downstream target of PI3-kinase/AKT survival signaling pathway and involved in the regulation of apoptosis,Drosophila Shaggy-Zeste-White 3 homolog,binding to APC-beta-catenin complex,
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [tau protein] = ADP + [tau protein] phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation at Tyr-216. In response to insulin, inhibited by phosphorylation at Ser-9 by PKB/AKT1 and RPS6KA3; phosphorylation at this site causes a conformational change, preventing access of substrates to the active site. Inhibited by lithium.
UniProtKB/Swiss-Prot Function:
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on Thr-548, decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at Thr-182, leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at Thr-687 upon T-cell activation. Phosphorylates NR1D1 st Ser-55 and Ser-59 and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT Ser-427 and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at Ser-17 and Ser-21 and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at Ser-3 or Ser-4 which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509).

Enzyme Numbers (IUBMB) for GSK3B Gene

Gene Ontology (GO) - Molecular Function for GSK3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding IPI 20864106
GO:0002020 protease binding IPI 25118933
GO:0002039 p53 binding IDA 14744935
GO:0004672 protein kinase activity TAS 22988876
GO:0004674 protein serine/threonine kinase activity TAS --
genes like me logo Genes that share ontologies with GSK3B: view
genes like me logo Genes that share phenotypes with GSK3B: view

Animal Models for GSK3B Gene

MGI Knock Outs for GSK3B:

Animal Model Products

CRISPR Products

miRNA for GSK3B Gene

miRTarBase miRNAs that target GSK3B

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GSK3B

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSK3B Gene

Localization for GSK3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSK3B Gene

Cytoplasm. Nucleus. Cell membrane. Note=The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSK3B gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 4
extracellular 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GSK3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 14744935
GO:0005737 cytoplasm IDA,IEA 14744935
GO:0005739 mitochondrion IEA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GSK3B: view

Pathways & Interactions for GSK3B Gene

SuperPathways for GSK3B Gene

SuperPathway Contained pathways
1 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
2 S45 mutants of beta-catenin arent phosphorylated
3 RET signaling
4 Regulation of lipid metabolism Insulin signaling-generic cascades
5 GAB1 signalosome
genes like me logo Genes that share pathways with GSK3B: view

Pathways by source for GSK3B Gene

Gene Ontology (GO) - Biological Process for GSK3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000320 re-entry into mitotic cell cycle IEA --
GO:0001837 epithelial to mesenchymal transition IMP 15448698
GO:0001954 positive regulation of cell-matrix adhesion IMP 18156211
GO:0005975 carbohydrate metabolic process IEA --
GO:0005977 glycogen metabolic process IDA 8638126
genes like me logo Genes that share ontologies with GSK3B: view

Drugs & Compounds for GSK3B Gene

(77) Drugs for GSK3B Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lithium Approved Pharma Target, inhibitor 0
Citalopram Approved Pharma 512
Fluoxetine Approved, Vet_approved Pharma Channel blocker 238
Adenosine triphosphate Approved Nutra 0
Alsterpaullone Experimental Pharma Target 0

(7) Additional Compounds for GSK3B Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(5) Tocris Compounds for GSK3B Gene

Compound Action Cas Number
AR-A 014418 Selective GSK-3 inhibitor 487021-52-3
Indirubin-3'-oxime GSK-3beta inhibitor. Also inhibits other protein kinases 160807-49-8
SB 216763 Potent, selective GSK-3 inhibitor 280744-09-4
SB 415286 Potent, selective GSK-3 inhibitor 264218-23-7
TCS 183 Fragment 1-13 of GSK-3beta sequence

(29) ApexBio Compounds for GSK3B Gene

Compound Action Cas Number
1-Azakenpaullone GSK-3β inhibitor,potent and selective,cell-permeable 676596-65-9
3F8 GSK-3β inhibitor 159109-11-2
A 1070722 1384424-80-9
AR-A014418 GSK3β inhibitor, ATP-competitive and selective 487021-52-3
AZD1080 GSK3βinhibitor 612487-72-6
AZD2858 GSK-3 inhibitor,potent and selective 486424-20-8
Bikinin GSK3 inhibitor and Brassinosteroid activator 188011-69-0
BIO-acetoxime 667463-85-6
CHIR 99021 trihydrochloride
CHIR-98014 GSK-3β inhibitor,selective and ATP-competitive 252935-94-7
CHIR-99021 (CT99021) GSK-3 inhibitor, Cell-permeable, ATP-competitive 252917-06-9
CHIR-99021 (CT99021) HCl GSK-3α/β inhibitor 252917-06-9
FRATide 251087-38-4
GSK-3 inhibitor 1 603272-51-1
GSK-3 Inhibitor IX (BIO) 667463-62-9
IM-12 1129669-05-1
Indirubin 479-41-4
Indirubin-3'-oxime 160807-49-8
L803-mts 1043881-55-5
LY2090314 Potent GSK-3 inhibitor 603288-22-8
SB 216763 GSK-3 inhibitor,ATP-competitive,potent and selective 280744-09-4
SB 415286 GSK-3 inhibitor,potent and selective 264218-23-7
TC-G 24 1257256-44-2
TCS 183
TCS 184 1315378-71-2
TCS 2002 GSK -3β inhibitor, potent 1005201-24-0
TDZD-8 GSK-3β inhibitor 327036-89-5
Tideglusib 865854-05-3
TWS119 GSK-3β inhibitor 601514-19-6
genes like me logo Genes that share compounds with GSK3B: view

Drug Products

Transcripts for GSK3B Gene

Unigene Clusters for GSK3B Gene

Glycogen synthase kinase 3 beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GSK3B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSK3B Gene

No ASD Table

Relevant External Links for GSK3B Gene

GeneLoc Exon Structure for
GSK3B
ECgene alternative splicing isoforms for
GSK3B

Expression for GSK3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GSK3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GSK3B Gene

This gene is overexpressed in Fetal Brain (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GSK3B Gene



Protein tissue co-expression partners for GSK3B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GSK3B Gene:

GSK3B

SOURCE GeneReport for Unigene cluster for GSK3B Gene:

Hs.445733

mRNA Expression by UniProt/SwissProt for GSK3B Gene:

P49841-GSK3B_HUMAN
Tissue specificity: Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain.

Evidence on tissue expression from TISSUES for GSK3B Gene

  • Liver(4.5)
  • Eye(4.3)
  • Nervous system(4)
  • Muscle(3)
  • Heart(2.8)
  • Kidney(2.6)
  • Intestine(2.5)
  • Blood(2.4)
  • Lung(2.4)
  • Adrenal gland(2.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with GSK3B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSK3B Gene

Orthologs for GSK3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GSK3B Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia GSK3B 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GSK3B 34 35
  • 98.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GSK3B 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GSK3B 34 35
  • 97 (n)
cow
(Bos Taurus)
Mammalia GSK3B 34 35
  • 96.37 (n)
mouse
(Mus musculus)
Mammalia Gsk3b 34 16 35
  • 92.73 (n)
rat
(Rattus norvegicus)
Mammalia Gsk3b 34
  • 92.4 (n)
chicken
(Gallus gallus)
Aves GSK3B 34 35
  • 88.52 (n)
lizard
(Anolis carolinensis)
Reptilia GSK3B 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gsk3b 34
  • 77.09 (n)
Str.19775 34
African clawed frog
(Xenopus laevis)
Amphibia Xgsk-3 34
zebrafish
(Danio rerio)
Actinopterygii GSK3B (2 of 2) 35
  • 90 (a)
OneToMany
gsk3b 34 35
  • 79.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta sgg 36 35
  • 75 (a)
gskt 36 35
  • 64 (a)
Pk34A 36
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea Y18D10A.5 36
  • 74 (a)
gsk-3 34 35
  • 64.84 (n)
C44H4.6 36
  • 42 (a)
R03D7.5 36
  • 38 (a)
F21F3.2 36
  • 32 (a)
C36B1.10 36
  • 31 (a)
Y106G6D.4 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM11 35 37
  • 48 (a)
ManyToMany
MRK1 35
  • 35 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SK13 34
  • 63.58 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7461 34
rice
(Oryza sativa)
Liliopsida Os05g0134000 34
  • 61.67 (n)
corn
(Zea mays)
Liliopsida Zm.6802 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 78 (a)
OneToMany
Species where no ortholog for GSK3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSK3B Gene

ENSEMBL:
Gene Tree for GSK3B (if available)
TreeFam:
Gene Tree for GSK3B (if available)

Paralogs for GSK3B Gene

Paralogs for GSK3B Gene

Pseudogenes.org Pseudogenes for GSK3B Gene

genes like me logo Genes that share paralogs with GSK3B: view

Variants for GSK3B Gene

Sequence variations from dbSNP and Humsavar for GSK3B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000011870 -- 119,985,952(+) ACAGT(A/C)ACCAA intron-variant
rs1000014717 -- 120,083,089(+) GCAAG(C/G)GTGAG intron-variant
rs1000016683 -- 119,859,106(+) AAATG(A/G)CACCA intron-variant
rs1000020021 -- 119,954,918(+) ACAAC(C/T)AGCAA intron-variant
rs1000026929 -- 120,040,637(+) AAGAA(A/G)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSK3B Gene

Variant ID Type Subtype PubMed ID
dgv883e199 CNV deletion 23128226
esv22981 CNV loss 19812545
esv2516850 CNV deletion 19546169
esv2631534 CNV deletion 19546169
esv2666502 CNV deletion 23128226
esv3562450 CNV deletion 23714750
esv3568979 CNV loss 25503493
esv3597569 CNV loss 21293372
nsv1073239 CNV deletion 25765185
nsv3964 CNV deletion 18451855
nsv478074 CNV novel sequence insertion 20440878
nsv478327 CNV novel sequence insertion 20440878
nsv507120 OTHER sequence alteration 20534489
nsv829696 CNV gain 17160897
nsv829697 CNV loss 17160897
nsv955330 CNV duplication 24416366

Variation tolerance for GSK3B Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSK3B Gene

Human Gene Mutation Database (HGMD)
GSK3B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSK3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSK3B Gene

Disorders for GSK3B Gene

MalaCards: The human disease database

(20) MalaCards diseases for GSK3B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • alzheimer disease, late-onset
bipolar disorder
  • bipolar depression
muscle hypertrophy
  • myostatin-related muscle hypertrophy
multiple symmetrical lipomatosis
  • lipomatosis, familial benign cervical
usher syndrome, type 2a
  • retinal disease in usher syndrome type iia, modifier of
- elite association - COSMIC cancer census association via MalaCards
Search GSK3B in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSK3B

Genetic Association Database (GAD)
GSK3B
Human Genome Epidemiology (HuGE) Navigator
GSK3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSK3B
genes like me logo Genes that share disorders with GSK3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSK3B Gene

Publications for GSK3B Gene

  1. Glycogen synthase kinase-3beta and tau genes interact in Alzheimer's disease. (PMID: 18991351) Kwok J.B. … Schofield P.R. (Ann. Neurol. 2008) 3 22 46 64
  2. First evidence of genetic association between AKT2 and polycystic ovary syndrome. (PMID: 18768676) Goodarzi M.O. … Azziz R. (Diabetes Care 2008) 3 22 46 64
  3. No significant association between the genetic polymorphisms in the GSK-3 beta gene and schizophrenia in the Chinese population. (PMID: 17368486) Meng J. … He L. (J Psychiatr Res 2008) 3 22 46 64
  4. Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism. (PMID: 17628506) Adli M. … Bauer M. (Biol. Psychiatry 2007) 3 22 25 64
  5. Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome. (PMID: 17270183) Goodarzi M.O. … Azziz R. (Fertil. Steril. 2007) 3 22 46 64

Products for GSK3B Gene

Sources for GSK3B Gene