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Aliases for GSK3B Gene

Aliases for GSK3B Gene

  • Glycogen Synthase Kinase 3 Beta 2 3 5
  • EC 2.7.11.26 4 63
  • Serine/Threonine-Protein Kinase GSK3B 4
  • EC 2.7.11.1 4
  • GSK-3 Beta 4
  • EC 2.7.11 63

External Ids for GSK3B Gene

Previous GeneCards Identifiers for GSK3B Gene

  • GC03M116184
  • GC03M119174
  • GC03M120822
  • GC03M120866
  • GC03M121028
  • GC03M119540
  • GC03M116916

Summaries for GSK3B Gene

Entrez Gene Summary for GSK3B Gene

  • The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for GSK3B Gene

GSK3B (Glycogen Synthase Kinase 3 Beta) is a Protein Coding gene. Diseases associated with GSK3B include Alzheimer Disease and Bipolar Disorder. Among its related pathways are Constitutive Signaling by AKT1 E17K in Cancer and Axon guidance. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is GSK3A.

UniProtKB/Swiss-Prot for GSK3B Gene

  • Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on Thr-548, decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at Thr-182, leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at Thr-687 upon T-cell activation. Phosphorylates NR1D1 st Ser-55 and Ser-59 and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT Ser-427 and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at Ser-17 and Ser-21 and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at Ser-3 or Ser-4 which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509).

Tocris Summary for GSK3B Gene

  • Glycogen synthase kinase 3 (GSK-3) is a serine-threonine kinase with two isoforms (alpha and beta), that was originally discovered as an important enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cellular division, proliferation, motility and survival.

Gene Wiki entry for GSK3B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSK3B Gene

Genomics for GSK3B Gene

Regulatory Elements for GSK3B Gene

Enhancers for GSK3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GSK3B on UCSC Golden Path with GeneCards custom track

Promoters for GSK3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GSK3B on UCSC Golden Path with GeneCards custom track

Genomic Location for GSK3B Gene

Chromosome:
3
Start:
119,821,321 bp from pter
End:
120,094,417 bp from pter
Size:
273,097 bases
Orientation:
Minus strand

Genomic View for GSK3B Gene

Genes around GSK3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSK3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSK3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSK3B Gene

Proteins for GSK3B Gene

  • Protein details for GSK3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49841-GSK3B_HUMAN
    Recommended name:
    Glycogen synthase kinase-3 beta
    Protein Accession:
    P49841
    Secondary Accessions:
    • D3DN89
    • Q9BWH3
    • Q9UL47

    Protein attributes for GSK3B Gene

    Size:
    420 amino acids
    Molecular mass:
    46744 Da
    Quaternary structure:
    • Monomer. Interacts with ARRB2, DISC1 and ZBED3 (By similarity). Interacts with CABYR, MMP2, MUC1, NIN and PRUNE Interacts with AXIN1; the interaction mediates hyperphosphorylation of CTNNB1 leading to its ubiquitination and destruction. Interacts with and phosphorylates SNAI1. Interacts with DNM1L (via a C-terminal domain). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Interacts with SGK3. Interacts with DAB2IP (via C2 domain); the interaction stimulates GSK3B kinase activation. Interacts (via C2 domain) with PPP2CA. Interacts with the CLOCK-ARNTL/BMAL1 heterodimer. Interacts with the ARNTL/BMAL1. Interacts with CTNND2 (PubMed:19706605). Interacts with NCYM (PubMed:24391509).
    Miscellaneous:
    • Higher expression and activity of GSK3B are found in the skeletal muscle (vastus lateralis) of patients with type 2 diabetes (PubMed:10868943). Several potent GSK3 (GSK3A and GSK3B) inhibitors have been identified and characterized in preclinical models for treatments of type 2 diabetes (PubMed:19366350).

    Three dimensional structures from OCA and Proteopedia for GSK3B Gene

    Alternative splice isoforms for GSK3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSK3B Gene

Proteomics data for GSK3B Gene at MOPED

Post-translational modifications for GSK3B Gene

  • Mono-ADP-ribosylation by PARP10 negatively regulates kinase activity.
  • Phosphorylated by AKT1 and ILK1. Upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3B, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-216.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSK3B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GSK3B Gene

Gene Families for GSK3B Gene

Graphical View of Domain Structure for InterPro Entry

P49841

UniProtKB/Swiss-Prot:

GSK3B_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
genes like me logo Genes that share domains with GSK3B: view

Function for GSK3B Gene

Molecular function for GSK3B Gene

GENATLAS Biochemistry:
glycogen synthase kinase 3 beta,dual specificity protein-kinase,regulating glycogen synthesis in skeletal muscle through Tyr activating or Ser/Thr inactivating prosphorylation,key downstream target of PI3-kinase/AKT survival signaling pathway and involved in the regulation of apoptosis,Drosophila Shaggy-Zeste-White 3 homolog,binding to APC-beta-catenin complex,
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [tau protein] = ADP + [tau protein] phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation at Tyr-216. In response to insulin, inhibited by phosphorylation at Ser-9 by PKB/AKT1 and RPS6KA3; phosphorylation at this site causes a conformational change, preventing access of substrates to the active site. Inhibited by lithium.
UniProtKB/Swiss-Prot Function:
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on Thr-548, decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at Thr-182, leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at Thr-687 upon T-cell activation. Phosphorylates NR1D1 st Ser-55 and Ser-59 and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT Ser-427 and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at Ser-17 and Ser-21 and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at Ser-3 or Ser-4 which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509).

Enzyme Numbers (IUBMB) for GSK3B Gene

Gene Ontology (GO) - Molecular Function for GSK3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008013 beta-catenin binding IEA,IPI 8638126
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with GSK3B: view
genes like me logo Genes that share phenotypes with GSK3B: view

Animal Models for GSK3B Gene

MGI Knock Outs for GSK3B:

Animal Model Products

miRNA for GSK3B Gene

miRTarBase miRNAs that target GSK3B

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSK3B Gene

Localization for GSK3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSK3B Gene

Cytoplasm. Nucleus. Cell membrane. Note=The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSK3B Gene COMPARTMENTS Subcellular localization image for GSK3B gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 5
mitochondrion 4
endoplasmic reticulum 2
extracellular 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GSK3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
GO:0030425 dendrite IEA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with GSK3B: view

Pathways & Interactions for GSK3B Gene

SuperPathways for GSK3B Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 IL-7 Signaling Pathways
3 S45 mutants of beta-catenin arent phosphorylated
4 PI3K events in ERBB4 signaling
5 Translation Insulin regulation of translation
genes like me logo Genes that share pathways with GSK3B: view

Pathways by source for GSK3B Gene

Gene Ontology (GO) - Biological Process for GSK3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000320 re-entry into mitotic cell cycle IEA --
GO:0001837 epithelial to mesenchymal transition IMP 15448698
GO:0005977 glycogen metabolic process IDA 8638126
GO:0006349 regulation of gene expression by genetic imprinting IEA --
GO:0006468 protein phosphorylation IEA,IDA 11035810
genes like me logo Genes that share ontologies with GSK3B: view

Drugs & Compounds for GSK3B Gene

(63) Drugs for GSK3B Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lithium Approved Pharma Target, inhibitor 0
Citalopram Approved Pharma 497
Fluoxetine Approved Pharma Channel blocker 228
Adenosine triphosphate Approved Nutra 0
Alsterpaullone Experimental Pharma Target 0

(9) Additional Compounds for GSK3B Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
10Z-Hymenialdisine
82005-12-7
Indirubin-3'-oxime
160807-49-8

(5) Tocris Compounds for GSK3B Gene

Compound Action Cas Number
10Z-Hymenialdisine Pan kinase inhibitor; potently inhibits MEK1 82005-12-7
Indirubin-3'-oxime GSK-3beta inhibitor. Also inhibits other protein kinases 160807-49-8
Kenpaullone Potent cyclin-dependent kinase inhibitor. Also inhibits GSK-3 142273-20-9
SB 216763 Potent, selective GSK-3 inhibitor 280744-09-4
SB 415286 Potent, selective GSK-3 inhibitor 264218-23-7

(15) ApexBio Compounds for GSK3B Gene

Compound Action Cas Number
1-Azakenpaullone GSK-3β inhibitor,potent and selective,cell-permeable 676596-65-9
AR-A014418 GSK3β inhibitor, ATP-competitive and selective 487021-52-3
AZD1080 GSK3βinhibitor 612487-72-6
AZD2858 GSK-3 inhibitor,potent and selective 486424-20-8
Bikinin GSK3 inhibitor and Brassinosteroid activator 188011-69-0
CHIR-98014 GSK-3β inhibitor,selective and ATP-competitive 252935-94-7
CHIR-99021 (CT99021) GSK-3 inhibitor, Cell-permeable, ATP-competitive 252917-06-9
CHIR-99021 (CT99021) HCl GSK-3α/β inhibitor 252917-06-9
GSK-3 Inhibitor IX (BIO) 667463-62-9
IM-12 1129669-05-1
Indirubin 479-41-4
SB 216763 GSK-3 inhibitor,ATP-competitive,potent and selective 280744-09-4
SB 415286 GSK-3 inhibitor,potent and selective 264218-23-7
Tideglusib 865854-05-3
TWS119 GSK-3β inhibitor 601514-19-6
genes like me logo Genes that share compounds with GSK3B: view

Drug Products

Transcripts for GSK3B Gene

Unigene Clusters for GSK3B Gene

Glycogen synthase kinase 3 beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSK3B Gene

No ASD Table

Relevant External Links for GSK3B Gene

GeneLoc Exon Structure for
GSK3B
ECgene alternative splicing isoforms for
GSK3B

Expression for GSK3B Gene

mRNA expression in normal human tissues for GSK3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GSK3B Gene

This gene is overexpressed in Fetal Brain (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GSK3B Gene



SOURCE GeneReport for Unigene cluster for GSK3B Gene Hs.445733

mRNA Expression by UniProt/SwissProt for GSK3B Gene

P49841-GSK3B_HUMAN
Tissue specificity: Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain.
genes like me logo Genes that share expression patterns with GSK3B: view

Protein tissue co-expression partners for GSK3B Gene

- Elite partner

No data available for mRNA differential expression in normal tissues for GSK3B Gene

Orthologs for GSK3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GSK3B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GSK3B 35
  • 96.37 (n)
  • 99.07 (a)
GSK3B 36
  • 50 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GSK3B 35
  • 97 (n)
  • 99.77 (a)
GSK3B 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gsk3b 35
  • 92.73 (n)
  • 99.02 (a)
Gsk3b 16
Gsk3b 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GSK3B 35
  • 98.46 (n)
  • 98.15 (a)
GSK3B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gsk3b 35
  • 92.4 (n)
  • 99.02 (a)
oppossum
(Monodelphis domestica)
Mammalia GSK3B 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GSK3B 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves GSK3B 35
  • 88.52 (n)
  • 97.39 (a)
GSK3B 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GSK3B 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gsk3b 35
  • 77.09 (n)
  • 91.28 (a)
Str.19775 35
African clawed frog
(Xenopus laevis)
Amphibia Xgsk-3 35
zebrafish
(Danio rerio)
Actinopterygii gsk3b 35
  • 79.82 (n)
  • 95.59 (a)
gsk3b 36
  • 94 (a)
OneToMany
GSK3B (2 of 2) 36
  • 90 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta gskt 37
  • 64 (a)
Pk34A 37
  • 39 (a)
sgg 37
  • 75 (a)
gskt 36
  • 49 (a)
ManyToMany
sgg 36
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C36B1.10 37
  • 31 (a)
C44H4.6 37
  • 42 (a)
F21F3.2 37
  • 32 (a)
R03D7.5 37
  • 38 (a)
Y106G6D.4 37
  • 31 (a)
Y18D10A.5 37
  • 74 (a)
gsk-3 35
  • 64.84 (n)
  • 77.74 (a)
gsk-3 36
  • 72 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRK1 36
  • 35 (a)
ManyToMany
RIM11 36
  • 48 (a)
ManyToMany
RIM11 38
thale cress
(Arabidopsis thaliana)
eudicotyledons SK13 35
  • 63.58 (n)
  • 68.12 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7461 35
rice
(Oryza sativa)
Liliopsida Os05g0134000 35
  • 61.67 (n)
  • 68.01 (a)
corn
(Zea mays)
Liliopsida Zm.6802 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 78 (a)
OneToMany
Species with no ortholog for GSK3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSK3B Gene

ENSEMBL:
Gene Tree for GSK3B (if available)
TreeFam:
Gene Tree for GSK3B (if available)

Paralogs for GSK3B Gene

Paralogs for GSK3B Gene

Pseudogenes.org Pseudogenes for GSK3B Gene

genes like me logo Genes that share paralogs with GSK3B: view

Variants for GSK3B Gene

Sequence variations from dbSNP and Humsavar for GSK3B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs334533 -- 120,074,035(-) gagca(A/G)cggca intron-variant
rs334534 -- 120,073,762(-) acaga(A/G)cctta intron-variant
rs334535 -- 120,073,457(-) GGTAA(A/G)AAGTG intron-variant
rs334536 -- 120,071,865(-) GGTTC(G/T)TAATG intron-variant
rs334551 -- 120,076,671(+) tagcc(A/G)ggcat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSK3B Gene

Variant ID Type Subtype PubMed ID
nsv482988 CNV Complex 15286789
nsv507120 CNV Insertion 20534489
nsv829696 CNV Gain 17160897
esv2516850 CNV Deletion 19546169
dgv883e199 CNV Deletion 23128226
esv22981 CNV Loss 19812545
esv2631534 CNV Deletion 19546169
nsv3964 CNV Loss 18451855
esv2666502 CNV Deletion 23128226
nsv829697 CNV Loss 17160897

Variation tolerance for GSK3B Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSK3B Gene

Human Gene Mutation Database (HGMD)
GSK3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSK3B Gene

Disorders for GSK3B Gene

MalaCards: The human disease database

(14) MalaCards diseases for GSK3B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • alzheimer disease, late-onset
bipolar disorder
  • major affective disorder 1
familial adenomatous polyposis
  • adenomatous polyposis coli
aneurysmal bone cysts
  • bone cysts aneurysmal
rippling muscle disease
  • rmd
- elite association - COSMIC cancer census association via MalaCards
Search GSK3B in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSK3B

Genetic Association Database (GAD)
GSK3B
Human Genome Epidemiology (HuGE) Navigator
GSK3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSK3B
genes like me logo Genes that share disorders with GSK3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSK3B Gene

Publications for GSK3B Gene

  1. Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism. (PMID: 17628506) Adli M. … Bauer M. (Biol. Psychiatry 2007) 3 23 25 26
  2. Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter. (PMID: 10486203) Lau K.F. … Shaw P.C. (Genomics 1999) 2 3 4 67
  3. PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder. (PMID: 16733521) Borsotto M. … Chumakov I. (Pharmacogenomics J. 2007) 23 25 26
  4. Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation. (PMID: 17590240) Lin C.L. … Lin J.K. (Neurobiol. Aging 2009) 3 23
  5. Loss of expression for the Wnt pathway components adenomatous polyposis coli and glycogen synthase kinase 3-beta in parathyroid carcinomas. (PMID: 19148484) Juhlin C.C. … HAPAPg A. (Int. J. Oncol. 2009) 3 23

Products for GSK3B Gene

Sources for GSK3B Gene

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