Aliases for GSK3A Gene
External Ids for GSK3A Gene
Previous GeneCards Identifiers for GSK3A Gene
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]
GeneCards Summary for GSK3A Gene
GSK3A (Glycogen Synthase Kinase 3 Alpha) is a Protein Coding gene. Diseases associated with GSK3A include Alzheimer Disease. Among its related pathways are Constitutive Signaling by AKT1 E17K in Cancer and FOXM1 transcription factor network. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is GSK3B.
UniProtKB/Swiss-Prot for GSK3A Gene
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
Glycogen synthase kinase 3 (GSK-3) is a serine-threonine kinase with two isoforms (alpha and beta), that was originally discovered as an important enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cellular division, proliferation, motility and survival.