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Aliases for GSK3A Gene

Aliases for GSK3A Gene

  • Glycogen Synthase Kinase 3 Alpha 2 3 5
  • EC 2.7.11.26 4 63
  • Serine/Threonine-Protein Kinase GSK3A 4
  • GSK-3 Alpha 4
  • EC 2.7.11.1 4
  • EC 2.7.11 63

External Ids for GSK3A Gene

Previous GeneCards Identifiers for GSK3A Gene

  • GC19M043380
  • GC19M043126
  • GC19M047410
  • GC19M047426
  • GC19M042734
  • GC19M039164

Summaries for GSK3A Gene

Entrez Gene Summary for GSK3A Gene

  • This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]

GeneCards Summary for GSK3A Gene

GSK3A (Glycogen Synthase Kinase 3 Alpha) is a Protein Coding gene. Diseases associated with GSK3A include alzheimer disease. Among its related pathways are Chemokine Signaling and Circadian entrainment. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is GSK3B.

UniProtKB/Swiss-Prot for GSK3A Gene

  • Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

Tocris Summary for GSK3A Gene

  • Glycogen synthase kinase 3 (GSK-3) is a serine-threonine kinase with two isoforms (alpha and beta), that was originally discovered as an important enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cellular division, proliferation, motility and survival.

Gene Wiki entry for GSK3A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSK3A Gene

Genomics for GSK3A Gene

Regulatory Elements for GSK3A Gene

Enhancers for GSK3A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GSK3A on UCSC Golden Path with GeneCards custom track

Genomic Location for GSK3A Gene

Chromosome:
19
Start:
42,230,186 bp from pter
End:
42,242,625 bp from pter
Size:
12,440 bases
Orientation:
Minus strand

Genomic View for GSK3A Gene

Genes around GSK3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSK3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSK3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSK3A Gene

Proteins for GSK3A Gene

  • Protein details for GSK3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49840-GSK3A_HUMAN
    Recommended name:
    Glycogen synthase kinase-3 alpha
    Protein Accession:
    P49840
    Secondary Accessions:
    • O14959

    Protein attributes for GSK3A Gene

    Size:
    483 amino acids
    Molecular mass:
    50981 Da
    Quaternary structure:
    • Monomer. Interacts with ARRB2 (By similarity). Interacts with AXIN1 and CTNNB1/beta-catenin. Interacts with CTNND2 (PubMed:19706605).
    Miscellaneous:
    • Higher expression and activity of GSK3A are found in the skeletal muscle (vastus lateralis) of patients with type 2 diabetes (PubMed:10868943). Several potent GSK3 (GSK3A and GSK3B) inhibitors have been identified and characterized in preclinical models for treatments of type 2 diabetes (PubMed:19366350).

    Three dimensional structures from OCA and Proteopedia for GSK3A Gene

neXtProt entry for GSK3A Gene

Proteomics data for GSK3A Gene at MOPED

Post-translational modifications for GSK3A Gene

  • Phosphorylated by AKT1 at Ser-21: upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3A, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-279.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSK3A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GSK3A Gene

Gene Families for GSK3A Gene

Suggested Antigen Peptide Sequences for GSK3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49840

UniProtKB/Swiss-Prot:

GSK3A_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
genes like me logo Genes that share domains with GSK3A: view

Function for GSK3A Gene

Molecular function for GSK3A Gene

GENATLAS Biochemistry:
glycogen synthase kinase 3 alpha,regulator of glycogen synthesis in skeletal muscle,unstabilized in response to insulin with both protein level and activity increased by heat stress
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [tau protein] = ADP + [tau protein] phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation at Tyr-279. In response to insulin, inhibited by phosphorylation at Ser-21 by PKB/AKT1; phosphorylation at this site causes a conformational change, preventing access of substrates to the active site. Inhibited by lithium.
UniProtKB/Swiss-Prot Function:
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

Enzyme Numbers (IUBMB) for GSK3A Gene

genes like me logo Genes that share phenotypes with GSK3A: view

Animal Models for GSK3A Gene

MGI Knock Outs for GSK3A:

Animal Model Products

  • Taconic Biosciences Mouse Models for GSK3A

miRNA for GSK3A Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSK3A Gene

Localization for GSK3A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSK3A Gene COMPARTMENTS Subcellular localization image for GSK3A gene
Compartment Confidence
cytosol 5
mitochondrion 4
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GSK3A Gene

Pathways & Interactions for GSK3A Gene

SuperPathways for GSK3A Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 PI3K events in ERBB4 signaling
3 IL-7 Signaling Pathways
4 Activation of cAMP-Dependent PKA
5 Immune System
genes like me logo Genes that share pathways with GSK3A: view

SIGNOR curated interactions for GSK3A Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for GSK3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003073 regulation of systemic arterial blood pressure ISS --
GO:0003214 cardiac left ventricle morphogenesis ISS --
GO:0006468 protein phosphorylation IEA,IDA 11035810
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with GSK3A: view

Drugs & Compounds for GSK3A Gene

(25) Drugs for GSK3A Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
AZD1080 Pharma GSK3βinhibitor 0
Tideglusib Pharma 0
SB 216763 Pharma GSK-3 inhibitor,ATP-competitive,potent and selective, Potent, selective GSK-3 inhibitor 0
SB 415286 Pharma GSK-3 inhibitor,potent and selective, Potent, selective GSK-3 inhibitor 0

(4) Additional Compounds for GSK3A Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
10Z-Hymenialdisine
82005-12-7
Indirubin-3'-oxime
160807-49-8

(5) Tocris Compounds for GSK3A Gene

Compound Action Cas Number
10Z-Hymenialdisine Pan kinase inhibitor; potently inhibits MEK1 82005-12-7
Indirubin-3'-oxime GSK-3beta inhibitor. Also inhibits other protein kinases 160807-49-8
Kenpaullone Potent cyclin-dependent kinase inhibitor. Also inhibits GSK-3 142273-20-9
SB 216763 Potent, selective GSK-3 inhibitor 280744-09-4
SB 415286 Potent, selective GSK-3 inhibitor 264218-23-7

(16) ApexBio Compounds for GSK3A Gene

Compound Action Cas Number
1-Azakenpaullone GSK-3β inhibitor,potent and selective,cell-permeable 676596-65-9
AR-A014418 GSK3β inhibitor, ATP-competitive and selective 487021-52-3
AZD1080 GSK3βinhibitor 612487-72-6
AZD2858 GSK-3 inhibitor,potent and selective 486424-20-8
Bikinin GSK3 inhibitor and Brassinosteroid activator 188011-69-0
CHIR-124 Chk1 inhibitor,novel and potent 405168-58-3
CHIR-98014 GSK-3β inhibitor,selective and ATP-competitive 252935-94-7
CHIR-99021 (CT99021) GSK-3 inhibitor, Cell-permeable, ATP-competitive 252917-06-9
CHIR-99021 (CT99021) HCl GSK-3α/β inhibitor 252917-06-9
GSK-3 Inhibitor IX (BIO) 667463-62-9
IM-12 1129669-05-1
Indirubin 479-41-4
SB 216763 GSK-3 inhibitor,ATP-competitive,potent and selective 280744-09-4
SB 415286 GSK-3 inhibitor,potent and selective 264218-23-7
Tideglusib 865854-05-3
TWS119 GSK-3β inhibitor 601514-19-6
genes like me logo Genes that share compounds with GSK3A: view

Drug Products

Transcripts for GSK3A Gene

Unigene Clusters for GSK3A Gene

Glycogen synthase kinase 3 alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSK3A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: -
SP2:
SP3:

Relevant External Links for GSK3A Gene

GeneLoc Exon Structure for
GSK3A
ECgene alternative splicing isoforms for
GSK3A

Expression for GSK3A Gene

mRNA expression in normal human tissues for GSK3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GSK3A Gene

This gene is overexpressed in Lung (12.1), Fetal Brain (7.1), and Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GSK3A Gene



SOURCE GeneReport for Unigene cluster for GSK3A Gene Hs.466828

genes like me logo Genes that share expression patterns with GSK3A: view

Protein tissue co-expression partners for GSK3A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GSK3A Gene

Orthologs for GSK3A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GSK3A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GSK3A 35
  • 93.52 (n)
  • 96.21 (a)
GSK3A 36
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia GSK3A 35
  • 93.22 (n)
  • 96.48 (a)
-- 36
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gsk3a 35
  • 89.53 (n)
  • 95.09 (a)
Gsk3a 16
Gsk3a 36
  • 93 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GSK3A 35
  • 99.59 (n)
  • 99.59 (a)
GSK3A 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gsk3a 35
  • 91.52 (n)
  • 97.01 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gsk3a 35
  • 75.37 (n)
  • 86.26 (a)
zebrafish
(Danio rerio)
Actinopterygii gsk3a 35
gsk3aa 35
  • 76.75 (n)
  • 88.52 (a)
gsk3aa 36
  • 74 (a)
ManyToMany
gsk3ab 36
  • 79 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1135 35
fruit fly
(Drosophila melanogaster)
Insecta CG6800 37
  • 35 (a)
gskt 37
  • 61 (a)
Pk34A 37
  • 40 (a)
sgg 37
  • 78 (a)
gskt 36
  • 47 (a)
ManyToMany
Pk34A 36
  • 36 (a)
ManyToMany
sgg 36
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C36B1.10 37
  • 30 (a)
C44H4.6 37
  • 44 (a)
F21F3.2 37
  • 32 (a)
R03D7.5 37
  • 37 (a)
Y106G6D.4 37
  • 31 (a)
Y18D10A.5 37
  • 76 (a)
gsk-3 36
  • 69 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR253W 35
  • 61.92 (n)
  • 60.6 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17006g 35
  • 54.53 (n)
  • 54.63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM11 35
  • 58.76 (n)
  • 59.32 (a)
MRK1 36
  • 37 (a)
ManyToMany
RIM11 36
  • 49 (a)
ManyToMany
MCK1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ATSK12 35
  • 62.75 (n)
  • 67.05 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3400 35
rice
(Oryza sativa)
Liliopsida Os01g0252100 35
  • 63.82 (n)
  • 67.24 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.3019 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5080 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04185 35
  • 67.57 (n)
  • 69.88 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gsk3 35
  • 55.28 (n)
  • 61.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 75 (a)
OneToMany
Species with no ortholog for GSK3A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GSK3A Gene

ENSEMBL:
Gene Tree for GSK3A (if available)
TreeFam:
Gene Tree for GSK3A (if available)

Paralogs for GSK3A Gene

Paralogs for GSK3A Gene

genes like me logo Genes that share paralogs with GSK3A: view

Variants for GSK3A Gene

Sequence variations from dbSNP and Humsavar for GSK3A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs35454502 - 42,230,863(+) TCAGT(A/T)AAAGC reference, missense
rs35978177 - 42,240,101(+) GCCTT(C/G)GCCTA reference, missense
rs851609 -- 42,232,115(+) GGGAT(A/G)AGAAT reference, synonymous-codon
rs851610 -- 42,235,531(+) TGACA(C/T)GGCTG intron-variant
rs12982923 -- 42,242,038(+) TTTTC(A/C)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSK3A Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
nsv520239 CNV Loss 19592680
nsv911782 CNV Loss 21882294
nsv833833 CNV Loss 17160897
nsv526186 CNV Gain 19592680
esv2422471 CNV Deletion 17116639
nsv833834 CNV Loss 17160897
dgv3884n71 CNV Loss 21882294
nsv911785 CNV Loss 21882294

Variation tolerance for GSK3A Gene

Residual Variation Intolerance Score: 20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSK3A Gene

HapMap Linkage Disequilibrium report
GSK3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSK3A Gene

Disorders for GSK3A Gene

MalaCards: The human disease database

(1) MalaCards diseases for GSK3A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search GSK3A in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSK3A

Genetic Association Database (GAD)
GSK3A
Human Genome Epidemiology (HuGE) Navigator
GSK3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSK3A
genes like me logo Genes that share disorders with GSK3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSK3A Gene

Publications for GSK3A Gene

  1. Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes. (PMID: 9809441) Shaw P.C. … Anderton B.H. (Genome 1998) 2 3 23 67
  2. Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells. (PMID: 17569761) Ciaraldi T.P. … Henry R.R. (Endocrinology 2007) 3 23
  3. Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization. (PMID: 14563837) Gregory M.A. … Hann S.R. (J. Biol. Chem. 2003) 3 23
  4. GSK-3 parameters in lymphocytes of schizophrenic patients. (PMID: 12379450) Nadri C. … Bersudsky Y. (Psychiatry Res 2002) 3 23
  5. Insulin receptor substrate-2 phosphorylation is necessary for protein kinase C zeta activation by insulin in L6hIR cells. (PMID: 11481324) Oriente F. … Beguinot F. (J. Biol. Chem. 2001) 3 23

Products for GSK3A Gene

Sources for GSK3A Gene

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