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Aliases for GRM3 Gene

Aliases for GRM3 Gene

  • Glutamate Receptor, Metabotropic 3 2 3
  • GPRC1C 3 4
  • MGLUR3 3 4
  • Glutamate Metabotropic Receptor 3 3
  • Metabotropic Glutamate Receptor 3 3
  • GLUR3 3
  • MGlu3 3

External Ids for GRM3 Gene

Previous GeneCards Identifiers for GRM3 Gene

  • GC07P084809
  • GC07P085871
  • GC07P085886
  • GC07P085885
  • GC07P085917
  • GC07P086111
  • GC07P086274
  • GC07P080884

Summaries for GRM3 Gene

Entrez Gene Summary for GRM3 Gene

  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRM3 Gene

GRM3 (Glutamate Receptor, Metabotropic 3) is a Protein Coding gene. Diseases associated with GRM3 include schizophrenia. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include G-protein coupled receptor activity and glutamate receptor activity. An important paralog of this gene is GRM1.

UniProtKB/Swiss-Prot for GRM3 Gene

  • G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Tocris Summary for GRM3 Gene

  • Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3. mGlu group II receptors are coupled to Gi/o which inhibits adenylyl cyclase, decreasing the formation of cAMP. mGlu group II receptors are involved in presynaptic inhibition and do not appear to affect postsynaptic membrane potential by themselves. The human genes for mGlu2 and mGlu3 receptors have been localized to chromosomes 3 (p21.1) and 7 (7q21.1-q21.2) respectively.

Gene Wiki entry for GRM3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRM3 Gene

Genomics for GRM3 Gene

Regulatory Elements for GRM3 Gene

Genomic Location for GRM3 Gene

86,643,914 bp from pter
86,864,884 bp from pter
220,971 bases
Plus strand

Genomic View for GRM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRM3 Gene

Proteins for GRM3 Gene

  • Protein details for GRM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metabotropic glutamate receptor 3
    Protein Accession:
    Secondary Accessions:
    • Q2PNZ6
    • Q75MV4
    • Q75N17
    • Q86YG6
    • Q8TBH9

    Protein attributes for GRM3 Gene

    879 amino acids
    Molecular mass:
    98879 Da
    Quaternary structure:
    • Interacts with GRASP.
    • Sequence=AAD15616.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=ABC47402.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA54796.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GRM3 Gene

    Alternative splice isoforms for GRM3 Gene


neXtProt entry for GRM3 Gene

Proteomics data for GRM3 Gene at MOPED

Post-translational modifications for GRM3 Gene

  • Glycosylation at Asn209, Asn292, Asn414, and Asn439
  • Modification sites at PhosphoSitePlus

Other Protein References for GRM3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GRM3 Gene

Domains for GRM3 Gene

Gene Families for GRM3 Gene

  • GRM :GPCR / Class C : Glutamate receptors, metabotropic
  • GR :Glutamate receptors

Graphical View of Domain Structure for InterPro Entry



  • Q14832
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GRM3: view

Function for GRM3 Gene

Molecular function for GRM3 Gene

GENATLAS Biochemistry:
metabotropic glutamate receptor 3,group II,G protein coupled receptor superfamily,linked to the inhibition of cAMP cascade
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Gene Ontology (GO) - Molecular Function for GRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001641 group II metabotropic glutamate receptor activity IBA --
GO:0001642 NOT group III metabotropic glutamate receptor activity IBA --
GO:0004930 G-protein coupled receptor activity TAS 8840013
GO:0005246 calcium channel regulator activity IEA --
GO:0008066 glutamate receptor activity TAS 8840013
genes like me logo Genes that share ontologies with GRM3: view

Phenotypes for GRM3 Gene

genes like me logo Genes that share phenotypes with GRM3: view

Animal Models for GRM3 Gene

MGI Knock Outs for GRM3:

Animal Model Products

miRNA for GRM3 Gene

miRTarBase miRNAs that target GRM3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRM3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GRM3 Gene

Localization for GRM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRM3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GRM3 Gene COMPARTMENTS Subcellular localization image for GRM3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0014069 postsynaptic density IEA --
GO:0016021 integral component of membrane --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with GRM3: view

Pathways for GRM3 Gene

genes like me logo Genes that share pathways with GRM3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007194 negative regulation of adenylate cyclase activity TAS 8840013
GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IBA --
GO:0007268 synaptic transmission TAS 8840013
GO:0050804 regulation of synaptic transmission --
genes like me logo Genes that share ontologies with GRM3: view

Compounds for GRM3 Gene

(5) Tocris Compounds for GRM3 Gene

Compound Action Cas Number
(S)-MCPG Non-selective mGlu antagonist. Active isomer of Cat. No. 0336 [150145-89-4]
DCG IV Very potent, selective group II mGlu agonist. Also NMDA agonist [147782-19-2]
LY 341495 Highly potent, selective group II antagonist [201943-63-7]
LY 341495 disodium salt Disodium salt of LY 341495 (Cat. No. 1209)
LY 354740 Potent and highly selective group II mGlu agonist [176199-48-7]

(1) Drugbank Compounds for GRM3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • 3-(Acetylamino)propanesulphonic acid
77337-76-9 target antagonist

(15) IUPHAR Ligand for GRM3 Gene

Ligand Type Action Affinity Pubmed IDs
Ro4491533 Allosteric regulator Negative 6.6
LY379268 Agonist Full agonist 6.4
L-CCG-I Agonist Full agonist 6.3
LY354740 Agonist Full agonist 5.5
DCG-IV Antagonist Antagonist 5.5
(2R,3R)-APDC Agonist Full agonist 5.3
L-glutamic acid Agonist Full agonist 5.2
compound 3 [PMID: 21105727] Allosteric regulator Positive 5.1
compound 4 [PMID: 21105727] Allosteric regulator Positive 4.98
compound 2 [PMID: 21105727] Allosteric regulator Positive 4.9
LY341495 Antagonist Antagonist 4.7
NAAG Agonist Full agonist 4.7
(1S,3R)-ACPD Agonist Full agonist 4.7
[3H]LY341495 Antagonist Antagonist 4.5
(+)-MCPG Antagonist Antagonist 3.2

(19) Novoseek inferred chemical compound relationships for GRM3 Gene

Compound -log(P) Hits PubMed IDs
naag 90.2 23
n-acetyl-aspartyl-glutamate 89.1 8
glutamate 82.7 98
mcpg 55.7 1
phencyclidine 50.1 1

(1) PharmGKB related drug/compound annotations for GRM3 Gene

Drug/compound Annotation
risperidone CA
genes like me logo Genes that share compounds with GRM3: view

Transcripts for GRM3 Gene

Unigene Clusters for GRM3 Gene

Glutamate receptor, metabotropic 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRM3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRM3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - -
SP2: - - - - - - -
SP3: - - -
SP4: -

Relevant External Links for GRM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRM3 Gene

mRNA expression in normal human tissues for GRM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRM3 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (6.7), Brain - Caudate (basal ganglia) (6.6), Brain - Nucleus accumbens (basal ganglia) (5.6), Brain - Spinal cord (cervical c-1) (4.7), Brain - Anterior cingulate cortex (BA24) (4.1), Brain - Frontal Cortex (BA9) (4.1), and Brain - Cortex (4.0).

Protein differential expression in normal tissues for GRM3 Gene

This gene is overexpressed in NK cells (36.3), Fetal Brain (13.8), Frontal cortex (12.4), and Pancreatic juice (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GRM3 Gene

SOURCE GeneReport for Unigene cluster for GRM3 Gene Hs.590575

mRNA Expression by UniProt/SwissProt for GRM3 Gene

Tissue specificity: Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.
genes like me logo Genes that share expressions with GRM3: view

Expression partners for GRM3 Gene

In Situ Assay Products

Orthologs for GRM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRM3 35
  • 92.07 (n)
  • 97.27 (a)
GRM3 36
  • 97 (a)
(Canis familiaris)
Mammalia GRM3 35
  • 92.03 (n)
  • 96.33 (a)
GRM3 36
  • 91 (a)
(Mus musculus)
Mammalia Grm3 35
  • 89.65 (n)
  • 96.7 (a)
Grm3 16
Grm3 36
  • 97 (a)
(Pan troglodytes)
Mammalia GRM3 35
  • 99.73 (n)
  • 99.66 (a)
GRM3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Grm3 35
  • 89.95 (n)
  • 96.59 (a)
(Monodelphis domestica)
Mammalia GRM3 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia GRM3 36
  • 87 (a)
(Gallus gallus)
Aves GRM3 35
  • 79.98 (n)
  • 91.01 (a)
GRM3 36
  • 90 (a)
(Anolis carolinensis)
Reptilia GRM3 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia grm3 35
  • 74.07 (n)
  • 86.21 (a)
(Danio rerio)
Actinopterygii grm3 35
  • 71.31 (n)
  • 78.57 (a)
grm3 36
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30361 37
  • 39 (a)
Glu-RA 37
  • 49 (a)
mGluRA 35
  • 54.48 (n)
  • 53.15 (a)
mGluRA 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea mgl-1 37
  • 41 (a)
mgl-1 35
  • 50.54 (n)
  • 45.11 (a)
mgl-1 36
  • 36 (a)
Species with no ortholog for GRM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRM3 Gene

Gene Tree for GRM3 (if available)
Gene Tree for GRM3 (if available)

Paralogs for GRM3 Gene

Paralogs for GRM3 Gene

Selected SIMAP similar genes for GRM3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with GRM3: view

Variants for GRM3 Gene

Sequence variations from dbSNP and Humsavar for GRM3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs17126 -- 86,842,597(+) GGTTC(A/G)GACAG intron-variant
rs166677 -- 86,642,978(+) TTGTA(C/T)GTGGT upstream-variant-2KB
rs274613 -- 86,647,495(+) CGCAC(A/G)CTGGA intron-variant
rs274614 -- 86,648,771(+) CACTT(A/G)AAATC intron-variant
rs274615 -- 86,649,621(+) TCAGT(A/T)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRM3 Gene

Variant ID Type Subtype PubMed ID
nsv888633 CNV Gain 21882294
nsv831053 CNV Gain 17160897
esv7104 CNV Gain 19470904
nsv824201 CNV Loss 20364138
esv269784 CNV Insertion 20981092
esv273882 CNV Insertion 20981092
esv2667611 CNV Deletion 23128226
esv271910 CNV Insertion 20981092
esv2504097 CNV Deletion 19546169

Relevant External Links for GRM3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRM3 Gene

Disorders for GRM3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for GRM3 Gene in MalaCards »

(1) Diseases for GRM3 Gene including...

(1) University of Copenhagen DISEASES for GRM3 Gene

(5) Novoseek inferred disease relationships for GRM3 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 65.7 48
bipolar disorder 37 2
glioma 17.1 3
epilepsy 12.6 1
genetic susceptibility 3.27 1

Relevant External Links for GRM3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GRM3: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for GRM3 Gene

Publications for GRM3 Gene

  1. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. (PMID: 8824806) Scherer S.W. … Tsui L.C. (Genomics 1996) 2 3 23
  2. Molecular characterization and localization of human metabotropic glutamate receptor type 3. (PMID: 8840013) Makoff A. … Emson P. (Brain Res. Mol. Brain Res. 1996) 3 4 23
  3. Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population. (PMID: 11840505) MartA- S.B. … NAPthen M. (Am. J. Med. Genet. 2002) 3 23 48
  4. Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. (PMID: 12782962) Fujii Y. … Fukumaki Y. (Psychiatr. Genet. 2003) 3 23 48
  5. A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population. (PMID: 15567072) Chen Q. … He L. (Schizophr. Res. 2005) 3 23 48

Products for GRM3 Gene

  • Addgene plasmids for GRM3

Sources for GRM3 Gene

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