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Aliases for CD274 Gene

Aliases for CD274 Gene

  • CD274 Molecule 2 3
  • CD274 Antigen 2 3 4
  • B7 Homolog 1 2 3 4
  • PDCD1 Ligand 1 3 4
  • PDCD1LG1 3 4
  • PDCD1L1 3 4
  • PD-L1 3 4
  • B7H1 3 4
  • PDL1 3 4
  • Programmed Cell Death 1 Ligand 1 2
  • Programmed Death Ligand 1 4
  • B7-H1 4
  • B7-H 3

External Ids for CD274 Gene

Previous HGNC Symbols for CD274 Gene

  • PDCD1LG1

Previous GeneCards Identifiers for CD274 Gene

  • GC09P005444

Summaries for CD274 Gene

Entrez Gene Summary for CD274 Gene

  • This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for CD274 Gene

CD274 (CD274 Molecule) is a Protein Coding gene. Diseases associated with CD274 include scrotum paget's disease and primary mediastinal large b-cell lymphoma. Among its related pathways are Immune System and CD28 co-stimulation. An important paralog of this gene is PDCD1LG2.

UniProtKB/Swiss-Prot for CD274 Gene

  • Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.

Gene Wiki entry for CD274 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD274 Gene

Genomics for CD274 Gene

Regulatory Elements for CD274 Gene

Genomic Location for CD274 Gene

Chromosome:
9
Start:
5,450,381 bp from pter
End:
5,470,567 bp from pter
Size:
20,187 bases
Orientation:
Plus strand

Genomic View for CD274 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD274 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD274 Gene

Proteins for CD274 Gene

  • Protein details for CD274 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZQ7-PD1L1_HUMAN
    Recommended name:
    Programmed cell death 1 ligand 1
    Protein Accession:
    Q9NZQ7
    Secondary Accessions:
    • B2RBA2
    • B4DU27
    • Q14CJ2
    • Q2V8D5
    • Q66RK1
    • Q6WEX4
    • Q9NUZ5

    Protein attributes for CD274 Gene

    Size:
    290 amino acids
    Molecular mass:
    33275 Da
    Quaternary structure:
    • Interacts with PDCD1.
    SequenceCaution:
    • Sequence=BAA91966.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD274 Gene

    Alternative splice isoforms for CD274 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD274 Gene

Proteomics data for CD274 Gene at MOPED

Post-translational modifications for CD274 Gene

  • Glycosylation at Asn 35, Asn 192, Asn 200, and Asn 219
  • Modification sites at PhosphoSitePlus

Other Protein References for CD274 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD274 (CD274)

No data available for DME Specific Peptides for CD274 Gene

Domains & Families for CD274 Gene

Protein Domains for CD274 Gene

Suggested Antigen Peptide Sequences for CD274 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZQ7

UniProtKB/Swiss-Prot:

PD1L1_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with CD274: view

Function for CD274 Gene

Molecular function for CD274 Gene

UniProtKB/Swiss-Prot Function:
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
UniProtKB/Swiss-Prot Induction:
Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking.

Gene Ontology (GO) - Molecular Function for CD274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with CD274: view
genes like me logo Genes that share phenotypes with CD274: view

Animal Models for CD274 Gene

MGI Knock Outs for CD274:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD274

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD274 Gene

Localization for CD274 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD274 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Endomembrane system; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD274 Gene COMPARTMENTS Subcellular localization image for CD274 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CD274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface --
GO:0012505 endomembrane system IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD274: view

Pathways & Interactions for CD274 Gene

genes like me logo Genes that share pathways with CD274: view

Pathways by source for CD274 Gene

1 Cell Signaling Technology pathway for CD274 Gene
1 KEGG pathway for CD274 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • T-cell & B-cell Activation in human,mouse,rat

SIGNOR curated interactions for CD274 Gene

Activates:

Gene Ontology (GO) - Biological Process for CD274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IDA 10581077
GO:0007165 signal transduction IDA 10581077
GO:0007166 cell surface receptor signaling pathway IDA 10581077
GO:0030335 positive regulation of cell migration IEA --
GO:0031295 T cell costimulation TAS --
genes like me logo Genes that share ontologies with CD274: view

Drugs & Compounds for CD274 Gene

(5) Drugs for CD274 Gene - From: NovoSeek and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
Nitric Oxide Approved Pharma 540
MDX-1105 Pharma antibody, immunotherapy Therapeutic Antibodies, Immunotherapies 0
MPDL3280A Pharma antibody, immunotherapy, inhibitor Therapeutic Antibodies, Immunotherapies 0
RG7446 Pharma Antibody 0

(1) Additional Compounds for CD274 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
IONOMYCIN
genes like me logo Genes that share compounds with CD274: view

Transcripts for CD274 Gene

Unigene Clusters for CD274 Gene

CD274 molecule:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD274

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD274 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1:
SP2: - -
SP3: -
SP4: - -

Relevant External Links for CD274 Gene

GeneLoc Exon Structure for
CD274
ECgene alternative splicing isoforms for
CD274

Expression for CD274 Gene

mRNA expression in normal human tissues for CD274 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD274 Gene

This gene is overexpressed in Breast (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD274 Gene



SOURCE GeneReport for Unigene cluster for CD274 Gene Hs.521989

mRNA Expression by UniProt/SwissProt for CD274 Gene

Q9NZQ7-PD1L1_HUMAN
Tissue specificity: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
genes like me logo Genes that share expression patterns with CD274: view

Protein tissue co-expression partners for CD274 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CD274 Gene

Orthologs for CD274 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD274 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD274 35
  • 83.1 (n)
  • 73.96 (a)
PD-L1 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD274 35
  • 83.97 (n)
  • 77 (a)
CD274 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd274 35
  • 76.36 (n)
  • 69.9 (a)
Cd274 16
Cd274 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD274 35
  • 99.54 (n)
  • 99.66 (a)
CD274 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd274 35
  • 76.59 (n)
  • 70.24 (a)
oppossum
(Monodelphis domestica)
Mammalia CD274 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD274 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD274 35
  • 55.9 (n)
  • 47.09 (a)
CD274 36
  • 23 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd274 35
  • 49.49 (n)
  • 37.44 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-241b2.5 35
  • 46.77 (n)
  • 30.8 (a)
CD274 36
  • 15 (a)
OneToMany
Species with no ortholog for CD274:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD274 Gene

ENSEMBL:
Gene Tree for CD274 (if available)
TreeFam:
Gene Tree for CD274 (if available)

Paralogs for CD274 Gene

Paralogs for CD274 Gene

(3) SIMAP similar genes for CD274 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD274: view

Variants for CD274 Gene

Sequence variations from dbSNP and Humsavar for CD274 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs822336 -- 5,448,690(+) GAGCA(C/G)CAAGC upstream-variant-2KB
rs822337 -- 5,449,154(+) GTACC(A/T)GTAAA upstream-variant-2KB
rs822338 -- 5,451,557(+) AATGA(C/T)AGTCG intron-variant
rs822339 -- 5,453,172(-) TTTCT(C/T)TCCTT intron-variant
rs822340 -- 5,453,260(-) ATGAG(C/T)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD274 Gene

Variant ID Type Subtype PubMed ID
nsv892141 CNV Gain 21882294
dgv2277e1 CNV Complex 17122850
nsv466108 CNV Gain 19166990
nsv519771 CNV Loss 19592680
nsv509292 CNV Insertion 20534489

Variation tolerance for CD274 Gene

Residual Variation Intolerance Score: 38.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD274 Gene

HapMap Linkage Disequilibrium report
CD274
Human Gene Mutation Database (HGMD)
CD274

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD274 Gene

Disorders for CD274 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CD274 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
scrotum paget's disease
  • scrotum paget disease
primary mediastinal large b-cell lymphoma
  • large cell lymphoma of the mediastinum
mediastinal malignant lymphoma
  • lymphoma of mediastinum
gray zone lymphoma
  • mediastinal gray zone lymphoma
scrotal carcinoma
  • carcinoma of scrotum
- elite association
Search CD274 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD274

Genetic Association Database (GAD)
CD274
Human Genome Epidemiology (HuGE) Navigator
CD274
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD274
genes like me logo Genes that share disorders with CD274: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD274 Gene

Publications for CD274 Gene

  1. Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation. (PMID: 11015443) Freeman G.J. … Honjo T. (J. Exp. Med. 2000) 2 23 67
  2. ERK/p38 MAP-kinases and PI3K are involved in the differential regulation of B7-H1 expression in DC subsets. (PMID: 19830728) Karakhanova S. … Enk A.H. (Eur. J. Immunol. 2010) 23 67
  3. Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. (PMID: 19950173) Seyerl M. … StAPckl J. (Eur. J. Immunol. 2010) 23 67
  4. Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1. (PMID: 20126379) Amarnath S. … Fowler D.H. (PLoS Biol. 2010) 23 67
  5. Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma. (PMID: 20143437) Hino R. … Tokura Y. (Cancer 2010) 23 67

Products for CD274 Gene

Sources for CD274 Gene

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