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Aliases for LGALS13 Gene

Aliases for LGALS13 Gene

  • Galectin 13 2 3 5
  • Lectin, Galactoside-Binding, Soluble, 13 2 3
  • Placental Tissue Protein 13 3 4
  • Placental Protein 13 3 4
  • Gal-13 3 4
  • PLAC8 3 4
  • PP13 3 4
  • Galactoside-Binding Soluble Lectin 13 3
  • Beta-Galactoside-Binding Lectin 3
  • Galectin-13 4
  • GAL13 3

External Ids for LGALS13 Gene

Previous GeneCards Identifiers for LGALS13 Gene

  • GC19P044786
  • GC19P044787
  • GC19P040093
  • GC19P036539

Summaries for LGALS13 Gene

Entrez Gene Summary for LGALS13 Gene

  • Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene has lysophospholipase activity. It is composed of two identical subunits which are held together by disulfide bonds. This protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS13 Gene

LGALS13 (Galectin 13) is a Protein Coding gene. Diseases associated with LGALS13 include Severe Pre-Eclampsia and Pre-Eclampsia. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include carbohydrate binding and lysophospholipase activity. An important paralog of this gene is LGALS16.

UniProtKB/Swiss-Prot for LGALS13 Gene

  • Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis.

Gene Wiki entry for LGALS13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS13 Gene

Genomics for LGALS13 Gene

Regulatory Elements for LGALS13 Gene

Enhancers for LGALS13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G039604 0.5 ENCODE 0.7 +1.8 1777 0.2 SCRT2 CEBPG GABPA LGALS13 ENSG00000269519
GH19G039602 0.4 ENCODE 0.7 +0.6 557 0.2 ZNF175 ZNF530 CNTD2 TTC9B LGALS13 ENSG00000269519
GH19G039631 0.9 ENCODE 0.3 +29.0 28957 0.2 ZNF473 ZSCAN4 ZEB1 ZNF302 ZNF366 ZSCAN5C ZNF548 ZNF391 ZNF280D CEBPB EID2B ENSG00000269519 LGALS13
GH19G039603 0.2 ENCODE 0.7 +1.0 997 0.2 CNTD2 TTC9B LGALS13 ENSG00000269519
GH19G039609 0.2 ENCODE 0.7 +4.9 4857 0.2 LGALS13 ENSG00000269519
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LGALS13 on UCSC Golden Path with GeneCards custom track

Genomic Location for LGALS13 Gene

Chromosome:
19
Start:
39,602,359 bp from pter
End:
39,607,476 bp from pter
Size:
5,118 bases
Orientation:
Plus strand

Genomic View for LGALS13 Gene

Genes around LGALS13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS13 Gene

Proteins for LGALS13 Gene

  • Protein details for LGALS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHV8-PP13_HUMAN
    Recommended name:
    Galactoside-binding soluble lectin 13
    Protein Accession:
    Q9UHV8
    Secondary Accessions:
    • C5HZ15

    Protein attributes for LGALS13 Gene

    Size:
    139 amino acids
    Molecular mass:
    16119 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for LGALS13 Gene

neXtProt entry for LGALS13 Gene

Post-translational modifications for LGALS13 Gene

No Post-translational modifications

Other Protein References for LGALS13 Gene

No data available for DME Specific Peptides for LGALS13 Gene

Domains & Families for LGALS13 Gene

Gene Families for LGALS13 Gene

Protein Domains for LGALS13 Gene

Suggested Antigen Peptide Sequences for LGALS13 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LGALS13: view

No data available for UniProtKB/Swiss-Prot for LGALS13 Gene

Function for LGALS13 Gene

Molecular function for LGALS13 Gene

UniProtKB/Swiss-Prot Function:
Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis.

Gene Ontology (GO) - Molecular Function for LGALS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 lysophospholipase activity IEA --
GO:0005515 protein binding IPI 23088713
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LGALS13: view

Phenotypes for LGALS13 Gene

GenomeRNAi human phenotypes for LGALS13:
genes like me logo Genes that share phenotypes with LGALS13: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LGALS13 Gene

Localization for LGALS13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LGALS13 gene
Compartment Confidence
extracellular 4
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LGALS13 Gene

Pathways & Interactions for LGALS13 Gene

genes like me logo Genes that share pathways with LGALS13: view

Pathways by source for LGALS13 Gene

1 BioSystems pathway for LGALS13 Gene

Gene Ontology (GO) - Biological Process for LGALS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS 10527825
GO:0006915 apoptotic process IEA --
GO:0070234 positive regulation of T cell apoptotic process IEA --
genes like me logo Genes that share ontologies with LGALS13: view

No data available for SIGNOR curated interactions for LGALS13 Gene

Drugs & Compounds for LGALS13 Gene

(8) Drugs for LGALS13 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Choline alfoscerate Experimental Pharma 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0

(5) Additional Compounds for LGALS13 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
Pentadecanoic acid
  • N-Pentadecanoate
  • N-Pentadecanoic acid
  • N-Pentadecylate
  • N-Pentadecylic acid
  • Pentadecanoate
1002-84-2
genes like me logo Genes that share compounds with LGALS13: view

Transcripts for LGALS13 Gene

Unigene Clusters for LGALS13 Gene

Lectin, galactoside-binding, soluble, 13:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS13 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4
SP1:
SP2: - -

Relevant External Links for LGALS13 Gene

GeneLoc Exon Structure for
LGALS13
ECgene alternative splicing isoforms for
LGALS13

Expression for LGALS13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LGALS13 Gene

mRNA differential expression in normal tissues according to GTEx for LGALS13 Gene

This gene is overexpressed in Testis (x15.5), Brain - Substantia nigra (x10.8), Brain - Cerebellum (x7.0), Brain - Cerebellar Hemisphere (x6.5), and Brain - Hypothalamus (x6.0).

Protein differential expression in normal tissues from HIPED for LGALS13 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LGALS13 Gene



Protein tissue co-expression partners for LGALS13 Gene

NURSA nuclear receptor signaling pathways regulating expression of LGALS13 Gene:

LGALS13

SOURCE GeneReport for Unigene cluster for LGALS13 Gene:

Hs.23671

mRNA Expression by UniProt/SwissProt for LGALS13 Gene:

Q9UHV8-PP13_HUMAN
Tissue specificity: Detected in adult and fetal spleen, fetal kidney, adult urinary bladder and placenta. Placental expression originates predominantly from the syncytiotrophoblast.
genes like me logo Genes that share expression patterns with LGALS13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS13 Gene

Orthologs for LGALS13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LGALS13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LGALS13 34 35
  • 96.88 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 43 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 38 (a)
OneToMany
Species where no ortholog for LGALS13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LGALS13 Gene

ENSEMBL:
Gene Tree for LGALS13 (if available)
TreeFam:
Gene Tree for LGALS13 (if available)

Paralogs for LGALS13 Gene

Paralogs for LGALS13 Gene

(11) SIMAP similar genes for LGALS13 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LGALS13: view

Variants for LGALS13 Gene

Sequence variations from dbSNP and Humsavar for LGALS13 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001064587 -- 39,604,435(+) ATGGG(C/T)CCGCC intron-variant
rs1001517022 -- 39,604,102(+) CTGGA(A/G)TGAAT intron-variant
rs1001629323 -- 39,605,828(+) GAGGT(-/TTTG)TTTGT intron-variant
rs1001799971 -- 39,605,695(+) ACAAT(A/G)TACTT intron-variant
rs1001934251 -- 39,605,673(+) ATTTT(A/C)ATTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LGALS13 Gene

Variant ID Type Subtype PubMed ID
esv2718554 CNV deletion 23290073
esv34120 CNV loss 18971310
nsv2481 CNV insertion 18451855
nsv579509 CNV gain 21841781

Variation tolerance for LGALS13 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LGALS13 Gene

Human Gene Mutation Database (HGMD)
LGALS13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LGALS13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS13 Gene

Disorders for LGALS13 Gene

MalaCards: The human disease database

(7) MalaCards diseases for LGALS13 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
severe pre-eclampsia
  • antepartum severe pre-eclampsia
pre-eclampsia
  • preeclampsia
patau syndrome
  • d1 trisomy
eclampsia
  • eclampsia in puerperium
preeclampsia/eclampsia 1
  • preeclampsia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LGALS13

Genetic Association Database (GAD)
LGALS13
Human Genome Epidemiology (HuGE) Navigator
LGALS13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LGALS13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LGALS13
genes like me logo Genes that share disorders with LGALS13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS13 Gene

Publications for LGALS13 Gene

  1. Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden crystal protein. (PMID: 10527825) Than N.G. … Bohn H. (Placenta 1999) 2 3 4 22 64
  2. A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. (PMID: 19497882) Than N.G. … Wildman D.E. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 22 64
  3. A novel exonic variant (221delT) in the LGALS13 gene encoding placental protein 13 (PP13) is associated with preterm labour in a low risk population. (PMID: 19818512) Gebhardt S. … Hillermann R. (J. Reprod. Immunol. 2009) 3 22 46 64
  4. Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13). (PMID: 11742106) Visegrady B. … Bohn H. (Protein Eng. 2001) 3 4 22 64
  5. Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17). (PMID: 6856484) Bohn H. … Winckler W. (Oncodev. Biol. Med. 1983) 2 3 4 64

Products for LGALS13 Gene

Sources for LGALS13 Gene

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