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Aliases for LGALS13 Gene

Aliases for LGALS13 Gene

  • Lectin, Galactoside-Binding, Soluble, 13 2 3
  • PP13 3 4 6
  • Placental Tissue Protein 13 3 4
  • Placental Protein 13 3 4
  • Galectin 13 2 3
  • Galectin-13 3 4
  • Gal-13 3 4
  • GAL13 3 6
  • PLAC8 3 4
  • Galactoside-Binding Soluble Lectin 13 3
  • Beta-Galactoside-Binding Lectin 3

External Ids for LGALS13 Gene

Previous GeneCards Identifiers for LGALS13 Gene

  • GC19P044786
  • GC19P044787
  • GC19P040093
  • GC19P036539

Summaries for LGALS13 Gene

Entrez Gene Summary for LGALS13 Gene

  • Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene has lysophospholipase activity. It is composed of two identical subunits which are held together by disulfide bonds. This protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS13 Gene

LGALS13 (Lectin, Galactoside-Binding, Soluble, 13) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and Gastric cancer network 2. GO annotations related to this gene include carbohydrate binding and lysophospholipase activity. An important paralog of this gene is CLC.

UniProtKB/Swiss-Prot for LGALS13 Gene

  • Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis.

Gene Wiki entry for LGALS13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS13 Gene

Genomics for LGALS13 Gene

Regulatory Elements for LGALS13 Gene

Genomic Location for LGALS13 Gene

Start:
39,602,501 bp from pter
End:
39,607,476 bp from pter
Size:
4,976 bases
Orientation:
Plus strand

Genomic View for LGALS13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LGALS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS13 Gene

Proteins for LGALS13 Gene

  • Protein details for LGALS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHV8-PP13_HUMAN
    Recommended name:
    Galactoside-binding soluble lectin 13
    Protein Accession:
    Q9UHV8
    Secondary Accessions:
    • C5HZ15

    Protein attributes for LGALS13 Gene

    Size:
    139 amino acids
    Molecular mass:
    16119 Da
    Quaternary structure:
    • Homodimer; disulfide-linked

    Three dimensional structures from OCA and Proteopedia for LGALS13 Gene

neXtProt entry for LGALS13 Gene

Proteomics data for LGALS13 Gene at MOPED

Post-translational modifications for LGALS13 Gene

No Post-translational modifications

Other Protein References for LGALS13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LGALS13 Gene

Domains for LGALS13 Gene

Gene Families for LGALS13 Gene

HGNC:
  • LGALS :Lectins, galactoside-binding

Protein Domains for LGALS13 Gene

Suggested Antigen Peptide Sequences for LGALS13 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHV8

UniProtKB/Swiss-Prot:

PP13_HUMAN :
  • Q9UHV8
Domain:
  • Contains 1 galectin domain.
genes like me logo Genes that share domains with LGALS13: view

Function for LGALS13 Gene

Molecular function for LGALS13 Gene

UniProtKB/Swiss-Prot Function: Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis.

Gene Ontology (GO) - Molecular Function for LGALS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 lysophospholipase activity IEA --
GO:0005515 protein binding IPI 23088713
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LGALS13: view

Phenotypes for LGALS13 Gene

GenomeRNAi human phenotypes for LGALS13:
genes like me logo Genes that share phenotypes with LGALS13: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LGALS13 Gene

Localization for LGALS13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LGALS13 Gene COMPARTMENTS Subcellular localization image for LGALS13 gene
Compartment Confidence
extracellular 3
cytosol 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LGALS13 Gene

Pathways for LGALS13 Gene

genes like me logo Genes that share pathways with LGALS13: view

Pathways by source for LGALS13 Gene

2 BioSystems pathways for LGALS13 Gene

Gene Ontology (GO) - Biological Process for LGALS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS 10527825
GO:0006915 apoptotic process IEA --
GO:0070234 positive regulation of T cell apoptotic process IEA --
genes like me logo Genes that share ontologies with LGALS13: view

Compounds for LGALS13 Gene

(10) HMDB Compounds for LGALS13 Gene

Compound Synonyms Cas Number PubMed IDs
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Glycerophosphocholine
  • 2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt
28319-77-9
Heptadecanoic acid
  • Heptadecanoate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoyl coenzyme A
3546-17-6

(2) Novoseek inferred chemical compound relationships for LGALS13 Gene

Compound -log(P) Hits PubMed IDs
n-acetyllactosamine 71.9 2
tyrosine 18.1 2
genes like me logo Genes that share compounds with LGALS13: view

Transcripts for LGALS13 Gene

mRNA/cDNA for LGALS13 Gene

Unigene Clusters for LGALS13 Gene

Lectin, galactoside-binding, soluble, 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS13 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4
SP1:
SP2: - -

Relevant External Links for LGALS13 Gene

GeneLoc Exon Structure for
LGALS13
ECgene alternative splicing isoforms for
LGALS13

Expression for LGALS13 Gene

mRNA expression in normal human tissues for LGALS13 Gene

mRNA differential expression in normal tissues according to GTEx for LGALS13 Gene

This gene is overexpressed in Testis (15.5), Brain - Substantia nigra (10.8), Brain - Cerebellum (7.0), Brain - Cerebellar Hemisphere (6.5), and Brain - Hypothalamus (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LGALS13 Gene

SOURCE GeneReport for Unigene cluster for LGALS13 Gene Hs.23671

mRNA Expression by UniProt/SwissProt for LGALS13 Gene

Q9UHV8-PP13_HUMAN
Tissue specificity: Detected in adult and fetal spleen, fetal kidney, adult urinary bladder and placenta. Placental expression originates predominantly from the syncytiotrophoblast.
genes like me logo Genes that share expressions with LGALS13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LGALS13 Gene

Orthologs for LGALS13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LGALS13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LGALS13 35
  • 96.88 (n)
  • 95.68 (a)
LGALS13 36
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 43 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
OneToMany
Species with no ortholog for LGALS13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LGALS13 Gene

ENSEMBL:
Gene Tree for LGALS13 (if available)
TreeFam:
Gene Tree for LGALS13 (if available)

Paralogs for LGALS13 Gene

Paralogs for LGALS13 Gene

Selected SIMAP similar genes for LGALS13 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LGALS13: view

Variants for LGALS13 Gene

Sequence variations from dbSNP and Humsavar for LGALS13 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1014206 -- 39,603,888(+) TAGTC(A/G)TCATA intron-variant
rs1801654 -- 39,607,352(+) GATCA(C/G)ACTCC utr-variant-3-prime
rs1986156 -- 39,603,281(+) GGGGG(C/T)GATGG intron-variant
rs2158964 -- 39,603,603(+) tccca(C/T)caatt intron-variant
rs2233702 -- 39,601,817(+) TACCC(C/T)GAACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LGALS13 Gene

Variant ID Type Subtype PubMed ID
esv34120 CNV Loss 18971310
nsv2481 CNV Insertion 18451855
esv2718554 CNV Deletion 23290073

Relevant External Links for LGALS13 Gene

HapMap Linkage Disequilibrium report
LGALS13
Human Gene Mutation Database (HGMD)
LGALS13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS13 Gene

Disorders for LGALS13 Gene

(1) University of Copenhagen DISEASES for LGALS13 Gene

(1) Novoseek inferred disease relationships for LGALS13 Gene

Disease -log(P) Hits PubMed IDs
preeclampsia 74.9 13

Relevant External Links for LGALS13

Genetic Association Database (GAD)
LGALS13
Human Genome Epidemiology (HuGE) Navigator
LGALS13
genes like me logo Genes that share disorders with LGALS13: view

No data available for UniProtKB/Swiss-Prot for LGALS13 Gene

Publications for LGALS13 Gene

  1. Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden crystal protein. (PMID: 10527825) Than N.G. … Bohn H. (Placenta 1999) 2 3 4 23
  2. Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13). (PMID: 11742106) Visegrady B. … Bohn H. (Protein Eng. 2001) 3 4 23
  3. A novel exonic variant (221delT) in the LGALS13 gene encoding placental protein 13 (PP13) is associated with preterm labour in a low risk population. (PMID: 19818512) Gebhardt S. … Hillermann R. (J. Reprod. Immunol. 2009) 3 23 48
  4. Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17). (PMID: 6856484) Bohn H. … Winckler W. (Oncodev. Biol. Med. 1983) 2 3 4
  5. A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. (PMID: 19497882) Than N.G. … Wildman D.E. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 23

Products for LGALS13 Gene

Sources for LGALS13 Gene

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