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Aliases for BRD7 Gene

Aliases for BRD7 Gene

  • Bromodomain Containing 7 2 3 5
  • 75 KDa Bromodomain Protein 3 4
  • Protein CELTIX-1 3 4
  • CELTIX1 3 4
  • BP75 3 4
  • Bromodomain-Containing Protein 7 3
  • Bromodomain-Containing 7 2
  • NAG4 3

External Ids for BRD7 Gene

Previous GeneCards Identifiers for BRD7 Gene

  • GC16M040766
  • GC16M050400
  • GC16M050088
  • GC16M050130
  • GC16M048910
  • GC16M036240

Summaries for BRD7 Gene

Entrez Gene Summary for BRD7 Gene

  • This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

GeneCards Summary for BRD7 Gene

BRD7 (Bromodomain Containing 7) is a Protein Coding gene. Diseases associated with BRD7 include Nasopharyngeal Carcinoma and Pharynx Cancer. Among its related pathways are Gene Expression and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include transcription factor binding and transcription regulatory region DNA binding. An important paralog of this gene is BRD9.

UniProtKB/Swiss-Prot for BRD7 Gene

  • Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at Tyr-216. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at Lys-9 (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at Lys-382, and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.

Gene Wiki entry for BRD7 Gene

Additional gene information for BRD7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRD7 Gene

Genomics for BRD7 Gene

GeneHancer (GH) Regulatory Elements for BRD7 Gene

Promoters and enhancers for BRD7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I050367 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 588.4 +0.2 178 2.7 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF2 POLR2B ZNF302 E2F8 ZNF143 BRD7 ENSG00000261393 ZNF423 PAPD5 SNX20
GH16I050333 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 44.4 +32.2 32157 6.7 HDAC1 PKNOX1 ATF1 EGR1 CREM ZNF263 ZNF592 MEF2D SMARCA4 IKZF1 GC16P050338 BRD7 PAPD5 CYLD ADCY7 MIR6771
GH16I050678 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.9 -313.6 -313638 8.8 HDGF PKNOX1 FOXA2 SMAD1 RB1 BATF KLF5 IRF4 RAD21 SCRT2 SNX20 NOD2 BRD7 CYLD ADCY7
GH16I050322 Enhancer 1 ENCODE dbSUPER 41.5 +45.0 45001 3.1 HDAC1 PKNOX1 SMAD1 NFIB RAD21 NCOA2 TCF12 EGR1 ZNF350 ATF7 BRD7 PAPD5 ENSG00000252526 ENSG00000205414 GC16P050338 MIR6771
GH16I050312 Enhancer 1 ENCODE dbSUPER 38.7 +54.5 54482 4.8 ELF3 FOXA2 MLX ARID4B RAD21 THRB ZNF48 RARA RCOR1 HMG20B BRD7 PAPD5 ENSG00000252526 LOC101927250 GC16P050338 MIR6771 ADCY7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BRD7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BRD7 gene promoter:

Genomic Locations for BRD7 Gene

Genomic Locations for BRD7 Gene
chr16:50,313,487-50,368,966
(GRCh38/hg38)
Size:
55,480 bases
Orientation:
Minus strand
chr16:50,347,398-50,402,845
(GRCh37/hg19)

Genomic View for BRD7 Gene

Genes around BRD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRD7 Gene

Proteins for BRD7 Gene

  • Protein details for BRD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPI1-BRD7_HUMAN
    Recommended name:
    Bromodomain-containing protein 7
    Protein Accession:
    Q9NPI1
    Secondary Accessions:
    • Q4VC09
    • Q8N2L9
    • Q96KA4
    • Q9BV48
    • Q9UH59

    Protein attributes for BRD7 Gene

    Size:
    651 amino acids
    Molecular mass:
    74139 Da
    Quaternary structure:
    • Interacts with TRIM24, PTPN13 and DVL1. Identified in a complex with SMARCA4/BRG1, SMARCC1/BAF155, SMARCE1/BAF57, DPF2/BAF45D and ARID2, subunits of the SWI/SNF-B (PBAF) chromatin remodeling complex (By similarity). Interacts with IRF2 and HNRPUL1. Interacts (via N-terminus) with TP53. Interacts (via C-terminus) with EP300. Interacts with BRCA1. Interacts (via bromo domain) with histone H3 (via N-terminus) acetylated at Lys-14 (H3K14ac). Has low affinity for histone H3 acetylated at Lys-9 (H3K9ac). Has the highest affinity for histone H3 that is acetylated both at Lys-9 (H3K9ac) and at Lys-14 (H3K14ac). Has very low affinity for non-acetylated histone H3. Interacts (via bromo domain) with histone H4 (via N-terminus) acetylated at Lys-8 (H3K8ac) (in vitro).
    SequenceCaution:
    • Sequence=AAH01611.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB55031.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11089.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRD7 Gene

    Alternative splice isoforms for BRD7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRD7 Gene

Post-translational modifications for BRD7 Gene

  • Ubiquitination at Lys21, Lys186, and posLast=305305

No data available for DME Specific Peptides for BRD7 Gene

Domains & Families for BRD7 Gene

Gene Families for BRD7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BRD7 Gene

Suggested Antigen Peptide Sequences for BRD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BRD7: view

No data available for UniProtKB/Swiss-Prot for BRD7 Gene

Function for BRD7 Gene

Molecular function for BRD7 Gene

UniProtKB/Swiss-Prot Function:
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at Tyr-216. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at Lys-9 (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at Lys-382, and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.

Phenotypes From GWAS Catalog for BRD7 Gene

Gene Ontology (GO) - Molecular Function for BRD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 20228809
GO:0003713 transcription coactivator activity IDA 20228809
GO:0003714 transcription corepressor activity ISS,IEA --
GO:0005515 protein binding IPI 12489984
GO:0008134 transcription factor binding IDA 11025449
genes like me logo Genes that share ontologies with BRD7: view
genes like me logo Genes that share phenotypes with BRD7: view

Animal Models for BRD7 Gene

MGI Knock Outs for BRD7:

Clone Products

  • Addgene plasmids for BRD7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRD7 Gene

Localization for BRD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRD7 Gene

Isoform 2: Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRD7 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BRD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS 11025449
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 10526152
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with BRD7: view

Pathways & Interactions for BRD7 Gene

genes like me logo Genes that share pathways with BRD7: view

Pathways by source for BRD7 Gene

Gene Ontology (GO) - Biological Process for BRD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IDA 12489984
GO:0007049 cell cycle IEA --
GO:0008285 negative regulation of cell proliferation IDA 20228809
genes like me logo Genes that share ontologies with BRD7: view

No data available for SIGNOR curated interactions for BRD7 Gene

Drugs & Compounds for BRD7 Gene

(12) Drugs for BRD7 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(-)-JQ1 Pharma BET bromodomain inhibitor 0
Bromodomain Inhibitor, (+)-JQ1 Pharma BET bromodomain inhibitor 0
CPI-203 Pharma BET bromodomain inhibitor 0
I-BET151 (GSK1210151A) Pharma Selective BET inhibitor 0
I-BET-762 Pharma BET inhibitor,highly potent 0

(11) ApexBio Compounds for BRD7 Gene

Compound Action Cas Number
(-)-JQ1 BET bromodomain inhibitor 1268524-71-5
Bromodomain Inhibitor, (+)-JQ1 BET bromodomain inhibitor 1268524-70-4
CPI-203 BET bromodomain inhibitor 1446144-04-2
I-BET151 (GSK1210151A) Selective BET inhibitor 1300031-49-5
I-BET-762 BET inhibitor,highly potent 1260907-17-2
MS436 BRD4 inhibitor 1395084-25-9
OF-1 BRPF1B and BRPF2 bromodomain inhibitor 919973-83-4
OTX-015 BRD inhibitor 202590-98-5
PFI-1 (PF-6405761) BET inhibitor 1403764-72-6
RVX-208 Potent BET bromodomain inhibitor 1044870-39-4
UNC1215 Chemical probe for the methyllysine (Kme) 1415800-43-9
genes like me logo Genes that share compounds with BRD7: view

Drug Products

Transcripts for BRD7 Gene

Unigene Clusters for BRD7 Gene

Bromodomain containing 7:
Representative Sequences:

Clone Products

  • Addgene plasmids for BRD7

Alternative Splicing Database (ASD) splice patterns (SP) for BRD7 Gene

No ASD Table

Relevant External Links for BRD7 Gene

GeneLoc Exon Structure for
BRD7
ECgene alternative splicing isoforms for
BRD7

Expression for BRD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BRD7 Gene

Protein differential expression in normal tissues from HIPED for BRD7 Gene

This gene is overexpressed in Bone marrow stromal cell (17.7), Cervix (12.8), Plasma (11.3), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BRD7 Gene



Protein tissue co-expression partners for BRD7 Gene

NURSA nuclear receptor signaling pathways regulating expression of BRD7 Gene:

BRD7

SOURCE GeneReport for Unigene cluster for BRD7 Gene:

Hs.437894

Evidence on tissue expression from TISSUES for BRD7 Gene

  • Nervous system(4.6)
  • Liver(4.4)
  • Blood(4.2)
  • Skin(4.2)
  • Kidney(2.4)
  • Lung(2.3)
  • Spleen(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with BRD7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRD7 Gene

Orthologs for BRD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRD7 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia BRD7 33 34
  • 92.09 (n)
cow
(Bos Taurus)
Mammalia BRD7 33 34
  • 91.18 (n)
mouse
(Mus musculus)
Mammalia Brd7 33 16 34
  • 87.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BRD7 34
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
OneToMany
-- 34
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves BRD7 33 34
  • 75.97 (n)
lizard
(Anolis carolinensis)
Reptilia BRD7 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brd7 33
  • 64.25 (n)
African clawed frog
(Xenopus laevis)
Amphibia BRD7 33
zebrafish
(Danio rerio)
Actinopterygii brd7 33 34
  • 61.43 (n)
Dr.23894 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009307 33
  • 47.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7154 34
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-298 33
  • 45.64 (n)
swsn-9 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
OneToMany
Species where no ortholog for BRD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRD7 Gene

ENSEMBL:
Gene Tree for BRD7 (if available)
TreeFam:
Gene Tree for BRD7 (if available)

Paralogs for BRD7 Gene

Paralogs for BRD7 Gene

(2) SIMAP similar genes for BRD7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BRD7: view

Variants for BRD7 Gene

Sequence variations from dbSNP and Humsavar for BRD7 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs796065051 likely-pathogenic, malignant granular cell tumor 50,319,953(-) G/A coding_sequence_variant, non_coding_transcript_variant, stop_gained
rs1000015838 -- 50,330,309(-) G/A intron_variant
rs1000031011 -- 50,336,663(-) G/A intron_variant
rs1000118189 -- 50,330,323(-) T/C intron_variant
rs1000145907 -- 50,364,375(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BRD7 Gene

Variant ID Type Subtype PubMed ID
esv1011295 OTHER inversion 20482838
nsv1805 CNV deletion 18451855
nsv1806 CNV insertion 18451855
nsv978324 CNV duplication 23825009

Variation tolerance for BRD7 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BRD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD7 Gene

Disorders for BRD7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BRD7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
nasopharyngeal carcinoma
  • npca
pharynx cancer
  • pharyngeal cancer
- elite association - COSMIC cancer census association via MalaCards
Search BRD7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BRD7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BRD7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BRD7 Gene

Publications for BRD7 Gene

  1. BRD7 is a candidate tumour suppressor gene required for p53 function. (PMID: 20228809) Drost J … Del Sal G (Nature cell biology 2010) 3 4 22 58
  2. Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2. (PMID: 11025449) Staal A … van Wijnen AJ (Journal of cellular physiology 2000) 3 4 22 58
  3. Identification and molecular characterization of BP75, a novel bromodomain-containing protein. (PMID: 10526152) Cuppen E … Hendriks W (FEBS letters 1999) 2 3 22 58
  4. BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription. (PMID: 20215511) Harte MT … Harkin DP (Cancer research 2010) 3 4 58
  5. Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. (PMID: 20660729) Burrows AE … Elledge SJ (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 58

Products for BRD7 Gene

  • Addgene plasmids for BRD7

Sources for BRD7 Gene

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