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Aliases for BRD7 Gene

Aliases for BRD7 Gene

  • Bromodomain Containing 7 2 3
  • 75 KDa Bromodomain Protein 3 4
  • Protein CELTIX-1 3 4
  • CELTIX1 3 4
  • BP75 3 4
  • Bromodomain-Containing Protein 7 3
  • Bromodomain-Containing 7 2
  • NAG4 3

External Ids for BRD7 Gene

Previous GeneCards Identifiers for BRD7 Gene

  • GC16M040766
  • GC16M050400
  • GC16M050088
  • GC16M050130
  • GC16M048910
  • GC16M036240

Summaries for BRD7 Gene

Entrez Gene Summary for BRD7 Gene

  • This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

GeneCards Summary for BRD7 Gene

BRD7 (Bromodomain Containing 7) is a Protein Coding gene. Diseases associated with BRD7 include nasopharynx carcinoma. Among its related pathways are Wnt signaling pathway (KEGG). GO annotations related to this gene include transcription factor binding and transcription corepressor activity. An important paralog of this gene is BRD9.

UniProtKB/Swiss-Prot for BRD7 Gene

  • Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at Tyr-216. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at Lys-9 (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at Lys-382, and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.

Gene Wiki entry for BRD7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRD7 Gene

Genomics for BRD7 Gene

Regulatory Elements for BRD7 Gene

Genomic Location for BRD7 Gene

Start:
50,313,487 bp from pter
End:
50,368,934 bp from pter
Size:
55,448 bases
Orientation:
Minus strand

Genomic View for BRD7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRD7 Gene

Proteins for BRD7 Gene

  • Protein details for BRD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPI1-BRD7_HUMAN
    Recommended name:
    Bromodomain-containing protein 7
    Protein Accession:
    Q9NPI1
    Secondary Accessions:
    • Q4VC09
    • Q8N2L9
    • Q96KA4
    • Q9BV48
    • Q9UH59

    Protein attributes for BRD7 Gene

    Size:
    651 amino acids
    Molecular mass:
    74139 Da
    Quaternary structure:
    • Interacts with TRIM24, PTPN13 and DVL1. Identified in a complex with SMARCA4/BRG1, SMARCC1/BAF155, SMARCE1/BAF57, DPF2/BAF45D and ARID2, subunits of the SWI/SNF-B (PBAF) chromatin remodeling complex (By similarity). Interacts with IRF2 and HNRPUL1. Interacts (via N-terminus) with TP53. Interacts (via C-terminus) with EP300. Interacts with BRCA1. Interacts (via bromo domain) with histone H3 (via N-terminus) acetylated at Lys-14 (H3K14ac). Has low affinity for histone H3 acetylated at Lys-9 (H3K9ac). Has the highest affinity for histone H3 that is acetylated both at Lys-9 (H3K9ac) and at Lys-14 (H3K14ac). Has very low affinity for non-acetylated histone H3. Interacts (via bromo domain) with histone H4 (via N-terminus) acetylated at Lys-8 (H3K8ac) (in vitro).
    SequenceCaution:
    • Sequence=AAH01611.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB55031.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11089.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRD7 Gene

    Alternative splice isoforms for BRD7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRD7 Gene

Proteomics data for BRD7 Gene at MOPED

Post-translational modifications for BRD7 Gene

  • Ubiquitination at Lys21, Lys186, and Lys305
  • Modification sites at PhosphoSitePlus

Other Protein References for BRD7 Gene

No data available for DME Specific Peptides for BRD7 Gene

Domains for BRD7 Gene

Protein Domains for BRD7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BRD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPI1

UniProtKB/Swiss-Prot:

BRD7_HUMAN :
  • Q9NPI1
Domain:
  • Contains 1 bromo domain.
genes like me logo Genes that share domains with BRD7: view

No data available for Gene Families for BRD7 Gene

Function for BRD7 Gene

Molecular function for BRD7 Gene

UniProtKB/Swiss-Prot Function: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at Tyr-216. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at Lys-9 (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at Lys-382, and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.

Gene Ontology (GO) - Molecular Function for BRD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 20228809
GO:0003713 transcription coactivator activity IDA 20228809
GO:0003714 transcription corepressor activity ISS --
GO:0005515 protein binding IPI 12489984
GO:0008134 transcription factor binding IDA 11025449
genes like me logo Genes that share ontologies with BRD7: view

Phenotypes for BRD7 Gene

genes like me logo Genes that share phenotypes with BRD7: view

miRNA for BRD7 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BRD7 Gene

Localization for BRD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRD7 Gene

Isoform 2: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRD7 Gene COMPARTMENTS Subcellular localization image for BRD7 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for BRD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11025449
GO:0005737 cytoplasm TAS 10526152
genes like me logo Genes that share ontologies with BRD7: view

Pathways for BRD7 Gene

SuperPathways for BRD7 Gene

Superpath Contained pathways
1 Wnt signaling pathway (KEGG)
genes like me logo Genes that share pathways with BRD7: view

Pathways by source for BRD7 Gene

1 BioSystems pathway for BRD7 Gene

Gene Ontology (GO) - Biological Process for BRD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 12489984
GO:0007049 cell cycle IEA --
GO:0008285 negative regulation of cell proliferation IDA 20228809
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with BRD7: view

Compounds for BRD7 Gene

(11) ApexBio Compounds for BRD7 Gene

Compound Action Cas Number
(-)-JQ1 Inactive stereoisomer of bromodomain inhibitor (+)-JQ1 [1268524-71-5]
(+)-JQ1 BET bromodomain inhibitor [1268524-70-4]
Bromosporine broad spectrum inhibitor for bromodomains
I-BET151 (GSK1210151A) BET bromodomain inhibitor(pIC50=6.1,BRD4) [1300031-49-5]
I-BET-762 inhibitor for BET proteins [1260907-17-2]
OTX-015 new potent BRD-inhibitor [202590-98-5]
PFI-1 (PF-6405761) selective BET inhibitor for BRD4 [1403764-72-6]
RVX-208 potent BET bromodomain inhibitor for BD2 [1044870-39-4]
SGC-CBP30 Potent CREBBP/EP300 bromodomain inhibitor
UNC1215 elective MBT antagonist [1415800-43-9]
UNC669 potent and selective MBT inhibitor [1314241-44-5]

(1) Novoseek inferred chemical compound relationships for BRD7 Gene

Compound -log(P) Hits PubMed IDs
lysine 24.6 1
genes like me logo Genes that share compounds with BRD7: view

Transcripts for BRD7 Gene

Unigene Clusters for BRD7 Gene

Bromodomain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRD7 Gene

No ASD Table

Relevant External Links for BRD7 Gene

GeneLoc Exon Structure for
BRD7
ECgene alternative splicing isoforms for
BRD7

Expression for BRD7 Gene

mRNA expression in normal human tissues for BRD7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRD7 Gene

SOURCE GeneReport for Unigene cluster for BRD7 Gene Hs.437894

genes like me logo Genes that share expressions with BRD7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BRD7 Gene

Orthologs for BRD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRD7 35
  • 99.54 (n)
  • 99.54 (a)
BRD7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BRD7 35
  • 91.18 (n)
  • 92.15 (a)
BRD7 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRD7 35
  • 92.09 (n)
  • 94.81 (a)
BRD7 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brd7 35
  • 87.35 (n)
  • 88.17 (a)
Brd7 16
Brd7 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia BRD7 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRD7 35
  • 75.97 (n)
  • 79.22 (a)
BRD7 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRD7 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia BRD7 35
tropical clawed frog
(Silurana tropicalis)
Amphibia brd7 35
  • 64.25 (n)
  • 64.25 (a)
zebrafish
(Danio rerio)
Actinopterygii brd7 35
  • 61.43 (n)
  • 58.02 (a)
brd7 36
  • 54 (a)
OneToOne
Dr.23894 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009307 35
  • 47.05 (n)
  • 39.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7154 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea swsn-9 36
  • 22 (a)
OneToMany
tag-298 35
  • 45.64 (n)
  • 33.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for BRD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRD7 Gene

ENSEMBL:
Gene Tree for BRD7 (if available)
TreeFam:
Gene Tree for BRD7 (if available)

Paralogs for BRD7 Gene

Paralogs for BRD7 Gene

Selected SIMAP similar genes for BRD7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BRD7: view

Variants for BRD7 Gene

Sequence variations from dbSNP and Humsavar for BRD7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs873269 -- 50,361,091(-) ttagt(A/G)tctcg intron-variant
rs1062348 -- 50,334,752(-) GATGC(C/T)GAAGC reference, synonymous-codon
rs1125066 -- 50,367,277(-) CCACT(A/G)CACTC intron-variant
rs1362563 -- 50,366,869(-) TTTTC(C/T)TCACC intron-variant
rs1362564 -- 50,366,797(-) GTAAA(A/G)TAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRD7 Gene

Variant ID Type Subtype PubMed ID
nsv1805 CNV Loss 18451855
nsv1806 CNV Insertion 18451855
esv1011295 OTHER Inversion 20482838

Relevant External Links for BRD7 Gene

HapMap Linkage Disequilibrium report
BRD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD7 Gene

Disorders for BRD7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for BRD7 Gene including...

Search for BRD7 Gene in MalaCards »

(1) University of Copenhagen DISEASES for BRD7 Gene

(1) Novoseek inferred disease relationships for BRD7 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3

Relevant External Links for BRD7

Genetic Association Database (GAD)
BRD7
Human Genome Epidemiology (HuGE) Navigator
BRD7
genes like me logo Genes that share disorders with BRD7: view

No data available for UniProtKB/Swiss-Prot for BRD7 Gene

Publications for BRD7 Gene

  1. Identification and molecular characterization of BP75, a novel bromodomain-containing protein. (PMID: 10526152) Cuppen E. … Hendriks W. (FEBS Lett. 1999) 2 3 23
  2. Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2. (PMID: 11025449) Staal A. … van Wijnen A.J. (J. Cell. Physiol. 2000) 3 4 23
  3. BRD7 is a candidate tumour suppressor gene required for p53 function. (PMID: 20228809) Drost J. … Del Sal G. (Nat. Cell Biol. 2010) 3 4 23
  4. TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells. (PMID: 19909775) Kikuchi M. … Hatakeyama S. (Biochim. Biophys. Acta 2009) 3 23
  5. [Expression of BRD7-interacting proteins,BRD2 and BRD3, in nasopharyngeal carcinoma tissues]. (PMID: 12600283) Zhou M. … Li G.Y. (Ai Zheng 2003) 3 23

Products for BRD7 Gene

Sources for BRD7 Gene

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