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Aliases for DROSHA Gene

Aliases for DROSHA Gene

  • Drosha, Ribonuclease Type III 2 3
  • RNASEN 3 4 6
  • RN3 3 4 6
  • Ribonuclease Type III, Nuclear 2 3
  • Protein Drosha 3 4
  • EC 3.1.26.3 4 64
  • RNase III 3 4
  • RANSE3L 3 6
  • RNASE3L 3 4
  • P241 3 4
  • Putative Protein P241 Which Interacts With Transcription Factor Sp1 3
  • Drosha, Double-Stranded RNA-Specific Endoribonuclease 3
  • Double-Stranded RNA-Specific Endoribonuclease 2
  • Putative Ribonuclease III 3
  • Ribonuclease III, Nuclear 3
  • Nuclear RNase III Drosha 3
  • Ribonuclease Type III 2
  • Ribonuclease III 4
  • Ribonuclease 3 3
  • HSA242976 3
  • Drosha 2
  • ETOHI2 3

External Ids for DROSHA Gene

Previous Symbols for DROSHA Gene

  • RNASEN

Summaries for DROSHA Gene

Entrez Gene Summary for DROSHA Gene

  • Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DROSHA Gene

DROSHA (Drosha, Ribonuclease Type III) is a Protein Coding gene. Among its related pathways are Proteoglycans in cancer and Translational Control. GO annotations related to this gene include RNA binding and ribonuclease III activity.

UniProtKB/Swiss-Prot for DROSHA Gene

  • Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3 and 5 strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.

Gene Wiki entry for DROSHA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DROSHA Gene

Genomics for DROSHA Gene

Genomic Location for DROSHA Gene

Start:
31,400,494 bp from pter
End:
31,532,196 bp from pter
Size:
131,703 bases
Orientation:
Minus strand

Genomic View for DROSHA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DROSHA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DROSHA Gene

No data available for Regulatory Elements for DROSHA Gene

Proteins for DROSHA Gene

  • Protein details for DROSHA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRR4-RNC_HUMAN
    Recommended name:
    Ribonuclease 3
    Protein Accession:
    Q9NRR4
    Secondary Accessions:
    • E7EMP9
    • Q7Z5V2
    • Q86YH0
    • Q9NW73
    • Q9Y2V9
    • Q9Y4Y0

    Protein attributes for DROSHA Gene

    Size:
    1374 amino acids
    Molecular mass:
    159316 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Component of the microprocessor complex, or pri-miRNA processing protein complex, which is composed of DROSHA and DGCR8. The microprocessor complex may contain multiple subunit of DGCR8 and DROSHA. Interacts with DGCR8, SP1 and SNIP1. Interacts with SRRT/ARS2.
    SequenceCaution:
    • Sequence=AAD29637.1; Type=Frameshift; Positions=775; Evidence={ECO:0000305}; Sequence=BAA91511.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DROSHA Gene

    Alternative splice isoforms for DROSHA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DROSHA Gene

Proteomics data for DROSHA Gene at MOPED

Selected DME Specific Peptides for DROSHA Gene

Post-translational modifications for DROSHA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys1250

Other Protein References for DROSHA Gene

Domains for DROSHA Gene

UniProtKB/Swiss-Prot:

RNC_HUMAN
Domain:
  • The 2 RNase III domains form an intramolecular dimer where the domain 1 cuts the 3strand while the domain 2 cleaves the 5strand of pri-miRNAs, independently of each other:
    • Q9NRR4
  • Contains 1 DRBM (double-stranded RNA-binding) domain.:
    • Q9NRR4
  • Contains 2 RNase III domains.:
    • Q9NRR4
genes like me logo Genes that share domains with DROSHA: view

No data available for Gene Families for DROSHA Gene

Function for DROSHA Gene

Molecular function for DROSHA Gene

UniProtKB/Swiss-Prot CatalyticActivity: Endonucleolytic cleavage to 5-phosphomonoester
UniProtKB/Swiss-Prot Function: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3 and 5 strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.

Enzyme Numbers (IUBMB) for DROSHA Gene

Gene Ontology (GO) - Molecular Function for DROSHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 20180804
GO:0003723 RNA binding --
GO:0003725 double-stranded RNA binding IBA --
GO:0004521 endoribonuclease activity --
GO:0004525 ribonuclease III activity IDA 14508493
genes like me logo Genes that share ontologies with DROSHA: view
genes like me logo Genes that share phenotypes with DROSHA: view

Animal Models for DROSHA Gene

MGI Knock Outs for DROSHA:

miRNA for DROSHA Gene

No data available for Transcription Factor Targeting and HOMER Transcription for DROSHA Gene

Localization for DROSHA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DROSHA Gene

Nucleus. Nucleus, nucleolus. Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies.

Gene Ontology (GO) - Cellular Components for DROSHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0070877 microprocessor complex IDA 15574589
genes like me logo Genes that share ontologies with DROSHA: view

Pathways for DROSHA Gene

genes like me logo Genes that share pathways with DROSHA: view

Pathways by source for DROSHA Gene

1 Cell Signaling Technology pathway for DROSHA Gene
1 BioSystems pathway for DROSHA Gene

Gene Ontology (GO) - Biological Process for DROSHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing --
GO:0010467 gene expression TAS --
GO:0010468 regulation of gene expression --
GO:0010586 miRNA metabolic process IEA --
GO:0016075 rRNA catabolic process IEA --
genes like me logo Genes that share ontologies with DROSHA: view

Compounds for DROSHA Gene

(3) Novoseek inferred chemical compound relationships for DROSHA Gene

Compound -log(P) Hits PubMed IDs
polynucleotide 61.3 7
leucine 0 1
adenylate 0 1
genes like me logo Genes that share compounds with DROSHA: view

Transcripts for DROSHA Gene

Unigene Clusters for DROSHA Gene

Drosha, ribonuclease type III:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DROSHA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11: -
SP12: -
SP13:
SP14:
SP15:

ExUns: 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12: -
SP13:
SP14:
SP15:

ExUns: 37b ^ 38 ^ 39a · 39b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for DROSHA Gene

GeneLoc Exon Structure for
DROSHA
ECgene alternative splicing isoforms for
DROSHA

Expression for DROSHA Gene

mRNA expression in normal human tissues for DROSHA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DROSHA Gene

SOURCE GeneReport for Unigene cluster for DROSHA Gene Hs.97997

mRNA Expression by UniProt/SwissProt for DROSHA Gene

Q9NRR4-RNC_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with DROSHA: view

Orthologs for DROSHA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DROSHA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DROSHA 36
  • 99.61 (n)
  • 99.93 (a)
DROSHA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DROSHA 36
  • 91.43 (n)
  • 97.45 (a)
DROSHA 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 97 (a)
OneToMany
-- 37
  • 100 (a)
OneToMany
DROSHA 36
  • 92.52 (n)
  • 97.16 (a)
mouse
(Mus musculus)
Mammalia Drosha 36
  • 87.8 (n)
  • 95.77 (a)
Drosha 16
Drosha 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DROSHA 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 81 (a)
OneToMany
-- 37
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Drosha 36
  • 88.63 (n)
  • 96.43 (a)
chicken
(Gallus gallus)
Aves DROSHA 36
  • 79.89 (n)
  • 88.48 (a)
DROSHA 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DROSHA 37
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15543 36
tropical clawed frog
(Silurana tropicalis)
Amphibia drosha 36
  • 76.26 (n)
  • 86.4 (a)
Str.11055 36
zebrafish
(Danio rerio)
Actinopterygii Dr.11510 36
rnasen 36
  • 71.94 (n)
  • 85.68 (a)
rnasen 37
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008087 36
  • 53.16 (n)
  • 51.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta drosha 36
  • 56.22 (n)
  • 55.09 (a)
drosha 37
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea drsh-1 36
  • 48.97 (n)
  • 38.12 (a)
drsh-1 37
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNT1 39
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1094 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2273 37
  • 58 (a)
OneToOne
Species with no ortholog for DROSHA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DROSHA Gene

ENSEMBL:
Gene Tree for DROSHA (if available)
TreeFam:
Gene Tree for DROSHA (if available)

Paralogs for DROSHA Gene

No data available for Paralogs for DROSHA Gene

Variants for DROSHA Gene

Sequence variations from dbSNP and Humsavar for DROSHA Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs10719 -- 31,401,340(-) ATGAA(C/T)GAAGT utr-variant-3-prime
rs474699 -- 31,457,655(+) gtggc(C/T)gaggc intron-variant
rs474972 -- 31,450,939(-) caggc(A/G)tgagc intron-variant
rs475682 -- 31,457,546(+) TGATT(A/G)CAGAG intron-variant
rs481079 -- 31,440,871(+) atata(C/T)ttctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DROSHA Gene

Variant ID Type Subtype PubMed ID
dgv1788e1 CNV Complex 17122850
nsv830249 CNV Gain 17160897
esv34132 CNV Loss 18971310
nsv881382 CNV Gain 21882294
nsv819630 CNV Gain 19587683
dgv340n21 CNV Loss 19592680
nsv4776 CNV Insertion 18451855

Relevant External Links for DROSHA Gene

HapMap Linkage Disequilibrium report
DROSHA
Human Gene Mutation Database (HGMD)
DROSHA

Disorders for DROSHA Gene

No disorders were found for DROSHA Gene.

No data available for UniProtKB/Swiss-Prot for DROSHA Gene

Publications for DROSHA Gene

  1. Human RNase III is a 160-kDa protein involved in preribosomal RNA processing. (PMID: 10948199) Wu H. … Crooke S.T. (J. Biol. Chem. 2000) 2 3 4 23
  2. The nuclear RNase III Drosha initiates microRNA processing. (PMID: 14508493) Lee Y. … Kim V.N. (Nature 2003) 3 4 23
  3. The Drosha-DGCR8 complex in primary microRNA processing. (PMID: 15574589) Han J. … Kim V.N. (Genes Dev. 2004) 3 4 23
  4. The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis. (PMID: 15589161) Landthaler M. … Tuschl T. (Curr. Biol. 2004) 3 4 23
  5. A novel type of RNase III family proteins in eukaryotes. (PMID: 10713462) Filippov V. … Gill S.S. (Gene 2000) 2 3 23

Products for DROSHA Gene

Sources for DROSHA Gene

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