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Aliases for DROSHA Gene

Aliases for DROSHA Gene

  • Drosha, Ribonuclease Type III 2 3
  • Ribonuclease Type III, Nuclear 2 3
  • Protein Drosha 3 4
  • EC 3.1.26.3 4 63
  • RNase III 3 4
  • RNASE3L 3 4
  • RNASEN 3 4
  • P241 3 4
  • RN3 3 4
  • Putative Protein P241 Which Interacts With Transcription Factor Sp1 3
  • Drosha, Double-Stranded RNA-Specific Endoribonuclease 3
  • Double-Stranded RNA-Specific Endoribonuclease 2
  • Putative Ribonuclease III 3
  • Ribonuclease III, Nuclear 3
  • Nuclear RNase III Drosha 3
  • Ribonuclease Type III 2
  • Ribonuclease III 4
  • HSA242976 3
  • RANSE3L 3
  • Drosha 2
  • ETOHI2 3

External Ids for DROSHA Gene

Previous HGNC Symbols for DROSHA Gene

  • RNASEN

Summaries for DROSHA Gene

Entrez Gene Summary for DROSHA Gene

  • Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DROSHA Gene

DROSHA (Drosha, Ribonuclease Type III) is a Protein Coding gene. Diseases associated with DROSHA include combat disorder and ovarian serous carcinoma. Among its related pathways are Proteoglycans in cancer and Translational Control. GO annotations related to this gene include poly(A) RNA binding and RNA binding.

UniProtKB/Swiss-Prot for DROSHA Gene

  • Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3 and 5 strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.

Gene Wiki entry for DROSHA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DROSHA Gene

Genomics for DROSHA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DROSHA Gene

Chromosome:
5
Start:
31,400,494 bp from pter
End:
31,532,196 bp from pter
Size:
131,703 bases
Orientation:
Minus strand

Genomic View for DROSHA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DROSHA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DROSHA Gene

No data available for Regulatory Elements for DROSHA Gene

Proteins for DROSHA Gene

  • Protein details for DROSHA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRR4-RNC_HUMAN
    Recommended name:
    Ribonuclease 3
    Protein Accession:
    Q9NRR4
    Secondary Accessions:
    • E7EMP9
    • Q7Z5V2
    • Q86YH0
    • Q9NW73
    • Q9Y2V9
    • Q9Y4Y0

    Protein attributes for DROSHA Gene

    Size:
    1374 amino acids
    Molecular mass:
    159316 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Component of the microprocessor complex, or pri-miRNA processing protein complex, which is composed of DROSHA and DGCR8. The microprocessor complex may contain multiple subunit of DGCR8 and DROSHA. Interacts with DGCR8, SP1 and SNIP1. Interacts with SRRT/ARS2.
    SequenceCaution:
    • Sequence=AAD29637.1; Type=Frameshift; Positions=775; Evidence={ECO:0000305}; Sequence=BAA91511.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DROSHA Gene

    Alternative splice isoforms for DROSHA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DROSHA Gene

Proteomics data for DROSHA Gene at MOPED

Selected DME Specific Peptides for DROSHA Gene

Post-translational modifications for DROSHA Gene

  • Ubiquitination at Lys 1250
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DROSHA (Drosha)

Domains & Families for DROSHA Gene

Suggested Antigen Peptide Sequences for DROSHA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRR4

UniProtKB/Swiss-Prot:

RNC_HUMAN :
  • The 2 RNase III domains form an intramolecular dimer where the domain 1 cuts the 3strand while the domain 2 cleaves the 5strand of pri-miRNAs, independently of each other
Domain:
  • The 2 RNase III domains form an intramolecular dimer where the domain 1 cuts the 3strand while the domain 2 cleaves the 5strand of pri-miRNAs, independently of each other
  • Contains 1 DRBM (double-stranded RNA-binding) domain.
  • Contains 2 RNase III domains.
genes like me logo Genes that share domains with DROSHA: view

No data available for Gene Families for DROSHA Gene

Function for DROSHA Gene

Molecular function for DROSHA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage to 5-phosphomonoester
UniProtKB/Swiss-Prot Function:
Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3 and 5 strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.

Enzyme Numbers (IUBMB) for DROSHA Gene

Gene Ontology (GO) - Molecular Function for DROSHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 20180804
GO:0003723 RNA binding --
GO:0003725 double-stranded RNA binding IBA --
GO:0004521 endoribonuclease activity --
GO:0004525 ribonuclease III activity IDA 14508493
genes like me logo Genes that share ontologies with DROSHA: view
genes like me logo Genes that share phenotypes with DROSHA: view

Animal Models for DROSHA Gene

MGI Knock Outs for DROSHA:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DROSHA

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DROSHA Gene

Localization for DROSHA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DROSHA Gene

Nucleus. Nucleus, nucleolus. Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies. {ECO:0000269 PubMed:22118463}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DROSHA Gene COMPARTMENTS Subcellular localization image for DROSHA gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DROSHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0070877 microprocessor complex IDA 15574589
genes like me logo Genes that share ontologies with DROSHA: view

Pathways & Interactions for DROSHA Gene

genes like me logo Genes that share pathways with DROSHA: view

Pathways by source for DROSHA Gene

1 Cell Signaling Technology pathway for DROSHA Gene
1 BioSystems pathway for DROSHA Gene

Gene Ontology (GO) - Biological Process for DROSHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing --
GO:0010467 gene expression TAS --
GO:0010468 regulation of gene expression --
GO:0010586 miRNA metabolic process IEA --
GO:0010628 positive regulation of gene expression IEA --
genes like me logo Genes that share ontologies with DROSHA: view

No data available for SIGNOR curated interactions for DROSHA Gene

Drugs & Compounds for DROSHA Gene

(1) Drugs for DROSHA Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
leucine Nutra 93

(2) Additional Compounds for DROSHA Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
adenylate
POLYNUCLEOTIDE
genes like me logo Genes that share compounds with DROSHA: view

Transcripts for DROSHA Gene

Unigene Clusters for DROSHA Gene

Drosha, ribonuclease type III:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DROSHA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DROSHA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11: -
SP12: -
SP13:
SP14:
SP15:

ExUns: 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12: -
SP13:
SP14:
SP15:

ExUns: 37b ^ 38 ^ 39a · 39b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for DROSHA Gene

GeneLoc Exon Structure for
DROSHA
ECgene alternative splicing isoforms for
DROSHA

Expression for DROSHA Gene

mRNA expression in normal human tissues for DROSHA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DROSHA Gene

This gene is overexpressed in Lung (62.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DROSHA Gene



SOURCE GeneReport for Unigene cluster for DROSHA Gene Hs.97997

mRNA Expression by UniProt/SwissProt for DROSHA Gene

Q9NRR4-RNC_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with DROSHA: view

Protein tissue co-expression partners for DROSHA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DROSHA Gene

Orthologs for DROSHA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DROSHA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DROSHA 35
  • 91.43 (n)
  • 97.45 (a)
DROSHA 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DROSHA 35
  • 92.52 (n)
  • 97.16 (a)
-- 36
  • 97 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Drosha 35
  • 87.8 (n)
  • 95.77 (a)
Drosha 16
Drosha 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DROSHA 35
  • 99.61 (n)
  • 99.93 (a)
DROSHA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Drosha 35
  • 88.63 (n)
  • 96.43 (a)
oppossum
(Monodelphis domestica)
Mammalia DROSHA 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves DROSHA 35
  • 79.89 (n)
  • 88.48 (a)
DROSHA 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DROSHA 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia drosha 35
  • 76.26 (n)
  • 86.4 (a)
Str.11055 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15543 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11510 35
rnasen 35
  • 71.94 (n)
  • 85.68 (a)
rnasen 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008087 35
  • 53.16 (n)
  • 51.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta drosha 35
  • 56.22 (n)
  • 55.09 (a)
drosha 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea drsh-1 35
  • 48.97 (n)
  • 38.12 (a)
drsh-1 36
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNT1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1094 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2273 36
  • 58 (a)
OneToOne
Species with no ortholog for DROSHA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DROSHA Gene

ENSEMBL:
Gene Tree for DROSHA (if available)
TreeFam:
Gene Tree for DROSHA (if available)

Paralogs for DROSHA Gene

No data available for Paralogs for DROSHA Gene

Variants for DROSHA Gene

Sequence variations from dbSNP and Humsavar for DROSHA Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_051866 -
VAR_061778 -

Structural Variations from Database of Genomic Variants (DGV) for DROSHA Gene

Variant ID Type Subtype PubMed ID
dgv1788e1 CNV Complex 17122850
nsv830249 CNV Gain 17160897
esv34132 CNV Loss 18971310
nsv881382 CNV Gain 21882294
nsv819630 CNV Gain 19587683
dgv340n21 CNV Loss 19592680
nsv4776 CNV Insertion 18451855

Variation tolerance for DROSHA Gene

Residual Variation Intolerance Score: 4.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.44; 85.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DROSHA Gene

HapMap Linkage Disequilibrium report
DROSHA
Human Gene Mutation Database (HGMD)
DROSHA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DROSHA Gene

Disorders for DROSHA Gene

MalaCards: The human disease database

(4) MalaCards diseases for DROSHA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
combat disorder
  • combat neurosis
ovarian serous carcinoma
  • ovarian serous adenocarcinoma
cervical squamous cell carcinoma
  • squamous cell carcinoma of cervix
digeorge syndrome
  • digeorge's syndrome
- elite association

Relevant External Links for DROSHA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DROSHA
genes like me logo Genes that share disorders with DROSHA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DROSHA Gene

Publications for DROSHA Gene

  1. A novel type of RNase III family proteins in eukaryotes. (PMID: 10713462) Filippov V. … Gill S.S. (Gene 2000) 2 23 67
  2. Human RNase III is a 160-kDa protein involved in preribosomal RNA processing. (PMID: 10948199) Wu H. … Crooke S.T. (J. Biol. Chem. 2000) 2 23 67
  3. Translational activation of rpoS mRNA by the non-coding RNA DsrA and Hfq does not require ribosome binding. (PMID: 19969548) Vecerek B. … BlAosi U. (Nucleic Acids Res. 2010) 23 67
  4. Solution structure of the Drosha double-stranded RNA-binding domain. (PMID: 20226070) Mueller G.A. … Hall T.M. (Silence 2010) 23 67
  5. MISSION esiRNA for RNAi screening in mammalian cells. (PMID: 20467416) Theis M. … Buchholz F. (J Vis Exp 2010) 23 67

Products for DROSHA Gene

Sources for DROSHA Gene

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