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Aliases for MRPL22 Gene

Aliases for MRPL22 Gene

  • Mitochondrial Ribosomal Protein L22 2 3 5
  • 39S Ribosomal Protein L25, Mitochondrial 3 4
  • MRP-L22 3 4
  • MRP-L25 3 4
  • RPML25 3 4
  • L22mt 3 4
  • L25mt 3 4
  • HSPC158 3
  • MRPL25 4

External Ids for MRPL22 Gene

Previous GeneCards Identifiers for MRPL22 Gene

  • GC05P154413
  • GC05P154303
  • GC05P154349
  • GC05P154300
  • GC05P149462

Summaries for MRPL22 Gene

Entrez Gene Summary for MRPL22 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL22 Gene

MRPL22 (Mitochondrial Ribosomal Protein L22) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPL22 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL22 Gene

Genomics for MRPL22 Gene

Regulatory Elements for MRPL22 Gene

Enhancers for MRPL22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL22 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL22 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL22 Gene

154,941,070 bp from pter
154,969,411 bp from pter
28,342 bases
Plus strand

Genomic View for MRPL22 Gene

Genes around MRPL22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL22 Gene

Proteins for MRPL22 Gene

  • Protein details for MRPL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L22, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6NGJ8
    • Q5H9Q1
    • Q96Q51
    • Q9P006

    Protein attributes for MRPL22 Gene

    206 amino acids
    Molecular mass:
    23641 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF29122.1; Type=Frameshift; Positions=197; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL22 Gene

    Alternative splice isoforms for MRPL22 Gene


neXtProt entry for MRPL22 Gene

Proteomics data for MRPL22 Gene at MOPED

Post-translational modifications for MRPL22 Gene

  • Ubiquitination at Lys 191
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL22 Gene

No data available for DME Specific Peptides for MRPL22 Gene

Domains & Families for MRPL22 Gene

Gene Families for MRPL22 Gene

Protein Domains for MRPL22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L22P family.
  • Belongs to the ribosomal protein L22P family.
genes like me logo Genes that share domains with MRPL22: view

Function for MRPL22 Gene

genes like me logo Genes that share phenotypes with MRPL22: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL22 Gene

Localization for MRPL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL22 Gene


Subcellular locations from

Jensen Localization Image for MRPL22 Gene COMPARTMENTS Subcellular localization image for MRPL22 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for MRPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL22: view

Pathways & Interactions for MRPL22 Gene

genes like me logo Genes that share pathways with MRPL22: view

Gene Ontology (GO) - Biological Process for MRPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPL22: view

No data available for SIGNOR curated interactions for MRPL22 Gene

Drugs & Compounds for MRPL22 Gene

No Compound Related Data Available

Transcripts for MRPL22 Gene

Unigene Clusters for MRPL22 Gene

Mitochondrial ribosomal protein L22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL22 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for MRPL22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL22 Gene

mRNA expression in normal human tissues for MRPL22 Gene

Protein differential expression in normal tissues from HIPED for MRPL22 Gene

This gene is overexpressed in Lung (31.2) and Pancreas (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL22 Gene

SOURCE GeneReport for Unigene cluster for MRPL22 Gene Hs.483924

genes like me logo Genes that share expression patterns with MRPL22: view

Protein tissue co-expression partners for MRPL22 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL22 Gene

Orthologs for MRPL22 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL22 35
  • 91.18 (n)
  • 90.69 (a)
MRPL22 36
  • 91 (a)
(Canis familiaris)
Mammalia MRPL22 35
  • 90.36 (n)
  • 91.18 (a)
MRPL22 36
  • 94 (a)
(Mus musculus)
Mammalia Mrpl22 35
  • 85.76 (n)
  • 89.32 (a)
Mrpl22 16
Mrpl22 36
  • 89 (a)
(Pan troglodytes)
Mammalia MRPL22 35
  • 99.51 (n)
  • 99.51 (a)
MRPL22 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrpl22 35
  • 85.6 (n)
  • 89.32 (a)
(Monodelphis domestica)
Mammalia MRPL22 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL22 36
  • 78 (a)
(Gallus gallus)
Aves MRPL22 35
  • 72.59 (n)
  • 76.14 (a)
MRPL22 36
  • 72 (a)
(Anolis carolinensis)
Reptilia MRPL22 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl22 35
  • 67.67 (n)
  • 77 (a)
Str.17424 35
(Danio rerio)
Actinopterygii Dr.13982 35
mrpl22 35
  • 71.46 (n)
  • 75.29 (a)
mrpl22 36
  • 66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12520 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000508 35
  • 51.63 (n)
  • 49.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL22 35
  • 55.94 (n)
  • 51.72 (a)
mRpL22 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea mrpl-22 35
  • 45.27 (n)
  • 32.1 (a)
mrpl-22 36
  • 22 (a)
Species with no ortholog for MRPL22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL22 Gene

Gene Tree for MRPL22 (if available)
Gene Tree for MRPL22 (if available)

Paralogs for MRPL22 Gene Pseudogenes for MRPL22 Gene

genes like me logo Genes that share paralogs with MRPL22: view

No data available for Paralogs for MRPL22 Gene

Variants for MRPL22 Gene

Sequence variations from dbSNP and Humsavar for MRPL22 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3749671 - 154,966,736(-) TCTGC(C/T)ATGGT reference, missense
rs7965 -- 154,966,765(+) GAGAA(A/G)GTTTA reference, synonymous-codon
rs14922 -- 154,966,699(-) CGTCC(C/T)GAGGT reference, synonymous-codon
rs2644746 -- 154,954,878(+) gctcc(A/G)cctcc intron-variant
rs2644747 -- 154,964,957(-) ACGGC(A/G)CGTCC intron-variant

Variation tolerance for MRPL22 Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MRPL22 Gene

Disorders for MRPL22 Gene

Relevant External Links for MRPL22

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL22 Gene

Publications for MRPL22 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 3

Products for MRPL22 Gene

Sources for MRPL22 Gene