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Aliases for ARHGAP35 Gene

Aliases for ARHGAP35 Gene

  • Rho GTPase Activating Protein 35 2 3 5
  • Glucocorticoid Receptor DNA Binding Factor 1 2 3
  • Glucocorticoid Receptor DNA-Binding Factor 1 3 4
  • Glucocorticoid Receptor Repression Factor 1 3 4
  • Rho GAP P190A 3 4
  • P190-A 3 4
  • GRLF1 3 4
  • GRF-1 3 4
  • P190ARhoGAP 3
  • P190RhoGAP 3
  • KIAA1722 4
  • P190A 3
  • GRF1 4

External Ids for ARHGAP35 Gene

Previous HGNC Symbols for ARHGAP35 Gene

  • GRLF1

Previous GeneCards Identifiers for ARHGAP35 Gene

  • GC19P047422

Summaries for ARHGAP35 Gene

Entrez Gene Summary for ARHGAP35 Gene

  • The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGAP35 Gene

ARHGAP35 (Rho GTPase Activating Protein 35) is a Protein Coding gene. Among its related pathways are Focal Adhesion and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. GO annotations related to this gene include GTP binding and transcription corepressor activity. An important paralog of this gene is ARHGAP9.

UniProtKB/Swiss-Prot for ARHGAP35 Gene

  • Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5-GAGAAAAGAAACTGGAGAAACTC-3. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.

Gene Wiki entry for ARHGAP35 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP35 Gene

Genomics for ARHGAP35 Gene

Regulatory Elements for ARHGAP35 Gene

Enhancers for ARHGAP35 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARHGAP35 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP35 Gene

Chromosome:
19
Start:
46,918,567 bp from pter
End:
47,005,077 bp from pter
Size:
86,511 bases
Orientation:
Plus strand

Genomic View for ARHGAP35 Gene

Genes around ARHGAP35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP35 Gene

Proteins for ARHGAP35 Gene

  • Protein details for ARHGAP35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRY4-RHG35_HUMAN
    Recommended name:
    Rho GTPase-activating protein 35
    Protein Accession:
    Q9NRY4
    Secondary Accessions:
    • A7E2A4
    • Q14452
    • Q9C0E1

    Protein attributes for ARHGAP35 Gene

    Size:
    1499 amino acids
    Molecular mass:
    170514 Da
    Quaternary structure:
    • Interacts with RASA1. Interacts with the general transcription factor GTF2I, the interaction sequesters GTF2I in the cytoplasm.
    SequenceCaution:
    • Sequence=AAA58618.1; Type=Frameshift; Positions=389, 533, 540, 607, 614, 1167, 1241, 1292, 1334, 1446; Evidence={ECO:0000305}; Sequence=AAF80386.1; Type=Frameshift; Positions=533, 540, 607, 614; Evidence={ECO:0000305}; Sequence=AAF80386.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP35 Gene

neXtProt entry for ARHGAP35 Gene

Proteomics data for ARHGAP35 Gene at MOPED

Post-translational modifications for ARHGAP35 Gene

  • Phosphorylation of Tyr-1105 by PTK6 promotes the association with RASA1, inactivating RHOA while activating RAS. Phosphorylation at Tyr-308 by PDGFRA inhibits binding to GTF2I.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGAP35 Gene

Domains & Families for ARHGAP35 Gene

Gene Families for ARHGAP35 Gene

Protein Domains for ARHGAP35 Gene

Suggested Antigen Peptide Sequences for ARHGAP35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRY4

UniProtKB/Swiss-Prot:

RHG35_HUMAN :
  • Contains 4 FF domains.
Domain:
  • Contains 4 FF domains.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP35: view

Function for ARHGAP35 Gene

Molecular function for ARHGAP35 Gene

UniProtKB/Swiss-Prot Function:
Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5-GAGAAAAGAAACTGGAGAAACTC-3. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.

Gene Ontology (GO) - Molecular Function for ARHGAP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 1894621
genes like me logo Genes that share ontologies with ARHGAP35: view
genes like me logo Genes that share phenotypes with ARHGAP35: view

Animal Models for ARHGAP35 Gene

MGI Knock Outs for ARHGAP35:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP35 Gene

Localization for ARHGAP35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP35 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP35 Gene COMPARTMENTS Subcellular localization image for ARHGAP35 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ARHGAP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0015629 actin cytoskeleton IEA --
genes like me logo Genes that share ontologies with ARHGAP35: view

Pathways & Interactions for ARHGAP35 Gene

genes like me logo Genes that share pathways with ARHGAP35: view

SIGNOR curated interactions for ARHGAP35 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ARHGAP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 1894621
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008360 regulation of cell shape IEA --
GO:0010976 positive regulation of neuron projection development IEA --
GO:0030900 forebrain development IEA --
genes like me logo Genes that share ontologies with ARHGAP35: view

Drugs & Compounds for ARHGAP35 Gene

(1) Drugs for ARHGAP35 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ARHGAP35: view

Transcripts for ARHGAP35 Gene

Unigene Clusters for ARHGAP35 Gene

Rho GTPase activating protein 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP35 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - -
SP3: - -
SP4:

Relevant External Links for ARHGAP35 Gene

GeneLoc Exon Structure for
ARHGAP35
ECgene alternative splicing isoforms for
ARHGAP35

Expression for ARHGAP35 Gene

mRNA expression in normal human tissues for ARHGAP35 Gene

Protein differential expression in normal tissues from HIPED for ARHGAP35 Gene

This gene is overexpressed in Brain (13.1), Fetal Brain (11.6), Plasma (8.0), and Frontal cortex (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP35 Gene



SOURCE GeneReport for Unigene cluster for ARHGAP35 Gene Hs.509447

genes like me logo Genes that share expression patterns with ARHGAP35: view

Protein tissue co-expression partners for ARHGAP35 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARHGAP35 Gene

Orthologs for ARHGAP35 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP35 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGAP35 35
  • 91.44 (n)
  • 98.13 (a)
ARHGAP35 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP35 35
  • 93.93 (n)
  • 98.87 (a)
ARHGAP35 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grlf1 35
  • 89.72 (n)
  • 97.86 (a)
Arhgap35 16
Grlf1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP35 35
  • 99.71 (n)
  • 99.93 (a)
ARHGAP35 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap35 35
  • 89.54 (n)
  • 97.8 (a)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP35 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP35 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP35 35
  • 73.1 (n)
  • 82.94 (a)
ARHGAP35 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGAP35 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap35 35
  • 71.38 (n)
  • 78.95 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100004299 35
  • 67.27 (n)
  • 71.42 (a)
arhgap35 36
  • 67 (a)
OneToMany
arhgap35a 36
  • 68 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000870 35
  • 49.17 (n)
  • 38.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAPp190 35
  • 48.47 (n)
  • 37.78 (a)
RhoGAPp190 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rga-5 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
Species with no ortholog for ARHGAP35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP35 Gene

ENSEMBL:
Gene Tree for ARHGAP35 (if available)
TreeFam:
Gene Tree for ARHGAP35 (if available)

Paralogs for ARHGAP35 Gene

(5) SIMAP similar genes for ARHGAP35 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGAP35: view

Variants for ARHGAP35 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP35 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7257157 -- 46,947,734(+) gccct(C/T)cacat intron-variant
rs7260419 -- 46,983,882(+) agtgc(A/G)gggat intron-variant
rs12977151 -- 46,983,053(+) tgtgt(A/C)caaaa intron-variant
rs7507485 -- 46,968,641(+) attcg(A/C/G)ccgta intron-variant
rs8101884 -- 46,966,849(+) CAGTC(A/T)GTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP35 Gene

Variant ID Type Subtype PubMed ID
nsv520664 CNV Gain+Loss 19592680
esv33665 CNV Loss 17666407
nsv912192 CNV Loss 21882294
esv2750638 CNV Gain 17666407

Variation tolerance for ARHGAP35 Gene

Residual Variation Intolerance Score: 0.892% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP35 Gene

HapMap Linkage Disequilibrium report
ARHGAP35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP35 Gene

Disorders for ARHGAP35 Gene

Relevant External Links for ARHGAP35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP35

No disorders were found for ARHGAP35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP35 Gene

Publications for ARHGAP35 Gene

  1. Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression. (PMID: 1894621) LeClerc S. … Govindan M.V. (J. Biol. Chem. 1991) 2 3 4 23 67
  2. Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice. (PMID: 20675588) NAcmeth T. … MA^csai A. (J. Immunol. 2010) 2 3
  3. A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. (PMID: 19435801) Tomar A. … Schlaepfer D.D. (J. Cell. Sci. 2009) 3 23
  4. Opposing roles of p190RhoGAP and Ect2 RhoGEF in regulating cytokinesis. (PMID: 18642445) Mikawa M. … Parsons S.J. (Cell Cycle 2008) 3 23
  5. Activated G(alpha)13 impairs cell invasiveness through p190RhoGAP-mediated inhibition of RhoA activity. (PMID: 18922893) BartolomAc R.A. … TeixidA^ J. (Cancer Res. 2008) 3 23

Products for ARHGAP35 Gene

Sources for ARHGAP35 Gene

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