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Aliases for MRPL15 Gene

Aliases for MRPL15 Gene

  • Mitochondrial Ribosomal Protein L15 2 3
  • MRP-L15 3 4
  • L15mt 3 4
  • 39S Ribosomal Protein L15, Mitochondrial 3
  • HSPC145 3
  • MRP-L7 3
  • RPML7 3

External Ids for MRPL15 Gene

Summaries for MRPL15 Gene

Entrez Gene Summary for MRPL15 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL15 Gene

MRPL15 (Mitochondrial Ribosomal Protein L15) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL15 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL15 Gene

Genomics for MRPL15 Gene

Genomic Location for MRPL15 Gene

Start:
54,135,210 bp from pter
End:
54,148,514 bp from pter
Size:
13,305 bases
Orientation:
Plus strand

Genomic View for MRPL15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL15 Gene

Regulatory Elements for MRPL15 Gene

Proteins for MRPL15 Gene

  • Protein details for MRPL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P015-RM15_HUMAN
    Recommended name:
    39S ribosomal protein L15, mitochondrial
    Protein Accession:
    Q9P015
    Secondary Accessions:
    • Q96Q54
    • Q9H0Y1

    Protein attributes for MRPL15 Gene

    Size:
    296 amino acids
    Molecular mass:
    33420 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL15 Gene

neXtProt entry for MRPL15 Gene

Proteomics data for MRPL15 Gene at MOPED

Post-translational modifications for MRPL15 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys28, Lys35, and Lys80

Other Protein References for MRPL15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL15 Gene

Domains for MRPL15 Gene

Gene Families for MRPL15 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL15 Gene

Suggested Antigen Peptide Sequences for MRPL15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P015

UniProtKB/Swiss-Prot:

RM15_HUMAN
Family:
  • Belongs to the ribosomal protein L15P family.:
    • Q9P015
genes like me logo Genes that share domains with MRPL15: view

Function for MRPL15 Gene

Gene Ontology (GO) - Molecular Function for MRPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 21516116
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL15: view

miRNA for MRPL15 Gene

miRTarBase miRNAs that target MRPL15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL15 Gene

Localization for MRPL15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL15 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL15 Gene COMPARTMENTS Subcellular localization image for MRPL15 gene
Compartment Confidence
mitochondrion 4
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MRPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IBA --
GO:0015934 large ribosomal subunit --
genes like me logo Genes that share ontologies with MRPL15: view

Pathways for MRPL15 Gene

SuperPathways for MRPL15 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPL15: view

Pathways by source for MRPL15 Gene

1 KEGG pathway for MRPL15 Gene

Gene Ontology (GO) - Biological Process for MRPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL15: view

Transcripts for MRPL15 Gene

mRNA/cDNA for MRPL15 Gene

Unigene Clusters for MRPL15 Gene

Mitochondrial ribosomal protein L15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL15 Gene

No ASD Table

Relevant External Links for MRPL15 Gene

GeneLoc Exon Structure for
MRPL15
ECgene alternative splicing isoforms for
MRPL15

Expression for MRPL15 Gene

mRNA expression in normal human tissues for MRPL15 Gene

mRNA differential expression in normal tissues according to GTEx for MRPL15 Gene

This gene is overexpressed in Muscle - Skeletal (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL15 Gene

SOURCE GeneReport for Unigene cluster for MRPL15 Gene Hs.18349

genes like me logo Genes that share expressions with MRPL15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MRPL15 Gene

Orthologs for MRPL15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL15 35
  • 99.77 (n)
  • 100 (a)
MRPL15 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL15 35
  • 83.22 (n)
  • 90.88 (a)
MRPL15 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL15 35
  • 90.54 (n)
  • 94.59 (a)
MRPL15 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl15 35
  • 85.76 (n)
  • 90.17 (a)
Mrpl15 16
Mrpl15 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL15 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL15 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL15 35
  • 74.77 (n)
  • 81.08 (a)
MRPL15 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL15 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19285 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl15 35
  • 70.23 (n)
  • 76.21 (a)
Str.7141 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.652 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18509 35
mrpl15 35
  • 65.16 (n)
  • 69.44 (a)
mrpl15 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011946 35
  • 52.55 (n)
  • 52.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL15 35
  • 53.41 (n)
  • 54.38 (a)
mRpL15 36
  • 53 (a)
OneToOne
mRpL15 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea mrpl-15 35
  • 45.18 (n)
  • 37.98 (a)
mrpl-15 36
  • 36 (a)
OneToOne
Y92H12BR.8 37
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL10 36
  • 25 (a)
OneToOne
MRPL10 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToOne
Species with no ortholog for MRPL15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL15 Gene

ENSEMBL:
Gene Tree for MRPL15 (if available)
TreeFam:
Gene Tree for MRPL15 (if available)

Paralogs for MRPL15 Gene

Pseudogenes.org Pseudogenes for MRPL15 Gene

genes like me logo Genes that share paralogs with MRPL15: view

No data available for Paralogs for MRPL15 Gene

Variants for MRPL15 Gene

Sequence variations from dbSNP and Humsavar for MRPL15 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs178130 -- 54,138,329(-) tattt(A/T)aaaaa intron-variant
rs311400 -- 54,143,293(-) aagac(A/T)gcctt intron-variant
rs413040 -- 54,133,529(-) ccagg(A/C)tggag upstream-variant-2KB
rs422715 -- 54,141,327(-) TCATA(A/G)ATGGA intron-variant
rs424325 -- 54,139,588(-) CCTAA(A/G)GATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL15 Gene

Variant ID Type Subtype PubMed ID
dgv7798n71 CNV Loss 21882294
nsv820132 CNV Gain 19587683
nsv510147 CNV Loss 20534489

Relevant External Links for MRPL15 Gene

HapMap Linkage Disequilibrium report
MRPL15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL15 Gene

Disorders for MRPL15 Gene

Relevant External Links for MRPL15

Genetic Association Database (GAD)
MRPL15
Human Genome Epidemiology (HuGE) Navigator
MRPL15
genes like me logo Genes that share disorders with MRPL15: view

No data available for UniProtKB/Swiss-Prot for MRPL15 Gene

Publications for MRPL15 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MRPL15 Gene

Sources for MRPL15 Gene

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