Aliases for NR3C1 Gene
Aliases for NR3C1 Gene
External Ids for NR3C1 Gene
- HGNC: 7978
- Entrez Gene: 2908
- Ensembl: ENSG00000113580
- OMIM: 138040
- UniProtKB: P04150
Previous HGNC Symbols for NR3C1 Gene
- GRL
Previous GeneCards Identifiers for NR3C1 Gene
- GC05M142559
- GC05M142687
- GC05M142639
- GC05M137804
Summaries for NR3C1 Gene
-
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
GeneCards Summary for NR3C1 Gene
NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) is a Protein Coding gene. Diseases associated with NR3C1 include Glucocorticoid Resistance, Generalized and Post-Traumatic Stress Disorder. Among its related pathways are PEDF Induced Signaling and Gene Expression. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is NR3C2.
UniProtKB/Swiss-Prot for NR3C1 Gene
-
Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5 UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).
-
Isoform Alpha: Has transcriptional activation and repression activity (PubMed:15866175, PubMed:19248771, PubMed:20484466, PubMed:23820903, PubMed:11435610, PubMed:15769988, PubMed:17635946, PubMed:19141540, PubMed:21664385). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity).
-
Isoform Beta: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:7769088, PubMed:8621628, PubMed:20484466). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253).
-
Isoform Alpha-2: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).
-
Isoform GR-P: Increases activity of isoform Alpha.
-
Isoform Alpha-B: More effective than isoform Alpha in transcriptional activation, but not repression activity.
-
Isoform 10: Has transcriptional activation activity.
-
Isoform Alpha-C1: Has transcriptional activation activity.
-
Isoform Alpha-C2: Has transcriptional activation activity.
-
Isoform Alpha-C3: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903).
-
Isoform Alpha-D1: Has transcriptional activation activity.
-
Isoform Alpha-D2: Has transcriptional activation activity.
-
Isoform Alpha-D3: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127).
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Glucocorticoid receptors (GRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, progesterone and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation.
Additional gene information for NR3C1 Gene
- Monarch Initiative
- Search for NR3C1 at DataMed
- Search for NR3C1 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR3C1 Gene
Genomics for NR3C1 Gene
GeneHancer (GH) Regulatory Elements for NR3C1 Gene
Promoters and enhancers for NR3C1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NR3C1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NR3C1 gene promoter:
Regulatory Element Products
Genomic Locations for NR3C1 Gene
Genomic Locations for NR3C1 Gene
- chr5:143,277,931-143,435,512
- (GRCh38/hg38)
- Size:
- 157,582 bases
- Orientation:
- Minus strand
- chr5:142,657,496-142,815,077
- (GRCh37/hg19)
Genomic View for NR3C1 Gene
Genes around NR3C1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.3 by Ensembl
- 5q31.3 by Entrez Gene
- 5q31.3 by HGNC
NR3C1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NR3C1 Gene
Proteins for NR3C1 Gene
-
Protein details for NR3C1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04150-GCR_HUMAN
- Recommended name:
- Glucocorticoid receptor
- Protein Accession:
- P04150
- A0ZXF9
- B0LPG8
- D3DQF4
- F5ATB7
- P04151
- Q53EP5
- Q6N0A4
Protein attributes for NR3C1 Gene
- Size:
- 777 amino acids
- Molecular mass:
- 85659 Da
- Quaternary structure:
-
- Heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B, and FKBP5 or another immunophilin such as PPID, STIP1, or the immunophilin homolog PPP5C (PubMed:21730050). Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates (By similarity). Directly interacts with UNC45A (PubMed:16478993). Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers (By similarity). Interacts with NRIP1, POU2F1, POU2F2 and TRIM28 (By similarity). Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6 (PubMed:10866662, PubMed:12151000, PubMed:12686538, PubMed:9154805, PubMed:9590696). Interaction with BAG1 inhibits transactivation (PubMed:10477749). Interacts with HEXIM1, PELP1 and TGFB1I1 (PubMed:12415108, PubMed:15211577, PubMed:15941832). Interacts with NCOA1 (PubMed:9590696). Interacts with NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1 (By similarity). Interacts with CLOCK, CRY1 and CRY2 in a ligand-dependent fashion (PubMed:19141540, PubMed:21980503, PubMed:22170608). Interacts with CIART (By similarity). Interacts with RWDD3 (By similarity). Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3 (By similarity). Interacts with GRIP1 (PubMed:15769988, PubMed:17635946). Interacts with NR4A3 (via nuclear receptor DNA-binding domain), represses transcription activity of NR4A3 on the POMC promoter Nur response element (NurRE) (PubMed:15591535). Directly interacts with PNRC2 to attract and form a complex with UPF1 and DCP1A; the interaction leads to rapid mRNA degradation (PubMed:25775514). Interacts with GSK3B (PubMed:18838540). Interacts with FNIP1 and FNIP2 (PubMed:27353360). Interacts (via C-terminus) with HNRNPU (via C-terminus) (PubMed:9353307).
- Miscellaneous:
-
- Can up- or down-modulate aggregation and nuclear localization of expanded polyglutamine polypeptides derived from AR and HD through specific regulation of gene expression. Aggregation and nuclear localization of expanded polyglutamine proteins are regulated cellular processes that can be modulated by this receptor, a well-characterized transcriptional regulator.
- Isoform Beta: High constitutive expression by neutrophils may provide a mechanism by which these cells escape glucocorticoid-induced cell death and up-regulation by proinflammatory cytokines such as IL8 further enhances their survival in the presence of glucocorticoids during inflammation.
Three dimensional structures from OCA and Proteopedia for NR3C1 Gene
Protein Expression for NR3C1 Gene
Post-translational modifications for NR3C1 Gene
- Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity.
- Increased proteasome-mediated degradation in response to glucocorticoids (PubMed:11555652). Isoform Alpha-B appears to be more susceptible to proteolytic degradation than isoform Alpha (PubMed:11435610).
- Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-203, Ser-226 and Ser-404-phosphorylated forms are mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear (PubMed:12000743, PubMed:18838540). Phosphorylation at Ser-211 increases transcriptional activity (PubMed:12000743, PubMed:18483179). Phosphorylation at Ser-203, Ser-226 and Ser-404 decreases signaling capacity (PubMed:12000743, PubMed:18483179, PubMed:18838540). Phosphorylation at Ser-404 may protect from glucocorticoid-induced apoptosis (PubMed:18838540). Phosphorylation at Ser-203 and Ser-211 is not required in regulation of chromosome segregation (PubMed:25847991). May be dephosphorylated by PPP5C, attenuates NR3C1 action (By similarity).
- Sumoylation at Lys-277 and Lys-293 negatively regulates its transcriptional activity (PubMed:12144530). Sumoylation at Lys-703 positively regulates its transcriptional activity in the presence of RWDD3 (By similarity). Sumoylation at Lys-277 and Lys-293 is dispensable whereas sumoylation at Lys-703 is critical for the stimulatory effect of RWDD3 on its transcriptional activity (By similarity). Heat shock increases sumoylation in a RWDD3-dependent manner (By similarity).
- Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.
- Ubiquitination at isoforms=10, 3, 8, 2, 6, 9, 5, 7419
Other Protein References for NR3C1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_000167.1
- NP_001018084.1
- NP_001018085.1
- NP_001018086.1
- NP_001018087.1
- NP_001018661.1
- NP_001019265.1
- NP_001191187.1
- NP_001191188.1
- NP_001191189.1
- NP_001191190.1
- NP_001191191.1
- NP_001191192.1
- NP_001191193.1
- NP_001191194.1
- XP_005268476.1
- XP_005268477.1
- XP_005268479.1
- XP_005268480.1
- XP_011535939.1
- XP_016864886.1
- XP_016864887.1
Antibody Products
- R&D Systems Antibodies for NR3C1 (GR/NR3C1)
- Cell Signaling Technology (CST) Antibodies for NR3C1 (GR)
-
Custom Antibody ServicesOriGene Antibodies for NR3C1
- CF806259
- TA806259
- CF806237
- TA806237
- CF806236
- TA806236
- CF806235
- TA806235
- CF806207
- TA806207
- CF806197
- TA806197
- CF806190
- TA806190
- CF806188
- TA806188
- CF806187
- TA806187
- TA350687
- TA350022
- TA347252
- TA327308
- TA325754
- TA325753
- TA325752
- TA325751
- TA325750
- TA325749
- TA325748
- TA324810
- TA324793
- TA324708
- TA313373
- TA313372
- TA313371
- TA313370
- TA313369
- TA313368
- TA308891
- SM1346P
- AP55889PU-S
- AP55889PU-N
- AP23379PU-N
- AP06390PU-N
- AM06570SU-N
- AM01131FC-N
- Novus Biologicals Antibodies for NR3C1
-
Abcam antibodies for NR3C1
-
Cloud-Clone Corp. Antibodies for NR3C1
- Invitrogen Antibodies for NR3C1
- antibodies-online: Search results for 304 available NR3C1 Antibodies ranked by validation data
- Compare Top NR3C1 Antibodies
-
Recommended
- 76 WB Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 3 FACS Antibodies (anti-rat)
- 1 IP Antibody (anti-rat)
- 88 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 5 FACS Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 225 WB Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 9 FACS Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- GeneTex NR3C1 antibody for NR3C1
-
Santa Cruz Biotechnology (SCBT) Antibodies for NR3C1
- Sino Biological Antibodies for NR3C1
Protein Products
-
OriGene Purified Proteins for NR3C1
- Search Origene for MassSpec and Protein Over-expression Lysates for NR3C1
- Origene Custom Protein Services for NR3C1
-
Cloud-Clone Corp. Proteins for NR3C1
- Search GeneTex for Proteins for NR3C1
-
Abcam proteins for NR3C1
Assay Products
-
Abcam assays for NR3C1
No data available for DME Specific Peptides for NR3C1 Gene
Domains & Families for NR3C1 Gene
Gene Families for NR3C1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- FDA approved drug targets
- Nuclear receptors
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NR3C1 Gene
Suggested Antigen Peptide Sequences for NR3C1 Gene
- GenScript: Design optimal peptide antigens:
-
- Glucocorticoid receptor (A0ZXF9_HUMAN)
- Glucocorticoid receptor (B6ZGU6_HUMAN)
- cDNA FLJ50281, highly similar to Glucocorticoid receptor (B7Z7I2_HUMAN)
- Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor), isoform CRA_b (E5KQF5_HUMAN)
- Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor), isoform CRA_a (E5KQF6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P04150UniProtKB/Swiss-Prot:
GCR_HUMAN :- Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain (PubMed:3841189). The ligand-binding domain is required for correct chromosome segregation during mitosis although ligand binding is not required (PubMed:25847991).
- Belongs to the nuclear hormone receptor family. NR3 subfamily.
- Domain:
-
- Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain (PubMed:3841189). The ligand-binding domain is required for correct chromosome segregation during mitosis although ligand binding is not required (PubMed:25847991).
- Family:
-
- Belongs to the nuclear hormone receptor family. NR3 subfamily.
Function for NR3C1 Gene
Molecular function for NR3C1 Gene
- GENATLAS Biochemistry:
- nuclear recptor subafamily 3,group C,member 1,steroid/thyroid hormone receptor superfamily,interacting with tissue-specific transcriptional activators required for receptor actin (see HNFS)
- UniProtKB/Swiss-Prot Function:
- Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5 UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).
- UniProtKB/Swiss-Prot Function:
- Isoform Alpha: Has transcriptional activation and repression activity (PubMed:15866175, PubMed:19248771, PubMed:20484466, PubMed:23820903, PubMed:11435610, PubMed:15769988, PubMed:17635946, PubMed:19141540, PubMed:21664385). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity).
- UniProtKB/Swiss-Prot Function:
- Isoform Beta: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:7769088, PubMed:8621628, PubMed:20484466). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253).
- UniProtKB/Swiss-Prot Function:
- Isoform Alpha-2: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).
- UniProtKB/Swiss-Prot Function:
- Isoform GR-P: Increases activity of isoform Alpha.
- UniProtKB/Swiss-Prot Function:
- Isoform Alpha-B: More effective than isoform Alpha in transcriptional activation, but not repression activity.
- UniProtKB/Swiss-Prot Function:
- Isoform 10: Has transcriptional activation activity.
- UniProtKB/Swiss-Prot Function:
- Isoform Alpha-C1: Has transcriptional activation activity.
- UniProtKB/Swiss-Prot Function:
- Isoform Alpha-C2: Has transcriptional activation activity.
- UniProtKB/Swiss-Prot Function:
- Isoform Alpha-C3: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903).
- UniProtKB/Swiss-Prot Function:
- Isoform Alpha-D1: Has transcriptional activation activity.
- UniProtKB/Swiss-Prot Function:
- Isoform Alpha-D2: Has transcriptional activation activity.
- UniProtKB/Swiss-Prot Function:
- Isoform Alpha-D3: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127).
- UniProtKB/Swiss-Prot Induction:
- Isoform Alpha: Up-regulated by TNF (at protein level). Isoform Beta: Up-regulated by TNF and becomes the predominant isoform which may lead to glucocorticoid resistance (at protein level).
Phenotypes From GWAS Catalog for NR3C1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 16728402 |
| GO:0001047 | core promoter binding | IDA | 17081986 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 16728402 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IDA,TAS | 15769988 |
Phenotypes for NR3C1 Gene
- MGI mutant phenotypes for NR3C1:
-
inferred from 13 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for NR3C1:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased shRNA abundance (Z-score < -2)
- Increased cell death HMECs cells
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased caspase 3/7 activity
- Decreased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NR3C1
-
- Search ViGene Biosciences for NR3C1
CRISPR Products
-
OriGene CRISPR knockouts for NR3C1
- genomics-online: gRNA clones - Search results for available NR3C1 gene related products
- Applied Biological Materials CRISPR for NR3C1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR3C1
- GenScript: Design CRISPR guide RNA sequences for NR3C1
miRNA for NR3C1 Gene
- miRTarBase miRNAs that target NR3C1
-
- hsa-mir-18a-5p (MIRT004545)
- hsa-mir-124-3p (MIRT004546)
- hsa-mir-590-3p (MIRT016193)
- hsa-mir-130b-3p (MIRT020164)
- hsa-mir-155-5p (MIRT020725)
- hsa-mir-32-5p (MIRT028300)
- hsa-mir-22-3p (MIRT030650)
- hsa-mir-19b-3p (MIRT031124)
- hsa-mir-421 (MIRT039437)
- hsa-mir-1279 (MIRT095597)
- hsa-mir-4699-3p (MIRT095600)
- hsa-mir-5580-3p (MIRT095604)
- hsa-mir-466 (MIRT095608)
- hsa-mir-3941 (MIRT095609)
- hsa-mir-4672 (MIRT095611)
- hsa-mir-5590-5p (MIRT095612)
- hsa-mir-369-3p (MIRT214857)
- hsa-mir-126-5p (MIRT214865)
- hsa-mir-618 (MIRT214899)
- hsa-mir-1277-5p (MIRT312331)
- hsa-mir-4528 (MIRT329361)
- hsa-mir-183-5p (MIRT378074)
- hsa-mir-192-3p (MIRT391240)
- hsa-mir-377-3p (MIRT440091)
- hsa-mir-374a-5p (MIRT440092)
- hsa-mir-6720-5p (MIRT471968)
- hsa-mir-6512-3p (MIRT471969)
- hsa-mir-4423-3p (MIRT471970)
- hsa-mir-593-5p (MIRT471971)
- hsa-mir-125b-1-3p (MIRT471972)
- hsa-mir-6849-3p (MIRT471973)
- hsa-mir-5586-5p (MIRT471974)
- hsa-mir-3622a-5p (MIRT471975)
- hsa-mir-5582-5p (MIRT471976)
- hsa-mir-603 (MIRT471977)
- hsa-mir-362-3p (MIRT471978)
- hsa-mir-329-3p (MIRT471979)
- hsa-mir-8485 (MIRT471980)
- hsa-mir-4282 (MIRT471981)
- hsa-mir-3162-5p (MIRT555964)
- hsa-mir-524-5p (MIRT555966)
- hsa-mir-520d-5p (MIRT555967)
- hsa-mir-4764-5p (MIRT555968)
- hsa-mir-511-3p (MIRT555969)
- hsa-mir-6757-5p (MIRT555970)
- hsa-mir-2355-3p (MIRT566604)
- hsa-mir-4646-3p (MIRT566605)
- hsa-mir-4433b-5p (MIRT566606)
- hsa-mir-190a-3p (MIRT566607)
- hsa-mir-5692c (MIRT566608)
- hsa-mir-5692b (MIRT566609)
- hsa-mir-1179 (MIRT566610)
- hsa-mir-6768-5p (MIRT566611)
- hsa-mir-144-3p (MIRT566612)
- hsa-mir-374b-5p (MIRT566613)
- hsa-mir-6868-3p (MIRT687429)
- hsa-mir-182-5p (MIRT687430)
- hsa-mir-4652-3p (MIRT687431)
- hsa-mir-544a (MIRT687432)
- hsa-mir-1263 (MIRT687433)
- hsa-mir-127-5p (MIRT687434)
- hsa-mir-4795-3p (MIRT687435)
- hsa-mir-496 (MIRT687436)
- hsa-mir-196a-3p (MIRT687437)
- hsa-mir-6131 (MIRT687438)
- hsa-mir-133a-5p (MIRT687439)
- hsa-mir-5186 (MIRT687440)
- hsa-mir-6806-3p (MIRT687441)
- hsa-mir-3928-5p (MIRT687442)
- hsa-mir-3182 (MIRT687443)
- hsa-mir-4793-3p (MIRT687444)
- hsa-mir-3130-3p (MIRT687445)
- hsa-mir-4714-3p (MIRT687446)
- hsa-mir-6800-3p (MIRT687447)
- hsa-mir-137 (MIRT687448)
- hsa-mir-138-5p (MIRT687449)
- hsa-mir-106a-5p (MIRT761124)
- hsa-mir-106b-5p (MIRT761132)
- hsa-mir-1237-3p (MIRT761488)
- hsa-mir-17-5p (MIRT762954)
- hsa-mir-204-5p (MIRT763718)
- hsa-mir-20a-5p (MIRT763761)
- hsa-mir-20b-5p (MIRT763773)
- hsa-mir-211-5p (MIRT763816)
- hsa-mir-3609 (MIRT765870)
- hsa-mir-3909 (MIRT767584)
- hsa-mir-4256 (MIRT768096)
- hsa-mir-4446-5p (MIRT769174)
- hsa-mir-4755-5p (MIRT771954)
- hsa-mir-4796-3p (MIRT772499)
- hsa-mir-5006-3p (MIRT772940)
- hsa-mir-5088-3p (MIRT773223)
- hsa-mir-5193 (MIRT773620)
- hsa-mir-519d-3p (MIRT773722)
- hsa-mir-526b-3p (MIRT773918)
- hsa-mir-548ah-5p (MIRT774107)
- hsa-mir-623 (MIRT776087)
- hsa-mir-660-3p (MIRT777393)
- hsa-mir-6852-3p (MIRT780449)
- hsa-mir-93-5p (MIRT782762)
Transcription Factor Targets for NR3C1 Gene
Targeted motifs for NR3C1 Gene
HOMER Transcription Factor Regulatory Elements motif NR3C1
- Consensus sequence: NAGAACAGNCTGTTCT Submotif: IR3 Cell Type: A549 GEO ID: GSE32465
miRNA Products
- Search ViGene Biosciences for NR3C1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NR3C1
- Browse OriGene Inhibitory RNA Products For NR3C1
- genomics-online: shRNA clones - Search results for available NR3C1 gene related products
Clone Products
-
OriGene ORF clones in human for NR3C1
- RC234127
- RG234127
- RC234110
- RG234110
- RG234691
- RC234691
- RG234170
- RC234170
- RG234706
- RC234706
- RG234719
- RC234719
- RG234726
- RC234726
- RG234827
- RC234827
- RG220476
- RC220476L2
- RC220476L1
- RC220476
- RG220377
- RC220377L2
- RC220377L1
- RC220377
- RG222342
- RC222342L2
- RC222342L1
- RC222342
- RG220235
- RC220235L2
- RC220235L1
- RC220235
- RG222167
- RC222167L2
- RC222167L1
- RC222167
- RG204878
- RC204878L2
- RC204878L1
- RC204878
- RG220189
- RC220189L2
- RC220189L1
- RC220189
- RC220476L2V
- RC220476L1V
- RC220377L2V
- RC220377L1V
- RC222342L2V
- RC222342L1V
- RC220235L2V
- RC220235L1V
- RC222167L2V
- RC222167L1V
- RC204878L2V
- RC204878L1V
- RC220189L2V
- RC220189L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for NR3C1 in any vector
- NM_001204263.1
- NM_001204265.1
- NM_001018076.1
- XM_005268422.2
- NM_001024094.1
- XM_011537636.1
- NM_001204259.1
- NM_001204262.1
- NM_001204264.1
- NM_001018075.1
- XM_005268419.2
- NM_001020825.1
- XM_005268423.2
- NM_001204258.1
- NM_001204261.1
- NM_000176.2
- NM_001018074.1
- NM_001018077.1
- XM_005268420.3
- XM_011537637.1
- NM_001204260.1
- Sino Biological Human cDNA Clone for NR3C1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NR3C1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NR3C1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NR3C1
- genomics-online: cdna clones - Search results for available NR3C1 gene related products
- orf clones - Search results for available NR3C1 gene related products
- Applied Biological Materials Clones for NR3C1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NR3C1
No data available for Enzyme Numbers (IUBMB) for NR3C1 Gene
Localization for NR3C1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NR3C1 Gene
- Isoform Alpha: Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=After ligand activation, translocates from the cytoplasm to the nucleus. {ECO:0000269 PubMed:18838540, ECO:0000269 PubMed:27120390, ECO:0000269 PubMed:8621628}.
- Isoform Beta: Nucleus. Cytoplasm. Note=Expressed predominantly in the nucleus with some expression also detected in the cytoplasm. {ECO:0000269 PubMed:19248771, ECO:0000269 PubMed:26711253}.
- Isoform Alpha-B: Nucleus. Cytoplasm. Note=After ligand activation, translocates from the cytoplasm to the nucleus. {ECO:0000269 PubMed:15866175}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 1 |
- Cytosol (4)
- Nucleoplasm (4)
- Mitochondria (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IDA | 9353307 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | TAS,IDA | 15769988 |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005759 | mitochondrial matrix | TAS | 10887960 |
Pathways & Interactions for NR3C1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics | ||
| 2 | PEDF Induced Signaling | ||
| 3 | BMAL1-CLOCK,NPAS2 activates circadian gene expression |
.68
|
|
| 4 | Gene Expression |
.48
|
|
| 5 | Nuclear Receptor transcription pathway | ||
Pathways by source for NR3C1 Gene
1 Cell Signaling Technology pathway for NR3C1 Gene
11 BioSystems pathways for NR3C1 Gene
8 Reactome pathways for NR3C1 Gene
2 PharmGKB pathways for NR3C1 Gene
1 KEGG pathway for NR3C1 Gene
7 GeneGo (Thomson Reuters) pathways for NR3C1 Gene
1 R&D Systems pathway for NR3C1 Gene
4 Qiagen pathways for NR3C1 Gene
Interacting Proteins for NR3C1 Gene
Selected Interacting proteins:
ENSP00000231509
P04150-GCR_HUMAN
for NR3C1 Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for NR3C1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 12902338 |
| GO:0006351 | transcription, DNA-templated | IDA | 17081986 |
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 19141540 |
| GO:0006366 | transcription by RNA polymerase II | TAS | 8621628 |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
Drugs & Compounds for NR3C1 Gene
(146) Drugs for NR3C1 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Fluticasone propionate | Approved | Pharma | Target, agonist, antagonist | Selective high affinity glucocorticoid receptor agonist | 0 | |
| Hydrocortisone | Approved, Vet_approved | Pharma | Agonist, Target, agonist | 713 | ||
| Mifepristone | Approved, Investigational | Pharma | Agonist, Target, antagonist | Progesterone receptor antagonist, Progesterone and glucocorticoid receptor antagonist | 167 | |
| Prednisolone | Approved, Vet_approved | Pharma | Agonist, Target, agonist, binder | 1277 | ||
| Triamcinolone | Approved, Vet_approved | Pharma | Agonist, Target, agonist, binder | 565 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(3) Tocris Compounds for NR3C1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Dexamethasone | Anti-inflammatory glucocorticoid | 50-02-2 |
| Fluticasone propionate | Selective high affinity glucocorticoid receptor agonist | 80474-14-2 |
| Methylprednisolone | Glucocorticoid receptor agonist | 83-43-2 |
(24) ApexBio Compounds for NR3C1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Beclomethasone dipropionate | Corticosteroid used for asthma and rhinitis | 5534-09-8 |
| Betamethasone | Glucocorticoid receptor agonist | 378-44-9 |
| Betamethasone Dipropionate | 5593-20-4 | |
| Betamethasone hydrochloride | Glucocorticoid receptor agonist | 956901-32-9 |
| Betamethasone Valerate | 2152-44-5 | |
| Budesonide | Anti-inflammatory corticosteroid | 51333-22-3 |
| Ciclesonide | 126544-47-6 | |
| Cortisone acetate | 1950-04-4 | |
| Deflazacort | 14484-47-0 | |
| Desonide | 638-94-8 | |
| Dexamethasone acetate | 1177-87-3 | |
| Flumethasone | 2135-17-3 | |
| Fluocinolone Acetonide | 67-73-2 | |
| Fluocinonide | 356-12-7 | |
| Fluorometholone Acetate | 3801-06-7 | |
| Fluticasone propionate | 80474-14-2 | |
| Glucocorticoid receptor agonist | 1245526-82-2 | |
| GSK 9027 | 1229096-88-1 | |
| Hydrocortisone | 50-23-7 | |
| Meprednisone | 1247-42-3 | |
| Methylprednisolone | Apoptosis inducer,GR agonist | 83-43-2 |
| Mifepristone | Progesterone receptor antagonist | 84371-65-3 |
| Prednisolone | 50-24-8 | |
| Triamcinolone | 124-94-7 |
Transcripts for NR3C1 Gene
mRNA/cDNA for NR3C1 Gene
- (22) REFSEQ mRNAs :
- (23) Additional mRNA sequences :
- (383) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NR3C1 Gene
- Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for NR3C1
- genomics-online: gRNA clones - Search results for available NR3C1 gene related products
- Applied Biological Materials CRISPR for NR3C1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR3C1
- GenScript: Design CRISPR guide RNA sequences for NR3C1
miRNA Products
- Search ViGene Biosciences for NR3C1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NR3C1
- Browse OriGene Inhibitory RNA Products For NR3C1
- genomics-online: shRNA clones - Search results for available NR3C1 gene related products
Clone Products
-
OriGene ORF clones in human for NR3C1
- RC234127
- RG234127
- RC234110
- RG234110
- RG234691
- RC234691
- RG234170
- RC234170
- RG234706
- RC234706
- RG234719
- RC234719
- RG234726
- RC234726
- RG234827
- RC234827
- RG220476
- RC220476L2
- RC220476L1
- RC220476
- RG220377
- RC220377L2
- RC220377L1
- RC220377
- RG222342
- RC222342L2
- RC222342L1
- RC222342
- RG220235
- RC220235L2
- RC220235L1
- RC220235
- RG222167
- RC222167L2
- RC222167L1
- RC222167
- RG204878
- RC204878L2
- RC204878L1
- RC204878
- RG220189
- RC220189L2
- RC220189L1
- RC220189
- RC220476L2V
- RC220476L1V
- RC220377L2V
- RC220377L1V
- RC222342L2V
- RC222342L1V
- RC220235L2V
- RC220235L1V
- RC222167L2V
- RC222167L1V
- RC204878L2V
- RC204878L1V
- RC220189L2V
- RC220189L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for NR3C1 in any vector
- NM_001204263.1
- NM_001204265.1
- NM_001018076.1
- XM_005268422.2
- NM_001024094.1
- XM_011537636.1
- NM_001204259.1
- NM_001204262.1
- NM_001204264.1
- NM_001018075.1
- XM_005268419.2
- NM_001020825.1
- XM_005268423.2
- NM_001204258.1
- NM_001204261.1
- NM_000176.2
- NM_001018074.1
- NM_001018077.1
- XM_005268420.3
- XM_011537637.1
- NM_001204260.1
- Sino Biological Human cDNA Clone for NR3C1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NR3C1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NR3C1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NR3C1
- genomics-online: cdna clones - Search results for available NR3C1 gene related products
- orf clones - Search results for available NR3C1 gene related products
- Applied Biological Materials Clones for NR3C1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for NR3C1 Gene
This gene is overexpressed in Monocytes (17.3), CD8 Tcells (9.6), and Peripheral blood mononuclear cells (8.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NR3C1 Gene
NURSA nuclear receptor signaling pathways regulating expression of NR3C1 Gene:
NR3C1SOURCE GeneReport for Unigene cluster for NR3C1 Gene:
Hs.122926mRNA Expression by UniProt/SwissProt for NR3C1 Gene:
P04150-GCR_HUMAN
Tissue specificity:
Widely expressed including bone, stomach, lung, liver, colon, breast, ovary, pancreas and kidney (PubMed:25847991). In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart (PubMed:10902803). Isoform Beta: Widely expressed including brain, bone marrow, thymus, spleen, liver, kidney, pancreas, lung, fat, skeletal muscle, heart, placenta and blood leukocytes (PubMed:7769088, PubMed:8621628). Isoform Alpha-2: Expressed at low level.
Evidence on tissue expression from TISSUES for NR3C1 Gene
- Kidney(4.6)
- Liver(4.6)
- Nervous system(4.5)
- Adrenal gland(3.4)
- Blood(3.2)
- Lung(3.1)
- Muscle(2.8)
- Heart(2.4)
- Pancreas(2.4)
- Skin(2.4)
- Thyroid gland(2.4)
- Intestine(2.3)
- Spleen(2.3)
- Bone marrow(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for NR3C1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- endocrine
- integumentary
- nervous
- skeletal muscle
- urinary
Organs:
Head and neck:
- brain
- ear
- head
Thorax:
- heart
Abdomen:
- adrenal gland
- kidney
- pancreas
General:
- blood vessel
- peripheral nerve
- peripheral nervous system
- skin
- sweat gland
Primer Products
-
OriGene qPCR primer pairs for NR3C1
-
OriGene qPCR primer pairs and template standards for NR3C1
- genomics-online: primer clones - Search results for available NR3C1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NR3C1 Gene
Orthologs for NR3C1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NR3C1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | GR-A 34 |
|
OneToOne | |
| NR3C1 33 |
|
||||
| dog (Canis familiaris) |
Mammalia | NR3C1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Nr3c1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nr3c1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NR3C1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NR3C1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NR3C1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | NR3C1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nr3c1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | xGR 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | nr3c1 33 34 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11855 33 |
|
- Species where no ortholog for NR3C1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for NR3C1 Gene
Paralogs for NR3C1 Gene
(15) SIMAP similar genes for NR3C1 Gene using alignment to 14 proteins:
Pseudogenes.org Pseudogenes for NR3C1 Gene
Variants for NR3C1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for NR3C1 Gene
- GCR_HUMAN-P04150
- Carriers of the 22-Glu-Lys-23 allele are relatively more resistant to the effects of GCs with respect to the sensitivity of the adrenal feedback mechanism than non-carriers, resulting in a better metabolic health profile. Carriers have a better survival than non-carriers, as well as lower serum CRP levels. The 22-Glu-Lys-23 polymorphism is associated with a sex-specific, beneficial body composition at young-adult age, as well as greater muscle strength in males.
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1011360027 | uncertain-significance, Glucocorticoid resistance, generalized | 143,278,423(-) | A/G | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1016505830 | uncertain-significance, Glucocorticoid resistance, generalized | 143,278,812(-) | C/A/T | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1027058734 | resistance, generalized (GCCR) [MIM:615962] | 143,282,038(-) | C/T | coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant | |
| rs10482622 | likely-benign, Glucocorticoid resistance, generalized | 143,399,961(-) | C/T | 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, synonymous_variant | |
| rs10482707 | uncertain-significance, Glucocorticoid resistance, generalized | 143,281,480(-) | GGGGGGGG/GGGGGGG/GGGGGGGGG | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1001228 | CNV | deletion | 20482838 |
| esv1765773 | CNV | deletion | 17803354 |
| esv1786342 | CNV | insertion | 17803354 |
| esv1954637 | CNV | deletion | 18987734 |
| esv2666615 | CNV | deletion | 23128226 |
| esv2730855 | CNV | deletion | 23290073 |
| esv2730856 | CNV | deletion | 23290073 |
| esv2730857 | CNV | deletion | 23290073 |
| esv2730858 | CNV | deletion | 23290073 |
| esv33748 | CNV | loss | 17666407 |
| esv3607020 | CNV | loss | 21293372 |
| nsv1129750 | CNV | tandem duplication | 24896259 |
| nsv1146130 | CNV | deletion | 26484159 |
| nsv327674 | CNV | deletion | 16902084 |
| nsv327858 | CNV | deletion | 16902084 |
| nsv328009 | CNV | deletion | 16902084 |
| nsv328818 | CNV | deletion | 16902084 |
| nsv5041 | CNV | deletion | 18451855 |
| nsv950421 | CNV | duplication | 24416366 |
| nsv980741 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.53;
44.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NR3C1 Gene
Disorders for NR3C1 Gene
(42) MalaCards diseases for NR3C1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| glucocorticoid resistance, generalized |
|
|
| post-traumatic stress disorder |
|
|
| acth-secreting pituitary adenoma |
|
|
| lymphosarcoma |
|
|
| ocular hypertension |
|
Search NR3C1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
GCR_HUMAN- Glucocorticoid resistance, generalized (GCCR) [MIM:615962]: An autosomal dominant disease characterized by increased plasma cortisol concentration and high urinary free cortisol, resistance to adrenal suppression by dexamethasone, and the absence of Cushing syndrome typical signs. Clinical features include hypoglycemia, hypertension, metabolic alkalosis, chronic fatigue and profound anxiety. {ECO:0000269 PubMed:11589680, ECO:0000269 PubMed:11701741, ECO:0000269 PubMed:12050230, ECO:0000269 PubMed:15769988, ECO:0000269 PubMed:1704018, ECO:0000269 PubMed:17635946, ECO:0000269 PubMed:20335448, ECO:0000269 PubMed:21362280, ECO:0000269 PubMed:23426617, ECO:0000269 PubMed:24483153, ECO:0000269 PubMed:26031419, ECO:0000269 PubMed:26541474, ECO:0000269 PubMed:27120390, ECO:0000269 PubMed:7683692}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for NR3C1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for NR3C1 Gene
Publications for NR3C1 Gene
- Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia. (PMID: 20015871) te Winkel ML … van den Heuvel-Eibrink MM (Haematologica 2010) 3 22 44 58
- A novel point mutation in helix 10 of the human glucocorticoid receptor causes generalized glucocorticoid resistance by disrupting the structure of the ligand-binding domain. (PMID: 20335448) Nader N … Kino T (The Journal of clinical endocrinology and metabolism 2010) 3 4 22 58
- Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders. (PMID: 20376328) Fingert JH … Clark AF (Molecular vision 2010) 3 22 44 58
- Glucocorticoid receptor phosphorylation differentially affects target gene expression. (PMID: 18483179) Chen W … Garabedian MJ (Molecular endocrinology (Baltimore, Md.) 2008) 3 4 22 58
- Glycogen synthase kinase 3beta-mediated serine phosphorylation of the human glucocorticoid receptor redirects gene expression profiles. (PMID: 18838540) Galliher-Beckley AJ … Cidlowski JA (Molecular and cellular biology 2008) 3 4 22 58
Products for NR3C1 Gene
- R&D Systems Antibodies for NR3C1 (GR/NR3C1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for NR3C1
- AM01131FC-N
- AM06570SU-N
- AP06390PU-N
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- SM1346P
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- CF806259
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NR3C1
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- OriGene qPCR primer pairs and template standards for NR3C1
- OriGene qPCR primer pairs for NR3C1
- OriGene CRISPR knockouts for NR3C1
- OriGene ORF clones in human for NR3C1
- RC220189L1V
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- RG234691
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NR3C1
- GenScript: Next-day shipping of latest version cDNA ORF clones for NR3C1 in any vector
- NM_001204260.1
- XM_011537637.1
- XM_005268420.3
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- GenScript Custom Purified and Recombinant Proteins Services for NR3C1
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- CloneReady with Over 120,000 Genes
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- GenScript Custom Peptide Services for NR3C1
- Cell Signaling Technology (CST) Antibodies for NR3C1 (GR)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for NR3C1
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- Sino Biological Antibodies for NR3C1
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for NR3C1
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- Novus Biologicals Tissue Microarrays
- Abcam antibodies for NR3C1
- Abcam proteins for NR3C1
- Abcam assays for NR3C1
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- Cloud-Clone Corp. Antibodies for NR3C1
- Cloud-Clone Corp. Proteins for NR3C1
- Browse Knockouts at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
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- Invitrogen Antibodies for NR3C1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for NR3C1
- Cyagen custom Knockout/knockin (KOKI) mouse models for NR3C1
- VectorBuilder custom plasmid, inducible vectors for NR3C1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NR3C1
- VectorBuilder Other custom vectors
- Mammalian expression: