Aliases for GRIN1 Gene
External Ids for GRIN1 Gene
Previous HGNC Symbols for GRIN1 Gene
Previous GeneCards Identifiers for GRIN1 Gene
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRIN1 Gene
GRIN1 (Glutamate Ionotropic Receptor NMDA Type Subunit 1) is a Protein Coding gene. Diseases associated with GRIN1 include Mental Retardation, Autosomal Dominant 8 and Autosomal Dominant Non-Syndromic Intellectual Disability. Among its related pathways are Calcium signaling pathway and RET signaling. GO annotations related to this gene include calcium ion binding and receptor binding. An important paralog of this gene is GRIN2A.
UniProtKB/Swiss-Prot for GRIN1 Gene
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations.