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Aliases for KLF15 Gene

Aliases for KLF15 Gene

  • Kruppel-Like Factor 15 2 3
  • KKLF 3 4 6
  • Kidney-Enriched Krueppel-Like Factor 3 4
  • Kidney-Enriched Kruppel-Like Factor 2 3
  • Krueppel-Like Factor 15 3

External Ids for KLF15 Gene

Previous GeneCards Identifiers for KLF15 Gene

  • GC03M122845
  • GC03M126092
  • GC03M127343
  • GC03M127382
  • GC03M127544
  • GC03M123442
  • GC03M126061

Summaries for KLF15 Gene

GeneCards Summary for KLF15 Gene

KLF15 (Kruppel-Like Factor 15) is a Protein Coding gene. Among its related pathways are Adipogenesis. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is KLF2.

UniProtKB/Swiss-Prot for KLF15 Gene

  • Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.

Gene Wiki entry for KLF15 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF15 Gene

Genomics for KLF15 Gene

Regulatory Elements for KLF15 Gene

Genomic Location for KLF15 Gene

Start:
126,342,635 bp from pter
End:
126,357,442 bp from pter
Size:
14,808 bases
Orientation:
Minus strand

Genomic View for KLF15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF15 Gene

Proteins for KLF15 Gene

  • Protein details for KLF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIH9-KLF15_HUMAN
    Recommended name:
    Krueppel-like factor 15
    Protein Accession:
    Q9UIH9
    Secondary Accessions:

    Protein attributes for KLF15 Gene

    Size:
    416 amino acids
    Molecular mass:
    43992 Da
    Quaternary structure:
    • Interacts with MYOCD and EP300.

    Three dimensional structures from OCA and Proteopedia for KLF15 Gene

neXtProt entry for KLF15 Gene

Proteomics data for KLF15 Gene at MOPED

Post-translational modifications for KLF15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF15 Gene

Domains for KLF15 Gene

Gene Families for KLF15 Gene

HGNC:
  • KLF :Kruppel-like transcription factors
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for KLF15 Gene

Suggested Antigen Peptide Sequences for KLF15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIH9

UniProtKB/Swiss-Prot:

KLF15_HUMAN :
  • Q9UIH9
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF15: view

Function for KLF15 Gene

Molecular function for KLF15 Gene

UniProtKB/Swiss-Prot Function: Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
UniProtKB/Swiss-Prot Induction: In podocytes, up-regulated by retinoic acid.

Gene Ontology (GO) - Molecular Function for KLF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IC 19767294
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 23999430
GO:0044212 transcription regulatory region DNA binding ISS --
genes like me logo Genes that share ontologies with KLF15: view
genes like me logo Genes that share phenotypes with KLF15: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KLF15 Gene

Localization for KLF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF15 Gene COMPARTMENTS Subcellular localization image for KLF15 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for KLF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17438289
genes like me logo Genes that share ontologies with KLF15: view

Pathways for KLF15 Gene

SuperPathways for KLF15 Gene

Superpath Contained pathways
1 Adipogenesis
genes like me logo Genes that share pathways with KLF15: view

Pathways by source for KLF15 Gene

1 BioSystems pathway for KLF15 Gene

Gene Ontology (GO) - Biological Process for KLF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0010001 glial cell differentiation IEA --
GO:0010468 regulation of gene expression --
GO:0014898 cardiac muscle hypertrophy in response to stress IEA --
GO:0015758 glucose transport IEA --
genes like me logo Genes that share ontologies with KLF15: view

Compounds for KLF15 Gene

(1) Novoseek inferred chemical compound relationships for KLF15 Gene

Compound -log(P) Hits PubMed IDs
zinc 33.3 1
genes like me logo Genes that share compounds with KLF15: view

Transcripts for KLF15 Gene

mRNA/cDNA for KLF15 Gene

Unigene Clusters for KLF15 Gene

Kruppel-like factor 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: - -
SP2: -
SP3:

Relevant External Links for KLF15 Gene

GeneLoc Exon Structure for
KLF15
ECgene alternative splicing isoforms for
KLF15

Expression for KLF15 Gene

mRNA expression in normal human tissues for KLF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLF15 Gene

SOURCE GeneReport for Unigene cluster for KLF15 Gene Hs.272215

mRNA Expression by UniProt/SwissProt for KLF15 Gene

Q9UIH9-KLF15_HUMAN
Tissue specificity: Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues.
genes like me logo Genes that share expressions with KLF15: view

No data available for mRNA differential expression in normal tissues for KLF15 Gene

Orthologs for KLF15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF15 35
  • 94.67 (n)
  • 93.3 (a)
KLF15 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLF15 35
  • 82.75 (n)
  • 82.34 (a)
KLF15 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLF15 35
  • 86.39 (n)
  • 87.44 (a)
KLF15 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf15 35
  • 82.81 (n)
  • 84.34 (a)
Klf15 16
Klf15 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLF15 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF15 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf15 35
  • 83.45 (n)
  • 83.37 (a)
chicken
(Gallus gallus)
Aves KLF15 35
  • 68 (n)
  • 69.58 (a)
KLF15 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF15 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf15 35
  • 62.93 (n)
  • 64.63 (a)
zebrafish
(Danio rerio)
Actinopterygii klf15 35
  • 59.02 (n)
  • 57.32 (a)
klf15 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Bteb2 36
  • 28 (a)
OneToOne
EP2237 37
  • 66 (a)
CG9895 37
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea F53F8.1 37
  • 61 (a)
mua-1 37
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FZF1 38
Species with no ortholog for KLF15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF15 Gene

ENSEMBL:
Gene Tree for KLF15 (if available)
TreeFam:
Gene Tree for KLF15 (if available)

Paralogs for KLF15 Gene

Selected SIMAP similar genes for KLF15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLF15: view

Variants for KLF15 Gene

Sequence variations from dbSNP and Humsavar for KLF15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs938384 -- 126,348,546(-) CTCAC(A/G)TCACA intron-variant
rs2363940 -- 126,358,078(+) CCCCC(A/C)ACCTG upstream-variant-2KB
rs3069759 -- 126,357,931(+) AATCA(-/AG/GA)CTTGC upstream-variant-2KB
rs3732542 -- 126,343,979(-) TGCAC(A/G)CCTTG intron-variant
rs5852479 -- 126,357,930(+) AAATC(-/AG/GA)ACTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLF15 Gene

Variant ID Type Subtype PubMed ID
nsv877432 CNV Loss 21882294
nsv877433 CNV Loss 21882294
nsv877434 CNV Gain 21882294
dgv5245n71 CNV Loss 21882294
nsv877436 CNV Loss 21882294
esv29660 CNV Loss 19812545

Relevant External Links for KLF15 Gene

HapMap Linkage Disequilibrium report
KLF15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF15 Gene

Disorders for KLF15 Gene

UniProtKB/Swiss-Prot

KLF15_HUMAN
  • Note=KLF15 deficiency results in loss of rhythmic QT variation and abnormal heart repolarization (PubMed:22367544). It may play a role in susceptibility to ventricular arrhythmias (PubMed:22367544), and development of pathological cardiac hypertrophy leading to heart failure (PubMed:20375365). {ECO:0000269 PubMed:20375365, ECO:0000269 PubMed:22367544}.

Relevant External Links for KLF15

Genetic Association Database (GAD)
KLF15
Human Genome Epidemiology (HuGE) Navigator
KLF15
genes like me logo Genes that share disorders with KLF15: view

Publications for KLF15 Gene

  1. Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kruppel-like factor, a novel zinc finger repressor. (PMID: 10982849) Uchida S. … Marumo F. (Mol. Cell. Biol. 2000) 2 3 4 23
  2. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. (PMID: 17438289) Fisch S. … Jain M.K. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 23
  3. KLF15 Is a transcriptional regulator of the human 17beta-hydroxysteroid dehydrogenase type 5 gene. A potential link between regulation of testosterone production and fat stores in women. (PMID: 19366843) Du X. … Qin K. (J. Clin. Endocrinol. Metab. 2009) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Single nucleotide polymorphisms in the gene encoding KrA1ppel-like factor 7 are associated with type 2 diabetes. (PMID: 15937668) Kanazawa A. … Maeda S. (Diabetologia 2005) 3 48

Products for KLF15 Gene

Sources for KLF15 Gene

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