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Aliases for KLF15 Gene

Aliases for KLF15 Gene

  • Kruppel-Like Factor 15 2 3 5
  • Kidney-Enriched Krueppel-Like Factor 3 4
  • Kidney-Enriched Kruppel-Like Factor 2 3
  • KKLF 3 4

External Ids for KLF15 Gene

Previous GeneCards Identifiers for KLF15 Gene

  • GC03M122845
  • GC03M126092
  • GC03M127343
  • GC03M127382
  • GC03M127544
  • GC03M123442
  • GC03M126061

Summaries for KLF15 Gene

GeneCards Summary for KLF15 Gene

KLF15 (Kruppel-Like Factor 15) is a Protein Coding gene. Diseases associated with KLF15 include aortic aneurysm. Among its related pathways are Adipogenesis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is KLF8.

UniProtKB/Swiss-Prot for KLF15 Gene

  • Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.

Gene Wiki entry for KLF15 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF15 Gene

Genomics for KLF15 Gene

Regulatory Elements for KLF15 Gene

Promoters for KLF15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLF15 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLF15 Gene

Chromosome:
3
Start:
126,342,635 bp from pter
End:
126,357,442 bp from pter
Size:
14,808 bases
Orientation:
Minus strand

Genomic View for KLF15 Gene

Genes around KLF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF15 Gene

Proteins for KLF15 Gene

  • Protein details for KLF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIH9-KLF15_HUMAN
    Recommended name:
    Krueppel-like factor 15
    Protein Accession:
    Q9UIH9

    Protein attributes for KLF15 Gene

    Size:
    416 amino acids
    Molecular mass:
    43992 Da
    Quaternary structure:
    • Interacts with MYOCD and EP300.

    Three dimensional structures from OCA and Proteopedia for KLF15 Gene

neXtProt entry for KLF15 Gene

Proteomics data for KLF15 Gene at MOPED

Post-translational modifications for KLF15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KLF15 Gene

Domains & Families for KLF15 Gene

Protein Domains for KLF15 Gene

Suggested Antigen Peptide Sequences for KLF15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIH9

UniProtKB/Swiss-Prot:

KLF15_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF15: view

Function for KLF15 Gene

Molecular function for KLF15 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
UniProtKB/Swiss-Prot Induction:
In podocytes, up-regulated by retinoic acid.

Gene Ontology (GO) - Molecular Function for KLF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 23999430
genes like me logo Genes that share ontologies with KLF15: view
genes like me logo Genes that share phenotypes with KLF15: view

Animal Models for KLF15 Gene

MGI Knock Outs for KLF15:

Animal Model Products

miRNA for KLF15 Gene

miRTarBase miRNAs that target KLF15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLF15 Gene

Localization for KLF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF15 Gene COMPARTMENTS Subcellular localization image for KLF15 gene
Compartment Confidence
nucleus 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for KLF15 Gene

Pathways & Interactions for KLF15 Gene

SuperPathways for KLF15 Gene

Superpath Contained pathways
1 Adipogenesis
genes like me logo Genes that share pathways with KLF15: view

Pathways by source for KLF15 Gene

1 BioSystems pathway for KLF15 Gene

SIGNOR curated interactions for KLF15 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KLF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 19767294
GO:1901653 cellular response to peptide IEA --
GO:2000757 negative regulation of peptidyl-lysine acetylation IEA,IMP 20375365
genes like me logo Genes that share ontologies with KLF15: view

Drugs & Compounds for KLF15 Gene

(1) Drugs for KLF15 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF15: view

Transcripts for KLF15 Gene

mRNA/cDNA for KLF15 Gene

Unigene Clusters for KLF15 Gene

Kruppel-like factor 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: - -
SP2: -
SP3:

Relevant External Links for KLF15 Gene

GeneLoc Exon Structure for
KLF15
ECgene alternative splicing isoforms for
KLF15

Expression for KLF15 Gene

mRNA expression in normal human tissues for KLF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLF15 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLF15 Gene



SOURCE GeneReport for Unigene cluster for KLF15 Gene Hs.272215

mRNA Expression by UniProt/SwissProt for KLF15 Gene

Q9UIH9-KLF15_HUMAN
Tissue specificity: Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues.
genes like me logo Genes that share expression patterns with KLF15: view

Protein tissue co-expression partners for KLF15 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KLF15 Gene

Orthologs for KLF15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLF15 35
  • 82.75 (n)
  • 82.34 (a)
KLF15 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLF15 35
  • 86.39 (n)
  • 87.44 (a)
KLF15 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf15 35
  • 82.81 (n)
  • 84.34 (a)
Klf15 16
Klf15 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLF15 35
  • 94.67 (n)
  • 93.3 (a)
KLF15 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf15 35
  • 83.45 (n)
  • 83.37 (a)
oppossum
(Monodelphis domestica)
Mammalia KLF15 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF15 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF15 35
  • 68 (n)
  • 69.58 (a)
KLF15 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF15 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf15 35
  • 62.93 (n)
  • 64.63 (a)
zebrafish
(Danio rerio)
Actinopterygii klf15 35
  • 59.02 (n)
  • 57.32 (a)
klf15 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9895 37
  • 65 (a)
EP2237 37
  • 66 (a)
Bteb2 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F53F8.1 37
  • 61 (a)
mua-1 37
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FZF1 38
Species with no ortholog for KLF15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF15 Gene

ENSEMBL:
Gene Tree for KLF15 (if available)
TreeFam:
Gene Tree for KLF15 (if available)

Paralogs for KLF15 Gene

Paralogs for KLF15 Gene

(1) SIMAP similar genes for KLF15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLF15: view

Variants for KLF15 Gene

Sequence variations from dbSNP and Humsavar for KLF15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs938384 -- 126,348,546(-) CTCAC(A/G)TCACA intron-variant
rs2363940 -- 126,358,078(+) CCCCC(A/C)ACCTG upstream-variant-2KB
rs3732542 -- 126,343,979(-) TGCAC(A/G)CCTTG intron-variant
rs3069759 -- 126,357,931(+) AATCA(-/AG/GA)CTTGC upstream-variant-2KB
rs5852479 -- 126,357,930(+) AAATC(-/AG/GA)ACTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLF15 Gene

Variant ID Type Subtype PubMed ID
nsv877432 CNV Loss 21882294
nsv877433 CNV Loss 21882294
nsv877434 CNV Gain 21882294
dgv5245n71 CNV Loss 21882294
nsv877436 CNV Loss 21882294
esv29660 CNV Loss 19812545

Variation tolerance for KLF15 Gene

Residual Variation Intolerance Score: 51.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF15 Gene

HapMap Linkage Disequilibrium report
KLF15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF15 Gene

Disorders for KLF15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLF15 Gene - From: GeneCards

Disorder Aliases PubMed IDs
aortic aneurysm
  • abdominal aortic aneurysm, ruptured
- elite association - COSMIC cancer census association via MalaCards
Search KLF15 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

KLF15_HUMAN
  • Note=KLF15 deficiency results in loss of rhythmic QT variation and abnormal heart repolarization (PubMed:22367544). It may play a role in susceptibility to ventricular arrhythmias (PubMed:22367544), and development of pathological cardiac hypertrophy leading to heart failure (PubMed:20375365). {ECO:0000269 PubMed:20375365, ECO:0000269 PubMed:22367544}.

Relevant External Links for KLF15

Genetic Association Database (GAD)
KLF15
Human Genome Epidemiology (HuGE) Navigator
KLF15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF15
genes like me logo Genes that share disorders with KLF15: view

No data available for Genatlas for KLF15 Gene

Publications for KLF15 Gene

  1. Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kruppel-like factor, a novel zinc finger repressor. (PMID: 10982849) Uchida S. … Marumo F. (Mol. Cell. Biol. 2000) 2 3 4 23 67
  2. KLF15 Is a transcriptional regulator of the human 17beta-hydroxysteroid dehydrogenase type 5 gene. A potential link between regulation of testosterone production and fat stores in women. (PMID: 19366843) Du X. … Qin K. (J. Clin. Endocrinol. Metab. 2009) 3 23
  3. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. (PMID: 17438289) Fisch S. … Jain M.K. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 23
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism. (PMID: 24407292) Prosdocimo D.A. … Haldar S.M. (J. Biol. Chem. 2014) 3

Products for KLF15 Gene

Sources for KLF15 Gene

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