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Aliases for RGCC Gene

Aliases for RGCC Gene

  • Regulator Of Cell Cycle 2 3 5
  • Response Gene To Complement 32 Protein 3 4
  • C13orf15 3 4
  • RGC-32 3 4
  • RGC32 3 4
  • Chromosome 13 Open Reading Frame 15 2
  • Response Gene To Complement 32 2
  • BA157L14.2 3

External Ids for RGCC Gene

Previous HGNC Symbols for RGCC Gene

  • C13orf15

Previous GeneCards Identifiers for RGCC Gene

  • GC13P042032

Summaries for RGCC Gene

Entrez Gene Summary for RGCC Gene

  • This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGCC Gene

RGCC (Regulator Of Cell Cycle) is a Protein Coding gene. Diseases associated with RGCC include renal fibrosis. Among its related pathways are Gene Expression and TP53 Regulates Transcription of Cell Cycle Genes. GO annotations related to this gene include protein kinase binding and R-SMAD binding.

UniProtKB/Swiss-Prot for RGCC Gene

  • Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.

Gene Wiki entry for RGCC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGCC Gene

Genomics for RGCC Gene

Regulatory Elements for RGCC Gene

Enhancers for RGCC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RGCC on UCSC Golden Path with GeneCards custom track

Promoters for RGCC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RGCC on UCSC Golden Path with GeneCards custom track

Genomic Location for RGCC Gene

Chromosome:
13
Start:
41,457,406 bp from pter
End:
41,470,882 bp from pter
Size:
13,477 bases
Orientation:
Plus strand

Genomic View for RGCC Gene

Genes around RGCC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGCC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGCC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGCC Gene

Proteins for RGCC Gene

  • Protein details for RGCC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4X1-RGCC_HUMAN
    Recommended name:
    Regulator of cell cycle RGCC
    Protein Accession:
    Q9H4X1
    Secondary Accessions:
    • Q6NZ48
    • Q9UL69

    Protein attributes for RGCC Gene

    Size:
    137 amino acids
    Molecular mass:
    14559 Da
    Quaternary structure:
    • Interacts with SMAD3 (By similarity). Interacts with CDK1 and PLK1.

    Alternative splice isoforms for RGCC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGCC Gene

Proteomics data for RGCC Gene at MOPED

Post-translational modifications for RGCC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGCC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGCC Gene

Domains & Families for RGCC Gene

Protein Domains for RGCC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RGCC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGCC: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RGCC Gene

Function for RGCC Gene

Molecular function for RGCC Gene

UniProtKB/Swiss-Prot Function:
Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.
UniProtKB/Swiss-Prot Induction:
By Epstein-Barr virus (EBV). Up-regulated in aorta endothelial cells in response to complement activation.
genes like me logo Genes that share phenotypes with RGCC: view

Animal Models for RGCC Gene

MGI Knock Outs for RGCC:
  • Rgcc tm1(KOMP)Wtsi

Animal Model Products

miRNA for RGCC Gene

miRTarBase miRNAs that target RGCC

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGCC Gene

Localization for RGCC Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGCC Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGCC Gene COMPARTMENTS Subcellular localization image for RGCC gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for RGCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11687586
genes like me logo Genes that share ontologies with RGCC: view

Pathways & Interactions for RGCC Gene

genes like me logo Genes that share pathways with RGCC: view

Gene Ontology (GO) - Biological Process for RGCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001100 negative regulation of exit from mitosis IDA 17146433
GO:0001937 negative regulation of endothelial cell proliferation IDA 19652095
GO:0003331 positive regulation of extracellular matrix constituent secretion IDA 19158077
GO:0006956 complement activation IMP 19162005
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with RGCC: view

No data available for SIGNOR curated interactions for RGCC Gene

Drugs & Compounds for RGCC Gene

No Compound Related Data Available

Transcripts for RGCC Gene

mRNA/cDNA for RGCC Gene

Unigene Clusters for RGCC Gene

Regulator of cell cycle:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGCC Gene

No ASD Table

Relevant External Links for RGCC Gene

GeneLoc Exon Structure for
RGCC
ECgene alternative splicing isoforms for
RGCC

Expression for RGCC Gene

mRNA expression in normal human tissues for RGCC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGCC Gene

This gene is overexpressed in Lung (x7.7).

Protein differential expression in normal tissues from HIPED for RGCC Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.5) and Platelet (20.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGCC Gene



SOURCE GeneReport for Unigene cluster for RGCC Gene Hs.507866

mRNA Expression by UniProt/SwissProt for RGCC Gene

Q9H4X1-RGCC_HUMAN
Tissue specificity: Detected in brain, heart and liver (at protein level). Highly expressed in liver, skeletal muscle, kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial cells. Overexpressed in colon, breast, prostate, bladder, lung, and ovarian cancer tissues.
genes like me logo Genes that share expression patterns with RGCC: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for RGCC Gene

Orthologs for RGCC Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGCC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RGCC 35
  • 89.79 (n)
  • 89.19 (a)
MGC148992 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgcc 35
  • 88.89 (n)
  • 88.29 (a)
Rgcc 16
Rgcc 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RGCC 35
  • 99.4 (n)
  • 100 (a)
RGCC 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgcc 35
  • 88.89 (n)
  • 91.89 (a)
dog
(Canis familiaris)
Mammalia RGCC 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGCC 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGCC 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H13ORF15 35
  • 80.91 (n)
  • 78.18 (a)
RGCC 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGCC 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgcc 35
  • 73.57 (n)
  • 76.58 (a)
Str.17679 35
zebrafish
(Danio rerio)
Actinopterygii rgcc 35
  • 70.87 (n)
  • 72.07 (a)
sbcb658 35
rgcc 36
  • 65 (a)
OneToOne
Species with no ortholog for RGCC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGCC Gene

ENSEMBL:
Gene Tree for RGCC (if available)
TreeFam:
Gene Tree for RGCC (if available)

Paralogs for RGCC Gene

No data available for Paralogs for RGCC Gene

Variants for RGCC Gene

Sequence variations from dbSNP and Humsavar for RGCC Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs7136 -- 41,458,436(-) CTGAC(A/G)CTGGC nc-transcript-variant, reference, synonymous-codon
rs396963 -- 41,470,372(+) AGCCC(A/G)GCATT intron-variant
rs872357 -- 41,464,502(+) TTCCC(A/G)AGTAA intron-variant
rs872718 -- 41,458,646(-) GCCCT(C/T)CAGCG intron-variant
rs874417 -- 41,464,568(+) TGTCC(C/T)GTGGT intron-variant

Variation tolerance for RGCC Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGCC Gene

HapMap Linkage Disequilibrium report
RGCC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RGCC Gene

Disorders for RGCC Gene

MalaCards: The human disease database

(1) MalaCards diseases for RGCC Gene - From: GeneCards

Disorder Aliases PubMed IDs
renal fibrosis
- elite association - COSMIC cancer census association via MalaCards
Search RGCC in MalaCards View complete list of genes associated with diseases

Relevant External Links for RGCC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGCC
genes like me logo Genes that share disorders with RGCC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGCC Gene

Publications for RGCC Gene

  1. RGC-32 mediates transforming growth factor-beta-induced epithelial- mesenchymal transition in human renal proximal tubular cells. (PMID: 19158077) Huang W.Y. … Chen S.Y. (J. Biol. Chem. 2009) 2 3 4 67
  2. Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor. (PMID: 19652095) An X. … Li J. (Circulation 2009) 2 3
  3. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. (PMID: 17146433) Saigusa K. … Inazawa J. (Oncogene 2007) 2 3
  4. Expression of RGC32 in human normal and preeclamptic placentas and its role in trophoblast cell invasion and migration. (PMID: 25655049) Wang Q.J. … Qu X. (Placenta 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for RGCC Gene

Sources for RGCC Gene

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