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Aliases for SLC27A6 Gene

Aliases for SLC27A6 Gene

  • Solute Carrier Family 27 (Fatty Acid Transporter), Member 6 2 3
  • Fatty-Acid-Coenzyme A Ligase, Very Long-Chain 2 3 4
  • Very Long-Chain Acyl-CoA Synthetase Homolog 1 3 4
  • Solute Carrier Family 27 Member 6 3 4
  • Fatty Acid Transport Protein 6 3 4
  • HVLCS-H1 3 4
  • ACSVL2 3 4
  • FACVL2 3 4
  • FATP-6 3 4
  • VLCSH1 3 4
  • Long-Chain Fatty Acid Transport Protein 6 3
  • Fatty-Acid-Coenzyme A Ligase 2
  • Very Long-Chain 2 2
  • EC 6.2.1.7 64
  • EC 6.2.1 64
  • VLCS-H1 3
  • FATP6 3
  • FATP1 4

External Ids for SLC27A6 Gene

Summaries for SLC27A6 Gene

Entrez Gene Summary for SLC27A6 Gene

  • This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC27A6 Gene

SLC27A6 (Solute Carrier Family 27 (Fatty Acid Transporter), Member 6) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include nucleotide binding and very long-chain fatty acid-CoA ligase activity. An important paralog of this gene is SLC27A1.

UniProtKB/Swiss-Prot for SLC27A6 Gene

  • Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart.

Gene Wiki entry for SLC27A6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC27A6 Gene

Genomics for SLC27A6 Gene

Genomic Location for SLC27A6 Gene

Start:
128,538,013 bp from pter
End:
129,033,642 bp from pter
Size:
495,630 bases
Orientation:
Plus strand

Genomic View for SLC27A6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC27A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC27A6 Gene

Regulatory Elements for SLC27A6 Gene

Proteins for SLC27A6 Gene

  • Protein details for SLC27A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2P4-S27A6_HUMAN
    Recommended name:
    Long-chain fatty acid transport protein 6
    Protein Accession:
    Q9Y2P4
    Secondary Accessions:
    • Q6IAM5
    • Q7Z6E6
    • Q86YF6

    Protein attributes for SLC27A6 Gene

    Size:
    619 amino acids
    Molecular mass:
    70112 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC27A6 Gene

Proteomics data for SLC27A6 Gene at MOPED

Selected DME Specific Peptides for SLC27A6 Gene

Post-translational modifications for SLC27A6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC27A6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for SLC27A6 Gene

Gene Families for SLC27A6 Gene

HGNC:
  • SLC :Solute carriers
  • ACS :Acyl-CoA synthetase family
IUPHAR :

Protein Domains for SLC27A6 Gene

UniProtKB/Swiss-Prot:

S27A6_HUMAN
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.:
    • Q9Y2P4
genes like me logo Genes that share domains with SLC27A6: view

Function for SLC27A6 Gene

Molecular function for SLC27A6 Gene

UniProtKB/Swiss-Prot Function: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart.

Enzyme Numbers (IUBMB) for SLC27A6 Gene

Gene Ontology (GO) - Molecular Function for SLC27A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003824 catalytic activity --
GO:0004467 long-chain fatty acid-CoA ligase activity IEA --
GO:0031957 very long-chain fatty acid-CoA ligase activity IEA --
genes like me logo Genes that share ontologies with SLC27A6: view

Phenotypes for SLC27A6 Gene

GenomeRNAi human phenotypes for SLC27A6:
genes like me logo Genes that share phenotypes with SLC27A6: view

miRNA for SLC27A6 Gene

miRTarBase miRNAs that target SLC27A6

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC27A6 Gene

Localization for SLC27A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC27A6 Gene

Membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC27A6 Gene COMPARTMENTS Subcellular localization image for SLC27A6 gene
Compartment Confidence
plasma membrane 4
peroxisome 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC27A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0042383 sarcolemma IEA --
genes like me logo Genes that share ontologies with SLC27A6: view

Pathways for SLC27A6 Gene

genes like me logo Genes that share pathways with SLC27A6: view

Interacting Proteins for SLC27A6 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000262462%0d%0a9606.ENSP00000348762%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000377900%0d%0a9606.ENSP00000337354%0d%0a9606.ENSP00000383901%0d%0a
Selected Interacting proteins: Q9Y2P4-S27A6_HUMAN ENSP00000262462 for SLC27A6 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for SLC27A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process TAS 10471116
GO:0001676 long-chain fatty acid metabolic process TAS 10471116
GO:0008152 metabolic process --
GO:0015909 long-chain fatty acid transport TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC27A6: view

Compounds for SLC27A6 Gene

(9) HMDB Compounds for SLC27A6 Gene

Compound Synonyms Cas Number PubMed IDs
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Heptadecanoic acid
  • Heptadecanoate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoyl coenzyme A
3546-17-6
Myristic acid
  • 1-Tridecanecarboxylate
544-63-8

(3) Novoseek inferred chemical compound relationships for SLC27A6 Gene

Compound -log(P) Hits PubMed IDs
fatty acid 69.5 15
triacylglycerol 54.8 2
lipid 22 2
genes like me logo Genes that share compounds with SLC27A6: view

Transcripts for SLC27A6 Gene

Unigene Clusters for SLC27A6 Gene

Solute carrier family 27 (fatty acid transporter), member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2:
SP3: - -
SP4: -
SP5: -
SP6: - -

Relevant External Links for SLC27A6 Gene

GeneLoc Exon Structure for
SLC27A6
ECgene alternative splicing isoforms for
SLC27A6

Expression for SLC27A6 Gene

mRNA expression in normal human tissues for SLC27A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC27A6 Gene

This gene is overexpressed in Heart - Left Ventricle (8.6), Esophagus - Muscularis (5.7), Heart - Atrial Appendage (5.2), and Adrenal Gland (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC27A6 Gene

SOURCE GeneReport for Unigene cluster for SLC27A6 Gene Hs.49765

mRNA Expression by UniProt/SwissProt for SLC27A6 Gene

Q9Y2P4-S27A6_HUMAN
Tissue specificity: Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus.
genes like me logo Genes that share expressions with SLC27A6: view

Orthologs for SLC27A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC27A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC27A6 36
  • 99.25 (n)
  • 99.03 (a)
SLC27A6 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC27A6 36
  • 83.98 (n)
  • 76.21 (a)
SLC27A6 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC27A6 36
  • 87.02 (n)
  • 83.36 (a)
SLC27A6 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc27a6 36
  • 80.29 (n)
  • 78.35 (a)
Slc27a6 16
Slc27a6 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc27a6 36
  • 81.48 (n)
  • 78.68 (a)
chicken
(Gallus gallus)
Aves SLC27A6 36
  • 72.11 (n)
  • 68.5 (a)
SLC27A6 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC27A6 37
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9882 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc27a6 36
  • 69.41 (n)
  • 65.27 (a)
Str.16676 36
zebrafish
(Danio rerio)
Actinopterygii LOC568883 36
  • 59.33 (n)
  • 53.18 (a)
slc27a6 37
  • 55 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAT1 37
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToMany
Species with no ortholog for SLC27A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC27A6 Gene

ENSEMBL:
Gene Tree for SLC27A6 (if available)
TreeFam:
Gene Tree for SLC27A6 (if available)

Paralogs for SLC27A6 Gene

Paralogs for SLC27A6 Gene

Selected SIMAP similar genes for SLC27A6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC27A6: view

Variants for SLC27A6 Gene

Sequence variations from dbSNP and Humsavar for SLC27A6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs31271 -- 129,023,554(-) CTTGT(A/G)CAAGC intron-variant
rs31272 -- 129,023,919(-) TATTA(C/T)GTATT intron-variant
rs31273 -- 129,025,384(-) TCCCT(A/G)TATTT intron-variant
rs40977 -- 129,024,498(-) TAATC(A/G)TCCAC intron-variant
rs42356 -- 129,020,392(-) TGATC(C/T)AATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC27A6 Gene

Variant ID Type Subtype PubMed ID
dgv6318n71 CNV Loss 21882294
esv2656691 CNV Deletion 23128226
nsv830485 CNV Gain 17160897
nsv819884 CNV Gain 19587683
dgv6319n71 CNV Loss 21882294
nsv882842 CNV Loss 21882294
esv274641 CNV Insertion 20981092
esv267726 CNV Insertion 20981092
nsv329438 CNV Insertion 16902084
nsv328601 CNV Insertion 16902084
dgv6320n71 CNV Loss 21882294
esv2730759 CNV Deletion 23290073
esv2730760 CNV Deletion 23290073
esv2407327 CNV Deletion 18987734
esv2730761 CNV Deletion 23290073
esv5198 CNV Deletion 18987735
nsv327282 CNV Loss 16902084
esv1008060 CNV Deletion 20482838
esv2730763 CNV Deletion 23290073
esv1641373 CNV Deletion 17803354
nsv329829 CNV Loss 16902084
nsv882846 CNV Loss 21882294
nsv4996 CNV Insertion 18451855
nsv882847 CNV Loss 21882294

Relevant External Links for SLC27A6 Gene

HapMap Linkage Disequilibrium report
SLC27A6

Disorders for SLC27A6 Gene

Relevant External Links for SLC27A6

Genetic Association Database (GAD)
SLC27A6
Human Genome Epidemiology (HuGE) Navigator
SLC27A6
genes like me logo Genes that share disorders with SLC27A6: view

No data available for UniProtKB/Swiss-Prot for SLC27A6 Gene

Publications for SLC27A6 Gene

  1. Characterization of a heart-specific fatty acid transport protein. (PMID: 12556534) Gimeno R.E. … Stahl A. (J. Biol. Chem. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. (PMID: 10479480) Steinberg S.J. … Watkins P.A. (Mol. Genet. Metab. 1999) 2 3
  4. The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase. (PMID: 10749848) Steinberg S.J. … Watkins P.A. (J. Biol. Chem. 2000) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC27A6 Gene

Sources for SLC27A6 Gene

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