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Aliases for DCPS Gene

Aliases for DCPS Gene

  • Decapping Enzyme, Scavenger 2 3
  • HINT5 3 4 6
  • DCS1 3 4 6
  • Histidine Triad Nucleotide-Binding Protein 5 3 4
  • Hint-Related 7meGMP-Directed Hydrolase 3 4
  • Scavenger MRNA-Decapping Enzyme DcpS 3 4
  • Histidine Triad Protein Member 5 3 4
  • Decapping Scavenger Enzyme 3 4
  • HINT-5 3 4
  • Homolog Of C. Elegans 7meGMP-Directed Hydrolase Dcs-1 3
  • Heat Shock-Like Protein 1 3
  • M7GpppX Diphosphatase 3
  • MRNA Decapping Enzyme 3
  • EC 3.6.1.59 4
  • HSPC015 3
  • DCS-1 4
  • HSL1 3

External Ids for DCPS Gene

Previous GeneCards Identifiers for DCPS Gene

  • GC11P128174
  • GC11P127686
  • GC11P126207
  • GC11P125711
  • GC11P125678
  • GC11P122121
  • GC11P126173

Summaries for DCPS Gene

GeneCards Summary for DCPS Gene

DCPS (Decapping Enzyme, Scavenger) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include m7G(5)pppN diphosphatase activity and RNA 7-methylguanosine cap binding.

UniProtKB/Swiss-Prot for DCPS Gene

  • Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3->5 exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5->3 mRNA decay pathway; m7GDP, the downstream product released by the 5->3 mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.

Gene Wiki entry for DCPS Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCPS Gene

Genomics for DCPS Gene

Regulatory Elements for DCPS Gene

Genomic Location for DCPS Gene

Start:
126,303,752 bp from pter
End:
126,345,749 bp from pter
Size:
41,998 bases
Orientation:
Plus strand

Genomic View for DCPS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCPS Gene

Proteins for DCPS Gene

  • Protein details for DCPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C86-DCPS_HUMAN
    Recommended name:
    m7GpppX diphosphatase
    Protein Accession:
    Q96C86
    Secondary Accessions:
    • Q8NHL8
    • Q9Y2S5

    Protein attributes for DCPS Gene

    Size:
    337 amino acids
    Molecular mass:
    38609 Da
    Quaternary structure:
    • Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.

    Three dimensional structures from OCA and Proteopedia for DCPS Gene

neXtProt entry for DCPS Gene

Proteomics data for DCPS Gene at MOPED

Post-translational modifications for DCPS Gene

  • Ubiquitination at Lys128 and Lys138
  • Modification sites at PhosphoSitePlus

Other Protein References for DCPS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DCPS Gene

Domains for DCPS Gene

Protein Domains for DCPS Gene

Suggested Antigen Peptide Sequences for DCPS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C86

UniProtKB/Swiss-Prot:

DCPS_HUMAN :
  • Q96C86
Domain:
  • The C-terminal histidine triad (HIT) motif and the N-terminal domain are required for the decapping activity. The N-terminus is necessary but not sufficient for binding cap structures.
Family:
  • Belongs to the HIT family.
genes like me logo Genes that share domains with DCPS: view

No data available for Gene Families for DCPS Gene

Function for DCPS Gene

Molecular function for DCPS Gene

UniProtKB/Swiss-Prot CatalyticActivity: A 5-(N(7)-methyl 5-triphosphoguanosine)-(mRNA) + H(2)O = N(7)-methylguanosine 5-phosphate + a 5-diphospho-(mRNA).
UniProtKB/Swiss-Prot EnzymeRegulation: The hydrolytic product 7-methylguanosine diphosphate (m7GDP) efficiently inhibits the decapping scavenger activity and acts as a competitive inhibitor in vitro. Inhibited by 2,4-diaminoquinazoline.
UniProtKB/Swiss-Prot Function: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3->5 exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5->3 mRNA decay pathway; m7GDP, the downstream product released by the 5->3 mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.
UniProtKB/Swiss-Prot Induction: Up-regulated by menadione. Up-regulated by the transcription factor LTF isoform delta-lactoferrin (at protein level).

Enzyme Numbers (IUBMB) for DCPS Gene

Gene Ontology (GO) - Molecular Function for DCPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000340 RNA 7-methylguanosine cap binding IDA 12198172
GO:0003824 catalytic activity --
GO:0005515 protein binding IPI 16140270
GO:0016787 hydrolase activity --
GO:0050072 m7G(5)pppN diphosphatase activity IDA 12198172
genes like me logo Genes that share ontologies with DCPS: view

Phenotypes for DCPS Gene

MGI mutant phenotypes for DCPS:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with DCPS: view

miRNA for DCPS Gene

miRTarBase miRNAs that target DCPS

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DCPS Gene

Localization for DCPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCPS Gene

Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCPS Gene COMPARTMENTS Subcellular localization image for DCPS gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 4

Gene Ontology (GO) - Cellular Components for DCPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12871939
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DCPS: view

Pathways for DCPS Gene

genes like me logo Genes that share pathways with DCPS: view

Pathways by source for DCPS Gene

1 KEGG pathway for DCPS Gene

Gene Ontology (GO) - Biological Process for DCPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS 12198172
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA --
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process --
GO:0016071 mRNA metabolic process --
genes like me logo Genes that share ontologies with DCPS: view

Compounds for DCPS Gene

(2) Novoseek inferred chemical compound relationships for DCPS Gene

Compound -log(P) Hits PubMed IDs
flavin 64.4 2
nadph 41.6 1
genes like me logo Genes that share compounds with DCPS: view

Transcripts for DCPS Gene

Unigene Clusters for DCPS Gene

Decapping enzyme, scavenger:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCPS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - -
SP2: -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for DCPS Gene

GeneLoc Exon Structure for
DCPS
ECgene alternative splicing isoforms for
DCPS

Expression for DCPS Gene

mRNA expression in normal human tissues for DCPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCPS Gene

This gene is overexpressed in Liver (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCPS Gene

SOURCE GeneReport for Unigene cluster for DCPS Gene Hs.504249

mRNA Expression by UniProt/SwissProt for DCPS Gene

Q96C86-DCPS_HUMAN
Tissue specificity: Detected in liver, brain, kidney, testis and prostate.
genes like me logo Genes that share expressions with DCPS: view

Orthologs for DCPS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCPS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCPS 35
  • 89.86 (n)
  • 88.51 (a)
DCPS 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCPS 35
  • 85.46 (n)
  • 88.72 (a)
DCPS 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCPS 35
  • 86.73 (n)
  • 88.32 (a)
DCPS 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcps 35
  • 86.37 (n)
  • 90.15 (a)
Dcps 16
Dcps 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCPS 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCPS 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcps 35
  • 86.07 (n)
  • 89.25 (a)
chicken
(Gallus gallus)
Aves DCPS 35
  • 68.18 (n)
  • 64.72 (a)
DCPS 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCPS 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hint5-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dcps 35
  • 63.95 (n)
  • 65.8 (a)
Str.16500 35
zebrafish
(Danio rerio)
Actinopterygii dcps 35
  • 64.08 (n)
  • 60.21 (a)
dcps 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010712 35
  • 53 (n)
  • 45.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2091 35
  • 53.73 (n)
  • 44.41 (a)
CG2091 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dcs-1 35
  • 51.35 (n)
  • 42.08 (a)
dcs-1 36
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR268W 35
  • 51.37 (n)
  • 37.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCS1 36
  • 28 (a)
OneToMany
DCS2 36
  • 31 (a)
OneToMany
DCS2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20229g 35
  • 48.43 (n)
  • 39.6 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06998 35
  • 47.09 (n)
  • 36.77 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nhm1 35
  • 46.62 (n)
  • 41.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for DCPS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCPS Gene

ENSEMBL:
Gene Tree for DCPS (if available)
TreeFam:
Gene Tree for DCPS (if available)

Paralogs for DCPS Gene

No data available for Paralogs for DCPS Gene

Variants for DCPS Gene

Sequence variations from dbSNP and Humsavar for DCPS Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs171270 -- 126,337,850(-) TAGGA(C/G)GCTGA intron-variant
rs171271 -- 126,334,016(-) CTATG(C/T)TCACC intron-variant
rs183577 -- 126,324,626(-) aaggc(A/C)gaaaa intron-variant
rs240541 -- 126,339,488(+) GGGTT(A/G)CACAG intron-variant
rs240542 -- 126,338,864(+) TGGAG(C/T)AGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCPS Gene

Variant ID Type Subtype PubMed ID
esv2663692 CNV Deletion 23128226

Relevant External Links for DCPS Gene

HapMap Linkage Disequilibrium report
DCPS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCPS Gene

Disorders for DCPS Gene

No disorders were found for DCPS Gene.

No data available for UniProtKB/Swiss-Prot for DCPS Gene

Publications for DCPS Gene

  1. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. (PMID: 12871939) Kwasnicka D.A. … Vincent S.R. (J. Biol. Chem. 2003) 3 4 23
  2. Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity. (PMID: 15068804) Gu M. … Lima C.D. (Mol. Cell 2004) 3 4 23
  3. Functional analysis of mRNA scavenger decapping enzymes. (PMID: 15273322) Liu S.-W. … Kiledjian M. (RNA 2004) 3 4 23
  4. Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. (PMID: 16140270) Kwasnicka-Crawford D.A. … Vincent S.R. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  5. The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. (PMID: 12198172) Liu H. … Kiledjian M. (EMBO J. 2002) 2 3 4

Products for DCPS Gene

Sources for DCPS Gene

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