Aliases for DCPS Gene
External Ids for DCPS Gene
Previous GeneCards Identifiers for DCPS Gene
GeneCards Summary for DCPS Gene
DCPS (Decapping Enzyme, Scavenger) is a Protein Coding gene. Diseases associated with DCPS include al-raqad syndrome and syndromic intellectual disability. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include hydrolase activity and RNA 7-methylguanosine cap binding.
UniProtKB/Swiss-Prot for DCPS Gene
Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3->5 exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5->3 mRNA decay pathway; m7GDP, the downstream product released by the 5->3 mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.