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Aliases for DCPS Gene

Aliases for DCPS Gene

  • Decapping Enzyme, Scavenger 2 3 5
  • Histidine Triad Nucleotide-Binding Protein 5 3 4
  • Hint-Related 7meGMP-Directed Hydrolase 3 4
  • Scavenger MRNA-Decapping Enzyme DcpS 3 4
  • Histidine Triad Protein Member 5 3 4
  • Decapping Scavenger Enzyme 3 4
  • HINT-5 3 4
  • HINT5 3 4
  • DCS1 3 4
  • Homolog Of C. Elegans 7meGMP-Directed Hydrolase Dcs-1 3
  • Heat Shock-Like Protein 1 3
  • MRNA Decapping Enzyme 3
  • EC 3.6.1.59 4
  • HSPC015 3
  • DCS-1 4
  • HSL1 3
  • ARS 3

External Ids for DCPS Gene

Previous GeneCards Identifiers for DCPS Gene

  • GC11P128174
  • GC11P127686
  • GC11P126207
  • GC11P125711
  • GC11P125678
  • GC11P122121
  • GC11P126173

Summaries for DCPS Gene

GeneCards Summary for DCPS Gene

DCPS (Decapping Enzyme, Scavenger) is a Protein Coding gene. Diseases associated with DCPS include Al-Raqad Syndrome and Syndromic Intellectual Disability. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include hydrolase activity and RNA 7-methylguanosine cap binding.

UniProtKB/Swiss-Prot for DCPS Gene

  • Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3->5 exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5->3 mRNA decay pathway; m7GDP, the downstream product released by the 5->3 mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.

Gene Wiki entry for DCPS Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCPS Gene

Genomics for DCPS Gene

Regulatory Elements for DCPS Gene

Enhancers for DCPS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DCPS on UCSC Golden Path with GeneCards custom track

Promoters for DCPS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCPS on UCSC Golden Path with GeneCards custom track

Genomic Location for DCPS Gene

Chromosome:
11
Start:
126,303,752 bp from pter
End:
126,345,754 bp from pter
Size:
42,003 bases
Orientation:
Plus strand

Genomic View for DCPS Gene

Genes around DCPS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCPS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCPS Gene

Proteins for DCPS Gene

  • Protein details for DCPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C86-DCPS_HUMAN
    Recommended name:
    m7GpppX diphosphatase
    Protein Accession:
    Q96C86
    Secondary Accessions:
    • Q8NHL8
    • Q9Y2S5

    Protein attributes for DCPS Gene

    Size:
    337 amino acids
    Molecular mass:
    38609 Da
    Quaternary structure:
    • Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.

    Three dimensional structures from OCA and Proteopedia for DCPS Gene

neXtProt entry for DCPS Gene

Proteomics data for DCPS Gene at MOPED

Post-translational modifications for DCPS Gene

  • Ubiquitination at Lys 138
  • Modification sites at PhosphoSitePlus

Other Protein References for DCPS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCPS Gene

Domains & Families for DCPS Gene

Protein Domains for DCPS Gene

Suggested Antigen Peptide Sequences for DCPS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C86

UniProtKB/Swiss-Prot:

DCPS_HUMAN :
  • The C-terminal histidine triad (HIT) motif and the N-terminal domain are required for the decapping activity. The N-terminus is necessary but not sufficient for binding cap structures.
  • Belongs to the HIT family.
Domain:
  • The C-terminal histidine triad (HIT) motif and the N-terminal domain are required for the decapping activity. The N-terminus is necessary but not sufficient for binding cap structures.
Family:
  • Belongs to the HIT family.
genes like me logo Genes that share domains with DCPS: view

No data available for Gene Families for DCPS Gene

Function for DCPS Gene

Molecular function for DCPS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 5-(N(7)-methyl 5-triphosphoguanosine)-[mRNA] + H(2)O = N(7)-methylguanosine 5-phosphate + a 5-diphospho-[mRNA].
UniProtKB/Swiss-Prot EnzymeRegulation:
The hydrolytic product 7-methylguanosine diphosphate (m7GDP) efficiently inhibits the decapping scavenger activity and acts as a competitive inhibitor in vitro. Inhibited by 2,4-diaminoquinazoline.
UniProtKB/Swiss-Prot Function:
Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3->5 exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5->3 mRNA decay pathway; m7GDP, the downstream product released by the 5->3 mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.
UniProtKB/Swiss-Prot Induction:
Up-regulated by menadione. Up-regulated by the transcription factor LTF isoform delta-lactoferrin (at protein level).

Enzyme Numbers (IUBMB) for DCPS Gene

Gene Ontology (GO) - Molecular Function for DCPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DCPS: view
genes like me logo Genes that share phenotypes with DCPS: view

Human Phenotype Ontology for DCPS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DCPS Gene

MGI Knock Outs for DCPS:
  • Dcps tm1b(EUCOMM)Hmgu

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for DCPS Gene

Localization for DCPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCPS Gene

Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCPS Gene COMPARTMENTS Subcellular localization image for DCPS gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 5
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for DCPS Gene

Pathways & Interactions for DCPS Gene

genes like me logo Genes that share pathways with DCPS: view

Pathways by source for DCPS Gene

1 KEGG pathway for DCPS Gene

Gene Ontology (GO) - Biological Process for DCPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA --
GO:0043069 negative regulation of programmed cell death IDA 16140270
GO:0045292 mRNA cis splicing, via spliceosome IDA 18426921
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic TAS --
genes like me logo Genes that share ontologies with DCPS: view

No data available for SIGNOR curated interactions for DCPS Gene

Drugs & Compounds for DCPS Gene

(8) Drugs for DCPS Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine Experimental Pharma Target 0
5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine Experimental Pharma Target 0
5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine Experimental Pharma Target 0
7-Methyl-Gpppa Experimental Pharma Target 0
7-methyl-guanosine-5'-triphosphate-5'-guanosine Experimental Pharma Target 0

(6) Additional Compounds for DCPS Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
7-Methylguanosine 5'-diphosphate
7-Methylguanosine 5'-phosphate
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DCPS: view

Transcripts for DCPS Gene

Unigene Clusters for DCPS Gene

Decapping enzyme, scavenger:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCPS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - -
SP2: -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for DCPS Gene

GeneLoc Exon Structure for
DCPS
ECgene alternative splicing isoforms for
DCPS

Expression for DCPS Gene

mRNA expression in normal human tissues for DCPS Gene

mRNA differential expression in normal tissues according to GTEx for DCPS Gene

This gene is overexpressed in Liver (x5.2).

Protein differential expression in normal tissues from HIPED for DCPS Gene

This gene is overexpressed in Lymph node (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCPS Gene



SOURCE GeneReport for Unigene cluster for DCPS Gene Hs.504249

mRNA Expression by UniProt/SwissProt for DCPS Gene

Q96C86-DCPS_HUMAN
Tissue specificity: Detected in liver, brain, kidney, testis and prostate.
genes like me logo Genes that share expression patterns with DCPS: view

Protein tissue co-expression partners for DCPS Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DCPS Gene

Orthologs for DCPS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCPS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCPS 35
  • 85.46 (n)
  • 88.72 (a)
DCPS 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCPS 35
  • 86.73 (n)
  • 88.32 (a)
DCPS 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcps 35
  • 86.37 (n)
  • 90.15 (a)
Dcps 16
Dcps 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCPS 35
  • 89.86 (n)
  • 88.51 (a)
DCPS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcps 35
  • 86.07 (n)
  • 89.25 (a)
oppossum
(Monodelphis domestica)
Mammalia DCPS 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCPS 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCPS 35
  • 68.18 (n)
  • 64.72 (a)
DCPS 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCPS 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcps 35
  • 63.95 (n)
  • 65.8 (a)
Str.16500 35
African clawed frog
(Xenopus laevis)
Amphibia hint5-A 35
zebrafish
(Danio rerio)
Actinopterygii dcps 35
  • 64.08 (n)
  • 60.21 (a)
dcps 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010712 35
  • 53 (n)
  • 45.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2091 35
  • 53.73 (n)
  • 44.41 (a)
CG2091 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dcs-1 35
  • 51.35 (n)
  • 42.08 (a)
dcs-1 36
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR268W 35
  • 51.37 (n)
  • 37.69 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20229g 35
  • 48.43 (n)
  • 39.6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCS1 36
  • 28 (a)
OneToMany
DCS2 36
  • 31 (a)
OneToMany
DCS2 38
bread mold
(Neurospora crassa)
Ascomycetes NCU06998 35
  • 47.09 (n)
  • 36.77 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nhm1 35
  • 46.62 (n)
  • 41.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for DCPS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCPS Gene

ENSEMBL:
Gene Tree for DCPS (if available)
TreeFam:
Gene Tree for DCPS (if available)

Paralogs for DCPS Gene

No data available for Paralogs for DCPS Gene

Variants for DCPS Gene

Sequence variations from dbSNP and Humsavar for DCPS Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11557735 - 126,306,586(+) CTCTG(A/G)GGATG reference, missense
VAR_073956 Al-Raqad syndrome (ARS)
rs583697 -- 126,310,125(-) CTCCA(A/G)TGATT intron-variant
rs586566 -- 126,329,723(+) TGAGT(C/T)CCAGC intron-variant, utr-variant-5-prime
rs589442 -- 126,328,101(-) TCTCC(A/G)GGCCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DCPS Gene

Variant ID Type Subtype PubMed ID
esv2663692 CNV Deletion 23128226

Variation tolerance for DCPS Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCPS Gene

Human Gene Mutation Database (HGMD)
DCPS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCPS Gene

Disorders for DCPS Gene

MalaCards: The human disease database

(4) MalaCards diseases for DCPS Gene - From: OMIM, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
al-raqad syndrome
  • ars
syndromic intellectual disability
subcutaneous mycosis
  • subcutaneous fungal disease
vaginal cancer
  • malignant neoplasm of vagina
- elite association - COSMIC cancer census association via MalaCards
Search DCPS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DCPS_HUMAN
  • Al-Raqad syndrome (ARS) [MIM:616459]: A syndrome characterized by delayed psychomotor development, moderate to severe intellectual disability, poor or absent speech, microcephaly, congenital hypotonia, and severe growth delay. {ECO:0000269 PubMed:25701870, ECO:0000269 PubMed:25712129}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DCPS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCPS
genes like me logo Genes that share disorders with DCPS: view

No data available for Genatlas for DCPS Gene

Publications for DCPS Gene

  1. DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway. (PMID: 14523240) van Dijk E. … Seraphin B. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 67
  2. Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme. (PMID: 18441014) Liu S.W. … Kiledjian M. (J. Biol. Chem. 2008) 3 23
  3. Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. (PMID: 16140270) Kwasnicka-Crawford D.A. … Vincent S.R. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity. (PMID: 15068804) Gu M. … Lima C.D. (Mol. Cell 2004) 3 23
  5. Functional analysis of mRNA scavenger decapping enzymes. (PMID: 15273322) Liu S.-W. … Kiledjian M. (RNA 2004) 3 23

Products for DCPS Gene

Sources for DCPS Gene

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