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Aliases for TRIB2 Gene

Aliases for TRIB2 Gene

  • Tribbles Pseudokinase 2 2 3 5
  • TRB2 3 4
  • Tribbles Homolog 2 (Drosophila) 2
  • Tribbles Homolog 2 3
  • GS3955 3
  • TRB-2 4
  • C5FW 3

External Ids for TRIB2 Gene

Previous GeneCards Identifiers for TRIB2 Gene

  • GC02P012879
  • GC02P012807
  • GC02P012856

Summaries for TRIB2 Gene

Entrez Gene Summary for TRIB2 Gene

  • This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for TRIB2 Gene

TRIB2 (Tribbles Pseudokinase 2) is a Protein Coding gene. Diseases associated with TRIB2 include Uveitis and Narcolepsy. Among its related pathways are DNA Damage and Wnt / Hedgehog / Notch. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TRIB1.

UniProtKB/Swiss-Prot for TRIB2 Gene

  • Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).

Gene Wiki entry for TRIB2 Gene

Additional gene information for TRIB2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIB2 Gene

Genomics for TRIB2 Gene

GeneHancer (GH) Regulatory Elements for TRIB2 Gene

Promoters and enhancers for TRIB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I012714 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.9 +1.8 1765 9.1 PKNOX1 ATF1 FOXA2 ARNT ZFP64 SIN3A ZNF2 ZNF48 YY1 GLIS2 TRIB2 MIR3125 ENSG00000261117
GH02I012168 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.4 -547.2 -547224 3 LEF1 EBF1 CEBPG ZNF644 RAD21 GATA3 ZNF766 ATF7 ZNF639 ZNF687 TRIB2 LPIN1 PIR50920 LOC105373433 MIR3681HG
GH02I012044 Enhancer 1.1 FANTOM5 Ensembl ENCODE 10.3 -671.2 -671166 2.9 EBF1 BATF IRF4 RELA POLR2A ETV6 IKZF2 RUNX3 ZNF687 ZBED1 TRIB2 MIR3681HG GC02M012031 ENSG00000238503 GC02P012005 LOC105373433
GH02I012428 Enhancer 1.1 Ensembl ENCODE 10.1 -287.1 -287058 3.6 HDAC1 YBX3 HDGF PKNOX1 SMAD1 ARNT NFXL1 YBX1 ZBTB40 BATF TRIB2 RNU6-843P GC02M012412 LOC105373431 MIR3681HG
GH02I011822 Enhancer 0.8 ENCODE 10.7 -893.9 -893917 1.2 PKNOX1 FOXA2 ARID4B DNMT3B ZNF48 RARA SP5 ZNF217 NFIL3 KLF16 ENSG00000230790 LPIN1 TRIB2 LOC105373430 MIR548S
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIB2 gene promoter:

Genomic Locations for TRIB2 Gene

Genomic Locations for TRIB2 Gene
25,863 bases
Plus strand

Genomic View for TRIB2 Gene

Genes around TRIB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIB2 Gene

Proteins for TRIB2 Gene

  • Protein details for TRIB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tribbles homolog 2
    Protein Accession:
    Secondary Accessions:
    • B2R851
    • D6W510

    Protein attributes for TRIB2 Gene

    343 amino acids
    Molecular mass:
    38801 Da
    Quaternary structure:
    • Interacts with RFWD2 (PubMed:27041596).
    • Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis.

neXtProt entry for TRIB2 Gene

Post-translational modifications for TRIB2 Gene

Other Protein References for TRIB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIB2 Gene

Domains & Families for TRIB2 Gene

Gene Families for TRIB2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for TRIB2 Gene

Suggested Antigen Peptide Sequences for TRIB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
genes like me logo Genes that share domains with TRIB2: view

Function for TRIB2 Gene

Molecular function for TRIB2 Gene

UniProtKB/Swiss-Prot Function:
Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).

Phenotypes From GWAS Catalog for TRIB2 Gene

Gene Ontology (GO) - Molecular Function for TRIB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 NOT nucleotide binding ISS --
GO:0004672 NOT protein kinase activity ISS --
GO:0004860 protein kinase inhibitor activity IEA --
GO:0005524 ATP binding IEA --
GO:0008134 transcription factor binding IEA,ISS 17576771
genes like me logo Genes that share ontologies with TRIB2: view
genes like me logo Genes that share phenotypes with TRIB2: view

Animal Models for TRIB2 Gene

MGI Knock Outs for TRIB2:

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIB2 Gene

Localization for TRIB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIB2 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=May associate with the cytoskeleton. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIB2 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm ISS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TRIB2: view

Pathways & Interactions for TRIB2 Gene

genes like me logo Genes that share pathways with TRIB2: view

Pathways by source for TRIB2 Gene

3 Cell Signaling Technology pathways for TRIB2 Gene

Gene Ontology (GO) - Biological Process for TRIB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 NOT protein phosphorylation ISS,IEA --
GO:0006469 negative regulation of protein kinase activity NAS 12791994
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA,ISS 20410507
GO:0043405 regulation of MAP kinase activity IBA,ISS --
GO:0045081 negative regulation of interleukin-10 biosynthetic process IMP 18643775
genes like me logo Genes that share ontologies with TRIB2: view

No data available for SIGNOR curated interactions for TRIB2 Gene

Drugs & Compounds for TRIB2 Gene

No Compound Related Data Available

Transcripts for TRIB2 Gene

Unigene Clusters for TRIB2 Gene

Tribbles homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2: -

Relevant External Links for TRIB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TRIB2 Gene:


SOURCE GeneReport for Unigene cluster for TRIB2 Gene:


mRNA Expression by UniProt/SwissProt for TRIB2 Gene:

Tissue specificity: Highly expressed in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for TRIB2 Gene

  • Nervous system(4.5)
  • Bone(4)
genes like me logo Genes that share expression patterns with TRIB2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIB2 Gene

Orthologs for TRIB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIB2 33 34
  • 99.9 (n)
(Canis familiaris)
Mammalia TRIB2 33 34
  • 95.82 (n)
(Bos Taurus)
Mammalia TRIB2 33 34
  • 94.46 (n)
(Monodelphis domestica)
Mammalia TRIB2 34
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia TRIB2 34
  • 94 (a)
(Mus musculus)
Mammalia Trib2 33 16 34
  • 91.64 (n)
(Gallus gallus)
Aves TRIB2 33 34
  • 84.16 (n)
(Anolis carolinensis)
Reptilia TRIB2 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trib2 33
  • 80.41 (n)
(Danio rerio)
Actinopterygii trib2 33 34
  • 72.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta trbl 33 34
  • 53.45 (n)
(Caenorhabditis elegans)
Secernentea nipi-3 34
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8356 34
  • 38 (a)
Species where no ortholog for TRIB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIB2 Gene

Gene Tree for TRIB2 (if available)
Gene Tree for TRIB2 (if available)

Paralogs for TRIB2 Gene

Paralogs for TRIB2 Gene

genes like me logo Genes that share paralogs with TRIB2: view

Variants for TRIB2 Gene

Sequence variations from dbSNP and Humsavar for TRIB2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000000040 -- 12,732,231(+) A/C intron_variant
rs1000050370 -- 12,733,681(+) G/A intron_variant
rs1000109832 -- 12,725,980(+) A/G intron_variant
rs1000214854 -- 12,716,724(+) C/G/T upstream_transcript_variant
rs1000265700 -- 12,717,032(+) C/T 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIB2 Gene

Variant ID Type Subtype PubMed ID
esv3589832 CNV loss 21293372

Variation tolerance for TRIB2 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIB2 Gene

Disorders for TRIB2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIB2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards
Search TRIB2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRIB2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRIB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIB2 Gene

Publications for TRIB2 Gene

  1. Tribbles-1 and -2 are tumour suppressors, down-regulated in human acute myeloid leukaemia. (PMID: 20005259) Gilby DC … Kiss-Toth E (Immunology letters 2010) 3 22 58
  2. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick DM … Bierut L (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  3. Human tribbles homologue 2 is expressed in unstable regions of carotid plaques and regulates macrophage IL-10 in vitro. (PMID: 18643775) Deng J … Davis B (Clinical science (London, England : 1979) 2009) 3 22 58
  4. Survival factor withdrawal-induced apoptosis of TF-1 cells involves a TRB2-Mcl-1 axis-dependent pathway. (PMID: 17545167) Lin KR … Yen JJ (The Journal of biological chemistry 2007) 3 22 58
  5. Tribbles: novel regulators of cell function; evolutionary aspects. (PMID: 16715410) Hegedus Z … Kiss-Toth E (Cellular and molecular life sciences : CMLS 2006) 2 3 58

Products for TRIB2 Gene

  • Addgene plasmids for TRIB2

Sources for TRIB2 Gene

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