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Aliases for TRIB2 Gene

Aliases for TRIB2 Gene

  • Tribbles Pseudokinase 2 2 3 5
  • TRB2 3 4
  • Tribbles Homolog 2 (Drosophila) 2
  • GS3955 3
  • TRB-2 4
  • C5FW 3

External Ids for TRIB2 Gene

Previous GeneCards Identifiers for TRIB2 Gene

  • GC02P012879
  • GC02P012807
  • GC02P012856

Summaries for TRIB2 Gene

Entrez Gene Summary for TRIB2 Gene

  • This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for TRIB2 Gene

TRIB2 (Tribbles Pseudokinase 2) is a Protein Coding gene. Diseases associated with TRIB2 include Uveitis and Narcolepsy. Among its related pathways are NF-kappaB Signaling and DNA Damage. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK40.

UniProtKB/Swiss-Prot for TRIB2 Gene

  • Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).

Gene Wiki entry for TRIB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIB2 Gene

Genomics for TRIB2 Gene

Regulatory Elements for TRIB2 Gene

Enhancers for TRIB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIB2 on UCSC Golden Path with GeneCards custom track

Promoters for TRIB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIB2 Gene

Chromosome:
2
Start:
12,716,872 bp from pter
End:
12,742,734 bp from pter
Size:
25,863 bases
Orientation:
Plus strand

Genomic View for TRIB2 Gene

Genes around TRIB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIB2 Gene

Proteins for TRIB2 Gene

  • Protein details for TRIB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92519-TRIB2_HUMAN
    Recommended name:
    Tribbles homolog 2
    Protein Accession:
    Q92519
    Secondary Accessions:
    • B2R851
    • D6W510

    Protein attributes for TRIB2 Gene

    Size:
    343 amino acids
    Molecular mass:
    38801 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis.

neXtProt entry for TRIB2 Gene

Proteomics data for TRIB2 Gene at MOPED

Post-translational modifications for TRIB2 Gene

  • Ubiquitination at Lys 20
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIB2 Gene

Domains & Families for TRIB2 Gene

Gene Families for TRIB2 Gene

Protein Domains for TRIB2 Gene

Suggested Antigen Peptide Sequences for TRIB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92519

UniProtKB/Swiss-Prot:

TRIB2_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
genes like me logo Genes that share domains with TRIB2: view

Function for TRIB2 Gene

Molecular function for TRIB2 Gene

UniProtKB/Swiss-Prot Function:
Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).

Gene Ontology (GO) - Molecular Function for TRIB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0031434 mitogen-activated protein kinase kinase binding IBA --
genes like me logo Genes that share ontologies with TRIB2: view
genes like me logo Genes that share phenotypes with TRIB2: view

Animal Models for TRIB2 Gene

MGI Knock Outs for TRIB2:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRIB2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIB2 Gene

Localization for TRIB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIB2 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=May associate with the cytoskeleton. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIB2 Gene COMPARTMENTS Subcellular localization image for TRIB2 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for TRIB2 Gene

Pathways & Interactions for TRIB2 Gene

genes like me logo Genes that share pathways with TRIB2: view

Pathways by source for TRIB2 Gene

3 Cell Signaling Technology pathways for TRIB2 Gene

Gene Ontology (GO) - Biological Process for TRIB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045081 negative regulation of interleukin-10 biosynthetic process IMP 18643775
GO:1904030 negative regulation of cyclin-dependent protein kinase activity IEA --
genes like me logo Genes that share ontologies with TRIB2: view

No data available for SIGNOR curated interactions for TRIB2 Gene

Drugs & Compounds for TRIB2 Gene

No Compound Related Data Available

Transcripts for TRIB2 Gene

Unigene Clusters for TRIB2 Gene

Tribbles homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2: -
SP3:

Relevant External Links for TRIB2 Gene

GeneLoc Exon Structure for
TRIB2
ECgene alternative splicing isoforms for
TRIB2

Expression for TRIB2 Gene

mRNA expression in normal human tissues for TRIB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for TRIB2 Gene Hs.467751

mRNA Expression by UniProt/SwissProt for TRIB2 Gene

Q92519-TRIB2_HUMAN
Tissue specificity: Highly expressed in peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with TRIB2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TRIB2 Gene

Orthologs for TRIB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIB2 35
  • 94.46 (n)
  • 99.13 (a)
TRIB2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIB2 35
  • 95.82 (n)
  • 99.71 (a)
TRIB2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trib2 35
  • 91.64 (n)
  • 98.25 (a)
Trib2 16
Trib2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIB2 35
  • 99.9 (n)
  • 99.71 (a)
TRIB2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIB2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIB2 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIB2 35
  • 84.16 (n)
  • 95.63 (a)
TRIB2 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIB2 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trib2 35
  • 80.41 (n)
  • 89.47 (a)
zebrafish
(Danio rerio)
Actinopterygii trib2 35
  • 72.22 (n)
  • 78.65 (a)
trib2 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta trbl 35
  • 53.45 (n)
  • 43.97 (a)
trbl 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nipi-3 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8356 36
  • 38 (a)
OneToMany
Species with no ortholog for TRIB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIB2 Gene

ENSEMBL:
Gene Tree for TRIB2 (if available)
TreeFam:
Gene Tree for TRIB2 (if available)

Paralogs for TRIB2 Gene

Paralogs for TRIB2 Gene

genes like me logo Genes that share paralogs with TRIB2: view

Variants for TRIB2 Gene

Sequence variations from dbSNP and Humsavar for TRIB2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs55813198 - 12,718,318(+) CATAC(A/G)CAGGT intron-variant, reference, missense
rs509761 -- 12,718,076(-) ACTCG(A/G)GTCTT intron-variant, utr-variant-5-prime
rs1803386 -- 12,740,780(+) TGGAC(C/T)CTTTC nc-transcript-variant, reference, missense
rs1803387 -- 12,742,435(+) GGAGG(A/G)CGGCT nc-transcript-variant, utr-variant-3-prime
rs1803388 -- 12,742,193(+) TCTAT(A/T)GCTGT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRIB2 Gene

Variant ID Type Subtype PubMed ID
dgv4056n71 CNV Loss 21882294
nsv873666 CNV Loss 21882294

Variation tolerance for TRIB2 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIB2 Gene

Disorders for TRIB2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIB2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
uveitis
narcolepsy
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards
Search TRIB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRIB2

Genetic Association Database (GAD)
TRIB2
Human Genome Epidemiology (HuGE) Navigator
TRIB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIB2
genes like me logo Genes that share disorders with TRIB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIB2 Gene

Publications for TRIB2 Gene

  1. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick D.M. … Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48 67
  2. Tribbles-1 and -2 are tumour suppressors, down-regulated in human acute myeloid leukaemia. (PMID: 20005259) Gilby D.C. … Kiss-Toth E. (Immunol. Lett. 2010) 3 23
  3. Human tribbles homologue 2 is expressed in unstable regions of carotid plaques and regulates macrophage IL-10 in vitro. (PMID: 18643775) Deng J. … Davis B. (Clin. Sci. 2009) 3 23
  4. Survival factor withdrawal-induced apoptosis of TF-1 cells involves a TRB2-Mcl-1 axis-dependent pathway. (PMID: 17545167) Lin K.R. … Yen J.J. (J. Biol. Chem. 2007) 3 23
  5. Tribbles: novel regulators of cell function; evolutionary aspects. (PMID: 16715410) Hegedus Z. … Kiss-Toth E. (Cell. Mol. Life Sci. 2006) 2 3

Products for TRIB2 Gene

Sources for TRIB2 Gene

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