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Aliases for TRIB2 Gene

Aliases for TRIB2 Gene

  • Tribbles Pseudokinase 2 2 3
  • TRB2 3 4
  • Tribbles Homolog 2 (Drosophila) 2
  • Tribbles Homolog 2 3
  • GS3955 3
  • TRB-2 4
  • C5FW 3

External Ids for TRIB2 Gene

Summaries for TRIB2 Gene

Entrez Gene Summary for TRIB2 Gene

  • This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for TRIB2 Gene

TRIB2 (Tribbles Pseudokinase 2) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and protein kinase activity. An important paralog of this gene is NUAK1.

UniProtKB/Swiss-Prot for TRIB2 Gene

  • Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).

Gene Wiki entry for TRIB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIB2 Gene

Genomics for TRIB2 Gene

Genomic Location for TRIB2 Gene

12,716,872 bp from pter
12,742,734 bp from pter
25,863 bases
Plus strand

Genomic View for TRIB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIB2 Gene

Regulatory Elements for TRIB2 Gene

Proteins for TRIB2 Gene

  • Protein details for TRIB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tribbles homolog 2
    Protein Accession:
    Secondary Accessions:
    • B2R851
    • D6W510

    Protein attributes for TRIB2 Gene

    343 amino acids
    Molecular mass:
    38801 Da
    Quaternary structure:
    No Data Available
    • Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis

neXtProt entry for TRIB2 Gene

Proteomics data for TRIB2 Gene at MOPED

Post-translational modifications for TRIB2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys20

Other Protein References for TRIB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIB2 Gene

Domains for TRIB2 Gene

Gene Families for TRIB2 Gene

Protein Domains for TRIB2 Gene

Suggested Antigen Peptide Sequences for TRIB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The protein kinase domain is predicted to be catalytically inactive:
    • Q92519
  • Contains 1 protein kinase domain.:
    • Q92519
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.:
    • Q92519
genes like me logo Genes that share domains with TRIB2: view

Function for TRIB2 Gene

Molecular function for TRIB2 Gene

UniProtKB/Swiss-Prot Function: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).

Gene Ontology (GO) - Molecular Function for TRIB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 NOT nucleotide binding ISS --
GO:0004672 NOT protein kinase activity ISS --
GO:0004713 protein tyrosine kinase activity --
GO:0004860 protein kinase inhibitor activity IEA --
GO:0005524 ATP binding --
genes like me logo Genes that share ontologies with TRIB2: view
genes like me logo Genes that share phenotypes with TRIB2: view

Animal Models for TRIB2 Gene

MGI Knock Outs for TRIB2:

miRNA for TRIB2 Gene

miRTarBase miRNAs that target TRIB2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TRIB2 Gene

Localization for TRIB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIB2 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=May associate with the cytoskeleton. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TRIB2 Gene COMPARTMENTS Subcellular localization image for TRIB2 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for TRIB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm ISS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TRIB2: view

Pathways for TRIB2 Gene

SuperPathways for TRIB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 NOT protein phosphorylation ISS --
GO:0006469 negative regulation of protein kinase activity NAS 12791994
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS 20410507
GO:0043405 regulation of MAP kinase activity ISS --
GO:0045081 negative regulation of interleukin-10 biosynthetic process IMP 18643775
genes like me logo Genes that share ontologies with TRIB2: view

No data available for Pathways by source for TRIB2 Gene

Transcripts for TRIB2 Gene

mRNA/cDNA for TRIB2 Gene

Unigene Clusters for TRIB2 Gene

Tribbles homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2: -

Relevant External Links for TRIB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIB2 Gene

mRNA expression in normal human tissues for TRIB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for TRIB2 Gene Hs.467751

mRNA Expression by UniProt/SwissProt for TRIB2 Gene

Tissue specificity: Highly expressed in peripheral blood leukocytes.
genes like me logo Genes that share expressions with TRIB2: view

No data available for mRNA differential expression in normal tissues and Protein expression for TRIB2 Gene

Orthologs for TRIB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIB2 35
  • 99.9 (n)
  • 99.71 (a)
TRIB2 36
  • 100 (a)
(Bos Taurus)
Mammalia TRIB2 35
  • 94.46 (n)
  • 99.13 (a)
TRIB2 36
  • 99 (a)
(Canis familiaris)
Mammalia TRIB2 35
  • 95.82 (n)
  • 99.71 (a)
TRIB2 36
  • 100 (a)
(Mus musculus)
Mammalia Trib2 35
  • 91.64 (n)
  • 98.25 (a)
Trib2 16
Trib2 36
  • 98 (a)
(Monodelphis domestica)
Mammalia TRIB2 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia TRIB2 36
  • 94 (a)
(Gallus gallus)
Aves TRIB2 35
  • 84.16 (n)
  • 95.63 (a)
TRIB2 36
  • 96 (a)
(Anolis carolinensis)
Reptilia TRIB2 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trib2 35
  • 80.41 (n)
  • 89.47 (a)
(Danio rerio)
Actinopterygii trib2 35
  • 72.22 (n)
  • 78.65 (a)
trib2 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta trbl 35
  • 53.45 (n)
  • 43.97 (a)
trbl 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea nipi-3 36
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8356 36
  • 38 (a)
Species with no ortholog for TRIB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIB2 Gene

Gene Tree for TRIB2 (if available)
Gene Tree for TRIB2 (if available)

Paralogs for TRIB2 Gene

Paralogs for TRIB2 Gene

genes like me logo Genes that share paralogs with TRIB2: view

Variants for TRIB2 Gene

Sequence variations from dbSNP and Humsavar for TRIB2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1176 -- 12,741,400(-) CCAGG(A/C)TATTA utr-variant-3-prime, nc-transcript-variant
rs16350 -- 12,742,700(-) ATTGA(-/AG)AGATT utr-variant-3-prime, nc-transcript-variant
rs509761 -- 12,718,076(-) ACTCG(A/G)GTCTT utr-variant-5-prime, intron-variant
rs890069 -- 12,727,378(-) CAGGC(A/G)AGCGA intron-variant
rs1035677 -- 12,742,189(-) CAATA(C/G)AAAAG utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIB2 Gene

Variant ID Type Subtype PubMed ID
dgv4056n71 CNV Loss 21882294
nsv873666 CNV Loss 21882294

Relevant External Links for TRIB2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIB2 Gene

Disorders for TRIB2 Gene

Relevant External Links for TRIB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TRIB2: view

No data available for UniProtKB/Swiss-Prot for TRIB2 Gene

Publications for TRIB2 Gene

  1. Survival factor withdrawal-induced apoptosis of TF-1 cells involves a TRB2-Mcl-1 axis-dependent pathway. (PMID: 17545167) Lin K.R. … Yen J.J. (J. Biol. Chem. 2007) 3 23
  2. Human tribbles homologue 2 is expressed in unstable regions of carotid plaques and regulates macrophage IL-10 in vitro. (PMID: 18643775) Deng J. … Davis B. (Clin. Sci. 2009) 3 23
  3. Tribbles-1 and -2 are tumour suppressors, down-regulated in human acute myeloid leukaemia. (PMID: 20005259) Gilby D.C. … Kiss-Toth E. (Immunol. Lett. 2010) 3 23
  4. Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. (PMID: 15299019) Kiss-Toth E. … Dower S.K. (J. Biol. Chem. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TRIB2 Gene

  • Addgene plasmids for TRIB2

Sources for TRIB2 Gene

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