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Aliases for GRIA3 Gene

Aliases for GRIA3 Gene

  • Glutamate Receptor, Ionotropic, AMPA 3 2 3
  • Glutamate Receptor, Ionotrophic, AMPA 3 2 3
  • AMPA-Selective Glutamate Receptor 3 3 4
  • GLUR-K3 3 4
  • GLUR-C 3 4
  • GluR-3 3 4
  • GLUR3 3 4
  • GLURC 3 4
  • GluA3 3 4
  • Glutamate Receptor Ionotropic, AMPA 3 4
  • Glutamate Receptor Subunit 3 3
  • Glutamate Receptor C 3
  • DJ1171F9.1 3
  • MRX94 3

External Ids for GRIA3 Gene

Previous HGNC Symbols for GRIA3 Gene

  • GLUR3

Previous GeneCards Identifiers for GRIA3 Gene

  • GC0XP117035
  • GC0XP119211
  • GC0XP120270
  • GC0XP121015
  • GC0XP122044
  • GC0XP122145
  • GC0XP122318
  • GC0XP111704

Summaries for GRIA3 Gene

Entrez Gene Summary for GRIA3 Gene

  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIA3 Gene

GRIA3 (Glutamate Receptor, Ionotropic, AMPA 3) is a Protein Coding gene. Diseases associated with GRIA3 include x-linked intellectual disability due to gria3 anomalies and rasmussen encephalitis. Among its related pathways are CREB Pathway and Neuroscience. GO annotations related to this gene include ionotropic glutamate receptor activity and AMPA glutamate receptor activity. An important paralog of this gene is GRID2.

UniProtKB/Swiss-Prot for GRIA3 Gene

  • Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Tocris Summary for GRIA3 Gene

  • AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission and play a role in hippocampal synaptic long-term potentiation and depression.

Gene Wiki entry for GRIA3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIA3 Gene

Genomics for GRIA3 Gene

Regulatory Elements for GRIA3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GRIA3 Gene

Chromosome:
X
Start:
123,184,153 bp from pter
End:
123,490,915 bp from pter
Size:
306,763 bases
Orientation:
Plus strand

Genomic View for GRIA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRIA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIA3 Gene

Proteins for GRIA3 Gene

  • Protein details for GRIA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42263-GRIA3_HUMAN
    Recommended name:
    Glutamate receptor 3
    Protein Accession:
    P42263
    Secondary Accessions:
    • D3DTF1
    • Q4VXD5
    • Q4VXD6
    • Q9HDA0
    • Q9HDA1
    • Q9HDA2
    • Q9P0H1

    Protein attributes for GRIA3 Gene

    Size:
    894 amino acids
    Molecular mass:
    101157 Da
    Quaternary structure:
    • Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with PRKCABP, GRIP1 and GRIP2 (By similarity). Found in a complex with GRIA1, GRIA2, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 (By similarity).
    Miscellaneous:
    • The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate

    Alternative splice isoforms for GRIA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIA3 Gene

Proteomics data for GRIA3 Gene at MOPED

Post-translational modifications for GRIA3 Gene

  • Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-621 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-847 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
  • Glycosylation at Asn 63, Asn 266, Asn 380, Asn 415, and Asn 422
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIA3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GRIA3 (GluR3)

No data available for DME Specific Peptides for GRIA3 Gene

Domains & Families for GRIA3 Gene

Graphical View of Domain Structure for InterPro Entry

P42263

UniProtKB/Swiss-Prot:

GRIA3_HUMAN :
  • The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily.
Domain:
  • The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily.
genes like me logo Genes that share domains with GRIA3: view

Function for GRIA3 Gene

Molecular function for GRIA3 Gene

GENATLAS Biochemistry:
glutamate receptor,subunit 3,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class,with flip and flop isoforms,mediating the fast component of excitatory post synaptic currents in the central nervous system,interacting with and signaling through the protein-kinase LYN
UniProtKB/Swiss-Prot Function:
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Gene Ontology (GO) - Molecular Function for GRIA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity --
GO:0004971 AMPA glutamate receptor activity IDA 21172611
GO:0005234 extracellular-glutamate-gated ion channel activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GRIA3: view
genes like me logo Genes that share phenotypes with GRIA3: view

Animal Models for GRIA3 Gene

MGI Knock Outs for GRIA3:

Animal Model Products

miRNA for GRIA3 Gene

miRTarBase miRNAs that target GRIA3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIA3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GRIA3 Gene

Localization for GRIA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIA3 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIA3 Gene COMPARTMENTS Subcellular localization image for GRIA3 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for GRIA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IBA --
GO:0030666 endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with GRIA3: view

Pathways & Interactions for GRIA3 Gene

genes like me logo Genes that share pathways with GRIA3: view

PCR Array Products

Interacting Proteins for GRIA3 Gene

Selected Interacting proteins: P42263-GRIA3_HUMAN for GRIA3 Gene via I2D

Gene Ontology (GO) - Biological Process for GRIA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 1709304
GO:0007215 glutamate receptor signaling pathway TAS 1709304
GO:0007268 synaptic transmission TAS --
GO:0034220 ion transmembrane transport IBA --
GO:0035235 ionotropic glutamate receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GRIA3: view

No data available for SIGNOR curated interactions for GRIA3 Gene

Drugs & Compounds for GRIA3 Gene

(48) Drugs for GRIA3 Gene - From: NovoSeek, ApexBio, IUPHAR, DGIdb, PharmGKB, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclothiazide Approved Pharma Positive, Allosteric regulator, inhibitor 0
Ethanol Approved Pharma Target 1708
Lithium Approved Pharma Target, potentiator 206
Citalopram Approved Pharma 485
Venlafaxine Approved Pharma Dual serotonin/noradrenalin re-uptake inhibitor 181

(8) Additional Compounds for GRIA3 Gene - From: Tocris and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(R)-AMPA
83654-13-1
(RS)-AMPA
74341-63-2
(RS)-AMPA hydrobromide
171259-81-7
(S)-(-)-5-Fluorowillardiine
140187-23-1
(S)-AMPA
83643-88-3
genes like me logo Genes that share compounds with GRIA3: view

Transcripts for GRIA3 Gene

Unigene Clusters for GRIA3 Gene

Glutamate receptor, ionotropic, AMPA 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIA3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIA3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - -
SP5: - - -

Relevant External Links for GRIA3 Gene

GeneLoc Exon Structure for
GRIA3
ECgene alternative splicing isoforms for
GRIA3

Expression for GRIA3 Gene

mRNA expression in normal human tissues for GRIA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIA3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.2), Brain - Anterior cingulate cortex (BA24) (x6.2), Brain - Cortex (x5.8), Brain - Putamen (basal ganglia) (x4.7), Brain - Hippocampus (x4.6), and Brain - Nucleus accumbens (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for GRIA3 Gene

This gene is overexpressed in Nasal epithelium (37.0), Synovial fluid (15.2), and Frontal cortex (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRIA3 Gene



SOURCE GeneReport for Unigene cluster for GRIA3 Gene Hs.377070

genes like me logo Genes that share expression patterns with GRIA3: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GRIA3 Gene

Orthologs for GRIA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRIA3 35
  • 96.01 (n)
  • 99.66 (a)
GRIA3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRIA3 35
  • 95.79 (n)
  • 99.55 (a)
GRIA3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gria3 35
  • 95.08 (n)
  • 99.55 (a)
Gria3 16
Gria3 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRIA3 35
  • 99.89 (n)
  • 99.78 (a)
GRIA3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gria3 35
  • 94.67 (n)
  • 99.66 (a)
oppossum
(Monodelphis domestica)
Mammalia GRIA3 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIA3 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRIA3 35
  • 83.93 (n)
  • 95.05 (a)
GRIA3 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIA3 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gria3 35
  • 80.98 (n)
  • 91.66 (a)
zebrafish
(Danio rerio)
Actinopterygii gria3 35
gria3b 35
  • 77.54 (n)
  • 88 (a)
gria3a 36
  • 86 (a)
OneToMany
gria3b 36
  • 89 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15627 37
  • 33 (a)
CG4226 37
  • 29 (a)
CG9935 37
  • 40 (a)
Glu-RI 37
  • 42 (a)
Glu-RIB 37
  • 37 (a)
Glu-RIIA 37
  • 31 (a)
Glu-RIB 35
  • 53.46 (n)
  • 50.25 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006027 35
  • 52.76 (n)
  • 50.12 (a)
worm
(Caenorhabditis elegans)
Secernentea glr-1 37
  • 48 (a)
glr-4 37
  • 31 (a)
glr-1 35
  • 50.13 (n)
  • 43.38 (a)
Species with no ortholog for GRIA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIA3 Gene

ENSEMBL:
Gene Tree for GRIA3 (if available)
TreeFam:
Gene Tree for GRIA3 (if available)

Paralogs for GRIA3 Gene

Paralogs for GRIA3 Gene

(10) SIMAP similar genes for GRIA3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with GRIA3: view

Variants for GRIA3 Gene

Sequence variations from dbSNP and Humsavar for GRIA3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs16680 -- 123,236,564(-) GTTGT(-/TGT)ACTTG intron-variant
rs695214 -- 123,263,410(-) GGAGT(C/T)GACAA intron-variant
rs713282 -- 123,327,556(+) ATATG(C/T)CCCCA intron-variant
rs713283 -- 123,327,826(+) CCCTT(C/T)CCCCC intron-variant
rs970665 -- 123,311,420(-) TTACG(C/T)TCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIA3 Gene

Variant ID Type Subtype PubMed ID
nsv511653 CNV Loss 21212237
nsv512696 CNV Loss 21212237
esv2662475 CNV Deletion 23128226
esv22122 CNV Loss 19812545
esv2740445 CNV Deletion 23290073
nsv508797 CNV Insertion 20534489
nsv7067 CNV Insertion 18451855

Variation tolerance for GRIA3 Gene

Residual Variation Intolerance Score: 6.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRIA3 Gene

HapMap Linkage Disequilibrium report
GRIA3
Human Gene Mutation Database (HGMD)
GRIA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIA3 Gene

Disorders for GRIA3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for GRIA3 Gene - From: Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
x-linked intellectual disability due to gria3 anomalies
rasmussen encephalitis
  • re
canavan disease
  • spongy degeneration of central nervous system
auditory neuropathy
  • auditory dys-synchrony
disease of mental health
  • mental health
- elite association
Search GRIA3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GRIA3_HUMAN
  • Mental retardation, X-linked 94 (MRX94) [MIM:300699]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX94 patients have moderate mental retardation. Other variable features are macrocephaly, seizures, myoclonic jerks, autistic behavior, asthenic body habitus, distal muscle weakness and hyporeflexia. {ECO:0000269 PubMed:17989220}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GRIA3

Genetic Association Database (GAD)
GRIA3
Human Genome Epidemiology (HuGE) Navigator
GRIA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRIA3
genes like me logo Genes that share disorders with GRIA3: view

No data available for Genatlas for GRIA3 Gene

Publications for GRIA3 Gene

  1. Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation. (PMID: 10644433) Gecz J. … Mulley J.C. (Genomics 1999) 2 23 67
  2. Are astrocytes the missing link between lack of brain aspartoacylase activity and the spongiform leukodystrophy in Canavan disease? (PMID: 19319678) Baslow M.H. … Guilfoyle D.N. (Neurochem. Res. 2009) 23 67
  3. Skewed X chromosome inactivation in fraternal female twins results in moderately severe and mild haemophilia B. (PMID: 18540891) Okumura K. … Kojima T. (Haemophilia 2008) 23 67
  4. Pathophysiologic characteristics of balloon cells in cortical dysplasia. (PMID: 17899129) Oh H.S. … Kim S.U. (Childs Nerv Syst 2008) 23 67
  5. Expression of SV2 in the developing chick cerebellum: comparison with Calbindin and AMPA glutamate receptors 2/3. (PMID: 18384060) Grabs D. … Bergmann M. (Anat Rec (Hoboken) 2008) 23 67

Products for GRIA3 Gene

Sources for GRIA3 Gene

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