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Aliases for GPX4 Gene

Aliases for GPX4 Gene

  • Glutathione Peroxidase 4 2 3 4 5
  • Phospholipid Hydroperoxidase 2 3
  • EC 4 63
  • GSHPx-4 3 4
  • GPx-4 3 4
  • PHGPx 3 4
  • Glutathione Peroxidase 4 (Phospholipid Hydroperoxidase) 2
  • Sperm Nucleus Glutathione Peroxidase 3
  • EC 1.11.1 63
  • SnPHGPx 3
  • SnGPx 3
  • MCSP 3
  • SMDS 3

External Ids for GPX4 Gene

Previous GeneCards Identifiers for GPX4 Gene

  • GC19P001181
  • GC19P001043
  • GC19P001054
  • GC19P000878

Summaries for GPX4 Gene

Entrez Gene Summary for GPX4 Gene

  • This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for GPX4 Gene

GPX4 (Glutathione Peroxidase 4) is a Protein Coding gene. Diseases associated with GPX4 include Spondylometaphyseal Dysplasia Sedaghatian Type and Steatitis. Among its related pathways are Arachidonic acid metabolism and Glutathione metabolism. GO annotations related to this gene include glutathione peroxidase activity and glutathione binding. An important paralog of this gene is GPX5.

UniProtKB/Swiss-Prot for GPX4 Gene

  • Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.

Gene Wiki entry for GPX4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX4 Gene

Genomics for GPX4 Gene

Regulatory Elements for GPX4 Gene

Enhancers for GPX4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPX4 on UCSC Golden Path with GeneCards custom track

Promoters for GPX4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPX4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GPX4 gene promoter:

Genomic Location for GPX4 Gene

1,103,926 bp from pter
1,106,791 bp from pter
2,866 bases
Plus strand

Genomic View for GPX4 Gene

Genes around GPX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX4 Gene

Proteins for GPX4 Gene

  • Protein details for GPX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • O43381
    • Q6PJ59
    • Q9UPK2

    Protein attributes for GPX4 Gene

    197 amino acids
    Molecular mass:
    22175 Da
    Quaternary structure:
    • Monomer. Has a tendency to form higher mass oligomers.

    Three dimensional structures from OCA and Proteopedia for GPX4 Gene

    Alternative splice isoforms for GPX4 Gene


neXtProt entry for GPX4 Gene

Proteomics data for GPX4 Gene at MOPED

Post-translational modifications for GPX4 Gene

  • Ubiquitination at Lys 162 and Lys 167
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for GPX4 (Glutathione Peroxidase 4/GPX4)

Domains & Families for GPX4 Gene

Protein Domains for GPX4 Gene

Suggested Antigen Peptide Sequences for GPX4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glutathione peroxidase family.
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX4: view

No data available for Gene Families for GPX4 Gene

Function for GPX4 Gene

Molecular function for GPX4 Gene

GENATLAS Biochemistry:
glutathione peroxidase 4,expressed in testis,catabolic pathway of activated oxygen species,free radical detoxification
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H(2)O.
UniProtKB/Swiss-Prot Function:
Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.

Enzyme Numbers (IUBMB) for GPX4 Gene

genes like me logo Genes that share phenotypes with GPX4: view

Human Phenotype Ontology for GPX4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GPX4 Gene

MGI Knock Outs for GPX4:

Animal Model Products

miRNA for GPX4 Gene

miRTarBase miRNAs that target GPX4

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for GPX4 Gene

Localization for GPX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX4 Gene

Isoform Mitochondrial: Mitochondrion.
Isoform Cytoplasmic: Cytoplasm.

Subcellular locations from

Jensen Localization Image for GPX4 Gene COMPARTMENTS Subcellular localization image for GPX4 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 3
endoplasmic reticulum 2
lysosome 2
peroxisome 2
vacuole 2
chloroplast 1
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for GPX4 Gene

Pathways & Interactions for GPX4 Gene

genes like me logo Genes that share pathways with GPX4: view

Gene Ontology (GO) - Biological Process for GPX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0019369 arachidonic acid metabolic process TAS --
GO:0019372 lipoxygenase pathway TAS --
GO:0098869 cellular oxidant detoxification IEA,TAS 9705830
genes like me logo Genes that share ontologies with GPX4: view

No data available for SIGNOR curated interactions for GPX4 Gene

Drugs & Compounds for GPX4 Gene

(15) Drugs for GPX4 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target, cofactor 0
Selenocysteine Experimental Pharma 0
Selenium Pharma 168
Hydrogen peroxide Pharma 47

(45) Additional Compounds for GPX4 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoic acid
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
  • 15-Hydroperoxyicosatetraenoate
5(S)-Hydroperoxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-HETE
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoate
  • 5(S)-Hydroxyeicosatetraenoic acid
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-HPETE
genes like me logo Genes that share compounds with GPX4: view

Transcripts for GPX4 Gene

Unigene Clusters for GPX4 Gene

Glutathione peroxidase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPX4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5: -

Relevant External Links for GPX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPX4 Gene

mRNA expression in normal human tissues for GPX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPX4 Gene

This gene is overexpressed in Testis (x4.3).

Protein differential expression in normal tissues from HIPED for GPX4 Gene

This gene is overexpressed in Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPX4 Gene

SOURCE GeneReport for Unigene cluster for GPX4 Gene Hs.433951

mRNA Expression by UniProt/SwissProt for GPX4 Gene

Tissue specificity: Present primarily in testis.
genes like me logo Genes that share expression patterns with GPX4: view

Protein tissue co-expression partners for GPX4 Gene

Primer Products

Orthologs for GPX4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPX4 35
  • 89.17 (n)
  • 92.39 (a)
GPX4 36
  • 66 (a)
(Mus musculus)
Mammalia Gpx4 35
  • 83.42 (n)
  • 88.11 (a)
Gpx4 16
Gpx4 36
  • 66 (a)
(Rattus norvegicus)
Mammalia Gpx4 35
  • 86.13 (n)
  • 91.37 (a)
(Monodelphis domestica)
Mammalia GPX4 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia GPX4 36
  • 83 (a)
(Pan troglodytes)
Mammalia GPX4 36
  • 76 (a)
(Anolis carolinensis)
Reptilia GPX4 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpx4 35
  • 64.94 (n)
  • 67.36 (a)
Str.6328 35
(Danio rerio)
Actinopterygii gpx4b 35
  • 68.78 (n)
  • 69.84 (a)
gpx4a 36
  • 71 (a)
gpx4b 36
  • 77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.584 35
fruit fly
(Drosophila melanogaster)
Insecta CG12013 37
  • 44 (a)
CG15116 36
  • 34 (a)
PHGPx 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea F26E4.12 37
  • 48 (a)
R05H10.5 37
  • 48 (a)
T09A12.2 37
  • 44 (a)
T09A12.2 35
  • 50.1 (n)
  • 45.4 (a)
gpx-1 36
  • 44 (a)
gpx-2 36
  • 41 (a)
gpx-6 36
  • 40 (a)
gpx-7 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPX2 35
  • 50.54 (n)
  • 43.14 (a)
GPX1 36
  • 36 (a)
GPX2 36
  • 41 (a)
HYR1 36
  • 40 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GPX7 35
  • 54.47 (n)
  • 51.63 (a)
(Glycine max)
eudicotyledons Gma.2160 35
(Oryza sativa)
Liliopsida Os.4833 35
(Triticum aestivum)
Liliopsida Ta.5358 35
(Zea mays)
Liliopsida Zm.6203 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for GPX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GPX4 Gene

Gene Tree for GPX4 (if available)
Gene Tree for GPX4 (if available)

Paralogs for GPX4 Gene

Paralogs for GPX4 Gene

(3) SIMAP similar genes for GPX4 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with GPX4: view

Variants for GPX4 Gene

Sequence variations from dbSNP and Humsavar for GPX4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8178967 - 1,104,048(+) GATGA(A/G)CCTCG upstream-variant-2KB, reference, missense
rs76201145 - 1,105,691(+) AGTTC(A/G)CCGCG reference, missense
rs12978338 -- 1,106,800(+) TGCGT(A/G)GGGGC downstream-variant-500B
rs7508538 -- 1,102,373(+) aatta(C/G)ctggg upstream-variant-2KB
rs8103169 -- 1,103,415(+) gtcag(A/G)agttt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPX4 Gene

Variant ID Type Subtype PubMed ID
dgv3513n71 CNV Loss 21882294
dgv3552n71 CNV Loss 21882294
nsv910292 CNV Loss 21882294
nsv910310 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
nsv469845 CNV Loss 16826518
essv258 CNV CNV 17122850
nsv833704 CNV Gain 17160897
dgv1055e1 CNV Complex 17122850
dgv3569n71 CNV Loss 21882294
dgv3574n71 CNV Loss 21882294
dgv3575n71 CNV Loss 21882294
nsv470102 CNV Loss 18288195
dgv3579n71 CNV Loss 21882294
nsv910412 CNV Loss 21882294
nsv910413 CNV Gain 21882294
dgv3580n71 CNV Loss 21882294
nsv470103 CNV Gain 18288195
nsv828366 CNV Loss 20364138
dgv3581n71 CNV Loss 21882294
dgv3582n71 CNV Loss 21882294
nsv910420 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3584n71 CNV Loss 21882294
nsv828367 CNV Gain 20364138

Variation tolerance for GPX4 Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPX4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX4 Gene

Disorders for GPX4 Gene

MalaCards: The human disease database

(15) MalaCards diseases for GPX4 Gene - From: ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spondylometaphyseal dysplasia sedaghatian type
  • lethal metaphyseal dysplasia
spermatic cord torsion
  • testicular torsion
pthirus pubis infestation
  • crabs
  • sulfemoglobinemia
- elite association - COSMIC cancer census association via MalaCards
Search GPX4 in MalaCards View complete list of genes associated with diseases


  • Spondylometaphyseal dysplasia, Sedaghatian type (SMDS) [MIM:250220]: A form of spondylometaphyseal dysplasia, a group of short stature disorders distinguished by abnormalities in the vertebrae and the metaphyses of the tubular bones. SMDS is a neonatal lethal form characterized by severe metaphyseal chondrodysplasia with mild limb shortening, platyspondyly, cardiac conduction defects, and central nervous system abnormalities. {ECO:0000269 PubMed:24706940}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GPX4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPX4: view

No data available for Genatlas for GPX4 Gene

Publications for GPX4 Gene

  1. Genetic variations of gpx-4 and male infertility in humans. (PMID: 12606444) Maiorino M. … Flohe L. (Biol. Reprod. 2003) 3 4 23 48 67
  2. Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx). (PMID: 12751792) Moreno S.G. … Conrad M. (Biol. Chem. 2003) 23 25 26
  3. Dual function of the selenoprotein PHGPx during sperm maturation. (PMID: 10464096) Ursini F. … FlohAc L. (Science 1999) 2 3 23
  4. The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively. (PMID: 8287691) Chu F.F. (Cytogenet. Cell Genet. 1994) 2 3 23
  5. Genetic variants in selenoprotein genes increase risk of colorectal cancer. (PMID: 20378690) MAcplan C. … Hesketh J.E. (Carcinogenesis 2010) 3 23

Products for GPX4 Gene

Sources for GPX4 Gene