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Aliases for GPX3 Gene

Aliases for GPX3 Gene

  • Glutathione Peroxidase 3 2 3
  • Extracellular Glutathione Peroxidase 3 4
  • Glutathione Peroxidase 3 (Plasma) 2 3
  • Plasma Glutathione Peroxidase 3 4
  • EC 1.11.1.9 4 63
  • GSHPx-3 3 4
  • GSHPx-P 3 4
  • GPx-3 3 4
  • GPx-P 3 4
  • EC 1.11.1 63
  • GPXP 4

External Ids for GPX3 Gene

Previous GeneCards Identifiers for GPX3 Gene

  • GC05P150468
  • GC05P150429
  • GC05P150430
  • GC05P150381
  • GC05P145545

Summaries for GPX3 Gene

Entrez Gene Summary for GPX3 Gene

  • This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPX3 Gene

GPX3 (Glutathione Peroxidase 3) is a Protein Coding gene. Diseases associated with GPX3 include keshan disease. Among its related pathways are Cellular Senescence and Insulin secretion. GO annotations related to this gene include transcription factor binding and selenium binding. An important paralog of this gene is GPX4.

UniProtKB/Swiss-Prot for GPX3 Gene

  • Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione

Gene Wiki entry for GPX3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX3 Gene

Genomics for GPX3 Gene

Regulatory Elements for GPX3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPX3 Gene

Start:
151,020,438 bp from pter
End:
151,028,993 bp from pter
Size:
8,556 bases
Orientation:
Plus strand

Genomic View for GPX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX3 Gene

Proteins for GPX3 Gene

  • Protein details for GPX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22352-GPX3_HUMAN
    Recommended name:
    Glutathione peroxidase 3
    Protein Accession:
    P22352
    Secondary Accessions:
    • O43787
    • Q86W78
    • Q9NZ74
    • Q9UEL1

    Protein attributes for GPX3 Gene

    Size:
    226 amino acids
    Molecular mass:
    25552 Da
    Quaternary structure:
    • Homotetramer

    Three dimensional structures from OCA and Proteopedia for GPX3 Gene

neXtProt entry for GPX3 Gene

Proteomics data for GPX3 Gene at MOPED

Post-translational modifications for GPX3 Gene

Other Protein References for GPX3 Gene

Antibody Products

  • R&D Systems Antibodies for GPX3 (Glutathione Peroxidase 3/GPX3)

Domains for GPX3 Gene

Protein Domains for GPX3 Gene

Suggested Antigen Peptide Sequences for GPX3 Gene

Graphical View of Domain Structure for InterPro Entry

P22352

UniProtKB/Swiss-Prot:

GPX3_HUMAN :
  • P22352
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX3: view

No data available for Gene Families for GPX3 Gene

Function for GPX3 Gene

Molecular function for GPX3 Gene

GENATLAS Biochemistry: glutathione peroxidase 3,plasma,expressed in kidney,lung,breast,placenta,catabolic pathway of activated oxygen species,free radical detoxification
UniProtKB/Swiss-Prot CatalyticActivity: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O
UniProtKB/Swiss-Prot Function: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione

Enzyme Numbers (IUBMB) for GPX3 Gene

Gene Ontology (GO) - Molecular Function for GPX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004602 glutathione peroxidase activity IDA 1897960
GO:0005515 protein binding IPI 25416956
GO:0008134 transcription factor binding TAS 8056346
GO:0008430 selenium binding IDA 2491950
genes like me logo Genes that share ontologies with GPX3: view
genes like me logo Genes that share phenotypes with GPX3: view

Animal Models for GPX3 Gene

MGI Knock Outs for GPX3:

Animal Model Products

CRISPR Products

miRNA for GPX3 Gene

miRTarBase miRNAs that target GPX3

No data available for Transcription Factor Targeting and HOMER Transcription for GPX3 Gene

Localization for GPX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPX3 Gene COMPARTMENTS Subcellular localization image for GPX3 gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GPX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 1897960
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with GPX3: view

Pathways for GPX3 Gene

genes like me logo Genes that share pathways with GPX3: view

Pathways by source for GPX3 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for GPX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0006979 response to oxidative stress --
GO:0006982 response to lipid hydroperoxide TAS 2491950
GO:0042744 hydrogen peroxide catabolic process TAS 2491950
GO:0051289 protein homotetramerization IDA 3693360
genes like me logo Genes that share ontologies with GPX3: view

Compounds for GPX3 Gene

(11) HMDB Compounds for GPX3 Gene

Compound Synonyms Cas Number PubMed IDs
15(S)-HETE
  • 15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • 5-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
71774-08-8
5-HETE
  • 5(S)-HETE
70608-72-9
5-HPETE
  • 5(S)-HPETE
74581-83-2

(1) Drugbank Compounds for GPX3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glutathione
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8 target cofactor

(40) Novoseek inferred chemical compound relationships for GPX3 Gene

Compound -log(P) Hits PubMed IDs
selenium 85.4 57
ce-ooh 69.3 1
selenocysteine 67.6 2
selenomethionine 66.1 1
linoleic acid hydroperoxide 64.4 1
genes like me logo Genes that share compounds with GPX3: view

Transcripts for GPX3 Gene

Unigene Clusters for GPX3 Gene

Glutathione peroxidase 3 (plasma):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPX3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPX3 Gene

No ASD Table

Relevant External Links for GPX3 Gene

GeneLoc Exon Structure for
GPX3
ECgene alternative splicing isoforms for
GPX3

Expression for GPX3 Gene

mRNA expression in normal human tissues for GPX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPX3 Gene

This gene is overexpressed in Kidney - Cortex (9.2), Adipose - Visceral (Omentum) (4.3), and Adipose - Subcutaneous (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPX3 Gene

SOURCE GeneReport for Unigene cluster for GPX3 Gene Hs.386793

mRNA Expression by UniProt/SwissProt for GPX3 Gene

P22352-GPX3_HUMAN
Tissue specificity: Secreted in plasma
genes like me logo Genes that share expressions with GPX3: view

In Situ Assay Products

Orthologs for GPX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPX3 35
  • 100 (n)
  • 100 (a)
GPX3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPX3 35
  • 88.2 (n)
  • 88.05 (a)
GPX3 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPX3 35
  • 90.86 (n)
  • 92.04 (a)
GPX3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpx3 35
  • 87.02 (n)
  • 89.38 (a)
Gpx3 16
Gpx3 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPX3 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gpx3 35
  • 87.61 (n)
  • 90.71 (a)
chicken
(Gallus gallus)
Aves GPX3 35
  • 73.93 (n)
  • 71.29 (a)
GPX3 36
  • 66 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.22088 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gpx3 35
  • 65.32 (n)
  • 67.17 (a)
MGC75694 35
zebrafish
(Danio rerio)
Actinopterygii gpx3 35
  • 67.92 (n)
  • 66.67 (a)
gpx3 36
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C11E4.2 37
  • 43 (a)
C11E4.1 37
  • 42 (a)
Species with no ortholog for GPX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPX3 Gene

ENSEMBL:
Gene Tree for GPX3 (if available)
TreeFam:
Gene Tree for GPX3 (if available)

Paralogs for GPX3 Gene

Paralogs for GPX3 Gene

Selected SIMAP similar genes for GPX3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with GPX3: view

Variants for GPX3 Gene

Sequence variations from dbSNP and Humsavar for GPX3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs4661 -- 151,028,754(+) TGTGA(C/T)AGCAA utr-variant-3-prime
rs11548 -- 151,028,222(+) CATCA(C/T)AGACC utr-variant-3-prime
rs869975 -- 151,026,811(+) CCAGC(A/G)GCACA intron-variant
rs869976 -- 151,026,876(+) CCCAC(A/G)TCTGC intron-variant
rs870406 -- 151,021,040(-) GCGAC(C/T)CTCGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPX3 Gene

Variant ID Type Subtype PubMed ID
nsv526224 CNV Gain 19592680

Relevant External Links for GPX3 Gene

HapMap Linkage Disequilibrium report
GPX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX3 Gene

Disorders for GPX3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GPX3 Gene including...

Search for GPX3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for GPX3 Gene

(23) Novoseek inferred disease relationships for GPX3 Gene

Disease -log(P) Hits PubMed IDs
selenium deficiency 63.8 2
renal failure chronic 29.2 2
preeclampsia 25.7 2
cataract 15.1 4
aqueous humor 11.7 2

Relevant External Links for GPX3

Genetic Association Database (GAD)
GPX3
Human Genome Epidemiology (HuGE) Navigator
GPX3
genes like me logo Genes that share disorders with GPX3: view

No data available for UniProtKB/Swiss-Prot for GPX3 Gene

Publications for GPX3 Gene

  1. The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively. (PMID: 8287691) Chu F.F. (Cytogenet. Cell Genet. 1994) 2 3 23
  2. Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents. (PMID: 1339300) Chu F.-F. … Liu X.F. (Blood 1992) 3 4 23
  3. Characterization and partial amino acid sequence of human plasma glutathione peroxidase. (PMID: 1897960) Esworthy R.S. … Doroshow J.H. (Arch. Biochem. Biophys. 1991) 3 4 23
  4. Primary structure of human plasma glutathione peroxidase deduced from cDNA sequences. (PMID: 2229017) Takahashi K. … Koyama J. (J. Biochem. 1990) 3 4 23
  5. The human plasma glutathione peroxidase-encoding gene: organization, sequence and localization to chromosome 5q32. (PMID: 8056346) Yoshimura S. … Moriuchi T. (Gene 1994) 3 4 23

Products for GPX3 Gene

  • Addgene plasmids for GPX3

Sources for GPX3 Gene

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