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Aliases for GPS2 Gene

Aliases for GPS2 Gene

  • G Protein Pathway Suppressor 2 2 3 5
  • GPS-2 3 4
  • AMF-1 3

External Ids for GPS2 Gene

Previous GeneCards Identifiers for GPS2 Gene

  • GC17M007614
  • GC17M007945
  • GC17M007158
  • GC17M007416
  • GC17M007156
  • GC17M007215
  • GC17M007112

Summaries for GPS2 Gene

Entrez Gene Summary for GPS2 Gene

  • This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPS2 Gene

GPS2 (G Protein Pathway Suppressor 2) is a Protein Coding gene. Among its related pathways are Chromatin organization and HTLV-I infection. GO annotations related to this gene include transcription corepressor activity and GTPase inhibitor activity.

UniProtKB/Swiss-Prot for GPS2 Gene

  • Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Gene Wiki entry for GPS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPS2 Gene

Genomics for GPS2 Gene

Regulatory Elements for GPS2 Gene

Promoters for GPS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPS2 Gene

Chromosome:
17
Start:
7,311,324 bp from pter
End:
7,315,564 bp from pter
Size:
4,241 bases
Orientation:
Minus strand

Genomic View for GPS2 Gene

Genes around GPS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPS2 Gene

Proteins for GPS2 Gene

  • Protein details for GPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13227-GPS2_HUMAN
    Recommended name:
    G protein pathway suppressor 2
    Protein Accession:
    Q13227
    Secondary Accessions:
    • B4DXA1
    • Q6FHM8

    Protein attributes for GPS2 Gene

    Size:
    327 amino acids
    Molecular mass:
    36689 Da
    Quaternary structure:
    • Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.
    SequenceCaution:
    • Sequence=CAB75677.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GPS2 Gene

    Alternative splice isoforms for GPS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPS2 Gene

Proteomics data for GPS2 Gene at MOPED

Post-translational modifications for GPS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPS2 Gene

Antibody Products

No data available for DME Specific Peptides for GPS2 Gene

Domains & Families for GPS2 Gene

Protein Domains for GPS2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GPS2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GPS2 Gene

Function for GPS2 Gene

Molecular function for GPS2 Gene

UniProtKB/Swiss-Prot Function:
Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Gene Ontology (GO) - Molecular Function for GPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005095 GTPase inhibitor activity TAS 8943324
genes like me logo Genes that share ontologies with GPS2: view

Phenotypes for GPS2 Gene

MGI mutant phenotypes for GPS2:
inferred from 1 alleles
GenomeRNAi human phenotypes for GPS2:
genes like me logo Genes that share phenotypes with GPS2: view

Animal Models for GPS2 Gene

MGI Knock Outs for GPS2:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPS2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPS2 Gene

Localization for GPS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPS2 Gene COMPARTMENTS Subcellular localization image for GPS2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GPS2 Gene

Pathways & Interactions for GPS2 Gene

genes like me logo Genes that share pathways with GPS2: view

Pathways by source for GPS2 Gene

1 KEGG pathway for GPS2 Gene

Gene Ontology (GO) - Biological Process for GPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11931768
GO:0000188 inactivation of MAPK activity TAS 8943324
GO:0007254 JNK cascade TAS 8943324
GO:0034260 negative regulation of GTPase activity TAS 8943324
genes like me logo Genes that share ontologies with GPS2: view

No data available for SIGNOR curated interactions for GPS2 Gene

Drugs & Compounds for GPS2 Gene

No Compound Related Data Available

Transcripts for GPS2 Gene

Unigene Clusters for GPS2 Gene

G protein pathway suppressor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPS2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: - -
SP2:
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c · 24d ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b · 29c ^ 30a · 30b
SP1: - -
SP2: - - -
SP3:
SP4:
SP5: -
SP6: - - - -
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for GPS2 Gene

GeneLoc Exon Structure for
GPS2
ECgene alternative splicing isoforms for
GPS2

Expression for GPS2 Gene

mRNA expression in normal human tissues for GPS2 Gene

Protein differential expression in normal tissues from HIPED for GPS2 Gene

This gene is overexpressed in Ovary (39.6), CD4 Tcells (8.7), and Spleen (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPS2 Gene



SOURCE GeneReport for Unigene cluster for GPS2 Gene Hs.438219

mRNA Expression by UniProt/SwissProt for GPS2 Gene

Q13227-GPS2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with GPS2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for GPS2 Gene

Orthologs for GPS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPS2 35
  • 91.54 (n)
  • 98.47 (a)
GPS2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPS2 35
  • 90.01 (n)
  • 98.47 (a)
GPS2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gps2 35
  • 91.13 (n)
  • 97.55 (a)
Gps2 16
Gps2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPS2 35
  • 99.49 (n)
  • 100 (a)
GPS2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gps2 35
  • 91.13 (n)
  • 97.55 (a)
oppossum
(Monodelphis domestica)
Mammalia GPS2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPS2 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gps2 35
  • 69.33 (n)
  • 68 (a)
Str.4949 35
African clawed frog
(Xenopus laevis)
Amphibia gps2-prov 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
gps2 35
  • 66.25 (n)
  • 63.75 (a)
gps2 36
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2137 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9458 36
  • 33 (a)
OneToOne
Species with no ortholog for GPS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPS2 Gene

ENSEMBL:
Gene Tree for GPS2 (if available)
TreeFam:
Gene Tree for GPS2 (if available)

Paralogs for GPS2 Gene

(1) SIMAP similar genes for GPS2 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for GPS2 Gene

genes like me logo Genes that share paralogs with GPS2: view

No data available for Paralogs for GPS2 Gene

Variants for GPS2 Gene

Sequence variations from dbSNP and Humsavar for GPS2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_021972 -
rs870892 -- 7,313,409(-) TGCTG(C/T)GCATG reference, missense
rs2270981 -- 7,313,221(-) GGCTT(C/T)TCCGA reference, synonymous-codon
rs3215130 -- 7,314,179(-) TTGAC(-/C)TGTCT intron-variant
rs2292064 -- 7,314,144(-) ACCCT(A/C/G/T)ACATC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for GPS2 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
esv2665200 CNV Deletion 23128226
dgv3053n71 CNV Loss 21882294
nsv907637 CNV Loss 21882294
nsv1963 CNV Loss 18451855
nsv907641 CNV Loss 21882294
nsv509650 CNV Insertion 20534489
nsv907642 CNV Loss 21882294

Variation tolerance for GPS2 Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPS2 Gene

HapMap Linkage Disequilibrium report
GPS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPS2 Gene

Disorders for GPS2 Gene

Relevant External Links for GPS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPS2

No disorders were found for GPS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPS2 Gene

Publications for GPS2 Gene

  1. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. (PMID: 8943324) Spain B.H. … Colicelli J. (Mol. Cell. Biol. 1996) 2 3 4 67
  2. G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation. (PMID: 19858209) Cheng X. … Kao H.Y. (J. Biol. Chem. 2009) 3 23
  3. AMF1 (GPS2) modulates p53 transactivation. (PMID: 11486030) Peng Y.C. … Androphy E.J. (Mol. Cell. Biol. 2001) 3 23
  4. AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins. (PMID: 10846067) Peng Y.C. … Androphy E.J. (J. Virol. 2000) 3 23
  5. Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation. (PMID: 26070566) Huang J. … Perissi V. (J. Biol. Chem. 2015) 3

Products for GPS2 Gene

Sources for GPS2 Gene

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