Aliases for ANK2 Gene
External Ids for ANK2 Gene
Previous HGNC Symbols for ANK2 Gene
Previous GeneCards Identifiers for ANK2 Gene
This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]
GeneCards Summary for ANK2 Gene
ANK2 (Ankyrin 2, Neuronal) is a Protein Coding gene. Diseases associated with ANK2 include Cardiac Arrhythmia, Ankyrin-B-Related and Familial Long Qt Syndrome. Among its related pathways are Developmental Biology and Transport to the Golgi and subsequent modification. GO annotations related to this gene include protein kinase binding and structural constituent of cytoskeleton. An important paralog of this gene is TANC1.
UniProtKB/Swiss-Prot for ANK2 Gene
In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (By similarity). Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate.