Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GRK4 Gene

Aliases for GRK4 Gene

  • G Protein-Coupled Receptor Kinase 4 2 3
  • GPRK2L 3 4 6
  • GPRK4 3 4 6
  • EC 2.7.11.16 4 64
  • ITI1 3 4
  • G Protein-Coupled Receptor Kinase 2-Like (Drosophila) 2
  • G Protein-Coupled Receptor Kinase GRK4 4
  • EC 2.7.11 64
  • GRK4a 3
  • IT11 3

External Ids for GRK4 Gene

Previous Symbols for GRK4 Gene

  • GPRK2L

Summaries for GRK4 Gene

Entrez Gene Summary for GRK4 Gene

  • This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for GRK4 Gene

GRK4 (G Protein-Coupled Receptor Kinase 4) is a Protein Coding gene. Diseases associated with GRK4 include aortic coarctation. Among its related pathways are Endocytosis and Chemokine Signaling. GO annotations related to this gene include G-protein coupled receptor kinase activity and rhodopsin kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for GRK4 Gene

  • Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.

Gene Wiki entry for GRK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRK4 Gene

Genomics for GRK4 Gene

Genomic Location for GRK4 Gene

Start:
2,963,505 bp from pter
End:
3,040,747 bp from pter
Size:
77,243 bases
Orientation:
Plus strand

Genomic View for GRK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRK4 Gene

Regulatory Elements for GRK4 Gene

Proteins for GRK4 Gene

  • Protein details for GRK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32298-GRK4_HUMAN
    Recommended name:
    G protein-coupled receptor kinase 4
    Protein Accession:
    P32298
    Secondary Accessions:
    • O00641
    • O00642
    • Q13293
    • Q13294
    • Q13295
    • Q14453
    • Q14725
    • Q15313
    • Q15314
    • Q15315
    • Q15316
    • Q17RH6
    • Q53EQ8

    Protein attributes for GRK4 Gene

    Size:
    578 amino acids
    Molecular mass:
    66583 Da
    Quaternary structure:
    • Interacts with DRD3.

    Alternative splice isoforms for GRK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRK4 Gene

Proteomics data for GRK4 Gene at MOPED

Post-translational modifications for GRK4 Gene

Other Protein References for GRK4 Gene

Domains for GRK4 Gene

UniProtKB/Swiss-Prot:

GRK4_HUMAN
Domain:
  • Contains 1 AGC-kinase C-terminal domain.:
    • P32298
  • Contains 1 protein kinase domain.:
    • P32298
  • Contains 1 RGS domain.:
    • P32298
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.:
    • P32298
genes like me logo Genes that share domains with GRK4: view

Function for GRK4 Gene

Molecular function for GRK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by heparin.
UniProtKB/Swiss-Prot Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.

Enzyme Numbers (IUBMB) for GRK4 Gene

Gene Ontology (GO) - Molecular Function for GRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004703 G-protein coupled receptor kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with GRK4: view
genes like me logo Genes that share phenotypes with GRK4: view

Animal Models for GRK4 Gene

MGI Knock Outs for GRK4:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for GRK4 Gene

Localization for GRK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRK4 Gene

Cytoplasm. Cytoplasm, cell cortex. Note=Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRK4 Gene COMPARTMENTS Subcellular localization image for GRK4 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005938 cell cortex IEA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with GRK4: view

Pathways for GRK4 Gene

genes like me logo Genes that share pathways with GRK4: view

Gene Ontology (GO) - Biological Process for GRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway --
GO:0002031 G-protein coupled receptor internalization IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 1338872
genes like me logo Genes that share ontologies with GRK4: view

Compounds for GRK4 Gene

(6) Novoseek inferred chemical compound relationships for GRK4 Gene

Compound -log(P) Hits PubMed IDs
sodium 56.4 9
dopamine 50.8 4
baclofen 32 1
serine 21.6 1
glutamate 10.1 5

(1) PharmGKB related drug/compound annotations for GRK4 Gene

Drug/compound Annotation
metoprolol CA
genes like me logo Genes that share compounds with GRK4: view

Transcripts for GRK4 Gene

Unigene Clusters for GRK4 Gene

G protein-coupled receptor kinase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRK4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: -
SP7:
SP8:

Relevant External Links for GRK4 Gene

GeneLoc Exon Structure for
GRK4
ECgene alternative splicing isoforms for
GRK4

Expression for GRK4 Gene

mRNA expression in normal human tissues for GRK4 Gene

mRNA differential expression in normal tissues according to GTEx for GRK4 Gene

This gene is overexpressed in Testis (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRK4 Gene

SOURCE GeneReport for Unigene cluster for GRK4 Gene Hs.32959

mRNA Expression by UniProt/SwissProt for GRK4 Gene

P32298-GRK4_HUMAN
Tissue specificity: Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium.
genes like me logo Genes that share expressions with GRK4: view

Orthologs for GRK4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRK4 36
  • 99.37 (n)
  • 99.13 (a)
GRK4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRK4 36
  • 77.72 (n)
  • 77.66 (a)
GRK4 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRK4 36
  • 83.65 (n)
  • 79.41 (a)
GRK4 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grk4 36
  • 80.94 (n)
  • 75.7 (a)
Grk4 16
Grk4 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRK4 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRK4 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grk4 36
  • 81.07 (n)
  • 75.96 (a)
chicken
(Gallus gallus)
Aves GRK4 36
  • 75.28 (n)
  • 75.75 (a)
GRK4 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 56 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia grk4 36
  • 71.8 (n)
  • 76.71 (a)
zebrafish
(Danio rerio)
Actinopterygii grk4 36
  • 68.73 (n)
  • 75.62 (a)
grk4 37
  • 75 (a)
OneToMany
grk4 37
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Gprk2 37
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea grk-1 37
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9515 37
  • 58 (a)
OneToMany
Species with no ortholog for GRK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRK4 Gene

ENSEMBL:
Gene Tree for GRK4 (if available)
TreeFam:
Gene Tree for GRK4 (if available)

Paralogs for GRK4 Gene

genes like me logo Genes that share paralogs with GRK4: view

Variants for GRK4 Gene

Sequence variations from dbSNP and Humsavar for GRK4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs729826 -- 3,015,063(-) GGTGG(G/T)ATTTG intron-variant
rs732859 -- 3,031,916(-) GCCAC(G/T)GCCAG intron-variant
rs1008210 -- 3,036,385(-) TTCAT(A/C)CCCTC intron-variant
rs1010290 -- 3,031,455(-) CCTGC(A/G)CCGTC intron-variant
rs1024322 -- 3,004,788(-) ccaac(C/T)cctcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRK4 Gene

Variant ID Type Subtype PubMed ID
nsv461163 CNV Gain 19166990
nsv878453 CNV Loss 21882294
esv2662217 CNV Deletion 23128226
esv2726868 CNV Deletion 23290073
esv2661728 CNV Deletion 23128226

Relevant External Links for GRK4 Gene

HapMap Linkage Disequilibrium report
GRK4
Human Gene Mutation Database (HGMD)
GRK4

Disorders for GRK4 Gene

(1) MalaCards Diseases for GRK4 Gene

Search for GRK4 Gene in MalaCards »

(2) Novoseek inferred disease relationships for GRK4 Gene

Disease -log(P) Hits PubMed IDs
genetic hypertension 79.4 2
essential hypertension 61.6 10

Relevant External Links for GRK4

Genetic Association Database (GAD)
GRK4
Human Genome Epidemiology (HuGE) Navigator
GRK4
genes like me logo Genes that share disorders with GRK4: view

No data available for UniProtKB/Swiss-Prot for GRK4 Gene

Publications for GRK4 Gene

  1. G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells. (PMID: 9092566) Sallese M. … de Blasi A. (J. Biol. Chem. 1997) 3 4 23
  2. Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning. (PMID: 8135832) Sallese M. … de Blasi A. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  3. Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. (PMID: 8626439) Premont R.T. … Lefkowitz R.J. (J. Biol. Chem. 1996) 3 4 23
  4. Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers. (PMID: 12446468) Bengra C. … Felder R.A. (Clin. Chem. 2002) 3 23 49
  5. Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. (PMID: 15097232) Speirs H.J. … Morris B.J. (J. Hypertens. 2004) 3 23 49

Products for GRK4 Gene

  • Addgene plasmids for GRK4

Sources for GRK4 Gene

Back to Top

Content