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Aliases for P2RY8 Gene

Aliases for P2RY8 Gene

  • Purinergic Receptor P2Y8 2 3
  • Purinergic Receptor P2Y, G-Protein Coupled, 8 2 3 5
  • P2Y8 3 4
  • G-Protein Coupled Purinergic Receptor P2Y8 3

External Ids for P2RY8 Gene

Previous GeneCards Identifiers for P2RY8 Gene

  • GC00U990860
  • GC0XM001162
  • GC0XM001226
  • GC0YM001625
  • GC0XM001625

Summaries for P2RY8 Gene

Entrez Gene Summary for P2RY8 Gene

  • The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY8 Gene

P2RY8 (Purinergic Receptor P2Y8) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is GPR132.

UniProtKB/Swiss-Prot for P2RY8 Gene

  • Probable receptor for purines coupled to G-proteins.

Tocris Summary for P2RY8 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY8 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY8 Gene

Genomics for P2RY8 Gene

Regulatory Elements for P2RY8 Gene

Enhancers for P2RY8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around P2RY8 on UCSC Golden Path with GeneCards custom track

Promoters for P2RY8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around P2RY8 on UCSC Golden Path with GeneCards custom track

Genomic Location for P2RY8 Gene

1,462,572 bp from pter
1,537,506 bp from pter
74,935 bases
Minus strand

Genomic View for P2RY8 Gene

Genes around P2RY8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY8 Gene

Proteins for P2RY8 Gene

  • Protein details for P2RY8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    P2Y purinoceptor 8
    Protein Accession:

    Protein attributes for P2RY8 Gene

    359 amino acids
    Molecular mass:
    40635 Da
    Quaternary structure:
    No Data Available
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

neXtProt entry for P2RY8 Gene

Proteomics data for P2RY8 Gene at MOPED

Post-translational modifications for P2RY8 Gene

  • Ubiquitination at Lys 132
  • Glycosylation at Asn 5 and Asn 11
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for P2RY8 Gene

Domains & Families for P2RY8 Gene

Protein Domains for P2RY8 Gene

Suggested Antigen Peptide Sequences for P2RY8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY8: view

Function for P2RY8 Gene

Molecular function for P2RY8 Gene

UniProtKB/Swiss-Prot Function:
Probable receptor for purines coupled to G-proteins.
UniProtKB/Swiss-Prot Induction:
Down-regulated during granulocytic regulation.

Gene Ontology (GO) - Molecular Function for P2RY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY8: view
genes like me logo Genes that share phenotypes with P2RY8: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for P2RY8 Gene

Localization for P2RY8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for P2RY8 Gene COMPARTMENTS Subcellular localization image for P2RY8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for P2RY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with P2RY8: view

Pathways & Interactions for P2RY8 Gene

genes like me logo Genes that share pathways with P2RY8: view

Pathways by source for P2RY8 Gene

1 KEGG pathway for P2RY8 Gene

Interacting Proteins for P2RY8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000370697 for P2RY8 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for P2RY8 Gene


No data available for SIGNOR curated interactions for P2RY8 Gene

Drugs & Compounds for P2RY8 Gene

(1) Drugs for P2RY8 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MC-1 Investigational Pharma 0

(5) Additional Compounds for P2RY8 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Methylthioadenosine diphosphate trisodium salt
2-Methylthioadenosine triphosphate tetrasodium salt
MRS 2365
MRS 2693 trisodium salt
PSB 0474

(5) Tocris Compounds for P2RY8 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
2-Methylthioadenosine triphosphate tetrasodium salt P2 purinergic agonist 100020-57-3
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
genes like me logo Genes that share compounds with P2RY8: view

Transcripts for P2RY8 Gene

Unigene Clusters for P2RY8 Gene

Purinergic receptor P2Y, G-protein coupled, 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY8 Gene

No ASD Table

Relevant External Links for P2RY8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for P2RY8 Gene

mRNA expression in normal human tissues for P2RY8 Gene

mRNA differential expression in normal tissues according to GTEx for P2RY8 Gene

This gene is overexpressed in Whole Blood (x12.5) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for P2RY8 Gene

This gene is overexpressed in Monocytes (27.4), CD8 Tcells (15.2), CD4 Tcells (12.3), and Blymphocyte (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for P2RY8 Gene

SOURCE GeneReport for Unigene cluster for P2RY8 Gene Hs.111377

mRNA Expression by UniProt/SwissProt for P2RY8 Gene

Tissue specificity: Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain.
genes like me logo Genes that share expression patterns with P2RY8: view

Protein tissue co-expression partners for P2RY8 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for P2RY8 Gene

Orthologs for P2RY8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia P2RY8 35
  • 82.57 (n)
  • 80.86 (a)
P2RY8 36
  • 80 (a)
(Canis familiaris)
Mammalia P2RY8 35
  • 81.22 (n)
  • 78.87 (a)
P2RY8 36
  • 78 (a)
(Pan troglodytes)
Mammalia P2RY8 35
  • 99.26 (n)
  • 99.16 (a)
P2RY8 36
  • 99 (a)
(Monodelphis domestica)
Mammalia P2RY8 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia P2RY8 36
  • 62 (a)
(Gallus gallus)
Aves P2RY8 35
  • 61.7 (n)
  • 60.11 (a)
P2RY8 36
  • 60 (a)
(Anolis carolinensis)
Reptilia P2RY8 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487194 35
  • 52.94 (n)
  • 52.94 (a)
(Danio rerio)
Actinopterygii LOC566497 35
  • 58.1 (n)
  • 52.98 (a)
p2ry8 36
  • 50 (a)
Species with no ortholog for P2RY8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY8 Gene

Gene Tree for P2RY8 (if available)
Gene Tree for P2RY8 (if available)

Paralogs for P2RY8 Gene

Paralogs for P2RY8 Gene

(18) SIMAP similar genes for P2RY8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with P2RY8: view

Variants for P2RY8 Gene

Structural Variations from Database of Genomic Variants (DGV) for P2RY8 Gene

Variant ID Type Subtype PubMed ID
esv29996 CNV Loss 17803354
esv2739721 CNV Deletion 23290073
esv2662997 CNV Deletion 23128226
esv2739722 CNV Deletion 23290073
esv2667421 CNV Deletion 23128226
dgv1361e201 CNV Deletion 23290073
esv2739724 CNV Deletion 23290073
esv2739726 CNV Deletion 23290073
esv2739727 CNV Deletion 23290073
esv2660373 CNV Deletion 23128226
esv2294449 CNV Deletion 18987734
esv2665018 CNV Deletion 23128226
esv2739728 CNV Deletion 23290073
esv2674649 CNV Deletion 23128226
dgv1362e201 CNV Deletion 23290073
esv2739731 CNV Deletion 23290073
esv2676182 CNV Deletion 23128226
nsv510811 CNV Loss 20534489
nsv510871 CNV Loss 20534489

Variation tolerance for P2RY8 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.95; 74.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for P2RY8 Gene

Disorders for P2RY8 Gene

Relevant External Links for P2RY8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for P2RY8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for P2RY8 Gene

Publications for P2RY8 Gene

  1. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PMID: 11004484) Adrian K. … Ogilvie A. (Biochim. Biophys. Acta 2000) 2 3 4 67
  2. Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening. (PMID: 17487742) Fujiwara S. … Mano H. (Leuk. Lymphoma 2007) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia. (PMID: 22484421) Palmi C. … Te Kronnie G. (Leukemia 2012) 3
  5. Small sizes and indolent evolutionary dynamics challenge the potential role of P2RY8-CRLF2-harboring clones as main relapse-driving force in childhood ALL. (PMID: 23091296) Morak M. … Panzer-GrA1mayer R. (Blood 2012) 3

Products for P2RY8 Gene

Sources for P2RY8 Gene