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Aliases for P2RY8 Gene

Aliases for P2RY8 Gene

  • Purinergic Receptor P2Y, G-Protein Coupled, 8 2 3
  • P2Y8 3 4 6
  • G-Protein Coupled Purinergic Receptor P2Y8 3
  • P2Y Purinoceptor 8 3

External Ids for P2RY8 Gene

Summaries for P2RY8 Gene

Entrez Gene Summary for P2RY8 Gene

  • The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY8 Gene

P2RY8 (Purinergic Receptor P2Y, G-Protein Coupled, 8) is a Protein Coding gene. Diseases associated with P2RY8 include follicular lymphoma. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is GPR132.

UniProtKB/Swiss-Prot for P2RY8 Gene

  • Probable receptor for purines coupled to G-proteins

Tocris Summary for P2RY8 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10 receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4 receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13 and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They have diverse physiological roles including regulation of platelet aggregation, muscle contraction, neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY8 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY8 Gene

Genomics for P2RY8 Gene

Genomic Location for P2RY8 Gene

Start:
1,462,572 bp from pter
End:
1,537,144 bp from pter
Size:
74,573 bases
Orientation:
Minus strand

Genomic View for P2RY8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for P2RY8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY8 Gene

Regulatory Elements for P2RY8 Gene

Proteins for P2RY8 Gene

  • Protein details for P2RY8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VZ1-P2RY8_HUMAN
    Recommended name:
    P2Y purinoceptor 8
    Protein Accession:
    Q86VZ1
    Secondary Accessions:

    Protein attributes for P2RY8 Gene

    Size:
    359 amino acids
    Molecular mass:
    40635 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes

neXtProt entry for P2RY8 Gene

Proteomics data for P2RY8 Gene at MOPED

Post-translational modifications for P2RY8 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys132
  • Glycosylation at Asn5 and Asn11

Other Protein References for P2RY8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for P2RY8 Gene

Domains for P2RY8 Gene

Gene Families for P2RY8 Gene

HGNC:
  • PAR1 :Pseudoautosomal regions / PAR1
  • P2R :Purinergic receptors
  • P2RY :GPCR / Class A : Purinergic receptors, P2Y
IUPHAR :

Protein Domains for P2RY8 Gene

UniProtKB/Swiss-Prot:

P2RY8_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q86VZ1
genes like me logo Genes that share domains with P2RY8: view

Function for P2RY8 Gene

Molecular function for P2RY8 Gene

UniProtKB/Swiss-Prot Function: Probable receptor for purines coupled to G-proteins
UniProtKB/Swiss-Prot Induction: Down-regulated during granulocytic regulation

Gene Ontology (GO) - Molecular Function for P2RY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY8: view

Phenotypes for P2RY8 Gene

GenomeRNAi human phenotypes for P2RY8:
genes like me logo Genes that share phenotypes with P2RY8: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for P2RY8 Gene

Localization for P2RY8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RY8 Gene COMPARTMENTS Subcellular localization image for P2RY8 gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for P2RY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with P2RY8: view

Pathways for P2RY8 Gene

genes like me logo Genes that share pathways with P2RY8: view

Pathways by source for P2RY8 Gene

1 KEGG pathway for P2RY8 Gene

Interacting Proteins for P2RY8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000370697%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000370697 for P2RY8 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for P2RY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with P2RY8: view

Compounds for P2RY8 Gene

(5) Tocris Compounds for P2RY8 Gene

Compound Action Cas Number
alpha,beta-Methyleneadenosine 5-triphosphate trisodium salt P2 agonist [7292-42-4]
MRS 2179 tetrasodium salt Selective P2Y1 antagonist [101204-49-3]
MRS 2365 Highly potent and selective P2Y1 agonist [436847-09-5]
MRS 2500 tetraammonium salt Extremely potent and selective P2Y1 antagonist [630103-23-0]
UTPgammaS trisodium salt Selective P2Y2/4 agonist [1266569-94-1]
genes like me logo Genes that share compounds with P2RY8: view

Transcripts for P2RY8 Gene

Unigene Clusters for P2RY8 Gene

Purinergic receptor P2Y, G-protein coupled, 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY8 Gene

No ASD Table

Relevant External Links for P2RY8 Gene

GeneLoc Exon Structure for
P2RY8
ECgene alternative splicing isoforms for
P2RY8

Expression for P2RY8 Gene

mRNA expression in normal human tissues for P2RY8 Gene

mRNA differential expression in normal tissues according to GTEx for P2RY8 Gene

This gene is overexpressed in Whole Blood (12.5) and Spleen (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for P2RY8 Gene

SOURCE GeneReport for Unigene cluster for P2RY8 Gene Hs.111377

mRNA Expression by UniProt/SwissProt for P2RY8 Gene

Q86VZ1-P2RY8_HUMAN
Tissue specificity: Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain.
genes like me logo Genes that share expressions with P2RY8: view

Orthologs for P2RY8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY8 36
  • 99.26 (n)
  • 99.16 (a)
P2RY8 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia P2RY8 36
  • 82.57 (n)
  • 80.86 (a)
P2RY8 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY8 36
  • 81.22 (n)
  • 78.87 (a)
P2RY8 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia P2RY8 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia P2RY8 37
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves P2RY8 36
  • 61.7 (n)
  • 60.11 (a)
P2RY8 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia P2RY8 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487194 36
  • 52.94 (n)
  • 52.94 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC566497 36
  • 58.1 (n)
  • 52.98 (a)
p2ry8 37
  • 50 (a)
OneToOne
Species with no ortholog for P2RY8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY8 Gene

ENSEMBL:
Gene Tree for P2RY8 (if available)
TreeFam:
Gene Tree for P2RY8 (if available)

Paralogs for P2RY8 Gene

Paralogs for P2RY8 Gene

Selected SIMAP similar genes for P2RY8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with P2RY8: view

Variants for P2RY8 Gene

Structural Variations from Database of Genomic Variants (DGV) for P2RY8 Gene

Variant ID Type Subtype PubMed ID
esv29996 CNV Loss 17803354
esv2739721 CNV Deletion 23290073
esv2662997 CNV Deletion 23128226
esv2739722 CNV Deletion 23290073
esv2667421 CNV Deletion 23128226
dgv1361e201 CNV Deletion 23290073
esv2739724 CNV Deletion 23290073
esv2739726 CNV Deletion 23290073
esv2739727 CNV Deletion 23290073
esv2660373 CNV Deletion 23128226
esv2294449 CNV Deletion 18987734
esv2665018 CNV Deletion 23128226
esv2739728 CNV Deletion 23290073
esv2674649 CNV Deletion 23128226
dgv1362e201 CNV Deletion 23290073
esv2739731 CNV Deletion 23290073
esv2676182 CNV Deletion 23128226
nsv510811 CNV Loss 20534489
nsv510871 CNV Loss 20534489

Relevant External Links for P2RY8 Gene

HapMap Linkage Disequilibrium report
P2RY8
Locus Specific Mutation Databases (LSDB)
P2RY8

No data available for Sequence variations from dbSNP and Humsavar for P2RY8 Gene

Disorders for P2RY8 Gene

(1) MalaCards Diseases for P2RY8 Gene

Search for P2RY8 Gene in MalaCards »

(2) University of Copenhagen DISEASES for P2RY8 Gene

genes like me logo Genes that share disorders with P2RY8: view

No data available for UniProtKB/Swiss-Prot for P2RY8 Gene

Publications for P2RY8 Gene

  1. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PMID: 11004484) Adrian K. … Ogilvie A. (Biochim. Biophys. Acta 2000) 2 3 4
  2. Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening. (PMID: 17487742) Fujiwara S. … Mano H. (Leuk. Lymphoma 2007) 3 23
  3. Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males. (PMID: 15466006) Cantagrel V. … Villard L. (J. Med. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for P2RY8 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate P2RY8
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for P2RY8
    • Block miRNA regulation of P2RY8 using miScript Target Protectors

    Sources for P2RY8 Gene

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