Aliases for P2RY8 Gene
External Ids for P2RY8 Gene
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]
GeneCards Summary for P2RY8 Gene
P2RY8 (Purinergic Receptor P2Y, G-Protein Coupled, 8) is a Protein Coding gene. Diseases associated with P2RY8 include follicular lymphoma. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is GPR132.
UniProtKB/Swiss-Prot for P2RY8 Gene
Probable receptor for purines coupled to G-proteins
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10 receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4 receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13 and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They have diverse physiological roles including regulation of platelet aggregation, muscle contraction, neurotransmission, and epithelial cell communication and migration.