Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DLL1 Gene

Aliases for DLL1 Gene

  • Delta-Like 1 (Drosophila) 2 3 5
  • Drosophila Delta Homolog 1 3 4
  • H-Delta-1 3 4
  • Delta1 3 4
  • Delta (Drosophila)-Like 1 2
  • Delta 3
  • DL1 3

External Ids for DLL1 Gene

Previous GeneCards Identifiers for DLL1 Gene

  • GC06M169786
  • GC06M170206
  • GC06M170447
  • GC06M170508
  • GC06M168099
  • GC06M170591

Summaries for DLL1 Gene

Entrez Gene Summary for DLL1 Gene

  • DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]

GeneCards Summary for DLL1 Gene

DLL1 (Delta-Like 1 (Drosophila)) is a Protein Coding gene. Diseases associated with DLL1 include Microform Holoprosencephaly and Septopreoptic Holoprosencephaly. Among its related pathways are Signaling by NOTCH1 and NOTCH2 Activation and Transmission of Signal to the Nucleus. GO annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is JAG1.

UniProtKB/Swiss-Prot for DLL1 Gene

  • Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:11006133). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (By similarity). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:11581320). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway. At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway. Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis. Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell. Plays a role in immune systeme development, namely the development of all T cells and marginal zone (MZ) B cells (By similarity). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (PubMed:11581320). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation. Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression. During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression. Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium. Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels. During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression. Controls sprouting angiogenesis and subsequent vertical branch formation througth regulation on tip cell differentiation. Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine. Plays a role during inner ear development; negatively regulates auditory hair cell differentiation. Plays a role during nephron development through Notch signaling pathway. Regulates growth, blood pressure and energy homeostasis (By similarity).

Gene Wiki entry for DLL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLL1 Gene

Genomics for DLL1 Gene

Regulatory Elements for DLL1 Gene

Enhancers for DLL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DLL1 on UCSC Golden Path with GeneCards custom track

Promoters for DLL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DLL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DLL1 Gene

Chromosome:
6
Start:
170,282,200 bp from pter
End:
170,306,565 bp from pter
Size:
24,366 bases
Orientation:
Minus strand

Genomic View for DLL1 Gene

Genes around DLL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLL1 Gene

Proteins for DLL1 Gene

  • Protein details for DLL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00548-DLL1_HUMAN
    Recommended name:
    Delta-like protein 1
    Protein Accession:
    O00548
    Secondary Accessions:
    • B2RAK7
    • B5M0B3
    • Q9NU41
    • Q9UJV2

    Protein attributes for DLL1 Gene

    Size:
    723 amino acids
    Molecular mass:
    78056 Da
    Quaternary structure:
    • Homodimer. Interacts with TJP1. Interacts with MAGI1 (via PDZ domain); forms a complex with CTNNB1 and CDH2 and promotes recruitment to the adherens junction and stabilization on the cell surface. Interacts with PSEN1; undergoes a presenilin-dependent gamma-secretase cleavage that releases a Dll1-intracellular form. Interacts with MFAP5. Interacts with MIB1. Interacts with NEURL1B; leads to ubiquitination. Interacts with NEURL1 (By similarity). Interacts with SYNJ2BP; enhances DLL1 protein stability, and promotes Notch signaling in endothelial cells (PubMed:24025447). Interacts with MAGI1, MAGI2, MAGI3 and MPDZ (PubMed:15509766). Interacts (via ubiquitin) with EPN1 (via IUM domain); binding with NOTCH1 attached to neighboring cell, promotes ligand ubiquitination and EPN1 interaction, leading to NECD transendocytosis and Notch signaling (By similarity).

    Three dimensional structures from OCA and Proteopedia for DLL1 Gene

    Alternative splice isoforms for DLL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLL1 Gene

Proteomics data for DLL1 Gene at MOPED

Post-translational modifications for DLL1 Gene

  • O-fucosylated. Can be elongated to a disaccharide by MFNG.
  • Phosphorylated in a membrane association-dependent manner. Phosphorylation at Ser-697 requires the presence of Ser-694, whereas phosphorylation at Ser-694 occurs independently of the other site. Phosphorylation is required for full ligand activity in vitro and affects surface presentation, ectodomain shedding, and endocytosis.
  • Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation (By similarity). Ubiquitinated; promotes recycling back to the plasma membrane and confers a strong affinity for NOTCH1. Multi-ubiquitination of LYS-613 by MIB1 promotes both cis and trans-interaction with NOTCH1, as well as activation of Notch signaling. Ubiquitinated by NEURL1B (By similarity).
  • Glycosylation at Asn 477
  • Modification sites at PhosphoSitePlus

Other Protein References for DLL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DLL1 (DLL1)
  • Abcam antibodies for DLL1

No data available for DME Specific Peptides for DLL1 Gene

Domains & Families for DLL1 Gene

Suggested Antigen Peptide Sequences for DLL1 Gene

Graphical View of Domain Structure for InterPro Entry

O00548

UniProtKB/Swiss-Prot:

DLL1_HUMAN :
  • Contains 1 DSL domain.
Domain:
  • Contains 1 DSL domain.
  • Contains 8 EGF-like domains.
genes like me logo Genes that share domains with DLL1: view

No data available for Gene Families for DLL1 Gene

Function for DLL1 Gene

Molecular function for DLL1 Gene

UniProtKB/Swiss-Prot Function:
Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:11006133). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (By similarity). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:11581320). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway. At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway. Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis. Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell. Plays a role in immune systeme development, namely the development of all T cells and marginal zone (MZ) B cells (By similarity). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (PubMed:11581320). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation. Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression. During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression. Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium. Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels. During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression. Controls sprouting angiogenesis and subsequent vertical branch formation througth regulation on tip cell differentiation. Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine. Plays a role during inner ear development; negatively regulates auditory hair cell differentiation. Plays a role during nephron development through Notch signaling pathway. Regulates growth, blood pressure and energy homeostasis (By similarity).

LifeMap Function Summary for DLL1 Gene

During embryonic development, DLL1 as signaling molecule is secreted from the following cells
genes like me logo Genes that share phenotypes with DLL1: view

Human Phenotype Ontology for DLL1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DLL1 Gene

MGI Knock Outs for DLL1:

Animal Model Products

miRNA for DLL1 Gene

miRTarBase miRNAs that target DLL1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for DLL1 Gene

Localization for DLL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLL1 Gene

Apical cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction. Membrane raft. Note=Distributed around adherens junction in the apical endfeet through interactions with MAGI1. {ECO:0000250 UniProtKB:Q61483}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLL1 Gene COMPARTMENTS Subcellular localization image for DLL1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DLL1 Gene

Pathways & Interactions for DLL1 Gene

genes like me logo Genes that share pathways with DLL1: view

SIGNOR curated interactions for DLL1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for DLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001709 cell fate determination NAS 11581320
GO:0001756 somitogenesis IEA,ISS --
GO:0001757 somite specification IEA --
GO:0001947 heart looping IEA,ISS --
GO:0002315 marginal zone B cell differentiation IEA,ISS --
genes like me logo Genes that share ontologies with DLL1: view

Drugs & Compounds for DLL1 Gene

No Compound Related Data Available

Transcripts for DLL1 Gene

Unigene Clusters for DLL1 Gene

Delta-like 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for DLL1 Gene

GeneLoc Exon Structure for
DLL1
ECgene alternative splicing isoforms for
DLL1

Expression for DLL1 Gene

mRNA expression in normal human tissues for DLL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLL1 Gene

This gene is overexpressed in Spleen (x5.2).

SOURCE GeneReport for Unigene cluster for DLL1 Gene Hs.379912

mRNA Expression by UniProt/SwissProt for DLL1 Gene

O00548-DLL1_HUMAN
Tissue specificity: Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.
genes like me logo Genes that share expression patterns with DLL1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DLL1 Gene

Orthologs for DLL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DLL1 35
  • 87.75 (n)
  • 89.6 (a)
DLL1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLL1 35
  • 89.07 (n)
  • 90.92 (a)
DLL1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dll1 35
  • 85.3 (n)
  • 88.77 (a)
Dll1 16
Dll1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DLL1 35
  • 99.49 (n)
  • 100 (a)
DLL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dll1 35
  • 85.2 (n)
  • 89.36 (a)
oppossum
(Monodelphis domestica)
Mammalia DLL1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DLL1 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves DLL1 35
  • 81.96 (n)
  • 84.94 (a)
DLL1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLL1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dll1 35
  • 72.98 (n)
  • 77.99 (a)
Str.15072 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52561 35
zebrafish
(Danio rerio)
Actinopterygii dld 35
  • 70.25 (n)
  • 72.31 (a)
dla 36
  • 60 (a)
OneToMany
dlb 36
  • 53 (a)
OneToMany
dlc 36
  • 50 (a)
OneToMany
dld 36
  • 70 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3500 35
fruit fly
(Drosophila melanogaster)
Insecta C901 37
  • 32 (a)
CG15388 37
  • 38 (a)
Dl 37
  • 47 (a)
Dl 35
  • 57.12 (n)
  • 51.09 (a)
Dl 36
  • 35 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010265 35
  • 53.97 (n)
  • 50.31 (a)
worm
(Caenorhabditis elegans)
Secernentea apx-1 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
CSA.7799 36
  • 34 (a)
ManyToMany
Species with no ortholog for DLL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DLL1 Gene

ENSEMBL:
Gene Tree for DLL1 (if available)
TreeFam:
Gene Tree for DLL1 (if available)

Paralogs for DLL1 Gene

Paralogs for DLL1 Gene

(4) SIMAP similar genes for DLL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DLL1: view

Variants for DLL1 Gene

Sequence variations from dbSNP and Humsavar for DLL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs16901311 - 170,283,949(+) GTCCA(C/T)GTTGT reference, missense
rs1028487 -- 170,281,792(-) CAGAC(G/T)GGGCG downstream-variant-500B
rs1033582 -- 170,283,094(-) AGCAT(C/T)TGAAA reference, missense
rs1033583 -- 170,282,835(-) TTAAA(A/C)TAAGT utr-variant-3-prime
rs1546949 -- 170,284,614(-) GGTGC(C/T)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLL1 Gene

Variant ID Type Subtype PubMed ID
nsv823936 CNV Gain 20364138
dgv7054n71 CNV Loss 21882294
nsv887028 CNV Loss 21882294
nsv887030 CNV Loss 21882294
nsv464226 CNV Loss 19166990
dgv2040e1 CNV Complex 17122850
esv344 CNV CNV 17122850
nsv428158 CNV Gain 18775914
nsv823937 CNV Gain 20364138

Variation tolerance for DLL1 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLL1 Gene

Human Gene Mutation Database (HGMD)
DLL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLL1 Gene

Disorders for DLL1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for DLL1 Gene - From: Orphanet and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search DLL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DLL1

Genetic Association Database (GAD)
DLL1
Human Genome Epidemiology (HuGE) Navigator
DLL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DLL1
genes like me logo Genes that share disorders with DLL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLL1 Gene

Publications for DLL1 Gene

  1. Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. (PMID: 11006133) Shimizu K. … Hirai H. (Biochem. Biophys. Res. Commun. 2000) 3 4 23 67
  2. Notch1 induces enhanced expression of Delta-like-1 in the U251MG glioma cell line. (PMID: 19724883) Qian C.F. … You Y.P. (Int. J. Mol. Med. 2009) 3 23
  3. MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface. (PMID: 15908431) Mizuhara E. … Takai Y. (J. Biol. Chem. 2005) 3 23
  4. Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells. (PMID: 15976178) Delaney C. … Bernstein I.D. (Blood 2005) 3 23
  5. The intracellular domain of Notch ligand Delta1 induces cell growth arrest. (PMID: 16225865) Kolev V. … Prudovsky I. (FEBS Lett. 2005) 3 23

Products for DLL1 Gene

Sources for DLL1 Gene

Content