Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NKIRAS2 Gene

Aliases for NKIRAS2 Gene

  • NFKB Inhibitor Interacting Ras Like 2 2 3
  • NFKB Inhibitor Interacting Ras-Like 2 2 3 5
  • NFKB Inhibitor Interacting Ras-Like Protein 2 2 3
  • I-Kappa-B-Interacting Ras-Like Protein 2 3 4
  • Kappa B-Ras Protein 2 3 4
  • KappaB-Ras2 3 4
  • KBRAS2 3 4

External Ids for NKIRAS2 Gene

Previous GeneCards Identifiers for NKIRAS2 Gene

  • GC17P040546
  • GC17P037422
  • GC17P040170
  • GC17P035934

Summaries for NKIRAS2 Gene

GeneCards Summary for NKIRAS2 Gene

NKIRAS2 (NFKB Inhibitor Interacting Ras Like 2) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is NKIRAS1.

UniProtKB/Swiss-Prot for NKIRAS2 Gene

  • Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).

Gene Wiki entry for NKIRAS2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKIRAS2 Gene

Genomics for NKIRAS2 Gene

Regulatory Elements for NKIRAS2 Gene

Genomic Location for NKIRAS2 Gene

Chromosome:
17
Start:
42,011,382 bp from pter
End:
42,025,644 bp from pter
Size:
14,263 bases
Orientation:
Plus strand

Genomic View for NKIRAS2 Gene

Genes around NKIRAS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKIRAS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKIRAS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKIRAS2 Gene

Proteins for NKIRAS2 Gene

  • Protein details for NKIRAS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYR9-KBRS2_HUMAN
    Recommended name:
    NF-kappa-B inhibitor-interacting Ras-like protein 2
    Protein Accession:
    Q9NYR9
    Secondary Accessions:
    • A6NCZ5
    • B3KNN0
    • B4DNM3
    • Q6PK52
    • Q96KC7
    • Q9NSX1

    Protein attributes for NKIRAS2 Gene

    Size:
    191 amino acids
    Molecular mass:
    21508 Da
    Quaternary structure:
    • Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo.
    SequenceCaution:
    • Sequence=BAB55006.1; Type=Miscellaneous discrepancy; Note=Absence of residues from position 133 within an exon that change the frame which is not the result of an alternative splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for NKIRAS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NKIRAS2 Gene

Proteomics data for NKIRAS2 Gene at MOPED

Post-translational modifications for NKIRAS2 Gene

  • Ubiquitination at Lys 167 and Lys 174
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NKIRAS2 Gene

Domains & Families for NKIRAS2 Gene

Gene Families for NKIRAS2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYR9

UniProtKB/Swiss-Prot:

KBRS2_HUMAN :
  • In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
  • Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
Domain:
  • In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
Family:
  • Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
genes like me logo Genes that share domains with NKIRAS2: view

Function for NKIRAS2 Gene

Molecular function for NKIRAS2 Gene

UniProtKB/Swiss-Prot Function:
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).
genes like me logo Genes that share phenotypes with NKIRAS2: view

Animal Models for NKIRAS2 Gene

MGI Knock Outs for NKIRAS2:

Animal Model Products

miRNA for NKIRAS2 Gene

miRTarBase miRNAs that target NKIRAS2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NKIRAS2 Gene

Localization for NKIRAS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKIRAS2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKIRAS2 Gene COMPARTMENTS Subcellular localization image for NKIRAS2 gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for NKIRAS2 Gene

Pathways & Interactions for NKIRAS2 Gene

genes like me logo Genes that share pathways with NKIRAS2: view

Pathways by source for NKIRAS2 Gene

1 BioSystems pathway for NKIRAS2 Gene
1 Qiagen pathway for NKIRAS2 Gene

Gene Ontology (GO) - Biological Process for NKIRAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with NKIRAS2: view

No data available for SIGNOR curated interactions for NKIRAS2 Gene

Drugs & Compounds for NKIRAS2 Gene

(1) Drugs for NKIRAS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with NKIRAS2: view

Transcripts for NKIRAS2 Gene

Unigene Clusters for NKIRAS2 Gene

NFKB inhibitor interacting Ras-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKIRAS2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
SP1: - - - -
SP2: - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - -

Relevant External Links for NKIRAS2 Gene

GeneLoc Exon Structure for
NKIRAS2
ECgene alternative splicing isoforms for
NKIRAS2

Expression for NKIRAS2 Gene

mRNA expression in normal human tissues for NKIRAS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NKIRAS2 Gene

This gene is overexpressed in Gallbladder (16.3), Fetal testis (9.3), Placenta (8.9), and Fetal Brain (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NKIRAS2 Gene



SOURCE GeneReport for Unigene cluster for NKIRAS2 Gene Hs.632252

mRNA Expression by UniProt/SwissProt for NKIRAS2 Gene

Q9NYR9-KBRS2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with NKIRAS2: view

Protein tissue co-expression partners for NKIRAS2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NKIRAS2 Gene

Orthologs for NKIRAS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKIRAS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKIRAS2 36
  • 100 (a)
OneToOne
NKIRAS2 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia NKIRAS2 36
  • 100 (a)
OneToOne
NKIRAS2 35
  • 93.19 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia NKIRAS2 35
  • 92.67 (n)
  • 100 (a)
NKIRAS2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkiras2 16
Nkiras2 35
  • 90.92 (n)
  • 98.95 (a)
Nkiras2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NKIRAS2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NKIRAS2 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nkiras2 35
  • 90.75 (n)
  • 98.95 (a)
chicken
(Gallus gallus)
Aves NKIRAS2 35
  • 82.37 (n)
  • 92.67 (a)
NKIRAS2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NKIRAS2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nkiras2 35
  • 75.84 (n)
  • 81.48 (a)
zebrafish
(Danio rerio)
Actinopterygii nkiras2 36
  • 77 (a)
OneToMany
nkiras2 36
  • 77 (a)
OneToMany
LOC100538046 35
  • 73.68 (n)
  • 78.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta kappaB-Ras 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F52A8.6 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for NKIRAS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NKIRAS2 Gene

ENSEMBL:
Gene Tree for NKIRAS2 (if available)
TreeFam:
Gene Tree for NKIRAS2 (if available)

Paralogs for NKIRAS2 Gene

Paralogs for NKIRAS2 Gene

genes like me logo Genes that share paralogs with NKIRAS2: view

Variants for NKIRAS2 Gene

Sequence variations from dbSNP and Humsavar for NKIRAS2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11540538 -- 42,024,111(+) TCCCC(A/C)TCCCA utr-variant-3-prime
rs34627459 -- 42,023,519(+) GTGGT(A/G)TGGAA intron-variant
rs141074120 -- 42,023,767(+) GTGTC(A/G)GTGGC reference, synonymous-codon, utr-variant-3-prime
rs147962346 -- 42,023,702(+) AGCGG(C/T)GTGTA reference, synonymous-codon, missense
rs146933261 -- 42,023,772(+) AGTGG(C/T)GGACC reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NKIRAS2 Gene

Variant ID Type Subtype PubMed ID
nsv908240 CNV Loss 21882294

Variation tolerance for NKIRAS2 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKIRAS2 Gene

HapMap Linkage Disequilibrium report
NKIRAS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKIRAS2 Gene

Disorders for NKIRAS2 Gene

Relevant External Links for NKIRAS2

Genetic Association Database (GAD)
NKIRAS2
Human Genome Epidemiology (HuGE) Navigator
NKIRAS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKIRAS2

No disorders were found for NKIRAS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKIRAS2 Gene

Publications for NKIRAS2 Gene

  1. A subclass of Ras proteins that regulate the degradation of IkappaB. (PMID: 10657303) Fenwick C. … Ghosh S. (Science 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. miR-125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas. (PMID: 24901050) Haemmig S. … Vassella E. (Cell Death Dis 2014) 3
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for NKIRAS2 Gene

Sources for NKIRAS2 Gene

Back to Top

Content