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Aliases for ANGPT2 Gene

Aliases for ANGPT2 Gene

  • Angiopoietin 2 2 3 5
  • ANG-2 3 4
  • Angiopoietin-2B 3
  • Angiopoietin-2a 3
  • Tie2-Ligand 3
  • AGPT2 3
  • ANG2 3

External Ids for ANGPT2 Gene

Previous GeneCards Identifiers for ANGPT2 Gene

  • GC08M006424
  • GC08M006614
  • GC08M006347
  • GC08M006139

Summaries for ANGPT2 Gene

Entrez Gene Summary for ANGPT2 Gene

  • The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANGPT2 Gene

ANGPT2 (Angiopoietin 2) is a Protein Coding gene. Diseases associated with ANGPT2 include placenta accreta and anca-associated vasculitis. Among its related pathways are Platelet activation, signaling and aggregation and ERK Signaling. GO annotations related to this gene include receptor binding and receptor tyrosine kinase binding. An important paralog of this gene is FGB.

UniProtKB/Swiss-Prot for ANGPT2 Gene

  • Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

Gene Wiki entry for ANGPT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPT2 Gene

Genomics for ANGPT2 Gene

Regulatory Elements for ANGPT2 Gene

Genomic Location for ANGPT2 Gene

Chromosome:
8
Start:
6,499,651 bp from pter
End:
6,563,409 bp from pter
Size:
63,759 bases
Orientation:
Minus strand

Genomic View for ANGPT2 Gene

Genes around ANGPT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPT2 Gene

Proteins for ANGPT2 Gene

  • Protein details for ANGPT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15123-ANGP2_HUMAN
    Recommended name:
    Angiopoietin-2
    Protein Accession:
    O15123
    Secondary Accessions:
    • A0AV38
    • A8K205
    • B7ZLM7
    • Q9NRR7
    • Q9P2Y7

    Protein attributes for ANGPT2 Gene

    Size:
    496 amino acids
    Molecular mass:
    56919 Da
    Quaternary structure:
    • Interacts with TEK/TIE2, competing for the same binding site as ANGPT1.

    Three dimensional structures from OCA and Proteopedia for ANGPT2 Gene

    Alternative splice isoforms for ANGPT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANGPT2 Gene

Proteomics data for ANGPT2 Gene at MOPED

Post-translational modifications for ANGPT2 Gene

  • Glycosylation at Asn 89, Asn 119, Asn 133, Asn 151, Asn 240, and Asn 304
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGPT2 Gene

Antibody Products

  • R&D Systems Antibodies for ANGPT2 (Angiopoietin-2)
  • Cell Signaling Technology (CST) Antibodies for ANGPT2 (ANGPT2)

Protein Products

  • Enzo Life Sciences proteins for ANGPT2

No data available for DME Specific Peptides for ANGPT2 Gene

Domains & Families for ANGPT2 Gene

Gene Families for ANGPT2 Gene

Suggested Antigen Peptide Sequences for ANGPT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15123

UniProtKB/Swiss-Prot:

ANGP2_HUMAN :
  • The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.
Domain:
  • The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ANGPT2: view

Function for ANGPT2 Gene

Molecular function for ANGPT2 Gene

GENATLAS Biochemistry:
angiopoietin 1,75kDa,secreted ligand,for the vascular endothelial restricted receptor tyrosine kinase TEK,including phosphorylation of TEK,expressed only at sites of vascular remodeling in adult,antagonizing ANGPT1 by blocking its ability to activate its ligand
UniProtKB/Swiss-Prot Function:
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

LifeMap Function Summary for ANGPT2 Gene

During embryonic development, ANGPT2 as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for ANGPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 9204896
genes like me logo Genes that share ontologies with ANGPT2: view
genes like me logo Genes that share phenotypes with ANGPT2: view

Animal Models for ANGPT2 Gene

MGI Knock Outs for ANGPT2:

Animal Model Products

CRISPR Products

miRNA for ANGPT2 Gene

miRTarBase miRNAs that target ANGPT2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANGPT2 Gene

Localization for ANGPT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPT2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANGPT2 Gene COMPARTMENTS Subcellular localization image for ANGPT2 gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 3
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ANGPT2 Gene

Pathways & Interactions for ANGPT2 Gene

genes like me logo Genes that share pathways with ANGPT2: view

Pathways by source for ANGPT2 Gene

SIGNOR curated interactions for ANGPT2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ANGPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0007165 signal transduction TAS 10766762
GO:0007281 germ cell development IEA --
GO:0007596 blood coagulation TAS --
GO:0009314 response to radiation IEA --
genes like me logo Genes that share ontologies with ANGPT2: view

Drugs & Compounds for ANGPT2 Gene

(22) Drugs for ANGPT2 Gene - From: Novoseek and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CVX-060 Pharma antibody Others 0
MED13617 Pharma antagonist Angiopoietin 2 antagonist 0
REGN910 Pharma 0
trebananib Pharma inhibitor 32

(16) Additional Compounds for ANGPT2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANGPT2: view

Transcripts for ANGPT2 Gene

Unigene Clusters for ANGPT2 Gene

Angiopoietin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPT2 Gene

No ASD Table

Relevant External Links for ANGPT2 Gene

GeneLoc Exon Structure for
ANGPT2
ECgene alternative splicing isoforms for
ANGPT2

Expression for ANGPT2 Gene

mRNA expression in normal human tissues for ANGPT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANGPT2 Gene

This gene is overexpressed in Artery - Tibial (x4.9).

Protein differential expression in normal tissues from HIPED for ANGPT2 Gene

This gene is overexpressed in Urinary Bladder (64.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANGPT2 Gene



SOURCE GeneReport for Unigene cluster for ANGPT2 Gene Hs.583870

genes like me logo Genes that share expression patterns with ANGPT2: view

Protein tissue co-expression partners for ANGPT2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ANGPT2 Gene

Orthologs for ANGPT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANGPT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANGPT2 35
  • 87.47 (n)
  • 90.1 (a)
ANGPT2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANGPT2 35
  • 88.6 (n)
  • 92.71 (a)
ANGPT2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Angpt2 35
  • 81.01 (n)
  • 85.66 (a)
Angpt2 16
Angpt2 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANGPT2 35
  • 99.53 (n)
  • 99.8 (a)
ANGPT2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Angpt2 35
  • 80.94 (n)
  • 86.87 (a)
oppossum
(Monodelphis domestica)
Mammalia ANGPT2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANGPT2 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANGPT2 35
  • 81.59 (n)
  • 85.82 (a)
ANGIOPOIETIN-2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANGPT2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485272 35
  • 62.12 (n)
  • 59.06 (a)
zebrafish
(Danio rerio)
Actinopterygii angpt2a 35
  • 64.28 (n)
  • 57.59 (a)
angpt2a 36
  • 56 (a)
OneToOne
Species with no ortholog for ANGPT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANGPT2 Gene

ENSEMBL:
Gene Tree for ANGPT2 (if available)
TreeFam:
Gene Tree for ANGPT2 (if available)

Paralogs for ANGPT2 Gene

Paralogs for ANGPT2 Gene

(13) SIMAP similar genes for ANGPT2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANGPT2: view

Variants for ANGPT2 Gene

Sequence variations from dbSNP and Humsavar for ANGPT2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_049069 -

Structural Variations from Database of Genomic Variants (DGV) for ANGPT2 Gene

Variant ID Type Subtype PubMed ID
nsv890034 CNV Gain 21882294
nsv890057 CNV Gain 21882294
nsv890058 CNV Gain 21882294
esv2422383 CNV Duplication 17116639
esv2736532 CNV Deletion 23290073
nsv397733 CNV Loss 16902084
nsv522043 CNV Loss 19592680

Variation tolerance for ANGPT2 Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANGPT2 Gene

HapMap Linkage Disequilibrium report
ANGPT2
Human Gene Mutation Database (HGMD)
ANGPT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPT2 Gene

Disorders for ANGPT2 Gene

MalaCards: The human disease database

(22) MalaCards diseases for ANGPT2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
placenta accreta
anca-associated vasculitis
  • anti-neutrophil cytoplasmic antibody-associated vasculitis
twin-to-twin transfusion syndrome
  • twin twin transfusion syndrome
pyogenic granuloma
  • lobular capillary hemangioma
macular holes
  • macular hole
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ANGPT2

Genetic Association Database (GAD)
ANGPT2
Human Genome Epidemiology (HuGE) Navigator
ANGPT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANGPT2
genes like me logo Genes that share disorders with ANGPT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANGPT2 Gene

Publications for ANGPT2 Gene

  1. Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. (PMID: 19223473) Yuan H.T. … Parikh S.M. (Mol. Cell. Biol. 2009) 3 4 23 67
  2. Maternal serum angiopoietin-1 and -2 and tie-2 in early pregnancy ending in preeclampsia or intrauterine growth retardation. (PMID: 19875484) Leinonen E. … Vuorela P. (J. Clin. Endocrinol. Metab. 2010) 3 23
  3. Angiopoietin-2 levels in glucose intolerance, hypertension, and metabolic syndrome in Asian Indians (Chennai Urban Rural Epidemiology Study-74). (PMID: 19913849) Anuradha S. … Dixit M. (Metab. Clin. Exp. 2010) 3 23
  4. Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface. (PMID: 19922791) Hansen T.M. … Brindle N.P. (Cell. Signal. 2010) 3 23
  5. Angiopoietin-2 promotes disease progression of neuroendocrine tumors. (PMID: 20068079) Detjen K.M. … Scholz A. (Clin. Cancer Res. 2010) 3 23

Products for ANGPT2 Gene

Sources for ANGPT2 Gene

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