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Aliases for SLC9C2 Gene

Aliases for SLC9C2 Gene

  • Solute Carrier Family 9 Member C2 (Putative) 2 3 5
  • Solute Carrier Family 9, Member 11 2 3
  • Na(+)/H(+) Exchanger 11 3 4
  • SLC9A11 3 4
  • NHE-11 3 4
  • Solute Carrier Family 9, Isoform 11 2
  • Solute Carrier Family 9, Member C2 2
  • Solute Carrier Family 9 Member 11 4
  • Solute Carrier Family 9 Member C2 4
  • Sodium/Hydrogen Exchanger 11 3
  • Solute Carrier Family 9 3

External Ids for SLC9C2 Gene

Previous HGNC Symbols for SLC9C2 Gene

  • SLC9A11

Summaries for SLC9C2 Gene

GeneCards Summary for SLC9C2 Gene

SLC9C2 (Solute Carrier Family 9 Member C2 (Putative)) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include solute:proton antiporter activity. An important paralog of this gene is SLC9C1.

UniProtKB/Swiss-Prot for SLC9C2 Gene

  • Involved in pH regulation.

Gene Wiki entry for SLC9C2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9C2 Gene

Genomics for SLC9C2 Gene

Regulatory Elements for SLC9C2 Gene

Enhancers for SLC9C2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G173506 1.4 Ensembl ENCODE 10 +95.7 95737 1.8 HDGF PKNOX1 FOXA2 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B GAS5 PRDX6 KLHL20 ANKRD45 RC3H1 ENSG00000238272 SUCO SLC9C2 PIR59510
GH01G173428 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6 +172.7 172652 3.5 PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A YY1 ZNF766 ZNF143 PRDX6 SLC9C2 GC01M173428 GC01P173448
GH01G173526 0.9 ENCODE 10.4 +75.8 75813 1.0 HDAC1 PKNOX1 CBX3 NFIB BRCA1 RAD21 CHAMP1 YY1 GTF3C2 POLR3A RC3H1 ENSG00000238272 PRDX6 SLC9C2 KLHL20 GAS5 ZBTB37 PIR59510
GH01G173423 1.4 Ensembl ENCODE dbSUPER 6.3 +177.9 177924 2.6 CBX3 PKNOX1 SIN3A RAD21 RFX5 TCF12 GATA2 FOS CREM ZHX1 PRDX6 SLC9C2 GC01M173428 LOC646870
GH01G173425 1.4 Ensembl ENCODE dbSUPER 6 +180.5 180453 0.3 ATF1 RFX5 ZNF766 ELK1 CREM CAVIN1 ZBTB11 HDAC8 ZNF592 MEF2D SLC9C2 GC01M173428 LOC646870
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC9C2 on UCSC Golden Path with GeneCards custom track

Promoters for SLC9C2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000015981 -306 401 HDAC1 ATF1 ARNT CHAMP1 TCF12 GATA2 CEBPB ZNF592 POLR2H SMARCA4

Genomic Location for SLC9C2 Gene

Chromosome:
1
Start:
173,500,464 bp from pter
End:
173,603,094 bp from pter
Size:
102,631 bases
Orientation:
Minus strand

Genomic View for SLC9C2 Gene

Genes around SLC9C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC9C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC9C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9C2 Gene

Proteins for SLC9C2 Gene

  • Protein details for SLC9C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TAH2-SL9C2_HUMAN
    Recommended name:
    Sodium/hydrogen exchanger 11
    Protein Accession:
    Q5TAH2
    Secondary Accessions:
    • Q86UF3

    Protein attributes for SLC9C2 Gene

    Size:
    1124 amino acids
    Molecular mass:
    129053 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC9C2 Gene

Post-translational modifications for SLC9C2 Gene

  • Glycosylation at isoforms=447 and Asn473
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC9C2 Gene

Domains & Families for SLC9C2 Gene

Gene Families for SLC9C2 Gene

Suggested Antigen Peptide Sequences for SLC9C2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TAH2

UniProtKB/Swiss-Prot:

SL9C2_HUMAN :
  • Contains an ion transport-like region is related to the membrane segments of voltage-gated ion channels.
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Domain:
  • Contains an ion transport-like region is related to the membrane segments of voltage-gated ion channels.
Family:
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
genes like me logo Genes that share domains with SLC9C2: view

Function for SLC9C2 Gene

Molecular function for SLC9C2 Gene

UniProtKB/Swiss-Prot Function:
Involved in pH regulation.

Gene Ontology (GO) - Molecular Function for SLC9C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015297 antiporter activity IEA --
GO:0015299 solute:proton antiporter activity IEA --
GO:0015385 sodium:proton antiporter activity IBA --
GO:0015386 potassium:proton antiporter activity IBA --
genes like me logo Genes that share ontologies with SLC9C2: view
genes like me logo Genes that share phenotypes with SLC9C2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC9C2 Gene

Localization for SLC9C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9C2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC9C2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC9C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC9C2: view

Pathways & Interactions for SLC9C2 Gene

genes like me logo Genes that share pathways with SLC9C2: view

Pathways by source for SLC9C2 Gene

Interacting Proteins for SLC9C2 Gene

Gene Ontology (GO) - Biological Process for SLC9C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0051453 regulation of intracellular pH IBA --
genes like me logo Genes that share ontologies with SLC9C2: view

No data available for SIGNOR curated interactions for SLC9C2 Gene

Transcripts for SLC9C2 Gene

Unigene Clusters for SLC9C2 Gene

Solute carrier family 9, member C2 (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9C2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2: -
SP3: - -
SP4:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:
SP3:
SP4:

Relevant External Links for SLC9C2 Gene

GeneLoc Exon Structure for
SLC9C2
ECgene alternative splicing isoforms for
SLC9C2

Expression for SLC9C2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC9C2 Gene

mRNA differential expression in normal tissues according to GTEx for SLC9C2 Gene

This gene is overexpressed in Testis (x20.6) and Brain - Caudate (basal ganglia) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of SLC9C2 Gene:

SLC9C2

SOURCE GeneReport for Unigene cluster for SLC9C2 Gene:

Hs.494981
genes like me logo Genes that share expression patterns with SLC9C2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC9C2 Gene

Orthologs for SLC9C2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC9C2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC9C2 34 35
  • 99.56 (n)
cow
(Bos Taurus)
Mammalia SLC9C2 34 35
  • 83.54 (n)
dog
(Canis familiaris)
Mammalia SLC9C2 34 35
  • 83.41 (n)
rat
(Rattus norvegicus)
Mammalia Slc9c2 34
  • 76.29 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 57 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC9C2 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
Species where no ortholog for SLC9C2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC9C2 Gene

ENSEMBL:
Gene Tree for SLC9C2 (if available)
TreeFam:
Gene Tree for SLC9C2 (if available)

Paralogs for SLC9C2 Gene

Paralogs for SLC9C2 Gene

(2) SIMAP similar genes for SLC9C2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC9C2: view

Variants for SLC9C2 Gene

Sequence variations from dbSNP and Humsavar for SLC9C2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000061607 -- 173,532,999(+) AGGTA(C/G)AGGGT intron-variant
rs1000090813 -- 173,540,035(+) AAAAT(G/T)GGGGT intron-variant
rs1000120936 -- 173,526,268(+) TTGCA(A/G)AAAAC intron-variant
rs1000124521 -- 173,572,057(+) TGCCC(A/G)GTCTA intron-variant
rs1000161307 -- 173,525,851(+) TCTGT(C/G)AACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC9C2 Gene

Variant ID Type Subtype PubMed ID
esv3587945 CNV loss 21293372
esv3587946 CNV loss 21293372
nsv831915 CNV gain+loss 17160897

Variation tolerance for SLC9C2 Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.96; 87.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC9C2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC9C2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC9C2 Gene

Disorders for SLC9C2 Gene

Relevant External Links for SLC9C2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC9C2

No disorders were found for SLC9C2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC9C2 Gene

Publications for SLC9C2 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for SLC9C2 Gene

Sources for SLC9C2 Gene

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