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Aliases for NEAT1 Gene

Subcategory (RNA class) for NEAT1 Gene

lncRNA

Quality Score for this RNA gene is

3

Aliases for NEAT1 Gene

  • Nuclear Paraspeckle Assembly Transcript 1 (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 84 2 3
  • Nuclear Enriched Abundant Transcript 1 2 3
  • Virus Inducible Non-Coding RNA 2 3
  • NCRNA00084 3 6
  • TncRNA 3 6
  • Trophoblast Derived Non-Protein Coding RNA 2
  • Trophoblast MHC Class II Suppressor 3
  • Trophoblast-Derived Noncoding RNA 3
  • Non-Protein Coding RNA 84 2
  • MENepsilon/Beta 3
  • LINC00084 3
  • VINC 3

External Ids for NEAT1 Gene

Previous HGNC Symbols for NEAT1 Gene

  • NCRNA00084

Previous GeneCards Identifiers for NEAT1 Gene

  • GC11U901304
  • GC11P065190

Summaries for NEAT1 Gene

Entrez Gene Summary for NEAT1 Gene

  • This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015]

GeneCards Summary for NEAT1 Gene

NEAT1 (Nuclear Paraspeckle Assembly Transcript 1 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the lncRNA class.

Gene Wiki entry for NEAT1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEAT1 Gene

Genomics for NEAT1 Gene

Genomic Location for NEAT1 Gene

Start:
65,422,774 bp from pter
End:
65,445,540 bp from pter
Size:
22,767 bases
Orientation:
Plus strand

Genomic View for NEAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEAT1 Gene

No data available for Regulatory Elements for NEAT1 Gene

Proteins for NEAT1 Gene

Post-translational modifications for NEAT1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NEAT1 Gene

Domains for NEAT1 Gene

Gene Families for NEAT1 Gene

HGNC:
  • LNCRNA :Long non-coding RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NEAT1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NEAT1 Gene

Function for NEAT1 Gene

Phenotypes for NEAT1 Gene

genes like me logo Genes that share phenotypes with NEAT1: view

Animal Models for NEAT1 Gene

MGI Knock Outs for NEAT1:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEAT1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for NEAT1 Gene

Localization for NEAT1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NEAT1 Gene

Pathways for NEAT1 Gene

SuperPathways for NEAT1 Gene

No Data Available

Interacting Proteins for NEAT1 Gene

Gene Ontology (GO) - Biological Process for NEAT1 Gene

None

No data available for Pathways by source for NEAT1 Gene

Transcripts for NEAT1 Gene

mRNA/cDNA for NEAT1 Gene

(11) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEAT1 Gene

Nuclear paraspeckle assembly transcript 1 (non-protein coding):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEAT1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NEAT1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEAT1 Gene

No ASD Table

Relevant External Links for NEAT1 Gene

GeneLoc Exon Structure for
NEAT1
ECgene alternative splicing isoforms for
NEAT1

Expression for NEAT1 Gene

mRNA expression in normal human tissues for NEAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for NEAT1 Gene Hs.523789

genes like me logo Genes that share expressions with NEAT1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for NEAT1 Gene

Orthologs for NEAT1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for NEAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-612 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neat1 16
Species with no ortholog for NEAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NEAT1 Gene

ENSEMBL:
Gene Tree for NEAT1 (if available)
TreeFam:
Gene Tree for NEAT1 (if available)

Paralogs for NEAT1 Gene

No data available for Paralogs for NEAT1 Gene

Variants for NEAT1 Gene

Sequence variations from dbSNP and Humsavar for NEAT1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs13355 -- 65,426,230(-) GAACC(A/C)AGAAG nc-transcript-variant
rs512715 -- 65,423,737(+) CATTA(C/G)CTGGT nc-transcript-variant
rs674400 -- 65,420,856(-) GGCCA(A/T)GGTGG upstream-variant-2KB
rs680413 -- 65,422,908(+) GAGAC(G/T)AGGGG nc-transcript-variant
rs1055519 -- 65,426,450(+) TAATT(C/T)TGTTA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for NEAT1 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
esv2422285 CNV Deletion 17116639
dgv1175n71 CNV Loss 21882294
nsv897717 CNV Loss 21882294
nsv897718 CNV Loss 21882294
nsv897719 CNV Loss 21882294

Relevant External Links for NEAT1 Gene

HapMap Linkage Disequilibrium report
NEAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEAT1 Gene

Disorders for NEAT1 Gene

Relevant External Links for NEAT1

Genetic Association Database (GAD)
NEAT1
genes like me logo Genes that share disorders with NEAT1: view

No data available for UniProtKB/Swiss-Prot for NEAT1 Gene

Publications for NEAT1 Gene

  1. Human trophoblast noncoding RNA suppresses CIITA promoter III activity in murine B-lymphocytes. (PMID: 12565840) Geirsson A. … Hammond G.L. (Biochem. Biophys. Res. Commun. 2003) 2 3
  2. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PMID: 9253601) Guru S.C. … Chandrasekharappa S.C. (Genome Res. 1997) 2 3
  3. Repression of major histocompatibility complex genes by a human trophoblast ribonucleic acid. (PMID: 9858482) Peyman J.A. (Biol. Reprod. 1999) 2 3
  4. Mammalian expression cloning of two human trophoblast suppressors of major histocompatibility complex genes. (PMID: 11458881) Peyman J.A. (Am. J. Reprod. Immunol. 2001) 3
  5. A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains. (PMID: 17270048) Hutchinson J.N. … Chess A. (BMC Genomics 2007) 3

Products for NEAT1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate NEAT1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NEAT1
    • Block miRNA regulation of NEAT1 using miScript Target Protectors

    Sources for NEAT1 Gene

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