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Aliases for GPR6 Gene

Aliases for GPR6 Gene

  • G Protein-Coupled Receptor 6 2 3
  • Sphingosine 1-Phosphate Receptor GPR6 4

External Ids for GPR6 Gene

Summaries for GPR6 Gene

GeneCards Summary for GPR6 Gene

GPR6 (G Protein-Coupled Receptor 6) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and sphingosine-1-phosphate receptor activity. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for GPR6 Gene

  • Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).

Gene Wiki entry for GPR6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR6 Gene

Genomics for GPR6 Gene

Genomic Location for GPR6 Gene

109,978,256 bp from pter
109,980,720 bp from pter
2,465 bases
Plus strand

Genomic View for GPR6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR6 Gene

Regulatory Elements for GPR6 Gene

Proteins for GPR6 Gene

  • Protein details for GPR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 6
    Protein Accession:
    Secondary Accessions:
    • B4DHS9
    • J3KQR3
    • Q17RJ7
    • Q5SYL0

    Protein attributes for GPR6 Gene

    362 amino acids
    Molecular mass:
    37881 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR6 Gene


neXtProt entry for GPR6 Gene

Proteomics data for GPR6 Gene at MOPED

Post-translational modifications for GPR6 Gene

  • Glycosylation at Asn2, Asn9, and Asn51

Other Protein References for GPR6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR6 Gene

Domains for GPR6 Gene

Gene Families for GPR6 Gene

  • GPCRAO :GPCR / Class A : Orphans

Suggested Antigen Peptide Sequences for GPR6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.:
    • P46095
genes like me logo Genes that share domains with GPR6: view

Function for GPR6 Gene

Molecular function for GPR6 Gene

GENATLAS Biochemistry: G protein coupled receptor 6,with close homology to GPR3,predominantly expressed in the putamen
UniProtKB/Swiss-Prot Function: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).

Gene Ontology (GO) - Molecular Function for GPR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 7832990
GO:0038036 sphingosine-1-phosphate receptor activity IEA --
genes like me logo Genes that share ontologies with GPR6: view
genes like me logo Genes that share phenotypes with GPR6: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GPR6 Gene

Localization for GPR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR6 Gene

Cell membrane; Multi-pass membrane protein. Note=Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor.

Subcellular locations from

Jensen Localization Image for GPR6 Gene COMPARTMENTS Subcellular localization image for GPR6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 7832990
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GPR6: view

Pathways for GPR6 Gene

SuperPathways for GPR6 Gene

genes like me logo Genes that share pathways with GPR6: view

Pathways by source for GPR6 Gene

1 BioSystems pathway for GPR6 Gene

Interacting Proteins for GPR6 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000275169 for GPR6 Gene via STRING

Gene Ontology (GO) - Biological Process for GPR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003376 sphingosine-1-phosphate signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 7832990
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with GPR6: view

Compounds for GPR6 Gene

(2) HMDB Compounds for GPR6 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • (-)-D-erythro-Sphingosine
genes like me logo Genes that share compounds with GPR6: view

Transcripts for GPR6 Gene

mRNA/cDNA for GPR6 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR6 Gene

G protein-coupled receptor 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR6 Gene

No ASD Table

Relevant External Links for GPR6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR6 Gene

mRNA expression in normal human tissues for GPR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR6 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (17.0), Brain - Putamen (basal ganglia) (15.9), and Brain - Caudate (basal ganglia) (10.9).

SOURCE GeneReport for Unigene cluster for GPR6 Gene Hs.46332

genes like me logo Genes that share expressions with GPR6: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for GPR6 Gene

Orthologs for GPR6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR6 35
  • 99.36 (n)
  • 100 (a)
GPR6 36
  • 100 (a)
(Bos Taurus)
Mammalia GPR6 35
  • 86.92 (n)
  • 93.09 (a)
GPR6 36
  • 93 (a)
(Canis familiaris)
Mammalia GPR6 35
  • 91.16 (n)
  • 94.48 (a)
GPR6 36
  • 94 (a)
(Mus musculus)
Mammalia Gpr6 35
  • 86.65 (n)
  • 93.37 (a)
Gpr6 16
Gpr6 36
  • 94 (a)
(Monodelphis domestica)
Mammalia GPR6 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
(Rattus norvegicus)
Mammalia Gpr6 35
  • 86.74 (n)
  • 93.37 (a)
(Gallus gallus)
Aves GPR6 35
  • 71.93 (n)
  • 77.63 (a)
GPR6 36
  • 74 (a)
(Anolis carolinensis)
Reptilia GPR6 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr6 35
  • 67.66 (n)
  • 72.94 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7224 35
(Danio rerio)
Actinopterygii LOC100538060 35
  • 69.44 (n)
  • 71.33 (a)
si:ch73-362m14.3 36
  • 49 (a)
Species with no ortholog for GPR6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR6 Gene

Gene Tree for GPR6 (if available)
Gene Tree for GPR6 (if available)

Paralogs for GPR6 Gene

Selected SIMAP similar genes for GPR6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR6: view

Variants for GPR6 Gene

Sequence variations from dbSNP and Humsavar for GPR6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs4267976 -- 109,978,319(+) CGCGG(A/C)GCCGG utr-variant-5-prime
rs4317449 -- 109,980,742(+) GACTA(C/T)AGAAT downstream-variant-500B
rs4354185 -- 109,980,458(+) TTCCT(A/G)TTCTG utr-variant-3-prime
rs4392757 -- 109,977,327(+) GTTCA(A/G)AAAAG upstream-variant-2KB
rs6568622 -- 109,977,104(+) AGCTG(A/C)GTTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR6 Gene

Variant ID Type Subtype PubMed ID
nsv823821 CNV Gain 20364138

Relevant External Links for GPR6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR6 Gene

Disorders for GPR6 Gene

Relevant External Links for GPR6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GPR6: view

No data available for UniProtKB/Swiss-Prot for GPR6 Gene

Publications for GPR6 Gene

  1. Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. (PMID: 8530049) Song Z.-H. … Bonner T.I. (Genomics 1995) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. (PMID: 12649592) Uhlenbrock K. … Kostenis E. (Cell. Physiol. Biochem. 2003) 3 23
  5. Lipid G protein-coupled receptor ligand identification using beta- arrestin PathHunter assay. (PMID: 19286662) Yin H. … Chen Y.A. (J. Biol. Chem. 2009) 4 23

Products for GPR6 Gene

Sources for GPR6 Gene

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