Aliases for ANG Gene
Aliases for ANG Gene
External Ids for ANG Gene
- HGNC: 483
- Entrez Gene: 283
- Ensembl: ENSG00000214274
- OMIM: 105850
- UniProtKB: P03950
Previous GeneCards Identifiers for ANG Gene
- GC14P018528
- GC14P014944
- GC14P019147
- GC14P019143
- GC14P019144
- GC14P020223
- GC14P021152
- GC14P001273
- GC14P020687
- GC14P020695
- GC14P020703
- GC14P020712
- GC14P020722
- GC14P020735
- GC14P020744
Summaries for ANG Gene
-
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014]
GeneCards Summary for ANG Gene
ANG (Angiogenin) is a Protein Coding gene. Diseases associated with ANG include Amyotrophic Lateral Sclerosis 9 and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Cell junction organization. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and actin binding. An important paralog of this gene is RNASE4.
UniProtKB/Swiss-Prot for ANG Gene
-
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Additional gene information for ANG Gene
- Monarch Initiative
- Search for ANG at DataMed
- Search for ANG at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANG Gene
Genomics for ANG Gene
GeneHancer (GH) Regulatory Elements for ANG Gene
Promoters and enhancers for ANG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ANG on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ANG gene promoter:
Regulatory Element Products
Genomic Locations for ANG Gene
Genomic Locations for ANG Gene
- chr14:20,684,177-20,698,971
- (GRCh38/hg38)
- Size:
- 14,795 bases
- Orientation:
- Plus strand
- chr14:21,152,336-21,167,130
- (GRCh37/hg19)
Genomic View for ANG Gene
Genes around ANG on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q11.2 by Ensembl
- 14q11.2 by Entrez Gene
- 14q11.2 by HGNC
ANG Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANG Gene
Proteins for ANG Gene
-
Protein details for ANG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P03950-ANGI_HUMAN
- Recommended name:
- Angiogenin
- Protein Accession:
- P03950
- Q05CV1
- Q53X86
- Q6P5T2
- Q8WXE7
Protein attributes for ANG Gene
- Size:
- 147 amino acids
- Molecular mass:
- 16550 Da
- Quaternary structure:
-
- Homodimer (PubMed:25372031). Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur.
- SequenceCaution:
-
- Sequence=AAH20704.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for ANG Gene
Selected DME Specific Peptides for ANG Gene
- P03950:
-
- LGLGLTP
- LPVHLDQSIFR
- FLTQHYDAKP
- YRATAGFR
- ENLRISKS
- PPTLAQD
- FQVTTCK
- PTLAQDN
- CENGLPVH
- MRRRGLTSPCK
- GGSPWPPC
Post-translational modifications for ANG Gene
No Post-translational modifications
Other Protein References for ANG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ANG (Angiogenin)
- Novus Biologicals Antibodies for ANG
-
Abcam antibodies for ANG
-
Cloud-Clone Corp. Antibodies for ANG
- Invitrogen Antibodies for ANG
- GeneTex ANG antibody for ANG
-
Custom Antibody ServicesProSci Antibodies for ANG
-
Santa Cruz Biotechnology (SCBT) Antibodies for ANG
- Sino Biological Antibodies for ANG
Protein Products
- R&D Systems Proteins and Enzymes for ANG (Angiogenin)
-
OriGene Purified Proteins for ANG
- Search Origene for MassSpec and Protein Over-expression Lysates for ANG
- Origene Custom Protein Services for ANG
- ProSpec Recombinant Proteins for ANG
-
Cloud-Clone Corp. Proteins for ANG
- Search GeneTex for Proteins for ANG
-
ProSci Proteins for ANG
-
Abcam proteins for ANG
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for ANG
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for ANG (Angiogenin)
-
Cloud-Clone Corp. Assay Kits for ANG
-
Abcam assays for ANG
Domains & Families for ANG Gene
Gene Families for ANG Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for ANG Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANG Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P03950- Family:
-
- Belongs to the pancreatic ribonuclease family.
Function for ANG Gene
Molecular function for ANG Gene
- GENATLAS Biochemistry:
- angiogenin,ribonuclease RNAse A family
- UniProtKB/Swiss-Prot Function:
- Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Enzyme Numbers (IUBMB) for ANG Gene
Phenotypes From GWAS Catalog for ANG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA,IC | 10649442 |
| GO:0003779 | actin binding | IDA | 7679494 |
| GO:0004518 | nuclease activity | IEA | -- |
| GO:0004519 | endonuclease activity | TAS | 10103013 |
Phenotypes for ANG Gene
- GenomeRNAi human phenotypes for ANG:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for ANG gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANG gene
- Search ViGene Biosciences for ANG
CRISPR Products
-
OriGene CRISPR knockouts for ANG
- genomics-online: gRNA clones - Search results for 132 available Angiogenin gene related products
- Overview of 132 available Angiogenin gene related products
- Applied Biological Materials CRISPR for ANG
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANG
- GenScript: Design CRISPR guide RNA sequences for ANG
miRNA for ANG Gene
- miRTarBase miRNAs that target ANG
-
- hsa-mir-409-3p (MIRT006649)
- hsa-mir-335-5p (MIRT018344)
- hsa-mir-215-5p (MIRT024617)
- hsa-mir-192-5p (MIRT026610)
- hsa-mir-874-3p (MIRT497608)
- hsa-mir-3157-3p (MIRT497609)
- hsa-mir-6790-5p (MIRT497610)
- hsa-mir-4658 (MIRT497611)
- hsa-mir-4758-5p (MIRT497612)
- hsa-mir-1238-5p (MIRT497613)
- hsa-mir-18b-3p (MIRT497614)
- hsa-mir-4745-5p (MIRT497615)
- hsa-mir-4481 (MIRT497616)
- hsa-mir-3927-5p (MIRT497617)
- hsa-mir-454-5p (MIRT497618)
- hsa-mir-3922-5p (MIRT497619)
- hsa-mir-3142 (MIRT497620)
- hsa-mir-1245b-5p (MIRT497621)
- hsa-mir-574-5p (MIRT517270)
- hsa-mir-223-5p (MIRT517271)
- hsa-mir-511-3p (MIRT517272)
- hsa-mir-5580-3p (MIRT517273)
- hsa-mir-6839-5p (MIRT551226)
- hsa-mir-378j (MIRT551227)
- hsa-mir-5698 (MIRT607920)
- hsa-mir-4309 (MIRT607921)
- hsa-mir-3198 (MIRT607922)
- hsa-mir-7641 (MIRT607923)
- hsa-mir-143-5p (MIRT607924)
- hsa-mir-4430 (MIRT607925)
- hsa-mir-3652 (MIRT607926)
- hsa-mir-122-5p (MIRT607927)
- hsa-mir-504-3p (MIRT607928)
- hsa-mir-4294 (MIRT607929)
- hsa-mir-1289 (MIRT607930)
- hsa-mir-3135b (MIRT607931)
- hsa-mir-6499-3p (MIRT607932)
- hsa-mir-8082 (MIRT607933)
- hsa-mir-4534 (MIRT607934)
- hsa-mir-4695-3p (MIRT607935)
- hsa-mir-6812-3p (MIRT607936)
- hsa-mir-5693 (MIRT607937)
- hsa-mir-6514-5p (MIRT607938)
- hsa-mir-6867-5p (MIRT707391)
- hsa-mir-93-5p (MIRT733293)
miRNA Products
- Search ViGene Biosciences for ANG
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ANG
- Browse OriGene Inhibitory RNA Products For ANG
- genomics-online: shRNA clones - Search results for 132 available Angiogenin gene related products
- Overview of 132 available Angiogenin gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ANG gene
Clone Products
- Sino Biological Human cDNA Clone for ANG
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for ANG
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ANG
-
ViGene Biosciences adenoviral particle packaged cDNA for ANG gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANG gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANG gene
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ANG Gene
Localization for ANG Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANG Gene
- Cytoplasmic vesicle, secretory vesicle lumen. Secreted. Nucleus. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (PubMed:12051708). {ECO:0000269 PubMed:12051708}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005605 | basal lamina | IDA | 15166501 |
| GO:0005615 | extracellular space | IDA | 3663649 |
| GO:0005634 | nucleus | IEA,IDA | 10649442 |
| GO:0005730 | nucleolus | ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ANG Gene
Pathways & Interactions for ANG Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell junction organization | ||
Pathways by source for ANG Gene
4 Reactome pathways for ANG Gene
Interacting Proteins for ANG Gene
Selected Interacting proteins:
P03950-ANGI_HUMAN
ENSP00000336762
for ANG Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | TAS | 16567967 |
| GO:0001541 | ovarian follicle development | NAS | 12770725 |
| GO:0001556 | oocyte maturation | NAS | 11438326 |
| GO:0001666 | response to hypoxia | NAS | 15776477 |
| GO:0001890 | placenta development | NAS | 11984825 |
No data available for SIGNOR curated interactions for ANG Gene
Drugs & Compounds for ANG Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for ANG Gene
mRNA/cDNA for ANG Gene
- (2) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (333) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANG Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANG
- genomics-online: gRNA clones - Search results for 132 available Angiogenin gene related products
- Overview of 132 available Angiogenin gene related products
- Applied Biological Materials CRISPR for ANG
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANG
- GenScript: Design CRISPR guide RNA sequences for ANG
miRNA Products
- Search ViGene Biosciences for ANG
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ANG
- Browse OriGene Inhibitory RNA Products For ANG
- genomics-online: shRNA clones - Search results for 132 available Angiogenin gene related products
- Overview of 132 available Angiogenin gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ANG gene
Clone Products
- Sino Biological Human cDNA Clone for ANG
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for ANG
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ANG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Angiogenic cell precursors
-
Placenta (Extraembryonic Tissues)
- Extravillous Cytotrophoblast Cells Extravillous Cytotrophoblast Layer
- Villous Cytotrophoblast Cells Chorionic Villus
- Kidney (Urinary System)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Colon (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells
- Endothelium (Cardiovascular System)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ANG Gene
This gene is overexpressed in Liver (x14.5).
This gene is overexpressed in Serum (36.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANG Gene
NURSA nuclear receptor signaling pathways regulating expression of ANG Gene:
ANGSOURCE GeneReport for Unigene cluster for ANG Gene:
Hs.283749mRNA Expression by UniProt/SwissProt for ANG Gene:
P03950-ANGI_HUMAN
Tissue specificity:
Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
Evidence on tissue expression from TISSUES for ANG Gene
- Liver(4.8)
- Intestine(4.5)
- Lung(2.8)
- Heart(2.5)
- Nervous system(2.4)
- Kidney(2.2)
- Muscle(2.1)
- Blood(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ANG Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- nervous
- respiratory
- skeletal muscle
- skeleton
Organs:
Head and neck:
- brain
- cerebellum
- cranial nerve
- ear
- epiglottis
- face
- head
- jaw
- larynx
- mandible
- maxilla
- mouth
- neck
- nose
- pharynx
- skull
- tongue
- vocal cord
Thorax:
- bronchus
- clavicle
- esophagus
- heart
- lung
- scapula
- trachea
Abdomen:
- biliary tract
- liver
- stomach
Limb:
- arm
- digit
- finger
- foot
- forearm
- hand
- humerus
- lower limb
- shin
- shoulder
- thigh
- toe
- upper limb
General:
- blood vessel
- peripheral nerve
- peripheral nervous system
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for ANG
-
OriGene qPCR primer pairs and template standards for ANG
- genomics-online: primer clones - Search results for 132 available Angiogenin gene related products
- Overview of 132 available Angiogenin gene related products
Orthologs for ANG Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANG 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ang 33 16 34 |
|
||
| Ang2 34 |
|
OneToMany | |||
| Ang4 34 |
|
OneToMany | |||
| Ang5 34 |
|
OneToMany | |||
| Ang6 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Ang 33 |
|
||
| cow (Bos Taurus) |
Mammalia | ANG 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| ANG2 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | ANG 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany |
- Species where no ortholog for ANG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for ANG Gene
Variants for ANG Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1032422334 | lateral sclerosis 9 (ALS9) [MIM:611895] | 20,693,676(+) | T/C | coding_sequence_variant, missense_variant | |
| rs1054016022 | uncertain-significance, Amyotrophic Lateral Sclerosis, Dominant | 20,684,253(+) | G/A | 5_prime_UTR_variant, genic_upstream_transcript_variant | |
| rs113950902 | likely-benign, Amyotrophic Lateral Sclerosis, Dominant | 20,684,394(+) | C/G | 5_prime_UTR_variant, genic_upstream_transcript_variant | |
| rs11701 | benign, likely-benign, not specified, Amyotrophic Lateral Sclerosis, Dominant | 20,693,894(+) | T/A/G | coding_sequence_variant, synonymous_variant | |
| rs117053048 | likely-benign, Amyotrophic Lateral Sclerosis, Dominant | 20,684,247(+) | T/C | 5_prime_UTR_variant, genic_upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv23438 | CNV | gain+loss | 19812545 |
| esv3633687 | CNV | loss | 21293372 |
| esv3633688 | CNV | loss | 21293372 |
| nsv1203 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.19;
4.19% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ANG Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANG Gene
Disorders for ANG Gene
(10) MalaCards diseases for ANG Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| amyotrophic lateral sclerosis 9 |
|
|
| amyotrophic lateral sclerosis 1 |
|
|
| venezuelan hemorrhagic fever |
|
|
| lateral sclerosis |
|
|
| lipodermatosclerosis |
|
|
Search ANG in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ANGI_HUMAN- Amyotrophic lateral sclerosis 9 (ALS9) [MIM:611895]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269 PubMed:15557516, ECO:0000269 PubMed:16501576, ECO:0000269 PubMed:17703939, ECO:0000269 PubMed:17886298, ECO:0000269 PubMed:17900154, ECO:0000269 PubMed:18087731, ECO:0000269 PubMed:22292843, ECO:0000269 PubMed:25372031}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Additional Disease Information for ANG
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ANG Gene
Publications for ANG Gene
- Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis. (PMID: 18087731) Gellera C … Silani V (Neurogenetics 2008) 3 4 22 44 58
- [Genetic determinants of cardiovascular remodeling in Uzbek patients with essential hypertension]. (PMID: 19253715) Eliseeva MR … Abdullaeva GZh (Terapevticheskii arkhiv 2009) 3 22 44 58
- Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis. (PMID: 19363631) Fernández-Santiago R … Ludolph A (Journal of neurology 2009) 3 22 44 58
- Absence of angiogenic genes modification in Italian ALS patients. (PMID: 17113198) Del Bo R … Comi GP (Neurobiology of aging 2008) 3 22 44 58
- A novel Angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy. (PMID: 17703939) Conforti FL … Quattrone A (Neuromuscular disorders : NMD 2008) 3 4 22 58
Products for ANG Gene
- R&D Systems Antibodies for ANG (Angiogenin)
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- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for ANG (Angiogenin)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse Peptides
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- Custom Antibody Services
- Custom Assay ServicesOriGene ELISA Kits for ANG
- OriGene Purified Proteins for ANG
- Search Origene for MassSpec and Protein Over-expression Lysates for ANG
- Origene Custom Protein Services for ANG
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANG
- Browse OriGene Inhibitory RNA Products For ANG
- OriGene qPCR primer pairs and template standards for ANG
- OriGene qPCR primer pairs for ANG
- OriGene CRISPR knockouts for ANG
- OriGene ORF clones in human for ANG
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ANG
- GenScript: Next-day shipping of latest version cDNA ORF clones for ANG in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ANG
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- GenScript Custom overexpressing Cell Line Services for ANG
- GenScript: Design CRISPR guide RNA sequences for ANG
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
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- GenScript Custom Peptide Services for ANG
- Sino Biological Human cDNA Clone for ANG
- Browse Sino Biological Cell Lysates
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- Sino Biological Antibodies for ANG
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- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ANG
- Novus Biologicals lysates and proteins for ANG
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for ANG
- Abcam proteins for ANG
- Abcam assays for ANG
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for ANG
- Cloud-Clone Corp. Antibodies for ANG
- Cloud-Clone Corp. Proteins for ANG
- Cloud-Clone Corp. Assay Kits for ANG
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for ANG
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online: Search results for 140 available Angiogenin Antibodies ranked by validation data
- Compare Top Angiogenin Antibodies
- antibodies-online: Search results for 82 available Angiogenin Elisa Kits ranked by validation data
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- antibodies-online: Search results for 35 available Angiogenin Proteins ranked by validation data
- Compare Top Angiogenin Proteins
- GeneTex ANG antibody for ANG
- Search GeneTex for Proteins for ANG
- ViGene Biosciences adenoviral particle packaged cDNA for ANG gene
- ViGene Biosciences lentiviral particle packaged cDNA for ANG gene
- ViGene Biosciences ready-to-package AAV shRNAs for ANG gene
- Search ViGene Biosciences for ANG
- Santa Cruz Biotechnology (SCBT) Antibodies for ANG
- Search Santa Cruz Biotechnology (SCBT) for ANG siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ANG
- Custom Antibody ServicesProSci Antibodies for ANG
- ProSci Proteins for ANG
- Horizon Cell Lines for ANG
- genomics-online: cdna clones - Search results for 132 available Angiogenin gene related products
- Overview of 132 available Angiogenin gene related products
- orf clones - Search results for 132 available Angiogenin gene related products
- Overview of 132 available Angiogenin gene related products
- genomics-online: gRNA clones - Search results for 132 available Angiogenin gene related products
- Overview of 132 available Angiogenin gene related products
- genomics-online: primer clones - Search results for 132 available Angiogenin gene related products
- Overview of 132 available Angiogenin gene related products
- genomics-online: shRNA clones - Search results for 132 available Angiogenin gene related products
- Overview of 132 available Angiogenin gene related products
Sources for ANG Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew