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OR10AG1 Gene(Protein Coding)

Olfactory Receptor Family 10 Subfamily AG Member 1

GCID:
GC11M055968
GIFtS:
42
Genes Participants
UDN Logo

Aliases for OR10AG1 Gene

Aliases for OR10AG1 Gene

  • Olfactory Receptor Family 10 Subfamily AG Member 1 2 3 5
  • Olfactory Receptor OR11-160 3 4
  • Olfactory Receptor, Family 10, Subfamily AG, Member 1 2
  • Olfactory Receptor 10AG1 3
  • OR11-160 3

External Ids for OR10AG1 Gene

Previous GeneCards Identifiers for OR10AG1 Gene

  • GC00U903069
  • GC11U900153
  • GC11M055493
  • GC11M055737

Summaries for OR10AG1 Gene

Entrez Gene Summary for OR10AG1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10AG1 Gene

OR10AG1 (Olfactory Receptor Family 10 Subfamily AG Member 1) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A4.

UniProtKB/Swiss-Prot for OR10AG1 Gene

  • Odorant receptor.

Gene Wiki entry for OR10AG1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10AG1 Gene

Genomics for OR10AG1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for OR10AG1 Gene


Transcription factor binding sites by QIAGEN in the OR10AG1 gene promoter:

Genomic Location for OR10AG1 Gene

Chromosome:
11
Start:
55,967,558 bp from pter
End:
55,968,463 bp from pter
Size:
906 bases
Orientation:
Minus strand

Genomic View for OR10AG1 Gene

Genes around OR10AG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10AG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10AG1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR10AG1 Gene

Proteins for OR10AG1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for OR10AG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH19-O10AG_HUMAN
    Recommended name:
    Olfactory receptor 10AG1
    Protein Accession:
    Q8NH19
    Secondary Accessions:
    • B2RNH4
    • Q6IEU3

    Protein attributes for OR10AG1 Gene

    Size:
    301 amino acids
    Molecular mass:
    34105 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10AG1 Gene

Post-translational modifications for OR10AG1 Gene

  • Glycosylation at posLast=8282
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10AG1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10AG1 Gene

Domains & Families for OR10AG1 Gene

Gene Families for OR10AG1 Gene

HGNC:

Protein Domains for OR10AG1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OR10AG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH19

UniProtKB/Swiss-Prot:

O10AG_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10AG1: view

Function for OR10AG1 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for OR10AG1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10AG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR10AG1: view
genes like me logo Genes that share phenotypes with OR10AG1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10AG1 Gene

Localization for OR10AG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10AG1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10AG1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10AG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10AG1: view

Pathways & Interactions for OR10AG1 Gene

genes like me logo Genes that share pathways with OR10AG1: view

Pathways by source for OR10AG1 Gene

1 KEGG pathway for OR10AG1 Gene

Interacting Proteins for OR10AG1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000311477%0d%0a9606.ENSP00000367869%0d%0a9606.ENSP00000248572%0d%0a9606.ENSP00000334051%0d%0a9606.ENSP00000366488%0d%0a9606.ENSP00000317578%0d%0a
Selected Interacting proteins: ENSP00000311477 for OR10AG1 Gene via STRING

Gene Ontology (GO) - Biological Process for OR10AG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10AG1: view

No data available for SIGNOR curated interactions for OR10AG1 Gene

Drugs & Compounds for OR10AG1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for OR10AG1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for OR10AG1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10AG1 Gene

No ASD Table

Relevant External Links for OR10AG1 Gene

GeneLoc Exon Structure for
OR10AG1
ECgene alternative splicing isoforms for
OR10AG1

Expression for OR10AG1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10AG1 Gene

mRNA expression in normal human tissues for OR10AG1 Gene
mRNA expression by BioGPS for OR10AG1 GenemRNA expression by GTEx for OR10AG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10AG1 Gene:

OR10AG1

SOURCE GeneReport for Unigene cluster for OR10AG1 Gene:

Hs.554525
genes like me logo Genes that share expression patterns with OR10AG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10AG1 Gene

Orthologs for OR10AG1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10AG1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia LOC100686203 34
  • 84.44 (n)
OR10AG1 35
  • 80 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Or10ag2 55 Olfr1123 34 16 35
  • 79.01 (n)
Or10ag56 55 Olfr1118 35
  • 72 (a)
 OneToMany
Or10ag57 55 Olfr1122 35
  • 66 (a)
 OneToMany
Or10ag52 55 Olfr1113
  • chr2:87,212,894-87,213,871
Or10ag53 55 Olfr1115
  • chr2:87,251,939-87,252,916
Or10ag54 55 Olfr1116
  • chr2:87,268,846-87,269,766
Or10ag55 55 Olfr1117
  • chr2:87,284,409-87,285,272
Or10ag58 55 Olfr1124
  • chr2:87,434,489-87,435,442
Or10ag59 55 Olfr1129
  • chr2:87,575,086-87,576,027
Or10ag60 55 Olfr1130
  • chr2:87,607,390-87,608,331
Or10ag61 55 Olfr1521
  • chr2:87,268,846-87,269,766
Or12e1 55 Olfr1112
  • chr2:87,191,689-87,192,642
Or12e10 55 Olfr1145
  • chr2:87,809,699-87,810,796
Or12e11-ps 55 Olfr1146-ps1
  • chr2:87,816,533-87,817,455
Or12e12-ps 55 Olfr1147-ps1
  • chr2:87,822,664-87,823,548
Or12e13 55 Olfr1148
  • chr2:87,833,041-87,833,982
Or12e14 55 Olfr1150
  • chr2:87,846,273-87,847,220
Or12e7 55 Olfr1126
  • chr2:87,457,167-87,458,108
Or12e8 55 Olfr1120
  • chr2:87,357,446-87,358,387
Or12e9 55 Olfr1121
  • chr2:87,371,444-87,372,475
rat
(Rattus norvegicus)
 Mammalia Olr561 34
  • 77.97 (n)
cow
(Bos Taurus)
 Mammalia LOC787428 34
  • 73.99 (n)
-- 35
  • 71 (a)
 OneToMany
-- 35
  • 63 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 59 (a)
 OneToMany
-- 35
  • 59 (a)
 OneToMany
-- 35
  • 59 (a)
 OneToMany
-- 35
  • 59 (a)
 OneToMany
-- 35
  • 59 (a)
 OneToMany
-- 35
  • 59 (a)
 OneToMany
-- 35
  • 58 (a)
 OneToMany
-- 35
  • 58 (a)
 OneToMany
-- 35
  • 58 (a)
 OneToMany
-- 35
  • 58 (a)
 OneToMany
-- 35
  • 58 (a)
 OneToMany
-- 35
  • 58 (a)
 OneToMany
-- 35
  • 58 (a)
 OneToMany
-- 35
  • 58 (a)
 OneToMany
-- 35
  • 58 (a)
 OneToMany
-- 35
  • 57 (a)
 OneToMany
-- 35
  • 57 (a)
 OneToMany
-- 35
  • 56 (a)
 OneToMany
-- 35
  • 56 (a)
 OneToMany
-- 35
  • 56 (a)
 OneToMany
-- 35
  • 56 (a)
 OneToMany
-- 35
  • 54 (a)
 OneToMany
-- 35
  • 54 (a)
 OneToMany
-- 35
  • 53 (a)
 OneToMany
-- 35
  • 52 (a)
 OneToMany
-- 35
  • 52 (a)
 OneToMany
-- 35
  • 52 (a)
 OneToMany
-- 35
  • 51 (a)
 OneToMany
Species where no ortholog for OR10AG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10AG1 Gene

ENSEMBL:
Gene Tree for OR10AG1 (if available)
TreeFam:
Gene Tree for OR10AG1 (if available)

Paralogs for OR10AG1 Gene

Paralogs for OR10AG1 Gene

(456) SIMAP similar genes for OR10AG1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR10AG1 Gene

genes like me logo Genes that share paralogs with OR10AG1: view

Variants for OR10AG1 Gene

Sequence variations from dbSNP and Humsavar for OR10AG1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000131384 -- 55,968,862(+) TTGTA(C/T)TGGTA upstream-variant-2KB
rs1000903424 -- 55,969,073(+) TAAAA(A/G)CACTA upstream-variant-2KB
rs1000935165 -- 55,968,972(+) AGAAT(A/C)AATTA upstream-variant-2KB
rs1001880008 -- 55,968,198(+) GTGTA(A/G)CACAA reference, missense
rs1001932121 -- 55,968,535(+) ACAGT(C/T)AATTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10AG1 Gene

Variant ID Type Subtype PubMed ID
dgv1205n100 CNV gain 25217958
dgv1206n100 CNV loss 25217958
dgv1905n54 CNV gain 21841781
dgv52e55 CNV loss 17911159
esv2751030 CNV gain 17911159
esv2759829 CNV loss 17122850
esv3579771 CNV gain 25503493
esv3579782 CNV gain 25503493
esv3626462 CNV loss 21293372
esv3626463 CNV gain 21293372
esv3626464 CNV loss 21293372
esv3626465 CNV gain 21293372
esv3892014 CNV loss 25118596
nsv1044174 CNV loss 25217958
nsv437718 CNV loss 16327808
nsv468568 CNV loss 19166990
nsv469959 CNV loss 18288195
nsv517590 CNV loss 19592680
nsv555080 CNV loss 21841781
nsv555093 CNV loss 21841781
nsv821668 CNV loss 15273396

Variation tolerance for OR10AG1 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10AG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10AG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10AG1 Gene

Disorders for OR10AG1 Gene

Relevant External Links for OR10AG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR10AG1

No disorders were found for OR10AG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10AG1 Gene

Publications for OR10AG1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR10AG1 Gene

Sources for OR10AG1 Gene

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