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Aliases for SLCO3A1 Gene

Aliases for SLCO3A1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 3A1 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 11 2 3
  • Solute Carrier Organic Anion Transporter Family, Member 3A1 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 3 3 4
  • Sodium-Independent Organic Anion Transporter D 3 4
  • Organic Anion-Transporting Polypeptide D 3 4
  • Solute Carrier Family 21 Member 11 3 4
  • PGE1 Transporter 3 4
  • SLC21A11 3 4
  • OATP-RP3 3 4
  • OATP3A1 3 4
  • OATPRP3 3 4
  • OATP-D 3 4
  • OATPD 3 4

External Ids for SLCO3A1 Gene

Previous HGNC Symbols for SLCO3A1 Gene

  • SLC21A11

Previous GeneCards Identifiers for SLCO3A1 Gene

  • GC15P090126
  • GC15P090197
  • GC15P092396
  • GC15P068535

Summaries for SLCO3A1 Gene

GeneCards Summary for SLCO3A1 Gene

SLCO3A1 (Solute Carrier Organic Anion Transporter Family Member 3A1) is a Protein Coding gene. Diseases associated with SLCO3A1 include Aneurysmal Bone Cysts. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of vitamins, nucleosides, and related molecules. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO1B7.

UniProtKB/Swiss-Prot for SLCO3A1 Gene

  • Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).

Gene Wiki entry for SLCO3A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO3A1 Gene

Genomics for SLCO3A1 Gene

Regulatory Elements for SLCO3A1 Gene

Enhancers for SLCO3A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLCO3A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLCO3A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLCO3A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLCO3A1 Gene

91,853,695 bp from pter
92,172,435 bp from pter
318,741 bases
Plus strand

Genomic View for SLCO3A1 Gene

Genes around SLCO3A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO3A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO3A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO3A1 Gene

Proteins for SLCO3A1 Gene

  • Protein details for SLCO3A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier organic anion transporter family member 3A1
    Protein Accession:
    Secondary Accessions:
    • A8K4A7
    • B3KPY5
    • B3KUR7
    • C6G486
    • Q9BW73
    • Q9GZV2

    Protein attributes for SLCO3A1 Gene

    710 amino acids
    Molecular mass:
    76553 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO3A1 Gene


neXtProt entry for SLCO3A1 Gene

Proteomics data for SLCO3A1 Gene at MOPED

Post-translational modifications for SLCO3A1 Gene

  • Glycosylation at Asn 153, Asn 169, Asn 381, Asn 457, Asn 502, Asn 505, and Asn 519
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO3A1 Gene

Antibody Products

No data available for DME Specific Peptides for SLCO3A1 Gene

Domains & Families for SLCO3A1 Gene

Gene Families for SLCO3A1 Gene

Suggested Antigen Peptide Sequences for SLCO3A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO3A1: view

Function for SLCO3A1 Gene

Molecular function for SLCO3A1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=101 nM for PGE1 (isoform 1) {ECO:0000269 PubMed:16971491}; KM=218 nM for PGE1 (isoform 2) {ECO:0000269 PubMed:16971491}; KM=219 nM for PGE2 (isoform 1) {ECO:0000269 PubMed:16971491}; KM=371 nM for PGE2 (isoform 2) {ECO:0000269 PubMed:16971491};
UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).
genes like me logo Genes that share phenotypes with SLCO3A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLCO3A1

CRISPR Products

miRNA for SLCO3A1 Gene

miRTarBase miRNAs that target SLCO3A1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLCO3A1 Gene

Localization for SLCO3A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO3A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLCO3A1 Gene COMPARTMENTS Subcellular localization image for SLCO3A1 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for SLCO3A1 Gene

Pathways & Interactions for SLCO3A1 Gene

genes like me logo Genes that share pathways with SLCO3A1: view

Interacting Proteins for SLCO3A1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000320634 Q9UIG8-SO3A1_HUMAN for SLCO3A1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLCO3A1 Gene


No data available for SIGNOR curated interactions for SLCO3A1 Gene

Drugs & Compounds for SLCO3A1 Gene

(12) Drugs for SLCO3A1 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iloprost Approved, Investigational Pharma Full agonist, Agonist, Transporter, substrate Others, Prostacyclin (PGI2) analog 77
Methotrexate Approved Pharma Transporter, substrate Folate antagonist,inhibits DFHR, Cytotoxic agent 1466
Penicillin G Approved Pharma Transporter, substrate 26
Alprostadil Approved, Investigational Pharma Transporter, inhibitor 66
Aminohippurate Approved Pharma Transporter, inhibitor 0
genes like me logo Genes that share compounds with SLCO3A1: view

Transcripts for SLCO3A1 Gene

Unigene Clusters for SLCO3A1 Gene

Solute carrier organic anion transporter family, member 3A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO3A1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1: - - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP6: - - - -
SP7: - -

Relevant External Links for SLCO3A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLCO3A1 Gene

mRNA expression in normal human tissues for SLCO3A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO3A1 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for SLCO3A1 Gene

This gene is overexpressed in Spinal cord (47.7) and Peripheral blood mononuclear cells (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLCO3A1 Gene

SOURCE GeneReport for Unigene cluster for SLCO3A1 Gene Hs.311187

mRNA Expression by UniProt/SwissProt for SLCO3A1 Gene

Tissue specificity: Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex.
genes like me logo Genes that share expression patterns with SLCO3A1: view

Primer Products

No data available for Protein tissue co-expression partners for SLCO3A1 Gene

Orthologs for SLCO3A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO3A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLCO3A1 35
  • 93.9 (n)
  • 97.18 (a)
SLCO3A1 36
  • 97 (a)
(Canis familiaris)
Mammalia SLCO3A1 35
  • 94.37 (n)
  • 97.61 (a)
SLCO3A1 36
  • 94 (a)
(Mus musculus)
Mammalia Slco3a1 35
  • 91.03 (n)
  • 97.89 (a)
Slco3a1 16
Slco3a1 36
  • 98 (a)
(Pan troglodytes)
Mammalia SLCO3A1 35
  • 99.4 (n)
  • 99.55 (a)
SLCO3A1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slco3a1 35
  • 90.99 (n)
  • 97.75 (a)
(Monodelphis domestica)
Mammalia SLCO3A1 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
-- 36
  • 94 (a)
(Gallus gallus)
Aves SLCO3A1 35
  • 83.62 (n)
  • 92.8 (a)
SLCO3A1 36
  • 92 (a)
(Anolis carolinensis)
Reptilia SLCO3A1 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slco3a1 35
  • 76.8 (n)
  • 88.42 (a)
(Danio rerio)
Actinopterygii slco3a1 35
  • 73.14 (n)
  • 80.27 (a)
slco3a1 36
  • 77 (a)
SLCO3A1 (2 of 2) 36
  • 75 (a)
Species with no ortholog for SLCO3A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLCO3A1 Gene

Gene Tree for SLCO3A1 (if available)
Gene Tree for SLCO3A1 (if available)

Paralogs for SLCO3A1 Gene

genes like me logo Genes that share paralogs with SLCO3A1: view

Variants for SLCO3A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO3A1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1517618 - 92,104,415(-) GCGGG(C/G)TCTGA nc-transcript-variant, reference, missense
rs1165 -- 92,171,066(+) GTAGC(G/T)CTGGG intron-variant
rs8174 -- 92,163,364(-) CGCGC(A/G)AGTGG intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime
rs22198 -- 92,092,890(-) ATAAG(C/G)TGCAT intron-variant
rs169618 -- 92,113,889(-) TGATG(C/T)TGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO3A1 Gene

Variant ID Type Subtype PubMed ID
esv275567 CNV Loss 21479260
esv2750034 CNV Deletion 23290073
esv2750035 CNV Deletion 23290073
nsv1667 CNV Insertion 18451855
nsv904498 CNV Loss 21882294
esv269383 CNV Insertion 20981092
esv273532 CNV Insertion 20981092
esv1359284 CNV Insertion 17803354
esv2662695 CNV Deletion 23128226
esv25947 CNV Loss 19812545
dgv779e1 CNV Complex 17122850
nsv1668 CNV Loss 18451855
esv27351 CNV Loss 19812545
esv1040768 CNV Insertion 17803354
esv1362653 CNV Insertion 17803354
esv1315861 CNV Insertion 17803354
nsv118 CNV Insertion 15895083
nsv1669 CNV Insertion 18451855
nsv119 CNV Insertion 15895083
nsv1670 CNV Insertion 18451855
nsv120 CNV Insertion 15895083
esv2663236 CNV Deletion 23128226
nsv819109 CNV Gain 19587683
dgv55e180 CNV Deletion 20482838
esv2657610 CNV Deletion 23128226
esv23264 CNV Gain+Loss 19812545
nsv821516 CNV Deletion 20802225
esv2661054 CNV Deletion 23128226
dgv446n67 CNV Gain 20364138
esv1261605 CNV Insertion 17803354
nsv524871 CNV Loss 19592680
esv2677093 CNV Deletion 23128226
esv2750036 CNV Deletion 23290073
esv2750037 CNV Deletion 23290073
esv2750038 CNV Deletion 23290073

Variation tolerance for SLCO3A1 Gene

Residual Variation Intolerance Score: 7.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLCO3A1 Gene

Disorders for SLCO3A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLCO3A1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
aneurysmal bone cysts
  • bone cysts aneurysmal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLCO3A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLCO3A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO3A1 Gene

Publications for SLCO3A1 Gene

  1. Molecular characterization of human and rat organic anion transporter OATP-D. (PMID: 14631946) Adachi H. … Abe T. (Am. J. Physiol. Renal Physiol. 2003) 3 23 25 26
  2. Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. (PMID: 22076464) Ellinghaus E. … Franke A. (Leukemia 2012) 3 48 67
  3. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PMID: 10873595) Tamai I. … Tsuji A. (Biochem. Biophys. Res. Commun. 2000) 3 25 26
  4. Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. (PMID: 24159190) SeppAolAo I. … LehtimAoki T. (Eur. Heart J. 2014) 3
  5. Genome-wide association study of smoking behaviours among Bangladeshi adults. (PMID: 24665060) Argos M. … Ahsan H. (J. Med. Genet. 2014) 3

Products for SLCO3A1 Gene

Sources for SLCO3A1 Gene