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Aliases for SLCO4A1 Gene

Aliases for SLCO4A1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 4A1 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 12 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 1 3 4
  • Sodium-Independent Organic Anion Transporter E 3 4
  • Solute Carrier Family 21 Member 12 3 4
  • Colon Organic Anion Transporter 3 4
  • SLC21A12 3 4
  • OATP-RP1 3 4
  • OATP4A1 3 4
  • OATPRP1 3 4
  • OATP-E 3 4
  • OATP1 3 4
  • OATPE 3 4
  • POAT 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 4A1 2
  • Organic Anion Transporting Polypeptide E 3
  • Organic Anion-Transporting Polypeptide E 4

External Ids for SLCO4A1 Gene

Previous HGNC Symbols for SLCO4A1 Gene

  • SLC21A12

Previous GeneCards Identifiers for SLCO4A1 Gene

  • GC20P062000
  • GC20P060744
  • GC20P061273
  • GC20P057991
  • GC20P062655
  • GC20P062702
  • GC20P062716
  • GC20P062751
  • GC20P062783

Summaries for SLCO4A1 Gene

GeneCards Summary for SLCO4A1 Gene

SLCO4A1 (Solute Carrier Organic Anion Transporter Family Member 4A1) is a Protein Coding gene. Diseases associated with SLCO4A1 include Mucinous Cystadenocarcinoma and Chronic Cholangitis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of vitamins, nucleosides, and related molecules. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO4C1.

UniProtKB/Swiss-Prot for SLCO4A1 Gene

  • Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.

Gene Wiki entry for SLCO4A1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO4A1 Gene

Genomics for SLCO4A1 Gene

Regulatory Elements for SLCO4A1 Gene

Enhancers for SLCO4A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G062708 1.4 Ensembl ENCODE dbSUPER 11.4 +68.5 68482 4.3 PKNOX1 ATF1 SIN3A YY1 ZNF766 GLIS2 REST ZNF592 CREB3 SMARCA4 RTEL1 ARFGAP1 TNFRSF6B ENSG00000223669 OGFR-AS1 OGFR SLCO4A1-AS1 SLCO4A1 MRGBP ENSG00000232121
GH20G062727 1 Ensembl ENCODE dbSUPER 11.2 +85.8 85756 2.0 MAX ZBTB33 REST MYC EZH2 LINC00659 SLCO4A1 ENSG00000232121 ENSG00000229882 OGFR OGFR-AS1 ENSG00000223669 NTSR1
GH20G062715 0.8 ENCODE dbSUPER 11.4 +74.0 73965 1.0 FOSL1 L3MBTL2 EP300 MAFK MGA OGFR-AS1 OGFR LINC00659 SLCO4A1-AS1 SLCO4A1 MIR133A2 MRGBP ENSG00000232121 ENSG00000229882 NTSR1
GH20G062752 0.7 Ensembl 11.7 +110.1 110056 0.6 SMARCE1 L3MBTL2 SAP30 MAX MNT ZNF48 FOSL1 JUND IKZF1 FOS NTSR1 LINC00659 SLCO4A1-AS1 SLCO4A1 MIR133A2 TCFL5 GC20M062750 ENSG00000223669
GH20G062751 0.5 ENCODE 11.7 +109.2 109219 0.1 PKNOX1 RAD51 EZH2 NTSR1 LINC00659 SLCO4A1-AS1 SLCO4A1 MIR133A2 GC20M062750 ENSG00000223669
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLCO4A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLCO4A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139766 255 1401 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SP3 SP5 ZHX2

Genomic Location for SLCO4A1 Gene

Chromosome:
20
Start:
62,642,445 bp from pter
End:
62,685,830 bp from pter
Size:
43,386 bases
Orientation:
Plus strand

Genomic View for SLCO4A1 Gene

Genes around SLCO4A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO4A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO4A1 Gene

Proteins for SLCO4A1 Gene

  • Protein details for SLCO4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BD0-SO4A1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 4A1
    Protein Accession:
    Q96BD0
    Secondary Accessions:
    • Q9H4T7
    • Q9H4T8
    • Q9H8P2
    • Q9NWX8
    • Q9UI35
    • Q9UIG7

    Protein attributes for SLCO4A1 Gene

    Size:
    722 amino acids
    Molecular mass:
    77193 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91247.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLCO4A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO4A1 Gene

Post-translational modifications for SLCO4A1 Gene

  • Ubiquitination at Lys66 and Lys353
  • Glycosylation at Asn499 and isoforms=2, 4557
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO4A1 Gene

No data available for DME Specific Peptides for SLCO4A1 Gene

Domains & Families for SLCO4A1 Gene

Gene Families for SLCO4A1 Gene

Suggested Antigen Peptide Sequences for SLCO4A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BD0

UniProtKB/Swiss-Prot:

SO4A1_HUMAN :
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO4A1: view

Function for SLCO4A1 Gene

Molecular function for SLCO4A1 Gene

UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.

Gene Ontology (GO) - Molecular Function for SLCO4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015349 thyroid hormone transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLCO4A1: view
genes like me logo Genes that share phenotypes with SLCO4A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLCO4A1

CRISPR Products

miRNA for SLCO4A1 Gene

miRTarBase miRNAs that target SLCO4A1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLCO4A1 Gene

Localization for SLCO4A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO4A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLCO4A1 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SLCO4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLCO4A1: view

Pathways & Interactions for SLCO4A1 Gene

genes like me logo Genes that share pathways with SLCO4A1: view

Gene Ontology (GO) - Biological Process for SLCO4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0043252 sodium-independent organic anion transport TAS --
GO:0070327 thyroid hormone transport IEA --
genes like me logo Genes that share ontologies with SLCO4A1: view

No data available for SIGNOR curated interactions for SLCO4A1 Gene

Drugs & Compounds for SLCO4A1 Gene

(18) Drugs for SLCO4A1 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Liotrix Approved Pharma Transporter, substrate, inhibitor 0
Penicillin G Approved, Vet_approved Pharma Transporter, substrate 31
conjugated estrogens Approved Pharma Transporter, substrate 0
Dextrothyroxine Approved Pharma Transporter 0
Digoxin Approved Pharma Transporter, substrate 139

(81) Additional Compounds for SLCO4A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxy-5b-Cholanoate
  • 1,3,12-Trihydroxy-5b-Cholanoic acid
  • 1,3,12-Trihydroxy-Cholan-24-oate
  • 1,3,12-Trihydroxy-Cholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oate
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
  • 1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholanoate
63266-89-7
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oic acid
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienate
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienic acid
  • 12a-Hydroxy-3-oxochola-4,6-dienate
13535-96-1
12b-Hydroxy-5b-cholanoic acid
  • 12-Hydroxy-(5b,12b)-Cholan-24-oate
  • 12-Hydroxy-(5b,12b)-Cholan-24-oic acid
  • 12b-Hydroxy-5b-Cholan-24-oate
  • 12b-Hydroxy-5b-Cholan-24-oic acid
  • 12b-Hydroxy-5b-cholanic acid
15173-23-6
genes like me logo Genes that share compounds with SLCO4A1: view

Transcripts for SLCO4A1 Gene

Unigene Clusters for SLCO4A1 Gene

Solute carrier organic anion transporter family, member 4A1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO4A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: - - - - -
SP2: - - - - - - - - - -
SP3:
SP4: - - - - - -
SP5: -
SP6: -
SP7:

Relevant External Links for SLCO4A1 Gene

GeneLoc Exon Structure for
SLCO4A1
ECgene alternative splicing isoforms for
SLCO4A1

Expression for SLCO4A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLCO4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLCO4A1 Gene

This gene is overexpressed in Placenta (65.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLCO4A1 Gene



Protein tissue co-expression partners for SLCO4A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLCO4A1 Gene:

SLCO4A1

SOURCE GeneReport for Unigene cluster for SLCO4A1 Gene:

Hs.235782

mRNA Expression by UniProt/SwissProt for SLCO4A1 Gene:

Q96BD0-SO4A1_HUMAN
Tissue specificity: Ubiquitous, with the exception of spleen and leukocytes.

Evidence on tissue expression from TISSUES for SLCO4A1 Gene

  • Kidney(4.4)
  • Pancreas(4.1)
  • Nervous system(4.1)
  • Intestine(2.8)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with SLCO4A1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO4A1 Gene

Orthologs for SLCO4A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO4A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLCO4A1 34 35
  • 98.59 (n)
cow
(Bos Taurus)
Mammalia SLCO4A1 34 35
  • 83.55 (n)
dog
(Canis familiaris)
Mammalia SLCO4A1 34 35
  • 83.05 (n)
mouse
(Mus musculus)
Mammalia Slco4a1 34 16 35
  • 79.66 (n)
rat
(Rattus norvegicus)
Mammalia Slco4a1 34
  • 78.87 (n)
oppossum
(Monodelphis domestica)
Mammalia SLCO4A1 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLCO4A1 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLCO4A1 34 35
  • 70.18 (n)
lizard
(Anolis carolinensis)
Reptilia SLCO4A1 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slco4a1 34
  • 66.12 (n)
zebrafish
(Danio rerio)
Actinopterygii slco4a1 34 35
  • 64.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta Oatp26F 35 34
  • 56.11 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008712 34
  • 55.95 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y70G10A.3 34
  • 46.75 (n)
Y70G10A.3 35
  • 33 (a)
ManyToMany
K02G10.5 35
  • 27 (a)
ManyToMany
F53B1.8 35
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToOne
Species where no ortholog for SLCO4A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLCO4A1 Gene

ENSEMBL:
Gene Tree for SLCO4A1 (if available)
TreeFam:
Gene Tree for SLCO4A1 (if available)

Paralogs for SLCO4A1 Gene

(13) SIMAP similar genes for SLCO4A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLCO4A1: view

Variants for SLCO4A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO4A1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000055912 -- 62,644,491(+) AAGGG(G/T)GGCCA intron-variant
rs1000187702 -- 62,654,533(+) GTCGC(C/T)GGCTG intron-variant, upstream-variant-2KB
rs1000213019 -- 62,680,396(+) ACAAT(A/G)TCAAA intron-variant
rs1000241589 -- 62,686,522(+) AGCAG(G/T)CCCTC intron-variant, downstream-variant-500B
rs1000261581 -- 62,660,840(+) CCACT(C/T)TGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO4A1 Gene

Variant ID Type Subtype PubMed ID
esv1387013 CNV deletion 17803354
esv2422398 CNV duplication 17116639
esv2722820 CNV deletion 23290073
esv2722821 CNV deletion 23290073
esv994234 CNV deletion 20482838
nsv1121582 CNV deletion 24896259
nsv1125917 CNV deletion 24896259
nsv1133514 CNV deletion 24896259
nsv1143192 CNV deletion 24896259
nsv1145774 CNV deletion 26484159
nsv428380 CNV loss 18775914
nsv459065 CNV gain 19166990
nsv476766 CNV novel sequence insertion 20440878
nsv481306 CNV novel sequence insertion 20440878
nsv586496 CNV gain 21841781
nsv586502 CNV loss 21841781
nsv586503 CNV gain 21841781
nsv586504 CNV loss 21841781
nsv834026 CNV loss 17160897
nsv953302 CNV deletion 24416366
nsv9822 CNV gain 18304495

Variation tolerance for SLCO4A1 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLCO4A1 Gene

Human Gene Mutation Database (HGMD)
SLCO4A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLCO4A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO4A1 Gene

Disorders for SLCO4A1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLCO4A1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mucinous cystadenocarcinoma
  • mucinous cystadenocarcinoma nos
chronic cholangitis
aneurysmal bone cysts
  • aneurysmal bone cyst
cystadenocarcinoma
  • cystadenocarcinoma nos
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLCO4A1

Genetic Association Database (GAD)
SLCO4A1
Human Genome Epidemiology (HuGE) Navigator
SLCO4A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLCO4A1
genes like me logo Genes that share disorders with SLCO4A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO4A1 Gene

Publications for SLCO4A1 Gene

  1. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. (PMID: 11316767) Fujiwara K. … Abe T. (Endocrinology 2001) 3 4 22 25 64
  2. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PMID: 10873595) Tamai I. … Tsuji A. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 25 64
  3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SLCO4A1 Gene

Sources for SLCO4A1 Gene

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