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Aliases for SLCO4A1 Gene

Aliases for SLCO4A1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 4A1 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 12 2 3
  • Solute Carrier Organic Anion Transporter Family, Member 4A1 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 1 3 4
  • Sodium-Independent Organic Anion Transporter E 3 4
  • Organic Anion-Transporting Polypeptide E 3 4
  • Solute Carrier Family 21 Member 12 3 4
  • Colon Organic Anion Transporter 3 4
  • SLC21A12 3 4
  • OATP-RP1 3 4
  • OATP4A1 3 4
  • OATPRP1 3 4
  • OATP-E 3 4
  • OATP1 3 4
  • OATPE 3 4
  • POAT 3 4
  • Organic Anion Transporting Polypeptide E 3

External Ids for SLCO4A1 Gene

Previous HGNC Symbols for SLCO4A1 Gene

  • SLC21A12

Previous GeneCards Identifiers for SLCO4A1 Gene

  • GC20P062000
  • GC20P060744
  • GC20P061273
  • GC20P057991
  • GC20P062655
  • GC20P062702

Summaries for SLCO4A1 Gene

GeneCards Summary for SLCO4A1 Gene

SLCO4A1 (Solute Carrier Organic Anion Transporter Family Member 4A1) is a Protein Coding gene. Diseases associated with SLCO4A1 include Mucinous Cystadenocarcinoma and Aneurysmal Bone Cysts. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of vitamins, nucleosides, and related molecules. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO1B7.

UniProtKB/Swiss-Prot for SLCO4A1 Gene

  • Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.

Gene Wiki entry for SLCO4A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO4A1 Gene

Genomics for SLCO4A1 Gene

Regulatory Elements for SLCO4A1 Gene

Enhancers for SLCO4A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLCO4A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLCO4A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLCO4A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLCO4A1 Gene

62,642,445 bp from pter
62,685,830 bp from pter
43,386 bases
Plus strand

Genomic View for SLCO4A1 Gene

Genes around SLCO4A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO4A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO4A1 Gene

Proteins for SLCO4A1 Gene

  • Protein details for SLCO4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier organic anion transporter family member 4A1
    Protein Accession:
    Secondary Accessions:
    • Q9H4T7
    • Q9H4T8
    • Q9H8P2
    • Q9NWX8
    • Q9UI35
    • Q9UIG7

    Protein attributes for SLCO4A1 Gene

    722 amino acids
    Molecular mass:
    77193 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91247.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLCO4A1 Gene


neXtProt entry for SLCO4A1 Gene

Proteomics data for SLCO4A1 Gene at MOPED

Post-translational modifications for SLCO4A1 Gene

  • Ubiquitination at Lys 66 and Lys 353
  • Glycosylation at Asn 499 and Asn 557
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO4A1 Gene

No data available for DME Specific Peptides for SLCO4A1 Gene

Domains & Families for SLCO4A1 Gene

Gene Families for SLCO4A1 Gene

Suggested Antigen Peptide Sequences for SLCO4A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO4A1: view

Function for SLCO4A1 Gene

Molecular function for SLCO4A1 Gene

UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.
genes like me logo Genes that share phenotypes with SLCO4A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLCO4A1

CRISPR Products

miRNA for SLCO4A1 Gene

miRTarBase miRNAs that target SLCO4A1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLCO4A1 Gene

Localization for SLCO4A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO4A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLCO4A1 Gene COMPARTMENTS Subcellular localization image for SLCO4A1 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SLCO4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLCO4A1: view

Pathways & Interactions for SLCO4A1 Gene

genes like me logo Genes that share pathways with SLCO4A1: view

Interacting Proteins for SLCO4A1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000217159 Q96BD0-SO4A1_HUMAN for SLCO4A1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLCO4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043252 sodium-independent organic anion transport TAS --
GO:0070327 thyroid hormone transport IEA,IBA --
genes like me logo Genes that share ontologies with SLCO4A1: view

No data available for SIGNOR curated interactions for SLCO4A1 Gene

Drugs & Compounds for SLCO4A1 Gene

(17) Drugs for SLCO4A1 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Liotrix Approved Pharma Transporter, substrate, inhibitor 0
Penicillin G Approved Pharma Transporter, substrate 26
Conjugated Estrogens Approved Pharma Transporter, substrate 0
Dextrothyroxine Approved Pharma Transporter 0
Digoxin Approved Pharma Transporter, substrate 130

(82) Additional Compounds for SLCO4A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxy-5b-Cholanoate
  • 1,3,12-Trihydroxy-5b-Cholanoic acid
  • 1,3,12-Trihydroxy-Cholan-24-oate
  • 1,3,12-Trihydroxy-Cholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oate
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
  • 1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholanoate
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oic acid
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienate
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienic acid
  • 12a-Hydroxy-3-oxochola-4,6-dienate
12b-Hydroxy-5b-cholanoic acid
  • 12-Hydroxy-(5b,12b)-Cholan-24-oate
  • 12-Hydroxy-(5b,12b)-Cholan-24-oic acid
  • 12b-Hydroxy-5b-Cholan-24-oate
  • 12b-Hydroxy-5b-Cholan-24-oic acid
  • 12b-Hydroxy-5b-cholanic acid
genes like me logo Genes that share compounds with SLCO4A1: view

Transcripts for SLCO4A1 Gene

Unigene Clusters for SLCO4A1 Gene

Solute carrier organic anion transporter family, member 4A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO4A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: - - - - -
SP2: - - - - - - - - - -
SP4: - - - - - -
SP5: -
SP6: -

Relevant External Links for SLCO4A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLCO4A1 Gene

mRNA expression in normal human tissues for SLCO4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLCO4A1 Gene

This gene is overexpressed in Placenta (65.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SLCO4A1 Gene

SOURCE GeneReport for Unigene cluster for SLCO4A1 Gene Hs.235782

mRNA Expression by UniProt/SwissProt for SLCO4A1 Gene

Tissue specificity: Ubiquitous, with the exception of spleen and leukocytes.
genes like me logo Genes that share expression patterns with SLCO4A1: view

Protein tissue co-expression partners for SLCO4A1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for SLCO4A1 Gene

Orthologs for SLCO4A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO4A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLCO4A1 35
  • 83.55 (n)
  • 80.11 (a)
SLCO4A1 36
  • 78 (a)
(Canis familiaris)
Mammalia SLCO4A1 35
  • 83.05 (n)
  • 80 (a)
SLCO4A1 36
  • 78 (a)
(Mus musculus)
Mammalia Slco4a1 35
  • 79.66 (n)
  • 76.72 (a)
Slco4a1 16
Slco4a1 36
  • 75 (a)
(Pan troglodytes)
Mammalia SLCO4A1 35
  • 98.59 (n)
  • 98.98 (a)
SLCO4A1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slco4a1 35
  • 78.87 (n)
  • 75.63 (a)
(Monodelphis domestica)
Mammalia SLCO4A1 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia SLCO4A1 36
  • 68 (a)
(Gallus gallus)
Aves SLCO4A1 35
  • 70.18 (n)
  • 70.91 (a)
SLCO4A1 36
  • 67 (a)
(Anolis carolinensis)
Reptilia SLCO4A1 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slco4a1 35
  • 66.12 (n)
  • 66.28 (a)
(Danio rerio)
Actinopterygii slco4a1 35
  • 64.76 (n)
  • 65.28 (a)
slco4a1 36
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008712 35
  • 55.95 (n)
  • 50.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oatp26F 35
  • 56.11 (n)
  • 46.12 (a)
Oatp26F 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y70G10A.3 35
  • 46.75 (n)
  • 37.95 (a)
F53B1.8 36
  • 26 (a)
K02G10.5 36
  • 27 (a)
Y70G10A.3 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for SLCO4A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLCO4A1 Gene

Gene Tree for SLCO4A1 (if available)
Gene Tree for SLCO4A1 (if available)

Paralogs for SLCO4A1 Gene

(13) SIMAP similar genes for SLCO4A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLCO4A1: view

Variants for SLCO4A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO4A1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_053678 -
VAR_053679 -
rs1055196 -- 62,672,214(+) GGCGG(C/T)GGGCC intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1815591 -- 62,645,662(+) TTTTC(A/T)AACCA intron-variant
rs872626 -- 62,659,008(+) CTAAG(C/T)GCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO4A1 Gene

Variant ID Type Subtype PubMed ID
esv2422398 CNV Duplication 17116639
dgv4603n71 CNV Loss 21882294
nsv459065 CNV Gain 19166990
nsv913073 CNV Loss 21882294
dgv1343e1 CNV Complex 17122850
nsv428380 CNV Loss 18775914
nsv834026 CNV Loss 17160897
nsv913106 CNV Loss 21882294
esv2722820 CNV Deletion 23290073
esv2722821 CNV Deletion 23290073
esv994234 CNV Deletion 20482838
esv1387013 CNV Deletion 17803354
nsv913108 CNV Loss 21882294
nsv9822 CNV Gain 18304495

Variation tolerance for SLCO4A1 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLCO4A1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO4A1 Gene

Disorders for SLCO4A1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLCO4A1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mucinous cystadenocarcinoma
  • mucinous cystadenocarcinoma nos
aneurysmal bone cysts
  • bone cysts aneurysmal
  • cystadenocarcinoma nos
chronic cholangitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLCO4A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLCO4A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO4A1 Gene

Publications for SLCO4A1 Gene

  1. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PMID: 10873595) Tamai I. … Tsuji A. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 25 26 67
  2. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. (PMID: 11316767) Fujiwara K. … Abe T. (Endocrinology 2001) 3 23 25 26
  3. Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. (PMID: 14993604) Mikkaichi T. … Abe T. (Proc. Natl. Acad. Sci. U.S.A. 2004) 25 26
  4. Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy. (PMID: 25301452) Brenner S. … Buxhofer-Ausch V. (Cancer Lett. 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SLCO4A1 Gene

Sources for SLCO4A1 Gene