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Aliases for PPP2R3B Gene

Aliases for PPP2R3B Gene

  • Protein Phosphatase 2, Regulatory Subunit B'', Beta 2
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B, Beta 2 3
  • Protein Phosphatase 2, Regulatory Subunit B, Beta 2 3
  • PPP2R3L 3 4
  • PR48 3 6
  • Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B Subunit Beta 3
  • Serine/Threonine Protein Phosphatase 2A, 48kDa Regulatory Subunit B 3
  • Protein Phosphatase 2A 48 KDa Regulatory Subunit 4
  • PP2A, Subunit B, PR48 Isoform 3
  • PP2A Subunit B Isoform PR48 4
  • NY-REN-8 Antigen 3
  • PPP2R3LY 3
  • NYREN8 3

External Ids for PPP2R3B Gene

Previous HGNC Symbols for PPP2R3B Gene

  • PPP2R3L

Previous GeneCards Identifiers for PPP2R3B Gene

  • GC00U991190
  • GC0YU900001
  • GC0XM000264

Summaries for PPP2R3B Gene

Entrez Gene Summary for PPP2R3B Gene

  • Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]

GeneCards Summary for PPP2R3B Gene

PPP2R3B (Protein Phosphatase 2, Regulatory Subunit B'', Beta) is a Protein Coding gene. Diseases associated with PPP2R3B include cavernous malformation. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include calcium ion binding and phosphoprotein phosphatase activity. An important paralog of this gene is PPP2R3C.

UniProtKB/Swiss-Prot for PPP2R3B Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment

Tocris Summary for PPP2R3B Gene

  • Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.

Gene Wiki entry for PPP2R3B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R3B Gene

Genomics for PPP2R3B Gene

Regulatory Elements for PPP2R3B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP2R3B Gene

Start:
333,933 bp from pter
End:
386,955 bp from pter
Size:
53,023 bases
Orientation:
Minus strand

Genomic View for PPP2R3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP2R3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R3B Gene

Proteins for PPP2R3B Gene

  • Protein details for PPP2R3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5P8-P2R3B_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A regulatory subunit B subunit beta
    Protein Accession:
    Q9Y5P8
    Secondary Accessions:
    • Q6P4G9
    • Q7RTT1
    • Q96H01

    Protein attributes for PPP2R3B Gene

    Size:
    575 amino acids
    Molecular mass:
    65061 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with N-terminal region of CDC6.
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes
    SequenceCaution:
    • Sequence=AAD38515.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPP2R3B Gene

    Alternative splice isoforms for PPP2R3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R3B Gene

Proteomics data for PPP2R3B Gene at MOPED

Post-translational modifications for PPP2R3B Gene

  • Ubiquitination at Lys170 and Lys179
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP2R3B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PPP2R3B Gene

Domains for PPP2R3B Gene

Gene Families for PPP2R3B Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • PAR1 :Pseudoautosomal regions / PAR1
  • PPP2R :Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

Protein Domains for PPP2R3B Gene

Suggested Antigen Peptide Sequences for PPP2R3B Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5P8

UniProtKB/Swiss-Prot:

P2R3B_HUMAN :
  • Q9Y5P8
Domain:
  • Contains 1 EF-hand domain.
genes like me logo Genes that share domains with PPP2R3B: view

Function for PPP2R3B Gene

Molecular function for PPP2R3B Gene

UniProtKB/Swiss-Prot Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment

Gene Ontology (GO) - Molecular Function for PPP2R3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity TAS --
GO:0004722 protein serine/threonine phosphatase activity ISS --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0008601 protein phosphatase type 2A regulator activity TAS 10629059
genes like me logo Genes that share ontologies with PPP2R3B: view

Phenotypes for PPP2R3B Gene

GenomeRNAi human phenotypes for PPP2R3B:
genes like me logo Genes that share phenotypes with PPP2R3B: view

miRNA for PPP2R3B Gene

miRTarBase miRNAs that target PPP2R3B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP2R3B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP2R3B Gene

Localization for PPP2R3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R3B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R3B Gene COMPARTMENTS Subcellular localization image for PPP2R3B gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PPP2R3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex ISS --
GO:0005634 nucleus TAS 10629059
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PPP2R3B: view

Pathways for PPP2R3B Gene

genes like me logo Genes that share pathways with PPP2R3B: view

Gene Ontology (GO) - Biological Process for PPP2R3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006470 protein dephosphorylation ISS --
GO:0007050 cell cycle arrest TAS 10629059
GO:0034047 regulation of protein phosphatase type 2A activity TAS 10629059
genes like me logo Genes that share ontologies with PPP2R3B: view

Compounds for PPP2R3B Gene

(5) Tocris Compounds for PPP2R3B Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor [101932-71-2]
Cyclosporin A Calcineurin inhibitor [59865-13-3]
FK 506 Potent calcineurin inhibitor; immunosuppressant [104987-11-3]
Okadaic acid Protein phosphatase 1 and 2A inhibitor [78111-17-8]
Salubrinal Selective inhibitor of eIF2alpha dephosphorylation [405060-95-9]

(3) HMDB Compounds for PPP2R3B Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with PPP2R3B: view

Transcripts for PPP2R3B Gene

Unigene Clusters for PPP2R3B Gene

Protein phosphatase 2, regulatory subunit B, beta:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP2R3B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R3B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for PPP2R3B Gene

GeneLoc Exon Structure for
PPP2R3B
ECgene alternative splicing isoforms for
PPP2R3B

Expression for PPP2R3B Gene

mRNA expression in normal human tissues for PPP2R3B Gene

Protein differential expression in normal tissues for PPP2R3B Gene

This gene is overexpressed in Fetal Liver (57.5) and Testis (11.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R3B Gene

SOURCE GeneReport for Unigene cluster for PPP2R3B Gene Hs.124942

genes like me logo Genes that share expressions with PPP2R3B: view

Expression partners for PPP2R3B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPP2R3B Gene

Orthologs for PPP2R3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R3B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PPP2R3B 35
  • 84.42 (n)
  • 86.55 (a)
-- 36
  • 86 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PPP2R3B 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP2R3B 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm20783 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R3B 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP2R3B 35
  • 68.29 (n)
  • 77.26 (a)
PPP2R3B 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2R3B 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r3b 35
  • 63.24 (n)
  • 67.73 (a)
zebrafish
(Danio rerio)
Actinopterygii ppp2r3b 35
  • 64.55 (n)
  • 65.26 (a)
ppp2r3b 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4733 35
  • 64.34 (n)
  • 59.69 (a)
CG4733 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06G1.5 36
  • 27 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G44090 35
  • 46.45 (n)
  • 38.51 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1088 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1843 36
  • 52 (a)
OneToMany
Species with no ortholog for PPP2R3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R3B Gene

ENSEMBL:
Gene Tree for PPP2R3B (if available)
TreeFam:
Gene Tree for PPP2R3B (if available)

Paralogs for PPP2R3B Gene

Paralogs for PPP2R3B Gene

Selected SIMAP similar genes for PPP2R3B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PPP2R3B Gene

genes like me logo Genes that share paralogs with PPP2R3B: view

Variants for PPP2R3B Gene

Sequence variations from dbSNP and Humsavar for PPP2R3B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_035109 -
VAR_055356 -

Structural Variations from Database of Genomic Variants (DGV) for PPP2R3B Gene

Variant ID Type Subtype PubMed ID
esv27923 CNV Loss 19812545
esv25834 CNV Gain+Loss 19812545
dgv2431e1 CNV Complex 17122850

Relevant External Links for PPP2R3B Gene

HapMap Linkage Disequilibrium report
PPP2R3B
Locus Specific Mutation Databases (LSDB)
PPP2R3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R3B Gene

Disorders for PPP2R3B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PPP2R3B Gene in MalaCards »

(1) Diseases for PPP2R3B Gene including...

genes like me logo Genes that share disorders with PPP2R3B: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PPP2R3B Gene

Publications for PPP2R3B Gene

  1. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with cdc6 and modulates DNA replication in human cells. (PMID: 10629059) Yan Z. … Williams R.S. (Mol. Cell. Biol. 2000) 3 4 23
  2. Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region. (PMID: 11173861) Schiebel K. … Rappold G. (Cytogenet. Cell Genet. 2000) 2 3
  3. Identification and characterization of B''-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues. (PMID: 12605688) Stevens I. … Van Hoof C. (Eur. J. Biochem. 2003) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for PPP2R3B Gene

Sources for PPP2R3B Gene

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