Aliases for PPP2R3B Gene
- Protein Phosphatase 2, Regulatory Subunit B'', Beta 2
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B, Beta 2 3
- Protein Phosphatase 2, Regulatory Subunit B, Beta 2 3
- PPP2R3L 3 4
- PR48 3 6
- Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B Subunit Beta 3
- Serine/Threonine Protein Phosphatase 2A, 48kDa Regulatory Subunit B 3
External Ids for PPP2R3B Gene
Previous Symbols for PPP2R3B Gene
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]
GeneCards Summary for PPP2R3B Gene
PPP2R3B (Protein Phosphatase 2, Regulatory Subunit B'', Beta) is a Protein Coding gene. Diseases associated with PPP2R3B include cavernous malformation. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include calcium ion binding and phosphoprotein phosphatase activity. An important paralog of this gene is PPP2R3C.
UniProtKB/Swiss-Prot for PPP2R3B Gene
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.