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GPLD1 Gene(Protein Coding)

Glycosylphosphatidylinositol Specific Phospholipase D1

GCID:
GC06M024425
GIFtS:
56
Genes Participants
UDN Logo

Aliases for GPLD1 Gene

Aliases for GPLD1 Gene

  • Glycosylphosphatidylinositol Specific Phospholipase D1 2 3 5
  • Glycoprotein Phospholipase D 3 4
  • GPI-Specific Phospholipase D 3 4
  • EC 3.1.4.50 4 61
  • PI-G PLD 3 4
  • GPI-PLD 3 4
  • PIGPLD1 3 4
  • Glycosyl-Phosphatidylinositol-Specific Phospholipase D 4
  • Phosphatidylinositol-Glycan-Specific Phospholipase D 3
  • GPIPLDM 3
  • GPIPLD 3
  • PIGPLD 3
  • PLD 3

External Ids for GPLD1 Gene

Previous GeneCards Identifiers for GPLD1 Gene

  • GC06M024485
  • GC06M024536
  • GC06M024377

Summaries for GPLD1 Gene

Entrez Gene Summary for GPLD1 Gene

  • Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPLD1 Gene

GPLD1 (Glycosylphosphatidylinositol Specific Phospholipase D1) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. GO annotations related to this gene include sodium channel regulator activity and glycosylphosphatidylinositol phospholipase D activity.

UniProtKB/Swiss-Prot for GPLD1 Gene

  • This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.

Gene Wiki entry for GPLD1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPLD1 Gene

Genomics for GPLD1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for GPLD1 Gene

Enhancers for GPLD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G024522 1.2 Ensembl ENCODE 12.3 -27.3 -27335 0.9 CAVIN1 TBX21 ZNF592 MEF2D CREB3 MAFF SMARCA4 MYNN NBN NR2C1 ALDH5A1 GPLD1 ACOT13 TDP2 PIR52732
GH06G024583 1.3 Ensembl ENCODE 10.4 -89.1 -89074 2.0 PKNOX1 ARNT FEZF1 ZNF2 ZNF121 ZNF143 ZNF207 KLF7 ZNF263 SP3 ACOT13 KIAA0319 TDP2 ALDH5A1 GPLD1 PIR39702 PIR60469
GH06G024689 0.9 dbSUPER 10.7 -197.7 -197658 6.3 HDGF FOXA2 ZNF133 FEZF1 YBX1 ZNF2 RAD21 YY1 ZNF121 EGR1 TDP2 KIAA0319 C6orf62 ACOT13 ALDH5A1 GPLD1 ENSG00000272345
GH06G024581 0.8 ENCODE 10.4 -86.1 -86053 0.1 CTCF ARID4B ZSCAN9 RAD21 RFX5 TEAD3 ZNF143 SMC3 ZNF600 HOMEZ TDP2 ACOT13 KIAA0319 ALDH5A1 GPLD1 PIR60469 PIR52732
GH06G025005 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.6 -512.9 -512920 4.6 TBP HDAC1 PKNOX1 ATF1 RAD21 YY1 ELK1 FOS RELB ETV6 RIPOR2 C6orf62 GPLD1 TDP2 ASS1P1 PPIAP29
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPLD1 on UCSC Golden Path with GeneCards custom track

Promoters for GPLD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000194780 105 1401 FOXA2 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Transcription factor binding sites by QIAGEN in the GPLD1 gene promoter:

Genomic Location for GPLD1 Gene

Chromosome:
6
Start:
24,424,565 bp from pter
End:
24,495,205 bp from pter
Size:
70,641 bases
Orientation:
Minus strand

Genomic View for GPLD1 Gene

Genes around GPLD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPLD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPLD1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GPLD1 Gene

Proteins for GPLD1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GPLD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80108-PHLD_HUMAN
    Recommended name:
    Phosphatidylinositol-glycan-specific phospholipase D
    Protein Accession:
    P80108
    Secondary Accessions:
    • Q15127
    • Q15128
    • Q2M2F2
    • Q5T3Y0
    • Q7Z6T8
    • Q8TCV0
    • Q8WW82
    • Q96ID6
    • Q9H167
    • Q9H4M1
    • Q9UJC9

    Protein attributes for GPLD1 Gene

    Size:
    840 amino acids
    Molecular mass:
    92336 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAA36444.1; Type=Miscellaneous discrepancy; Note=This sequence has numerous of conflicts with the human genome.; Evidence={ECO:0000305};

    Alternative splice isoforms for GPLD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPLD1 Gene

Protein Expression for GPLD1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for GPLD1 Gene

P80108:
  • HQDAYQAG
  • CNLPENPLFI
  • AGDFGGDVLSQFEF
  • DGLDEII

Post-translational modifications for GPLD1 Gene

  • Glycosylation at posLast=9494, isoforms=271, posLast=292292, isoforms=307, isoforms=321, posLast=501501, isoforms=568, isoforms=591, isoforms=604, and posLast=659659
  • Modification sites at PhosphoSitePlus

Other Protein References for GPLD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for GPLD1

Domains & Families for GPLD1 Gene

Protein Domains for GPLD1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GPLD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P80108

UniProtKB/Swiss-Prot:

PHLD_HUMAN :
  • Belongs to the GPLD1 family.
Family:
  • Belongs to the GPLD1 family.
genes like me logo Genes that share domains with GPLD1: view

No data available for Gene Families for GPLD1 Gene

Function for GPLD1 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for GPLD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(2)O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate.
UniProtKB/Swiss-Prot Function:
This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.

Enzyme Numbers (IUBMB) for GPLD1 Gene

Gene Ontology (GO) - Molecular Function for GPLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004621 glycosylphosphatidylinositol phospholipase D activity TAS 2017684
GO:0004630 phospholipase D activity IDA 2760042
GO:0016787 hydrolase activity IEA --
GO:0017080 sodium channel regulator activity ISS --
genes like me logo Genes that share ontologies with GPLD1: view
genes like me logo Genes that share phenotypes with GPLD1: view

Animal Models for GPLD1 Gene

MGI Knock Outs for GPLD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPLD1

miRNA for GPLD1 Gene

miRTarBase miRNAs that target GPLD1

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPLD1 Gene

Localization for GPLD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPLD1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPLD1 gene
Compartment Confidence
extracellular 5
lysosome 5
plasma membrane 3
cytosol 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GPLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix ISS --
GO:0005615 extracellular space IDA 1833386
GO:0005622 intracellular IDA 15907827
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with GPLD1: view

Pathways & Interactions for GPLD1 Gene

genes like me logo Genes that share pathways with GPLD1: view

Gene Ontology (GO) - Biological Process for GPLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification ISS --
GO:0002042 cell migration involved in sprouting angiogenesis IMP 17720976
GO:0002062 chondrocyte differentiation ISS --
GO:0002430 complement receptor mediated signaling pathway IDA 15907827
GO:0006501 C-terminal protein lipidation TAS --
genes like me logo Genes that share ontologies with GPLD1: view

No data available for SIGNOR curated interactions for GPLD1 Gene

Drugs & Compounds for GPLD1 Gene

Products:

  1. Drug

(10) Drugs for GPLD1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0

(30) Additional Compounds for GPLD1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
6-(alpha-D-Glucosaminyl)-1D-myo-inositol
  • (1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
  • (1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl 2-amino-2-deoxy-alpha-delta-glucopyranoside
  • 6-O-(2-Amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
  • 6-O-(2-Amino-2-deoxy-alpha-delta-glucopyranosyl)-1D-myo-inositol
  • Glucosaminyl-(alpha-6)-D-myo-inositol
LPA(0:0/16:0)
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
LPA(0:0/18:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
LPA(0:0/18:1(9Z))
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
genes like me logo Genes that share compounds with GPLD1: view

Transcripts for GPLD1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GPLD1 Gene

(5) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(84) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPLD1 Gene

Glycosylphosphatidylinositol specific phospholipase D1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPLD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP2:
SP3: -
SP4:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:

Relevant External Links for GPLD1 Gene

GeneLoc Exon Structure for
GPLD1
ECgene alternative splicing isoforms for
GPLD1

Expression for GPLD1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPLD1 Gene

mRNA expression in normal human tissues for GPLD1 Gene
mRNA expression by BioGPS for GPLD1 GenemRNA expression by GTEx for GPLD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPLD1 Gene

This gene is overexpressed in Liver (x8.5), Brain - Cerebellar Hemisphere (x5.2), and Brain - Cerebellum (x5.0).

Protein differential expression in normal tissues from HIPED for GPLD1 Gene

This gene is overexpressed in Serum (32.0), Plasma (15.3), and Synovial fluid (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPLD1 Gene



Protein tissue co-expression partners for GPLD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPLD1 Gene:

GPLD1

SOURCE GeneReport for Unigene cluster for GPLD1 Gene:

Hs.533291

Evidence on tissue expression from TISSUES for GPLD1 Gene

  • Liver(4.5)
  • Pancreas(4.3)
  • Bone marrow(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with GPLD1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPLD1 Gene

Orthologs for GPLD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GPLD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia GPLD1 34 35
  • 98.25 (n)
cow
(Bos Taurus)
 Mammalia GPLD1 34 35
  • 84.62 (n)
dog
(Canis familiaris)
 Mammalia GPLD1 34 35
  • 84.55 (n)
rat
(Rattus norvegicus)
 Mammalia Gpld1 34
  • 81.31 (n)
mouse
(Mus musculus)
 Mammalia Gpld1 34 16 35
  • 80.4 (n)
oppossum
(Monodelphis domestica)
 Mammalia GPLD1 35
  • 69 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia GPLD1 35
  • 63 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves GPLD1 34 35
  • 65.83 (n)
lizard
(Anolis carolinensis)
 Reptilia GPLD1 35
  • 59 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100493339 34
  • 63.94 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes -- 35
  • 18 (a)
 OneToOne
-- 37
Species where no ortholog for GPLD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GPLD1 Gene

ENSEMBL:
Gene Tree for GPLD1 (if available)
TreeFam:
Gene Tree for GPLD1 (if available)

Paralogs for GPLD1 Gene

No data available for Paralogs for GPLD1 Gene

Variants for GPLD1 Gene

Sequence variations from dbSNP and Humsavar for GPLD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs185042766 Likely benign 24,495,126(+) CCCAG(C/G)TCCGC reference, missense, utr-variant-5-prime
rs200793796 Likely benign 24,495,006(+) CGACC(G/T)GCATT reference, missense
rs4646832 Likely benign 24,495,102(+) CCTCC(C/G)GGCCT reference, missense, utr-variant-5-prime
rs535825137 Uncertain significance 24,495,289(+) AGAGG(C/G)CCGCG upstream-variant-2KB, reference, missense
rs572861590 Uncertain significance 24,495,364(+) GCCCG(A/G)ATGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPLD1 Gene

Variant ID Type Subtype PubMed ID
esv2229610 CNV deletion 18987734
esv2731712 CNV deletion 23290073
esv2763542 CNV gain 21179565
esv34020 CNV loss 18971310
esv3608368 CNV loss 21293372
nsv1026638 CNV gain 25217958
nsv476616 CNV novel sequence insertion 20440878
nsv515988 CNV loss 19592680
nsv519552 CNV gain 19592680
nsv525943 CNV loss 19592680
nsv820266 CNV gain 19587683

Variation tolerance for GPLD1 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.80; 73.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPLD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPLD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPLD1 Gene

Disorders for GPLD1 Gene

Relevant External Links for GPLD1

Genetic Association Database (GAD)
GPLD1
Human Genome Epidemiology (HuGE) Navigator
GPLD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPLD1

No disorders were found for GPLD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPLD1 Gene

Publications for GPLD1 Gene

  1. Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene. (PMID: 11072085) Schofield J.N. … Rademacher T.W. (Biochim. Biophys. Acta 2000) 2 3 4 22 64
  2. Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins. (PMID: 1606959) Hoener M.C. … Brodbeck U. (Eur. J. Biochem. 1992) 3 4 22 64
  3. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers J.C. … Kooner J.S. (Nat. Genet. 2011) 3 46 64
  4. [Expression and activity of glycosylphosphatidylinositol-specific phospholipase d mRNA in bone marrow mononuclear cells isolated from patient with acute myeloid leukemia and their significance]. (PMID: 20137110) Xiao G.F. … Zeng C. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010) 3 22 64
  5. PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. (PMID: 20648472) Speliotes E.K. … Hirschhorn J.N. (Hepatology 2010) 3 46 64

Products for GPLD1 Gene

  • Cloud-Clone Corp. Antibodies for GPLD1
  • Cloud-Clone Corp. Proteins for GPLD1
  • Cloud-Clone Corp Assay Kits for GPLD1

Sources for GPLD1 Gene

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