Aliases for GPI Gene
External Ids for GPI Gene
Previous GeneCards Identifiers for GPI Gene
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for GPI Gene
GPI (Glucose-6-Phosphate Isomerase) is a Protein Coding gene. Diseases associated with GPI include Hemolytic Anemia, Nonspherocytic, Due To Glucose Phosphate Isomerase Deficiency and Hemolytic Anemia Due To Glucophosphate Isomerase Deficiency. Among its related pathways are Glycosaminoglycan metabolism and Gene Expression. GO annotations related to this gene include cytokine activity and monosaccharide binding.
UniProtKB/Swiss-Prot for GPI Gene
Besides its role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.