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Aliases for GP5 Gene

Aliases for GP5 Gene

  • Glycoprotein V (Platelet) 2 3
  • Glycoprotein 5 3 4
  • GPV 3 4
  • Platelet Glycoprotein V 3
  • CD42d Antigen 4
  • CD42d 3

External Ids for GP5 Gene

Previous GeneCards Identifiers for GP5 Gene

  • GC03M193330
  • GC03M197566
  • GC03M195514
  • GC03M195433
  • GC03M195595
  • GC03M194115
  • GC03M191495

Summaries for GP5 Gene

Entrez Gene Summary for GP5 Gene

  • Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]

GeneCards Summary for GP5 Gene

GP5 (Glycoprotein V (Platelet)) is a Protein Coding gene. Diseases associated with GP5 include cervix uteri carcinoma in situ and gray platelet syndrome. Among its related pathways are Hemostasis and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. GO annotations related to this gene include collagen binding. An important paralog of this gene is LRRTM2.

UniProtKB/Swiss-Prot for GP5 Gene

  • The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis

Gene Wiki entry for GP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GP5 Gene

Genomics for GP5 Gene

Regulatory Elements for GP5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GP5 Gene

Start:
194,394,821 bp from pter
End:
194,399,266 bp from pter
Size:
4,446 bases
Orientation:
Minus strand

Genomic View for GP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GP5 Gene

Proteins for GP5 Gene

  • Protein details for GP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40197-GPV_HUMAN
    Recommended name:
    Platelet glycoprotein V
    Protein Accession:
    P40197
    Secondary Accessions:
    • D1MER9

    Protein attributes for GP5 Gene

    Size:
    560 amino acids
    Molecular mass:
    60959 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GP5 Gene

Proteomics data for GP5 Gene at MOPED

Post-translational modifications for GP5 Gene

  • The N-terminus is blocked
  • Glycosylation at Asn51, Asn181, Asn243, Asn267, Asn298, Asn312, Asn385, and Asn499
  • Modification sites at PhosphoSitePlus

Other Protein References for GP5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GP5 Gene

Domains for GP5 Gene

Gene Families for GP5 Gene

HGNC:
  • CD :CD molecules

Suggested Antigen Peptide Sequences for GP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P40197

UniProtKB/Swiss-Prot:

GPV_HUMAN :
  • P40197
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 13 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with GP5: view

Function for GP5 Gene

Molecular function for GP5 Gene

GENATLAS Biochemistry: platelet glycoprotein V,83kDa,non covalently bound to the GP1B and GP9 complex in the von Willebrand receptor
UniProtKB/Swiss-Prot Function: The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis

Gene Ontology (GO) - Molecular Function for GP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005518 collagen binding IEA --
genes like me logo Genes that share ontologies with GP5: view

Phenotypes for GP5 Gene

genes like me logo Genes that share phenotypes with GP5: view

Animal Models for GP5 Gene

MGI Knock Outs for GP5:

Animal Model Products

CRISPR Products

miRNA for GP5 Gene

miRTarBase miRNAs that target GP5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GP5 Gene

Localization for GP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GP5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GP5 Gene COMPARTMENTS Subcellular localization image for GP5 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7690959
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GP5: view

Pathways for GP5 Gene

genes like me logo Genes that share pathways with GP5: view

Interacting Proteins for GP5 Gene

Selected Interacting proteins: P40197-GPV_HUMAN for GP5 Gene via I2D

Gene Ontology (GO) - Biological Process for GP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion NAS 7690959
GO:0007160 cell-matrix adhesion IEA --
GO:0007596 blood coagulation TAS --
GO:0007597 blood coagulation, intrinsic pathway TAS --
GO:0010544 negative regulation of platelet activation IEA --
genes like me logo Genes that share ontologies with GP5: view

Compounds for GP5 Gene

(4) Novoseek inferred chemical compound relationships for GP5 Gene

Compound -log(P) Hits PubMed IDs
aspirin 31.3 1
fibrinogen 27.2 3
leucine 9.75 1
lactate 0 1
genes like me logo Genes that share compounds with GP5: view

Transcripts for GP5 Gene

mRNA/cDNA for GP5 Gene

(1) REFSEQ mRNAs :
(8) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GP5 Gene

Glycoprotein V (platelet):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GP5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GP5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GP5 Gene

No ASD Table

Relevant External Links for GP5 Gene

GeneLoc Exon Structure for
GP5
ECgene alternative splicing isoforms for
GP5

Expression for GP5 Gene

mRNA expression in normal human tissues for GP5 Gene

mRNA differential expression in normal tissues according to GTEx for GP5 Gene

This gene is overexpressed in Whole Blood (7.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GP5 Gene

SOURCE GeneReport for Unigene cluster for GP5 Gene Hs.73734

mRNA Expression by UniProt/SwissProt for GP5 Gene

P40197-GPV_HUMAN
Tissue specificity: Platelets and megakaryocytes
genes like me logo Genes that share expressions with GP5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GP5 Gene

Orthologs for GP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GP5 35
  • 99.29 (n)
  • 99.11 (a)
GP5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GP5 35
  • 82.64 (n)
  • 76.89 (a)
GP5 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gp5 35
  • 78.73 (n)
  • 70.97 (a)
Gp5 16
Gp5 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves GP5 36
  • 34 (a)
OneToOne
LOC100857508 35
  • 52.85 (n)
  • 45.01 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gp5 35
  • 48.22 (n)
  • 39.56 (a)
zebrafish
(Danio rerio)
Actinopterygii GP5 36
  • 35 (a)
OneToOne
LOC101884430 35
  • 47.63 (n)
  • 38.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16974 36
  • 10 (a)
OneToMany
Species with no ortholog for GP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GP5 Gene

ENSEMBL:
Gene Tree for GP5 (if available)
TreeFam:
Gene Tree for GP5 (if available)

Paralogs for GP5 Gene

Selected SIMAP similar genes for GP5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GP5: view

Variants for GP5 Gene

Sequence variations from dbSNP and Humsavar for GP5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3047 -- 194,396,413(-) CTCAC(A/G)GGCCC utr-variant-3-prime
rs1223989 -- 194,398,145(-) GCGCT(A/G)GGCCT reference, synonymous-codon
rs1238773 -- 194,400,891(-) tttca(A/G)agagc upstream-variant-2KB
rs1466733 -- 194,400,269(-) taaaa(C/T)catgc upstream-variant-2KB
rs1538863 -- 194,398,379(-) CGAAA(A/G)GATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GP5 Gene

Variant ID Type Subtype PubMed ID
nsv4178 CNV Insertion 18451855

Relevant External Links for GP5 Gene

HapMap Linkage Disequilibrium report
GP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GP5 Gene

Disorders for GP5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for GP5 Gene including...

Search for GP5 Gene in MalaCards »

(4) University of Copenhagen DISEASES for GP5 Gene

(7) Novoseek inferred disease relationships for GP5 Gene

Disease -log(P) Hits PubMed IDs
bernard-soulier syndrome 93.9 8
gray platelet syndrome 79 1
platelet disorder 67.6 2
autoimmune thrombocytopenia 60.9 1
coagulopathy 59.9 1

Relevant External Links for GP5

Genetic Association Database (GAD)
GP5
Human Genome Epidemiology (HuGE) Navigator
GP5
genes like me logo Genes that share disorders with GP5: view

No data available for UniProtKB/Swiss-Prot for GP5 Gene

Publications for GP5 Gene

  1. Application of a diagnostic algorithm for inherited thrombocytopenias to 46 consecutive patients. (PMID: 15477207) Noris P. … Balduini C.L. (Haematologica 2004) 3 23 48
  2. Rapid purification and characterization of human platelet glycoprotein V: the amino acid sequence contains leucine-rich repetitive modules as in glycoprotein Ib. (PMID: 2350580) Shimomura T. … Kuramoto A. (Blood 1990) 3 4 23
  3. Human platelet glycoprotein V: a surface leucine-rich glycoprotein related to adhesion. (PMID: 2372284) Roth G.J. … Williams S.A. (Biochem. Biophys. Res. Commun. 1990) 3 4 23
  4. Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation. (PMID: 8407908) Lanza F. … Phillips D.R. (J. Biol. Chem. 1993) 3 4 23
  5. Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins. (PMID: 7690959) Hickey M.J. … Roth G.J. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4

Products for GP5 Gene

  • Addgene plasmids for GP5

Sources for GP5 Gene

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